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Identifier: 16519896

GI number: 16519896

Start: 274518

End: 275912

Strand: Reverse

Name: Not Available

Synonym: NGR_a02090

Alternate gene names: 16519896

Gene position: 275912-274518 (Counterclockwise)

Preceding gene: 16519895

Following gene: 16519905

Centisome position: 51.46

GC content: 60.72

Gene sequence:

>1395_bases
ATGAGCCGTCTCGTCATTGTTTCCAATCGCGTACCTGTTCCGGACAAGGGTGGCATTGCGCCGGCCGGTGGGCTGGCGGT
CGCGCTGAAAGTCGCCCTCGAAGAGCAGGGCGGCGGCATATGGATGGGCTGGTCGGGAAAGTCGAGTGGCGAGGACGAGC
CGGCGCCGCTTGCGCAACTGCAGCAGGGCAATATTACCTATGCACTGACGGATCTGACCGATACCGACGTAGAGGAATAC
TACCACGGCTTCGCCAACCGCGTTCTCTGGCCGATTTGCCACTACCGCCTTGATCTCGCCGAATACGGTCGCAAGGAAAT
GGCCGGGTATTTCCGCGTCAACCGCTTCTTCGCCCATCGCCTGGCGCCGCTTGTCAAACCCGATGACGTCATTTGGGTGC
ACGACTACCCCTTGATTCCTCTCGCCGCGGAACTGCGTCAGATGGGCCTGGAGAACCGCATCGGCTTCTTCCTCCACATT
CCCTGGCCGCCTGCAGACGTACTCTTCACGATGCCCGTTCACGAGGAGATCATGCGCGGCCTGTCGCACTACGACGTCGT
CGGCTTTCAGACCGATCATGACCTTGAGAACTTCGCCAGCTGCCTCAGGCGGGAAGGCATCGGCGACGCACTTGGCGGAG
GCCGCTTGAGTGCCTATGGCCGCATATTCAAAGGCGGCGTCTATGCAATCGGCATCGAGACTGCGGCCTTCGCCGAATTC
GCCAAAAAGGCATCGACCAACAGCACGGTCAAAAAGGCGCGTGAAAGCATCGAGCGCCGCAGCCTCATCATCGGTGTCGA
TCGCCTCGATTATTCCAAGGGACTGACGCAGCGCATCGAAGCGTTTGAGCGCTTCATCCTGGCCAATCCGGCACAGCGGG
GGCGTGTCACCTATCTGCAAATCACGCCAAAGTCGCGCTCCGAAGTGCCGGAATATGAAGCCATGCAACGCACTGTTGCC
GAACAGGCCGGCAGGGTGAACGGCGCGCTCGGCGCCGTCGATTGGGTGCCTATGCGCTACATCAACCGCTCGGTGGGCCG
CCGCGTTCTTGCAGGGCTTTACCGGCTTGGCAAAGTCGGCCTCGTGACGCCGCTTCGAGACGGCAAGAACCTCGTCGCAA
AGGAATATGTTGCCGCGCAGGATCCGGACGATCCGGGCGTGCTTGTTCTTTCGCGCTTCGCGGGCGCTGCCCGCGAGCTA
CAGGGAGCACTTCTTGTCAATCCCTACGACATAGAGGGCACCGCCAACGCCATGGCGCGCTCGCTCAGCATGCCGCTGGA
AGAGCGGCAGGAACGCTGGACGACGATGATGGATCAATTGCTGGAACACGACGTTTCGCGCTGGTGCCGGGATTTTCTCA
ATGATCTGACGGCATCATCAGATCGATGTGGTTAG

Upstream 100 bases:

>100_bases
TCCATCCCTTCTGCCGAGGCCCTGCGCGGCATCATCGCCGCATTGGCCCTCCTGAATATTTGAGCACCTGACATATTTTC
TTGCATGAAAGGAATTCGGC

Downstream 100 bases:

