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The map label for this gene is shc

Identifier: 16519641

GI number: 16519641

Start: 56458

End: 58401

Strand: Direct

Name: shc

Synonym: NGR_a00460

Alternate gene names: 16519641

Gene position: 56458-58401 (Clockwise)

Preceding gene: 16519642

Following gene: 16520036

Centisome position: 10.53

GC content: 60.7

Gene sequence:

>1944_bases
GTGAATAAGCATTCCGGAAATCGCACTGCCATCGATCCCGCCGCGCTGGAAATGAGCATCGCCTCAGCCACTGAGGCGCT
GCTCGCTTATCGTCATGCCGACGGCCATTGGGCGTTCGAGCTTGAAGCGGATTCCACCATCCCTTCCGAATACATCCTGC
TACGTCATTACCTGGCCGAGCCCATTGACGTCGTGCTCGAAGCCAAAATCGGAAATTATCTGCGCCGCACTCAAGGCGCG
CACGGCGGCTGGCCGCTGGTGCATGACGGGCCCTTCGATATGAGCGCAAGCGTGAAGTCTTACTTCGCGCTCAAGATGAT
CGGTGATTCCGTCGACGCGGCTCATATGGTGAAGGCGCGCGAGGCGATCCGCGCGCGCGGCGGCGCCGCCAACAGCAACG
TACTCACGCGCTTCCTGCTCGCGCTCTATGGCGTAGTTAGCTGGCGCGCGGTGCCGGTTCTGCCAATCGAGATCGTGCTA
CTGCCAATCTGGTCGCCGTTCCACCTCTACAAGATCTCCTACTGGGCGCGCACCACTATTGTGCCGCTGATGGTTCTTGC
AGTGCTGAAGCCGCGTGCGAAGAATCCTAAGGGCGTCGGCATCGAAGAACTGTTCCTTCAGGATACCAAGAGCGTAGGCA
TGAACCCGAAGGCGCCGCACCAGAGCTGGGGCTGGTTCTTGCTGTTCCGCGGCATCGACGGCATCCTGCGGGTTATTGAG
CCGCATCTTCCGAAGAAACTTCGTGAGCGCGCGATCGCGAGTGCGCTCGCCTTCACTGAAGAGCGGCTCAACGGTGAAGA
TGGCATGGGCGCGATCTATCCGTCGATGGCCAATATCGTGATGATGTATGACGCGCTCGGTAAAGACGATCATTTTCCGC
CGCGCGCGATAGCACGTCGCGCTATTGACAAGCTCTTGGTGATCGGCGAGGAAGAGGCCTATTGCCAGCCCTGCCTGTCG
CCGGTCTGGGACACCGCGCTGACGTGCCACGCACTTCAGGAGGTGGGCGGCGCTAACGCCGTGGCGAAAGCGAAGCAGGG
CCTGGACTGGCTGAAGCCGCGGCAGGTACTGGACGTGAAGGGCGACTGGGCAGTGAAGGCGCCCAACATCAGGCCCGGCG
GCTGGCCGTTTCAATACAACAACGCGCACTATCCCGATCTCGATGACACTGCAGTGGTGGTCATGGCCATGGACCGCGCG
CAGCGGCACGCCGGCAGCAAGGAATACGCCACCGCGATCGCACGTGGCCGGGAATGGATCGAAGGCATGCAAAGCCGGGA
TGGCGGCTGGGCCGCCTTCGACGTCAACAATCTCGAATACTACCTGAATAACCTCCCATTCGCGGACCATGGCGCGCTGC
TCGACCCGCCGACCGAAGACGTTACCGCACGGTGCGTCTCGATGTTGGCCCAGGTCGGCGAATTCACCCAAAGGAGCAAG
GCAGTCGCCGAGGGGATTGCATATTTGCGCCGCACCCAACACGCGGAAGGATCATGGTACGGCCGCTGGGGCCTGAACTA
CATCTACGGTACCTGGTCGGTGTTGTGCGCGCTGAATGCCGCAGGGATCGATCACCAAGACCCCATGATAAGGAAGGCGG
TGGAATGGCTAGTATCCATCCAGAGTTGGGACGGCGGTTGGGGCGAGGATGCAATCAGCTACCGACTCGACTATAGCGGA
TATGAGCAGGCGCCTTCCACGTCCTCCCAAACGGCGTGGGCCTTGCTTGGACTGATGGCGGCCGGCGAGGTGGAGCATCC
GGCCGTCGCACGCGGGGTGAACTACCTAAAAAACGCACAAACCGAGAACGGTCTGTGGGATGAGCAGCGCTACACCGCCA
CGGGTTTTCCGCGGGTGTTTTATTTGCGATATCACGGCTACTCCAAGTTCTTTCCGCTCTGGGCATTAGCACGGTACCGG
AACTTGAGGAGCACGAACGTTTGA

