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The map label for this gene is uraP

Identifier: 15607101

GI number: 15607101

Start: 1524118

End: 1524744

Strand: Direct

Name: uraP

Synonym: aq_2163

Alternate gene names: 15607101

Gene position: 1524118-1524744 (Clockwise)

Preceding gene: 15607100

Following gene: 15607106

Centisome position: 98.25

GC content: 42.9

Gene sequence:

>627_bases
ATGATCGTGGAATTATCTCACCCCCTGATAAAGCACAAGGTAAACACAGCAAGAATACAGGACACTTCCGCAGAAAAGCT
CAGGAAAACCTTAAAGGAACTTGGTTTTATGCTTGTATATGAAGCCCTAAAAGACATACTTTTAGAGGAAAAGGAAGTCA
GAACGTGGATAGGTAACAAAAGATTTAATTACTTGAATGAAGAAGAAATAGTATTCGTTCCCATACTGAGGGCGGGACTT
TCCTTTCTGGAGGGAGCACTCCAAGTCGTACCGAACGCAAAGGTAGGATTTCTAGGAATAAAGAGAAACGAAGAGACTCT
TGAATCTCACATATACTACTCAAGACTGCCAGAGCTGAAGGGAAAAATCGTAGTTATACTTGACCCCATGCTTGCAACCG
GAGGAACGCTGGAAGTGGCGTTAAGGGAAATCCTCAAACACTCACCTCTTAAGGTAAAGAGCGTGCACGCGATAGCCGCC
CCGGAGGGTCTAAAAAGGATAGAAGAAAAGTTTAAAGAAGTGGAAATCTTTGTGGGAAATGTAGATGAAAGATTAAACGA
CAAGGGATACATAATCCCGGGTCTGGGAGACATAGGCGACAGGTTATACGCGGTAAGTGTGTATTGA

Upstream 100 bases:

>100_bases
GACGGCAAAGTGGTGGAAGAAGGAGACGTTTTTGAGATTTTTGACAATCCTAAGCACGAATACACAAAAAAACTTCTCTC
TGCGATTTAAAATAGAAGGA

Downstream 100 bases:

>100_bases
TTTCTTTTCTTTGATCATTTTCGCTATTTCCTCATAGTTGTCGTTCAGTCTTCTGTCTATTTTTTCCACAACTAGCTCCA
CGTTTTCTGGTATGGATATC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MIVELSHPLIKHKVNTARIQDTSAEKLRKTLKELGFMLVYEALKDILLEEKEVRTWIGNKRFNYLNEEEIVFVPILRAGL
SFLEGALQVVPNAKVGFLGIKRNEETLESHIYYSRLPELKGKIVVILDPMLATGGTLEVALREILKHSPLKVKSVHAIAA
PEGLKRIEEKFKEVEIFVGNVDERLNDKGYIIPGLGDIGDRLYAVSVY

Sequences:

>Translated_208_residues
MIVELSHPLIKHKVNTARIQDTSAEKLRKTLKELGFMLVYEALKDILLEEKEVRTWIGNKRFNYLNEEEIVFVPILRAGL
SFLEGALQVVPNAKVGFLGIKRNEETLESHIYYSRLPELKGKIVVILDPMLATGGTLEVALREILKHSPLKVKSVHAIAA
PEGLKRIEEKFKEVEIFVGNVDERLNDKGYIIPGLGDIGDRLYAVSVY
>Mature_208_residues
MIVELSHPLIKHKVNTARIQDTSAEKLRKTLKELGFMLVYEALKDILLEEKEVRTWIGNKRFNYLNEEEIVFVPILRAGL
SFLEGALQVVPNAKVGFLGIKRNEETLESHIYYSRLPELKGKIVVILDPMLATGGTLEVALREILKHSPLKVKSVHAIAA
PEGLKRIEEKFKEVEIFVGNVDERLNDKGYIIPGLGDIGDRLYAVSVY

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=209, Percent_Identity=27.7511961722488, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI57863312, Length=209, Percent_Identity=27.7511961722488, Blast_Score=74, Evalue=8e-14,
Organism=Escherichia coli, GI87082118, Length=205, Percent_Identity=39.5121951219512, Blast_Score=166, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17539892, Length=204, Percent_Identity=25, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=204, Percent_Identity=25, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=140, Percent_Identity=37.1428571428571, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28573516, Length=204, Percent_Identity=29.9019607843137, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573514, Length=204, Percent_Identity=29.9019607843137, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573512, Length=204, Percent_Identity=29.9019607843137, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45550449, Length=205, Percent_Identity=29.7560975609756, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_AQUAE (O67914)

Other databases:

- EMBL:   AE000657
- PIR:   F70485
- RefSeq:   NP_214483.1
- PDB:   2E55
- PDBsum:   2E55
- ProteinModelPortal:   O67914
- SMR:   O67914
- GeneID:   1193903
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_2163
- NMPDR:   fig|224324.1.peg.1498
- HOGENOM:   HBG326432
- OMA:   VYVLDPM
- PhylomeDB:   O67914
- BioCyc:   AAEO224324:AQ_2163-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23533; Mature: 23533

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: BINDING 77-77 BINDING 102-102 BINDING 191-191 BINDING 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVELSHPLIKHKVNTARIQDTSAEKLRKTLKELGFMLVYEALKDILLEEKEVRTWIGNK
CEEECCCHHHHHCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCC
RFNYLNEEEIVFVPILRAGLSFLEGALQVVPNAKVGFLGIKRNEETLESHIYYSRLPELK
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCC
GKIVVILDPMLATGGTLEVALREILKHSPLKVKSVHAIAAPEGLKRIEEKFKEVEIFVGN
CCEEEEECCCHHCCCHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHHEEEECC
VDERLNDKGYIIPGLGDIGDRLYAVSVY
HHHHCCCCCEEECCCCCCCCCEEEEEEC
>Mature Secondary Structure
MIVELSHPLIKHKVNTARIQDTSAEKLRKTLKELGFMLVYEALKDILLEEKEVRTWIGNK
CEEECCCHHHHHCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCC
RFNYLNEEEIVFVPILRAGLSFLEGALQVVPNAKVGFLGIKRNEETLESHIYYSRLPELK
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCC
GKIVVILDPMLATGGTLEVALREILKHSPLKVKSVHAIAAPEGLKRIEEKFKEVEIFVGN
CCEEEEECCCHHCCCHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHHEEEECC
VDERLNDKGYIIPGLGDIGDRLYAVSVY
HHHHCCCCCEEECCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320