>100_bases
GGCTCCTTCAATCAAAGATCATCATCGTGCCATTAATGAAGTCCGGCGACCGGCTGCGGCGTTATCGCCATAGCCGCCTG
GCCGCATTTGGATCGTCGGC

Product: alpha,alpha-trehalose-6-phosphate synthase

Products: NA

Alternate protein names: Osmoregulatory trehalose synthesis protein A; Trehalose-6-phosphate synthase; UDP-glucose-glucosephosphate glucosyltransferase

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSRLVIVSNRVPVPDKGGIAPAGGLAVALKVALEEQGGGIWMGWSGKSSGEDEPAPLAQLQQGNITYALTDLTDTDVEEY
YHGFANRVLWPICHYRLDLAEYGRKEMAGYFRVNRFFAHRLAPLVKPDDVIWVHDYPLIPLAAELRQMGLENRIGFFLHI
PWPPADVLFTMPVHEEIMRGLSHYDVVGFQTDHDLENFASCLRREGIGDALGGGRLSAYGRIFKGGVYAIGIETAAFAEF
AKKASTNSTVKKARESIERRSLIIGVDRLDYSKGLTQRIEAFERFILANPAQRGRVTYLQITPKSRSEVPEYEAMQRTVA
EQAGRVNGALGAVDWVPMRYINRSVGRRVLAGLYRLGKVGLVTPLRDGKNLVAKEYVAAQDPDDPGVLVLSRFAGAAREL
QGALLVNPYDIEGTANAMARSLSMPLEERQERWTTMMDQLLEHDVSRWCRDFLNDLTASSDRCG

Sequences:

>Translated_464_residues
MSRLVIVSNRVPVPDKGGIAPAGGLAVALKVALEEQGGGIWMGWSGKSSGEDEPAPLAQLQQGNITYALTDLTDTDVEEY
YHGFANRVLWPICHYRLDLAEYGRKEMAGYFRVNRFFAHRLAPLVKPDDVIWVHDYPLIPLAAELRQMGLENRIGFFLHI
PWPPADVLFTMPVHEEIMRGLSHYDVVGFQTDHDLENFASCLRREGIGDALGGGRLSAYGRIFKGGVYAIGIETAAFAEF
AKKASTNSTVKKARESIERRSLIIGVDRLDYSKGLTQRIEAFERFILANPAQRGRVTYLQITPKSRSEVPEYEAMQRTVA
EQAGRVNGALGAVDWVPMRYINRSVGRRVLAGLYRLGKVGLVTPLRDGKNLVAKEYVAAQDPDDPGVLVLSRFAGAAREL
QGALLVNPYDIEGTANAMARSLSMPLEERQERWTTMMDQLLEHDVSRWCRDFLNDLTASSDRCG
>Mature_463_residues
SRLVIVSNRVPVPDKGGIAPAGGLAVALKVALEEQGGGIWMGWSGKSSGEDEPAPLAQLQQGNITYALTDLTDTDVEEYY
HGFANRVLWPICHYRLDLAEYGRKEMAGYFRVNRFFAHRLAPLVKPDDVIWVHDYPLIPLAAELRQMGLENRIGFFLHIP
WPPADVLFTMPVHEEIMRGLSHYDVVGFQTDHDLENFASCLRREGIGDALGGGRLSAYGRIFKGGVYAIGIETAAFAEFA
KKASTNSTVKKARESIERRSLIIGVDRLDYSKGLTQRIEAFERFILANPAQRGRVTYLQITPKSRSEVPEYEAMQRTVAE
QAGRVNGALGAVDWVPMRYINRSVGRRVLAGLYRLGKVGLVTPLRDGKNLVAKEYVAAQDPDDPGVLVLSRFAGAARELQ
GALLVNPYDIEGTANAMARSLSMPLEERQERWTTMMDQLLEHDVSRWCRDFLNDLTASSDRCG

Specific function: Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate

COG id: COG0380

COG function: function code G; Trehalose-6-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 20 family

Homologues:

