Click here to switch to the map view.

The map label for this gene is ispA

Identifier: 16519830

GI number: 16519830

Start: 363585

End: 364583

Strand: Direct

Name: ispA

Synonym: NGR_a02750

Alternate gene names: 16519830

Gene position: 363585-364583 (Clockwise)

Preceding gene: 16519831

Following gene: 16519829

Centisome position: 67.81

GC content: 67.57

Gene sequence:

>999_bases
ATGCAGACCGGTTCCACGCTACACGACGACCGAACTAGCGTTTCCGCCCTCGGCGGATTGGGCGCGCGGGCGCGCGGCGC
ATCCGGCAGGCTGCTGCCGGAGATCTGGATGCAGAACGGCGCAAAGCGGGTCGAACAGGCGCTAGCGCGTCTTCTCTGCG
CCGAAGACCACGGTGAGACCGAGCTTATGGCGGCGATGCGCTACGCCACCTTGCATGGCGGGAAGCGCACCCGCGCCCTG
CTCTGTCTGGCTGCTGGAGCACTGGCCGACACGCCGGCGCACATACTCGACGACGTCGGCGCCGCCATCGAGATGATGCA
CGCTTGTACCCTGGTCCACGACGACCTGCCCGCAATGGACGACGACGTGCTTCGCCGCGGCCTTCCGACCGTGCATGTCA
AGTTCGGCGAAGCCACTGCGATCCTGGTCGGCGATGCGCTGCAGGCACACGCCTTCCTGACCCTGGCAAGCCTGGATGCG
CCGGGCGACAACCGTATCGCGCTCGTGCGCGAACTGGCGCAGGCGGTGTCTGCCGAGGGTGCCGCAGGCGGGCAGGCCAT
GGATCTGTCGCTGGTCGGAAAGCACGTCGAGCTGGACAGGATCGTAGCGATGCACCGGATGAAGTGCGGAGCGCTAGTGC
GTGCGTCCGTTCGCATGGGCGCCCTATGCGCCATCGCGGAGGATGCCGCGGACGCTACGCTGTACTGTGCGCTCGATCAC
TACAGCGCCTGTTTCGGCCTGGCGTTGCAGGTGGTCGACGACATTCTCGACGCGACAGCGGATACCGCGACGCTGGGCAA
GACCCCCGGCAAGGACGCGGCGGCGCAGAAACCGACCTGCGCGTCGATCATGGGGCTGCAGGCAGCGCGCCAGTTCGCGC
TGGATCTGTTGTGTGAGGCCGGGGAGGCCATTGCCCCGCTGGGGCCGCGTGCGGAACGGTTGGCGCAGATGCTGCAGCGG
GCCAGTGCGTACCTGTTCAAGCACGCGCCATCCGCATGA

Upstream 100 bases:

>100_bases
TTGCTGCATTCGGCGCGCGCGTTCGGTGCGACGCGGCAACACCGCGGCGGCTCGACGCTCGCCGTGGCCGTCTCCTGTCA
GGTACAAGGACATGAACAAC

Downstream 100 bases:

>100_bases
GCGCGCCCGTCCGCATGGAGTCGCCCCTGTGCCGCTGCGATCGGCCGGCGGCAGCCATGCATGCAGCACTGTGTCCGAGT
CCGCGGCGCCGATCGCCGCG

Product: geranyltransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MQTGSTLHDDRTSVSALGGLGARARGASGRLLPEIWMQNGAKRVEQALARLLCAEDHGETELMAAMRYATLHGGKRTRAL
LCLAAGALADTPAHILDDVGAAIEMMHACTLVHDDLPAMDDDVLRRGLPTVHVKFGEATAILVGDALQAHAFLTLASLDA
PGDNRIALVRELAQAVSAEGAAGGQAMDLSLVGKHVELDRIVAMHRMKCGALVRASVRMGALCAIAEDAADATLYCALDH
YSACFGLALQVVDDILDATADTATLGKTPGKDAAAQKPTCASIMGLQAARQFALDLLCEAGEAIAPLGPRAERLAQMLQR
ASAYLFKHAPSA

Sequences:

>Translated_332_residues
MQTGSTLHDDRTSVSALGGLGARARGASGRLLPEIWMQNGAKRVEQALARLLCAEDHGETELMAAMRYATLHGGKRTRAL
LCLAAGALADTPAHILDDVGAAIEMMHACTLVHDDLPAMDDDVLRRGLPTVHVKFGEATAILVGDALQAHAFLTLASLDA
PGDNRIALVRELAQAVSAEGAAGGQAMDLSLVGKHVELDRIVAMHRMKCGALVRASVRMGALCAIAEDAADATLYCALDH
YSACFGLALQVVDDILDATADTATLGKTPGKDAAAQKPTCASIMGLQAARQFALDLLCEAGEAIAPLGPRAERLAQMLQR
ASAYLFKHAPSA
>Mature_332_residues
MQTGSTLHDDRTSVSALGGLGARARGASGRLLPEIWMQNGAKRVEQALARLLCAEDHGETELMAAMRYATLHGGKRTRAL
LCLAAGALADTPAHILDDVGAAIEMMHACTLVHDDLPAMDDDVLRRGLPTVHVKFGEATAILVGDALQAHAFLTLASLDA
PGDNRIALVRELAQAVSAEGAAGGQAMDLSLVGKHVELDRIVAMHRMKCGALVRASVRMGALCAIAEDAADATLYCALDH
YSACFGLALQVVDDILDATADTATLGKTPGKDAAAQKPTCASIMGLQAARQFALDLLCEAGEAIAPLGPRAERLAQMLQR
ASAYLFKHAPSA

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=273, Percent_Identity=47.6190476190476, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1789578, Length=217, Percent_Identity=32.258064516129, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17505681, Length=179, Percent_Identity=30.7262569832402, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 34689; Mature: 34689

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTGSTLHDDRTSVSALGGLGARARGASGRLLPEIWMQNGAKRVEQALARLLCAEDHGET
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCHH
ELMAAMRYATLHGGKRTRALLCLAAGALADTPAHILDDVGAAIEMMHACTLVHDDLPAMD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DDVLRRGLPTVHVKFGEATAILVGDALQAHAFLTLASLDAPGDNRIALVRELAQAVSAEG
HHHHHCCCCEEEEEECCEEEEEECCHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCC
AAGGQAMDLSLVGKHVELDRIVAMHRMKCGALVRASVRMGALCAIAEDAADATLYCALDH
CCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
YSACFGLALQVVDDILDATADTATLGKTPGKDAAAQKPTCASIMGLQAARQFALDLLCEA
HHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GEAIAPLGPRAERLAQMLQRASAYLFKHAPSA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQTGSTLHDDRTSVSALGGLGARARGASGRLLPEIWMQNGAKRVEQALARLLCAEDHGET
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCHH
ELMAAMRYATLHGGKRTRALLCLAAGALADTPAHILDDVGAAIEMMHACTLVHDDLPAMD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DDVLRRGLPTVHVKFGEATAILVGDALQAHAFLTLASLDAPGDNRIALVRELAQAVSAEG
HHHHHCCCCEEEEEECCEEEEEECCHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCC
AAGGQAMDLSLVGKHVELDRIVAMHRMKCGALVRASVRMGALCAIAEDAADATLYCALDH
CCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
YSACFGLALQVVDDILDATADTATLGKTPGKDAAAQKPTCASIMGLQAARQFALDLLCEA
HHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GEAIAPLGPRAERLAQMLQRASAYLFKHAPSA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]