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The map label for this gene is cpxU

Identifier: 16519831

GI number: 16519831

Start: 362088

End: 363431

Strand: Direct

Name: cpxU

Synonym: NGR_a02740

Alternate gene names: 16519831

Gene position: 362088-363431 (Clockwise)

Preceding gene: 16519832

Following gene: 16519830

Centisome position: 67.53

GC content: 67.41

Gene sequence:

>1344_bases
ATGAACGTGCTGCTCAACCCCCTAAACCGTCGGCACCGGCTGCGGTACGACATCCCCGTCATGCCCGGCGCTTTCCCCCT
GGTCGGGCATCTTCCCGCCATCGTCTGCGACCTGCCGCGCCTGCTGCGGCGCGCGGAACGGACGCTGGGCAGCCACTTCT
GGCTGGATTTCGGCCCTGCCGGACACCTGATGACCTGCGTGGATCCGCATGCGTTCGCACTGCTCCGGCACAAGGACGTG
TCCTCGGCGCTGATCGAAGAGATCGCGCCCGAATTGCTTGGCGGAACGTTGGTCGCCCAGGACGGCGGCGCGCACCGGCA
GGCGCGCGATGCGATTAAGGCGGCGTTCCTGCCCGAGGGGCTGACCCAGGCCGGCATCGGCGACCTGTTCGCGCCCGTTA
TCCGGGCGCGGGTGCAGGCGTGGCGCGACCGCGGCGACGTAACCATCCTGCCCGAAACCGGCGACCTGATGCTCAAGCTC
ATCTTCACCCTCATGGGAGTCCCTGCGCAGGACCTGCCGGGATGGCATCGCAAGTACCGGCAACTACTGCAGTTGATCGT
CGCGCCCTCGGTCGACCTGCCTGGACTGCCCTTGCGGCGCGGCCGCGCCGCCCGCGACTGGATCGACGCGCAGTTGCGCC
AGTTCGTCCGCGACGCACGCGCGCATGCCGCGCGCACCGGGTTGATCAACGACATGGTGAGTGCCTTCGACCGCAGCGAC
GATGCGCTCTCCGATGACCTCCTGGTCGCCAATATCCGCTTGCTGCTGCTTGCCGGTCACGACACCACCGCCTCGACGAT
GGCCTGGATGGTGATCGAACTGGCGCGGCAGCCTATGCTGTGGGATGCCCTGGTCGAGGAGGCACAACGCGTAGGCGCGG
TGCCGACCCGGCACGCGGACCTGGAGCAGTGTCCGGTCGCCGAGGCGCTGTTCCGCGAGACGCTGCGCGTGCATCCGGCG
ACGACGCTCCTGCCGCGTCGCGCGCTGCAGGAACTGCAACTCGGCCAACGGCGCATTCCGGCGGGCACCCATCTGTGCAT
CCCGCTGCTGCATTTCTCGACCTCGGCGCTGCTGCACGAGGCGCCTGATCAGTTCCGCCTGGCGCGGTGGCTGCAACGTA
CGGAGCCGATTCGGCCGGTGGACATGCTGCAGTTCGGTACCGGCCCACACGTTTGCATCGGCTATCACCTGGTATGGCTG
GAACTGGTGCAGTTCTCCATCGCCTTGGCGCTGACCATGCACAAGGCCGGGGTGCGGCCGCTGTTGCTGAGCGGCGTCGA
AAAAGGCCGGCGCTATTACCCGACCGCACATCCGTCCATGACAATCCGCATCGGATTCTCATGA

Upstream 100 bases:

>100_bases
TCGACGGCGGCATGCTGGCGCATATGCCGACGTACGCCGACGGTGGCAACAGCTGCGCCGGGCGGACTGCGGGCGACACC
GCCGAAACGGCGCGCTGCTG

Downstream 100 bases:

>100_bases
GCTGGCATCGCATGCCCCGTGTGGCGAGGCAGCGGCACCGGCGACGCGCGGCATTGCTGCATTCGGCGCGCGCGTTCGGT
GCGACGCGGCAACACCGCGG

Product: cytochrome P450

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MNVLLNPLNRRHRLRYDIPVMPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPAGHLMTCVDPHAFALLRHKDV
SSALIEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPEGLTQAGIGDLFAPVIRARVQAWRDRGDVTILPETGDLMLKL
IFTLMGVPAQDLPGWHRKYRQLLQLIVAPSVDLPGLPLRRGRAARDWIDAQLRQFVRDARAHAARTGLINDMVSAFDRSD
DALSDDLLVANIRLLLLAGHDTTASTMAWMVIELARQPMLWDALVEEAQRVGAVPTRHADLEQCPVAEALFRETLRVHPA
TTLLPRRALQELQLGQRRIPAGTHLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVCIGYHLVWL
ELVQFSIALALTMHKAGVRPLLLSGVEKGRRYYPTAHPSMTIRIGFS

Sequences:

>Translated_447_residues
MNVLLNPLNRRHRLRYDIPVMPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPAGHLMTCVDPHAFALLRHKDV
SSALIEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPEGLTQAGIGDLFAPVIRARVQAWRDRGDVTILPETGDLMLKL
IFTLMGVPAQDLPGWHRKYRQLLQLIVAPSVDLPGLPLRRGRAARDWIDAQLRQFVRDARAHAARTGLINDMVSAFDRSD
DALSDDLLVANIRLLLLAGHDTTASTMAWMVIELARQPMLWDALVEEAQRVGAVPTRHADLEQCPVAEALFRETLRVHPA
TTLLPRRALQELQLGQRRIPAGTHLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVCIGYHLVWL
ELVQFSIALALTMHKAGVRPLLLSGVEKGRRYYPTAHPSMTIRIGFS
>Mature_447_residues
MNVLLNPLNRRHRLRYDIPVMPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPAGHLMTCVDPHAFALLRHKDV
SSALIEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPEGLTQAGIGDLFAPVIRARVQAWRDRGDVTILPETGDLMLKL
IFTLMGVPAQDLPGWHRKYRQLLQLIVAPSVDLPGLPLRRGRAARDWIDAQLRQFVRDARAHAARTGLINDMVSAFDRSD
DALSDDLLVANIRLLLLAGHDTTASTMAWMVIELARQPMLWDALVEEAQRVGAVPTRHADLEQCPVAEALFRETLRVHPA
TTLLPRRALQELQLGQRRIPAGTHLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVCIGYHLVWL
ELVQFSIALALTMHKAGVRPLLLSGVEKGRRYYPTAHPSMTIRIGFS

Specific function: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family

Homologues:

Organism=Homo sapiens, GI55770850, Length=165, Percent_Identity=34.5454545454545, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI16933530, Length=425, Percent_Identity=24.2352941176471, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4503231, Length=200, Percent_Identity=28.5, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI167466231, Length=170, Percent_Identity=35.2941176470588, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4503213, Length=238, Percent_Identity=32.3529411764706, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI16933528, Length=348, Percent_Identity=25.2873563218391, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI153218646, Length=172, Percent_Identity=30.8139534883721, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI153218654, Length=172, Percent_Identity=30.8139534883721, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4503211, Length=175, Percent_Identity=29.1428571428571, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI6005737, Length=210, Percent_Identity=26.1904761904762, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI13435386, Length=196, Percent_Identity=27.0408163265306, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI150036266, Length=235, Percent_Identity=26.8085106382979, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI193083180, Length=200, Percent_Identity=26, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI193083178, Length=200, Percent_Identity=26, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI16933533, Length=210, Percent_Identity=24.7619047619048, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI262290932, Length=196, Percent_Identity=25.5102040816327, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4503195, Length=172, Percent_Identity=33.7209302325581, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI13435391, Length=239, Percent_Identity=24.2677824267782, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI119220562, Length=239, Percent_Identity=24.6861924686192, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI261278372, Length=299, Percent_Identity=26.7558528428094, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI261278370, Length=299, Percent_Identity=26.7558528428094, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI195972896, Length=299, Percent_Identity=26.7558528428094, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI195972898, Length=299, Percent_Identity=26.7558528428094, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71998720, Length=202, Percent_Identity=25.7425742574257, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI72001056, Length=170, Percent_Identity=25.8823529411765, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17536183, Length=217, Percent_Identity=28.110599078341, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17536177, Length=169, Percent_Identity=29.585798816568, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17553064, Length=201, Percent_Identity=28.3582089552239, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17553062, Length=202, Percent_Identity=29.7029702970297, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321795, Length=238, Percent_Identity=24.7899159663866, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17933518, Length=164, Percent_Identity=28.0487804878049, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24639289, Length=191, Percent_Identity=26.7015706806283, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639287, Length=191, Percent_Identity=26.7015706806283, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24642101, Length=173, Percent_Identity=27.1676300578035, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24656064, Length=169, Percent_Identity=28.4023668639053, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330299, Length=196, Percent_Identity=26.0204081632653, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45552561, Length=163, Percent_Identity=30.6748466257669, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573913, Length=163, Percent_Identity=30.6748466257669, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45552577, Length=370, Percent_Identity=24.5945945945946, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24652454, Length=163, Percent_Identity=30.6748466257669, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24943083, Length=370, Percent_Identity=24.5945945945946, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24641483, Length=158, Percent_Identity=31.0126582278481, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571357, Length=158, Percent_Identity=31.0126582278481, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24648130, Length=165, Percent_Identity=29.0909090909091, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24641418, Length=228, Percent_Identity=26.7543859649123, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CPXU_RHISN (P55540)