Organism=Escherichia coli, GI1788206, Length=458, Percent_Identity=46.2882096069869, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI115533560, Length=417, Percent_Identity=29.2565947242206, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI115533558, Length=417, Percent_Identity=29.2565947242206, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71987012, Length=436, Percent_Identity=25.9174311926606, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319602, Length=467, Percent_Identity=31.9057815845824, Blast_Score=276, Evalue=6e-75,
Organism=Saccharomyces cerevisiae, GI6323917, Length=458, Percent_Identity=27.0742358078603, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6323537, Length=434, Percent_Identity=26.7281105990783, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6320279, Length=400, Percent_Identity=27.25, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI19920676, Length=492, Percent_Identity=35.9756097560976, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTSA_RHISN (P55612)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_444016.1
- ProteinModelPortal:   P55612
- SMR:   P55612
- GeneID:   962413
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a02090
- HOGENOM:   HBG559076
- ProtClustDB:   CLSK891867
- InterPro:   IPR001830
- InterPro:   IPR012766
- TIGRFAMs:   TIGR02400

Pfam domain/function: PF00982 Glyco_transf_20

EC number: =2.4.1.15

Molecular weight: Translated: 51628; Mature: 51496

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 81-81 BINDING 135-135 BINDING 268-268 BINDING 273-273 BINDING 306-306 BINDING 340-340

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLVIVSNRVPVPDKGGIAPAGGLAVALKVALEEQGGGIWMGWSGKSSGEDEPAPLAQL
CCCEEEEECCCCCCCCCCCCCCCHHHHHHEEEEEECCCEEEEECCCCCCCCCCCCCHHHH
QQGNITYALTDLTDTDVEEYYHGFANRVLWPICHYRLDLAEYGRKEMAGYFRVNRFFAHR
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LAPLVKPDDVIWVHDYPLIPLAAELRQMGLENRIGFFLHIPWPPADVLFTMPVHEEIMRG
HCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCEEEECCHHHHHHHC
LSHYDVVGFQTDHDLENFASCLRREGIGDALGGGRLSAYGRIFKGGVYAIGIETAAFAEF
HHHCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEECCHHHHHHH
AKKASTNSTVKKARESIERRSLIIGVDRLDYSKGLTQRIEAFERFILANPAQRGRVTYLQ
HHHCCCHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
ITPKSRSEVPEYEAMQRTVAEQAGRVNGALGAVDWVPMRYINRSVGRRVLAGLYRLGKVG
ECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LVTPLRDGKNLVAKEYVAAQDPDDPGVLVLSRFAGAARELQGALLVNPYDIEGTANAMAR
EECCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHH
SLSMPLEERQERWTTMMDQLLEHDVSRWCRDFLNDLTASSDRCG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SRLVIVSNRVPVPDKGGIAPAGGLAVALKVALEEQGGGIWMGWSGKSSGEDEPAPLAQL
CCEEEEECCCCCCCCCCCCCCCHHHHHHEEEEEECCCEEEEECCCCCCCCCCCCCHHHH
QQGNITYALTDLTDTDVEEYYHGFANRVLWPICHYRLDLAEYGRKEMAGYFRVNRFFAHR
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LAPLVKPDDVIWVHDYPLIPLAAELRQMGLENRIGFFLHIPWPPADVLFTMPVHEEIMRG
HCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCEEEECCHHHHHHHC
LSHYDVVGFQTDHDLENFASCLRREGIGDALGGGRLSAYGRIFKGGVYAIGIETAAFAEF
HHHCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEECCHHHHHHH
AKKASTNSTVKKARESIERRSLIIGVDRLDYSKGLTQRIEAFERFILANPAQRGRVTYLQ
HHHCCCHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
ITPKSRSEVPEYEAMQRTVAEQAGRVNGALGAVDWVPMRYINRSVGRRVLAGLYRLGKVG
ECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LVTPLRDGKNLVAKEYVAAQDPDDPGVLVLSRFAGAARELQGALLVNPYDIEGTANAMAR
EECCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHH
SLSMPLEERQERWTTMMDQLLEHDVSRWCRDFLNDLTASSDRCG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424