Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 16519864

GI number: 16519864

Start: 317713

End: 319893

Strand: Direct

Name: Not Available

Synonym: NGR_a02410

Alternate gene names: 16519864

Gene position: 317713-319893 (Clockwise)

Preceding gene: 16519865

Following gene: 16519862

Centisome position: 59.26

GC content: 58.96

Gene sequence:

>2181_bases
ATGCTCACTACATTTCTGAACAGCTTGATGATGGCGATGACTATGGTCACCATGACGGCTCCCGCCCAGCCCCAGATGAC
CACCGTCGCCACGGCGATTGATTCCAACCCCAACAAAGCTTCCAAGGACGCCTCCGATCCTCGCGCCTATCTGAACGAGA
TCGACGGCGACAAGGCGATGACCTGGGTCGAGGCGCATAACCTTTCGACCGTCGATAAGCTGTCGAAAGATCCGCGTTAC
AGCGAGTACCAGGCCGACGCTCTGACGATCCTACAGGCGACCGACCGCATTGCTTCGCCCAGCTTCGCGCGCGACGGGAT
GATCGACAACTTCTGGCAGGACGGCACGCACGTGCAGGGCCTATGGCGGCGCACGACCTGGGAGTCCTACAGGTCCGGCA
ACCCGCAATGGCGCACAATTCTCGACGTCGATGCGCTATCCAAGGCCGAGGGCAAGACCTGGGTATTCGAAGGCGGGGAC
TGCCTGCCGCCCACGAGCAATCTCTGCCTCATCCGCCTGTCCGATGGCGGCAAGGATGCGGATGTGGTCCGCGAATTCGA
CATTGCCAAGGGTGAATTCGTTAAGGAAGGCTTCGTCCTACCCGAAGGCAAGCAGTCCGTGACCTGGGTGGACGAGAACA
CCATCTACGTGACCCGGGAATGGACGCCGGGTGAAGTGACCTCTTCCGGCTATGCCTACGTCACCAAGGTGGTAAAGCGC
GGCCAGAGCTTGGATCAGGCGGTCGAGATTTTCCGCGGCCAAAAGAAGGACGTCTCGGCTGAGCGCGGCGTGCTACGCGA
CATCGATGGCAAGTATGTTATGGACACCTCGTATCGCGGCCTCGACTTCTTCAATACCGAACTAGCCTTTTACCCAAACG
GCCACCCCGATACGCGCAAGGTGGTCCTGCCCCTACCGACCACGGCCGTCTTTAGCGGCTACTACAAGGGCCAGGCAATC
TATTGGTTGAAGTCGGACTGGACCTCGGCCAAAGGCACCGTCTTCCACAATGGTGCGATTATCGCTTTCGATCTCAAGGC
GGCGCTCGCCGATCCAGCGCGCGTTGAACCGCTTGTGCTGTTCATGCCAAACGAGCATCAATCTGTCGCAGGCACTACCC
AGACCAAAAATCGTCTCGTGCTGTCGATCCTATCGAATGTCACCAGCGAGGTGCGCAGCTTCGATTTCGGCAAGGGCGGC
TGGTCGTCTTTCAAGCTGGCTCTGCCGGAAAATTCGACGCTGTCCCTGACGTCTAGCGACGATGAGAGCGATCAGTTGTT
CGTCTTCTCAGAAGGGTTCCTCGAACCCTCAACTCTGTTTTGCGCCGATGCTGCAACCGGCCAAGTCGAGAAGATCACTT
CGACCCCAGCACGCTTCGATGCCGGAGGCCTGCAAGCACAGCAGTTCTGGGCGACCTCGAAGGATGGAACGAAGGTTCCA
TACTTCCTCGTAGCGCGCAAGGACGTCAAGCTGGACGGCACGAACCCGACCATCCTCTATGCCTATGGCGGTTTCCAAAT
TCCAATGCAGCCCAGCTATTCGGCGGTGCTCGGCAAACTGTGGCTGGAAAAGGGTGGTGCCTACGCGCTCGCGAATATCC
GCGGCGGCGGCGAATTCGGCCCGAAATGGCACGACGCCGGTTTGAAGACAAATCGTCAGCGCGTCTATGACGACTTCCAG
GCCGTTGCGCAGGACCTGATCGCCAAGAAGGTCACCTCGACACCGCATCTCGGGATCATGGGGGGTTCGAACGGCGGCCT
GCTCATGGGCGTGCAAATGATCCAGCGCCCCGACCTGTGGAACGCAGTCGTGATCCAGGTGCCGCTTCTCGACATGGTCA
ATTTCACCCGCATGTCGGCAGGAGCCTCCTGGCAAGCCGAATATGGCAGTCCCGACGATCCGGTTGAAGGCGCCTTCCTG
CGCTCGATCTCGCCTTATCACAACGTCAAGGCGGGCGTAGCGTATCCGGAACCCTTCTTTGAAACTTCGACAAAGGATGA
CCGCGTCGGCCCAGTGCACGCGCGCAAGATGGCCGCGCTGTTCGAAGACATGGGCCTGCCCTTCTACTATTATGAAAATA
TCGAGGGCGGTCACGCCGCCGCCGCCAACCTGCAGGAACACGCCCGCCGCTACGCCCTCGAATACATCTACATGTTTCAA
AAACTCATGGATAATAAGTGA