Upstream 100 bases:

>100_bases
GCGGTCGGGTAACCGTGCCGCCGATCTGGCTCTTTCAGAGACAAACACTTGATTGATAAATCCAGACGGTTTTGCACGCT
GCCGAACACGCAGGAAGTCA

Downstream 100 bases:

>100_bases
TGAGAAGAGTTTGGTCGTTAGGAGAACTCGTGAGGGTGAATGTCGACTCGATTGCATTTAAGTTTTCACCTGCGCCCATT
TGCCTGACTTTATGGAGGTG

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MNKHSGNRTAIDPAALEMSIASATEALLAYRHADGHWAFELEADSTIPSEYILLRHYLAEPIDVVLEAKIGNYLRRTQGA
HGGWPLVHDGPFDMSASVKSYFALKMIGDSVDAAHMVKAREAIRARGGAANSNVLTRFLLALYGVVSWRAVPVLPIEIVL
LPIWSPFHLYKISYWARTTIVPLMVLAVLKPRAKNPKGVGIEELFLQDTKSVGMNPKAPHQSWGWFLLFRGIDGILRVIE
PHLPKKLRERAIASALAFTEERLNGEDGMGAIYPSMANIVMMYDALGKDDHFPPRAIARRAIDKLLVIGEEEAYCQPCLS
PVWDTALTCHALQEVGGANAVAKAKQGLDWLKPRQVLDVKGDWAVKAPNIRPGGWPFQYNNAHYPDLDDTAVVVMAMDRA
QRHAGSKEYATAIARGREWIEGMQSRDGGWAAFDVNNLEYYLNNLPFADHGALLDPPTEDVTARCVSMLAQVGEFTQRSK
AVAEGIAYLRRTQHAEGSWYGRWGLNYIYGTWSVLCALNAAGIDHQDPMIRKAVEWLVSIQSWDGGWGEDAISYRLDYSG
YEQAPSTSSQTAWALLGLMAAGEVEHPAVARGVNYLKNAQTENGLWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYR
NLRSTNV

Sequences:

>Translated_647_residues
MNKHSGNRTAIDPAALEMSIASATEALLAYRHADGHWAFELEADSTIPSEYILLRHYLAEPIDVVLEAKIGNYLRRTQGA
HGGWPLVHDGPFDMSASVKSYFALKMIGDSVDAAHMVKAREAIRARGGAANSNVLTRFLLALYGVVSWRAVPVLPIEIVL
LPIWSPFHLYKISYWARTTIVPLMVLAVLKPRAKNPKGVGIEELFLQDTKSVGMNPKAPHQSWGWFLLFRGIDGILRVIE
PHLPKKLRERAIASALAFTEERLNGEDGMGAIYPSMANIVMMYDALGKDDHFPPRAIARRAIDKLLVIGEEEAYCQPCLS
PVWDTALTCHALQEVGGANAVAKAKQGLDWLKPRQVLDVKGDWAVKAPNIRPGGWPFQYNNAHYPDLDDTAVVVMAMDRA
QRHAGSKEYATAIARGREWIEGMQSRDGGWAAFDVNNLEYYLNNLPFADHGALLDPPTEDVTARCVSMLAQVGEFTQRSK
AVAEGIAYLRRTQHAEGSWYGRWGLNYIYGTWSVLCALNAAGIDHQDPMIRKAVEWLVSIQSWDGGWGEDAISYRLDYSG
YEQAPSTSSQTAWALLGLMAAGEVEHPAVARGVNYLKNAQTENGLWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYR
NLRSTNV
>Mature_647_residues
MNKHSGNRTAIDPAALEMSIASATEALLAYRHADGHWAFELEADSTIPSEYILLRHYLAEPIDVVLEAKIGNYLRRTQGA
HGGWPLVHDGPFDMSASVKSYFALKMIGDSVDAAHMVKAREAIRARGGAANSNVLTRFLLALYGVVSWRAVPVLPIEIVL
LPIWSPFHLYKISYWARTTIVPLMVLAVLKPRAKNPKGVGIEELFLQDTKSVGMNPKAPHQSWGWFLLFRGIDGILRVIE
PHLPKKLRERAIASALAFTEERLNGEDGMGAIYPSMANIVMMYDALGKDDHFPPRAIARRAIDKLLVIGEEEAYCQPCLS
PVWDTALTCHALQEVGGANAVAKAKQGLDWLKPRQVLDVKGDWAVKAPNIRPGGWPFQYNNAHYPDLDDTAVVVMAMDRA
QRHAGSKEYATAIARGREWIEGMQSRDGGWAAFDVNNLEYYLNNLPFADHGALLDPPTEDVTARCVSMLAQVGEFTQRSK
AVAEGIAYLRRTQHAEGSWYGRWGLNYIYGTWSVLCALNAAGIDHQDPMIRKAVEWLVSIQSWDGGWGEDAISYRLDYSG
YEQAPSTSSQTAWALLGLMAAGEVEHPAVARGVNYLKNAQTENGLWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYR
NLRSTNV

