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The map label for this gene is cobB

Identifier: 15607106

GI number: 15607106

Start: 1528662

End: 1529381

Strand: Direct

Name: cobB

Synonym: aq_2170

Alternate gene names: 15607106

Gene position: 1528662-1529381 (Clockwise)

Preceding gene: 15607101

Following gene: 15607107

Centisome position: 98.54

GC content: 49.31

Gene sequence:

>720_bases
ATGGAAAACCTGAATATAGTCACCCTAACGGGAGCAGGGATATCCGCGGAAAGTGGTATACCCACCTTTAGGGGTAAAGA
CGGGCTCTGGAACAAGTTCAAACCCGAAGAACTCGCAACACCGGAAGCTTTCTTCAGAAACCCGAAACTCGTCTGGGAGT
GGTACGACTGGAAGAGGCAGCTAATAGCGAAAGCCCAACCCAACGAAGGACACAAAATACTTACAAAAATGGAAGAGGAG
TTCCCGAACTTTTACCTTATAACCCAGAACGTTGACGGACTTCACCAAAGGGCGGGTTCAAAAAAGGTTATAGAACTCCA
CGGAAACATATGGAAGGTAAGGTGTGTGGAGTGCGGAAACGAAAGGTACGAGTACACAACACCTCTTCCCGAAATTCCTC
CAAAGTGTGAGAAGTGCGGAGGGCTTTTGAGACCCGGGGTAGTCTGGTTCGGAGAGAGCCTGCCGGTGGATGCCCTGAGC
AGGGCTTATGAGCTATCAAGGGAAGCCCACGTGTTCATAGTTGTAGGAACTTCGGGAGTCGTGTATCCCGCTGCGGAACT
CCCCTTCGTGGCAAAAGAAAACGGAGCCCAAGTAATAGAAGTAAACCCGGAAGAGACTCCAATAACGAAGATTGCGGACA
TGCACTTTAAGGAAAAGGCGAGCACGGGACTGAAAAAAGTTTACGATTACCTGAGGGAAAAGTATGGCTCTAAGGGATAG

Upstream 100 bases:

>100_bases
GTTATGTTTATGAGTGAGAGAAACCTGTCCCTCAATTACAAAGAGCAGTAAAAGAATTGCTACTAAAATTCTCATTTAAC
GTTTAGTATCTTATTTTAAC

Downstream 100 bases:

>100_bases
GGTGAAGAAATTAAAACTCCTCATAATGGACATAGACGGCGTTCTTACCGACGGGAAACTCTACTACACGGAACACGGGG
AAACGATTAAAGTTTTCAAC

Product: hypothetical protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MENLNIVTLTGAGISAESGIPTFRGKDGLWNKFKPEELATPEAFFRNPKLVWEWYDWKRQLIAKAQPNEGHKILTKMEEE
FPNFYLITQNVDGLHQRAGSKKVIELHGNIWKVRCVECGNERYEYTTPLPEIPPKCEKCGGLLRPGVVWFGESLPVDALS
RAYELSREAHVFIVVGTSGVVYPAAELPFVAKENGAQVIEVNPEETPITKIADMHFKEKASTGLKKVYDYLREKYGSKG

Sequences:

>Translated_239_residues
MENLNIVTLTGAGISAESGIPTFRGKDGLWNKFKPEELATPEAFFRNPKLVWEWYDWKRQLIAKAQPNEGHKILTKMEEE
FPNFYLITQNVDGLHQRAGSKKVIELHGNIWKVRCVECGNERYEYTTPLPEIPPKCEKCGGLLRPGVVWFGESLPVDALS
RAYELSREAHVFIVVGTSGVVYPAAELPFVAKENGAQVIEVNPEETPITKIADMHFKEKASTGLKKVYDYLREKYGSKG
>Mature_239_residues
MENLNIVTLTGAGISAESGIPTFRGKDGLWNKFKPEELATPEAFFRNPKLVWEWYDWKRQLIAKAQPNEGHKILTKMEEE
FPNFYLITQNVDGLHQRAGSKKVIELHGNIWKVRCVECGNERYEYTTPLPEIPPKCEKCGGLLRPGVVWFGESLPVDALS
RAYELSREAHVFIVVGTSGVVYPAAELPFVAKENGAQVIEVNPEETPITKIADMHFKEKASTGLKKVYDYLREKYGSKG