Upstream 100 bases:

>100_bases
TTGCCCACACAGACTGGCACAGCATTTGCTGAGAAGGGTGCGAAGCGATTGATTTTAAACGCTTCCAATACGTTTATCGA
GGCTTTCGAAGAGGCAAACC

Downstream 100 bases:

>100_bases
GTGCGTAAAGCCTTAGGCCATGTCGGGCAAATCTGAGCAAAATGAACCCAGTGGCGAGAACCGACGAAGGAGGCGAAGTT
TCGCCTTTCTTCTCGCCCCA

Product: S9B family peptidase

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 726; Mature: 726

Protein sequence:

>726_residues
MLTTFLNSLMMAMTMVTMTAPAQPQMTTVATAIDSNPNKASKDASDPRAYLNEIDGDKAMTWVEAHNLSTVDKLSKDPRY
SEYQADALTILQATDRIASPSFARDGMIDNFWQDGTHVQGLWRRTTWESYRSGNPQWRTILDVDALSKAEGKTWVFEGGD
CLPPTSNLCLIRLSDGGKDADVVREFDIAKGEFVKEGFVLPEGKQSVTWVDENTIYVTREWTPGEVTSSGYAYVTKVVKR
GQSLDQAVEIFRGQKKDVSAERGVLRDIDGKYVMDTSYRGLDFFNTELAFYPNGHPDTRKVVLPLPTTAVFSGYYKGQAI
YWLKSDWTSAKGTVFHNGAIIAFDLKAALADPARVEPLVLFMPNEHQSVAGTTQTKNRLVLSILSNVTSEVRSFDFGKGG
WSSFKLALPENSTLSLTSSDDESDQLFVFSEGFLEPSTLFCADAATGQVEKITSTPARFDAGGLQAQQFWATSKDGTKVP
YFLVARKDVKLDGTNPTILYAYGGFQIPMQPSYSAVLGKLWLEKGGAYALANIRGGGEFGPKWHDAGLKTNRQRVYDDFQ
AVAQDLIAKKVTSTPHLGIMGGSNGGLLMGVQMIQRPDLWNAVVIQVPLLDMVNFTRMSAGASWQAEYGSPDDPVEGAFL
RSISPYHNVKAGVAYPEPFFETSTKDDRVGPVHARKMAALFEDMGLPFYYYENIEGGHAAAANLQEHARRYALEYIYMFQ
KLMDNK

Sequences:

