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The map label for this gene is msrA

Identifier: 16079228

GI number: 16079228

Start: 2287529

End: 2288062

Strand: Reverse

Name: msrA

Synonym: BSU21690

Alternate gene names: 16079228

Gene position: 2288062-2287529 (Counterclockwise)

Preceding gene: 16079230

Following gene: 16079227

Centisome position: 54.28

GC content: 45.32

Gene sequence:

>534_bases
ATGTCTGAAAAAAAAGAAATCGCCACATTTGCAGGAGGCTGTTTTTGGTGTATGGTTAAACCTTTTGACGAACAGCCGGG
AATTGAAAAAGTGGTGTCCGGGTATACAGGCGGCCATACTGAAAACCCTACGTACGAAGAGGTGTGCAGTGAAACGACGG
GACATCGTGAAGCCGTTCAAATCACGTTTCATCCTGATGTATTCCCTTATGAAAAACTGCTTGAATTATTTTGGCAGCAA
ATCGATCCGACAGATGCCGGAGGGCAATTTGCTGATCGCGGCAGTTCCTATCGCGCAGCCATTTTTTATCATAATGATAA
ACAAAAGGAGCTTGCGGAAGCTTCCAAGCAACGTCTGGCGGAAAGCGGCATCTTTAAAGATCCGATTGTAACGGACATTT
TAAAAGCTGAACCTTTCTATGAAGCGGAAGGCTACCATCAGCATTTTTATAAAAAGAATCCAGCACATTATCAGCGCTAC
CGGACAGGTTCCGGACGAGCGGGATTTATCAGCGAGCATTGGGGGGCTAAATAA

Upstream 100 bases:

>100_bases
CTTAAAACCTATAGATTTTATTGAAAAGCAGAATCATTTTCATTCTATTTTTACATGCTATAATATAATAATACCACGTA
TTAACAAAGGAGGCACCAGT

Downstream 100 bases:

>100_bases
ATGGCGTACAATAAAGAAGAAAAAATAAAGTCATTAAATCGCATGCAATATGAAGTAACGCAAAATAACGGCACGGAGCC
GCCATTTCAAAATGAATATT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPTYEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQ
IDPTDAGGQFADRGSSYRAAIFYHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY
RTGSGRAGFISEHWGAK

Sequences:

>Translated_177_residues
MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPTYEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQ
IDPTDAGGQFADRGSSYRAAIFYHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY
RTGSGRAGFISEHWGAK
>Mature_176_residues
SEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPTYEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQI
DPTDAGGQFADRGSSYRAAIFYHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRYR
TGSGRAGFISEHWGAK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. May deal with oxidative damage to alpha/beta-type SASP in sp

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=42.7672955974843, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=42.7672955974843, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI208609993, Length=111, Percent_Identity=42.3423423423423, Blast_Score=87, Evalue=7e-18,
Organism=Escherichia coli, GI1790665, Length=157, Percent_Identity=44.5859872611465, Blast_Score=136, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=34.4594594594595, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=32.3170731707317, Blast_Score=79, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=33.7931034482759, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=33.1034482758621, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=32.8467153284672, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_BACSU (P54154)

Other databases:

- EMBL:   L77246
- EMBL:   AL009126
- PIR:   E69940
- RefSeq:   NP_390052.1
- ProteinModelPortal:   P54154
- SMR:   P54154
- EnsemblBacteria:   EBBACT00000000043
- GeneID:   939099
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU21690
- NMPDR:   fig|224308.1.peg.2175
- GenoList:   BSU21690
- GeneTree:   EBGT00050000000580
- HOGENOM:   HBG748152
- OMA:   SIFPYEK
- PhylomeDB:   P54154
- ProtClustDB:   PRK14054
- BioCyc:   BSUB:BSU21690-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 20183; Mature: 20051

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: ACT_SITE 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPTYEEVCSETTGHREAVQ
CCCHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEE
ITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIFYHNDKQKELAEASKQRLA
EEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCEEEEEEEECCHHHHHHHHHHHHHH
ESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRYRTGSGRAGFISEHWGAK
HCCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPTYEEVCSETTGHREAVQ
CCHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEE
ITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIFYHNDKQKELAEASKQRLA
EEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCEEEEEEEECCHHHHHHHHHHHHHH
ESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRYRTGSGRAGFISEHWGAK
HCCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9573155