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI300795542, Length=231, Percent_Identity=44.5887445887446, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI6912664, Length=249, Percent_Identity=42.570281124498, Blast_Score=185, Evalue=3e-47,
Organism=Homo sapiens, GI13787215, Length=234, Percent_Identity=43.5897435897436, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI6912662, Length=251, Percent_Identity=29.4820717131474, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI300797577, Length=245, Percent_Identity=30.6122448979592, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7657575, Length=222, Percent_Identity=29.2792792792793, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI13775602, Length=199, Percent_Identity=30.6532663316583, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI13775600, Length=199, Percent_Identity=30.6532663316583, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI6912660, Length=203, Percent_Identity=31.5270935960591, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI300797705, Length=190, Percent_Identity=30, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI63054862, Length=199, Percent_Identity=31.6582914572864, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI300797597, Length=232, Percent_Identity=29.3103448275862, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7706712, Length=158, Percent_Identity=29.746835443038, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI308199517, Length=211, Percent_Identity=43.6018957345972, Blast_Score=168, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17541892, Length=216, Percent_Identity=30.5555555555556, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17567771, Length=261, Percent_Identity=31.8007662835249, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71990482, Length=261, Percent_Identity=31.0344827586207, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71990487, Length=263, Percent_Identity=30.7984790874525, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325242, Length=215, Percent_Identity=33.4883720930233, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320163, Length=240, Percent_Identity=24.5833333333333, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28571445, Length=266, Percent_Identity=30.0751879699248, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24648389, Length=196, Percent_Identity=33.6734693877551, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137536, Length=219, Percent_Identity=26.9406392694064, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571443, Length=213, Percent_Identity=28.169014084507, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571441, Length=213, Percent_Identity=28.169014084507, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24645650, Length=245, Percent_Identity=27.3469387755102, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD_AQUAE (O67919)

Other databases:

- EMBL:   AE000657
- PIR:   C70486
- RefSeq:   NP_214488.1
- ProteinModelPortal:   O67919
- SMR:   O67919
- GeneID:   1193908
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_2170
- NMPDR:   fig|224324.1.peg.1503
- HOGENOM:   HBG641281
- OMA:   RPSSDMA
- PhylomeDB:   O67919
- ProtClustDB:   CLSK2748570
- BioCyc:   AAEO224324:AQ_2170-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26999; Mature: 26999

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENLNIVTLTGAGISAESGIPTFRGKDGLWNKFKPEELATPEAFFRNPKLVWEWYDWKRQ
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHCCCCEEEEHHHHHHH
LIAKAQPNEGHKILTKMEEEFPNFYLITQNVDGLHQRAGSKKVIELHGNIWKVRCVECGN
HHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCEEEEECCCEEEEEEEECCC
ERYEYTTPLPEIPPKCEKCGGLLRPGVVWFGESLPVDALSRAYELSREAHVFIVVGTSGV
CCEEEECCCCCCCCCHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCE
VYPAAELPFVAKENGAQVIEVNPEETPITKIADMHFKEKASTGLKKVYDYLREKYGSKG
EECCCCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MENLNIVTLTGAGISAESGIPTFRGKDGLWNKFKPEELATPEAFFRNPKLVWEWYDWKRQ
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHCCCCEEEEHHHHHHH
LIAKAQPNEGHKILTKMEEEFPNFYLITQNVDGLHQRAGSKKVIELHGNIWKVRCVECGN
HHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCEEEEECCCEEEEEEEECCC
ERYEYTTPLPEIPPKCEKCGGLLRPGVVWFGESLPVDALSRAYELSREAHVFIVVGTSGV
CCEEEECCCCCCCCCHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCE
VYPAAELPFVAKENGAQVIEVNPEETPITKIADMHFKEKASTGLKKVYDYLREKYGSKG
EECCCCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320