>Translated_726_residues
MLTTFLNSLMMAMTMVTMTAPAQPQMTTVATAIDSNPNKASKDASDPRAYLNEIDGDKAMTWVEAHNLSTVDKLSKDPRY
SEYQADALTILQATDRIASPSFARDGMIDNFWQDGTHVQGLWRRTTWESYRSGNPQWRTILDVDALSKAEGKTWVFEGGD
CLPPTSNLCLIRLSDGGKDADVVREFDIAKGEFVKEGFVLPEGKQSVTWVDENTIYVTREWTPGEVTSSGYAYVTKVVKR
GQSLDQAVEIFRGQKKDVSAERGVLRDIDGKYVMDTSYRGLDFFNTELAFYPNGHPDTRKVVLPLPTTAVFSGYYKGQAI
YWLKSDWTSAKGTVFHNGAIIAFDLKAALADPARVEPLVLFMPNEHQSVAGTTQTKNRLVLSILSNVTSEVRSFDFGKGG
WSSFKLALPENSTLSLTSSDDESDQLFVFSEGFLEPSTLFCADAATGQVEKITSTPARFDAGGLQAQQFWATSKDGTKVP
YFLVARKDVKLDGTNPTILYAYGGFQIPMQPSYSAVLGKLWLEKGGAYALANIRGGGEFGPKWHDAGLKTNRQRVYDDFQ
AVAQDLIAKKVTSTPHLGIMGGSNGGLLMGVQMIQRPDLWNAVVIQVPLLDMVNFTRMSAGASWQAEYGSPDDPVEGAFL
RSISPYHNVKAGVAYPEPFFETSTKDDRVGPVHARKMAALFEDMGLPFYYYENIEGGHAAAANLQEHARRYALEYIYMFQ
KLMDNK
>Mature_726_residues
MLTTFLNSLMMAMTMVTMTAPAQPQMTTVATAIDSNPNKASKDASDPRAYLNEIDGDKAMTWVEAHNLSTVDKLSKDPRY
SEYQADALTILQATDRIASPSFARDGMIDNFWQDGTHVQGLWRRTTWESYRSGNPQWRTILDVDALSKAEGKTWVFEGGD
CLPPTSNLCLIRLSDGGKDADVVREFDIAKGEFVKEGFVLPEGKQSVTWVDENTIYVTREWTPGEVTSSGYAYVTKVVKR
GQSLDQAVEIFRGQKKDVSAERGVLRDIDGKYVMDTSYRGLDFFNTELAFYPNGHPDTRKVVLPLPTTAVFSGYYKGQAI
YWLKSDWTSAKGTVFHNGAIIAFDLKAALADPARVEPLVLFMPNEHQSVAGTTQTKNRLVLSILSNVTSEVRSFDFGKGG
WSSFKLALPENSTLSLTSSDDESDQLFVFSEGFLEPSTLFCADAATGQVEKITSTPARFDAGGLQAQQFWATSKDGTKVP
YFLVARKDVKLDGTNPTILYAYGGFQIPMQPSYSAVLGKLWLEKGGAYALANIRGGGEFGPKWHDAGLKTNRQRVYDDFQ
AVAQDLIAKKVTSTPHLGIMGGSNGGLLMGVQMIQRPDLWNAVVIQVPLLDMVNFTRMSAGASWQAEYGSPDDPVEGAFL
RSISPYHNVKAGVAYPEPFFETSTKDDRVGPVHARKMAALFEDMGLPFYYYENIEGGHAAAANLQEHARRYALEYIYMFQ
KLMDNK

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family

Homologues:

Organism=Homo sapiens, GI41349456, Length=400, Percent_Identity=33.5, Blast_Score=211, Evalue=3e-54,
Organism=Homo sapiens, GI284172438, Length=229, Percent_Identity=25.764192139738, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI284172431, Length=229, Percent_Identity=25.764192139738, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI284172420, Length=229, Percent_Identity=25.764192139738, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI284172413, Length=229, Percent_Identity=25.764192139738, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI70778815, Length=229, Percent_Identity=25.764192139738, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI108860686, Length=229, Percent_Identity=25.764192139738, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI108860692, Length=201, Percent_Identity=25.8706467661692, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1788150, Length=240, Percent_Identity=34.1666666666667, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24583414, Length=281, Percent_Identity=37.3665480427046, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI221510989, Length=317, Percent_Identity=33.4384858044164, Blast_Score=179, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4NA_RHISN (P55577)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_443984.1
- ProteinModelPortal:   P55577
- GeneID:   962371
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a02410
- HOGENOM:   HBG666023
- GO:   GO:0006508
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106
- PANTHER:   PTHR11757
- PRINTS:   PR00862

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N; SSF50993 Peptidase_S9A_N

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 80337; Mature: 80337

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: ACT_SITE 583-583 ACT_SITE 698-698