Other databases:

- EMBL:   U00090
- PIR:   T10876
- RefSeq:   NP_443951.1
- ProteinModelPortal:   P55540
- GeneID:   962613
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a02740
- HOGENOM:   HBG688697
- ProtClustDB:   CLSK864467
- InterPro:   IPR001128
- InterPro:   IPR017972
- InterPro:   IPR002403
- Gene3D:   G3DSA:1.10.630.10
- PANTHER:   PTHR19383
- PRINTS:   PR00465
- PRINTS:   PR00385

Pfam domain/function: PF00067 p450; SSF48264 Cytochrome_P450

EC number: NA

Molecular weight: Translated: 49856; Mature: 49856

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLLNPLNRRHRLRYDIPVMPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPA
CCCCCCCCCHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GHLMTCVDPHAFALLRHKDVSSALIEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPEG
CCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCC
LTQAGIGDLFAPVIRARVQAWRDRGDVTILPETGDLMLKLIFTLMGVPAQDLPGWHRKYR
CHHHCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
QLLQLIVAPSVDLPGLPLRRGRAARDWIDAQLRQFVRDARAHAARTGLINDMVSAFDRSD
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DALSDDLLVANIRLLLLAGHDTTASTMAWMVIELARQPMLWDALVEEAQRVGAVPTRHAD
CCCCCCHHHEEEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
LEQCPVAEALFRETLRVHPATTLLPRRALQELQLGQRRIPAGTHLCIPLLHFSTSALLHE
HHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHCCCCCCHHHHHHHHHHHHHHHHC
APDQFRLARWLQRTEPIRPVDMLQFGTGPHVCIGYHLVWLELVQFSIALALTMHKAGVRP
CCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LLLSGVEKGRRYYPTAHPSMTIRIGFS
HHHHHHHHCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MNVLLNPLNRRHRLRYDIPVMPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPA
CCCCCCCCCHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GHLMTCVDPHAFALLRHKDVSSALIEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPEG
CCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCC
LTQAGIGDLFAPVIRARVQAWRDRGDVTILPETGDLMLKLIFTLMGVPAQDLPGWHRKYR
CHHHCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
QLLQLIVAPSVDLPGLPLRRGRAARDWIDAQLRQFVRDARAHAARTGLINDMVSAFDRSD
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DALSDDLLVANIRLLLLAGHDTTASTMAWMVIELARQPMLWDALVEEAQRVGAVPTRHAD
CCCCCCHHHEEEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
LEQCPVAEALFRETLRVHPATTLLPRRALQELQLGQRRIPAGTHLCIPLLHFSTSALLHE
HHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHCCCCCCHHHHHHHHHHHHHHHHC
APDQFRLARWLQRTEPIRPVDMLQFGTGPHVCIGYHLVWLELVQFSIALALTMHKAGVRP
CCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LLLSGVEKGRRYYPTAHPSMTIRIGFS
HHHHHHHHCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424