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTTFLNSLMMAMTMVTMTAPAQPQMTTVATAIDSNPNKASKDASDPRAYLNEIDGDKAM
CHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCEE
TWVEAHNLSTVDKLSKDPRYSEYQADALTILQATDRIASPSFARDGMIDNFWQDGTHVQG
EEEECCCCCHHHHHCCCCCCCCHHHHHHHEEHHHHHHCCCCCCCCCCCHHHHCCCCHHHH
LWRRTTWESYRSGNPQWRTILDVDALSKAEGKTWVFEGGDCLPPTSNLCLIRLSDGGKDA
HHHHCCHHHHHCCCCCEEEEEEHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCH
DVVREFDIAKGEFVKEGFVLPEGKQSVTWVDENTIYVTREWTPGEVTSSGYAYVTKVVKR
HHHHHHCCCCCCHHHCCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHC
GQSLDQAVEIFRGQKKDVSAERGVLRDIDGKYVMDTSYRGLDFFNTELAFYPNGHPDTRK
CCCHHHHHHHHCCCCCCCCHHCCCHHCCCCCEEEECCCCCCEEECCEEEECCCCCCCCCE
VVLPLPTTAVFSGYYKGQAIYWLKSDWTSAKGTVFHNGAIIAFDLKAALADPARVEPLVL
EEEECCHHHHHHCEECCEEEEEEECCCCCCCCEEEECCEEEEEECHHHHCCCCCCCEEEE
FMPNEHQSVAGTTQTKNRLVLSILSNVTSEVRSFDFGKGGWSSFKLALPENSTLSLTSSD
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEECCC
DESDQLFVFSEGFLEPSTLFCADAATGQVEKITSTPARFDAGGLQAQQFWATSKDGTKVP
CCCCEEEEEECCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCCHHHHEECCCCCCCCC
YFLVARKDVKLDGTNPTILYAYGGFQIPMQPSYSAVLGKLWLEKGGAYALANIRGGGEFG
EEEEEEEEEEECCCCCEEEEEECCEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCC
PKWHDAGLKTNRQRVYDDFQAVAQDLIAKKVTSTPHLGIMGGSNGGLLMGVQMIQRPDLW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEHHHCCCCCC
NAVVIQVPLLDMVNFTRMSAGASWQAEYGSPDDPVEGAFLRSISPYHNVKAGVAYPEPFF
CEEEEEECHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHCCCCHHCCCCCCCCCCCCC
ETSTKDDRVGPVHARKMAALFEDMGLPFYYYENIEGGHAAAANLQEHARRYALEYIYMFQ
CCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KLMDNK
HHHCCC
>Mature Secondary Structure
MLTTFLNSLMMAMTMVTMTAPAQPQMTTVATAIDSNPNKASKDASDPRAYLNEIDGDKAM
CHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCEE
TWVEAHNLSTVDKLSKDPRYSEYQADALTILQATDRIASPSFARDGMIDNFWQDGTHVQG
EEEECCCCCHHHHHCCCCCCCCHHHHHHHEEHHHHHHCCCCCCCCCCCHHHHCCCCHHHH
LWRRTTWESYRSGNPQWRTILDVDALSKAEGKTWVFEGGDCLPPTSNLCLIRLSDGGKDA
HHHHCCHHHHHCCCCCEEEEEEHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCH
DVVREFDIAKGEFVKEGFVLPEGKQSVTWVDENTIYVTREWTPGEVTSSGYAYVTKVVKR
HHHHHHCCCCCCHHHCCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHC
GQSLDQAVEIFRGQKKDVSAERGVLRDIDGKYVMDTSYRGLDFFNTELAFYPNGHPDTRK
CCCHHHHHHHHCCCCCCCCHHCCCHHCCCCCEEEECCCCCCEEECCEEEECCCCCCCCCE
VVLPLPTTAVFSGYYKGQAIYWLKSDWTSAKGTVFHNGAIIAFDLKAALADPARVEPLVL
EEEECCHHHHHHCEECCEEEEEEECCCCCCCCEEEECCEEEEEECHHHHCCCCCCCEEEE
FMPNEHQSVAGTTQTKNRLVLSILSNVTSEVRSFDFGKGGWSSFKLALPENSTLSLTSSD
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEECCC
DESDQLFVFSEGFLEPSTLFCADAATGQVEKITSTPARFDAGGLQAQQFWATSKDGTKVP
CCCCEEEEEECCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCCHHHHEECCCCCCCCC
YFLVARKDVKLDGTNPTILYAYGGFQIPMQPSYSAVLGKLWLEKGGAYALANIRGGGEFG
EEEEEEEEEEECCCCCEEEEEECCEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCC
PKWHDAGLKTNRQRVYDDFQAVAQDLIAKKVTSTPHLGIMGGSNGGLLMGVQMIQRPDLW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEHHHCCCCCC
NAVVIQVPLLDMVNFTRMSAGASWQAEYGSPDDPVEGAFLRSISPYHNVKAGVAYPEPFF
CEEEEEECHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHCCCCHHCCCCCCCCCCCCC
ETSTKDDRVGPVHARKMAALFEDMGLPFYYYENIEGGHAAAANLQEHARRYALEYIYMFQ
CCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KLMDNK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} 0.47 {tosyl-Lys-methyl} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424