Specific function: Catalyzes the cyclization of squalene into hopene. Probably part of an operon y4aABCD involved in the synthesis of an isoprenoid compound

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats

Homologues:

Organism=Homo sapiens, GI47933395, Length=647, Percent_Identity=26.4296754250386, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI47933397, Length=647, Percent_Identity=26.4296754250386, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI224177558, Length=647, Percent_Identity=26.4296754250386, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI224177556, Length=647, Percent_Identity=25.6568778979907, Blast_Score=169, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321863, Length=164, Percent_Identity=34.1463414634146, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SQHC_RHISN (P55348)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_443761.1
- ProteinModelPortal:   P55348
- GeneID:   962250
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a00460
- HOGENOM:   HBG535807
- ProtClustDB:   CLSK2393506
- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930
- TIGRFAMs:   TIGR01507
- TIGRFAMs:   TIGR01787

Pfam domain/function: PF00432 Prenyltrans; SSF48239 Terp_cyc_toroid

EC number: =5.4.99.17

Molecular weight: Translated: 72131; Mature: 72131

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS01074 TERPENE_SYNTHASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKHSGNRTAIDPAALEMSIASATEALLAYRHADGHWAFELEADSTIPSEYILLRHYLAE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCHHHHHHHHHHHC
PIDVVLEAKIGNYLRRTQGAHGGWPLVHDGPFDMSASVKSYFALKMIGDSVDAAHMVKAR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
EAIRARGGAANSNVLTRFLLALYGVVSWRAVPVLPIEIVLLPIWSPFHLYKISYWARTTI
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHEEEHHHHHHHH
VPLMVLAVLKPRAKNPKGVGIEELFLQDTKSVGMNPKAPHQSWGWFLLFRGIDGILRVIE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHC
PHLPKKLRERAIASALAFTEERLNGEDGMGAIYPSMANIVMMYDALGKDDHFPPRAIARR
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AIDKLLVIGEEEAYCQPCLSPVWDTALTCHALQEVGGANAVAKAKQGLDWLKPRQVLDVK
HHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHCCCCCEEECC
GDWAVKAPNIRPGGWPFQYNNAHYPDLDDTAVVVMAMDRAQRHAGSKEYATAIARGREWI
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHHHHHHHH
EGMQSRDGGWAAFDVNNLEYYLNNLPFADHGALLDPPTEDVTARCVSMLAQVGEFTQRSK
HHHHCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVAEGIAYLRRTQHAEGSWYGRWGLNYIYGTWSVLCALNAAGIDHQDPMIRKAVEWLVSI
HHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
QSWDGGWGEDAISYRLDYSGYEQAPSTSSQTAWALLGLMAAGEVEHPAVARGVNYLKNAQ
HCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
TENGLWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYRNLRSTNV
CCCCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKHSGNRTAIDPAALEMSIASATEALLAYRHADGHWAFELEADSTIPSEYILLRHYLAE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCHHHHHHHHHHHC
PIDVVLEAKIGNYLRRTQGAHGGWPLVHDGPFDMSASVKSYFALKMIGDSVDAAHMVKAR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
EAIRARGGAANSNVLTRFLLALYGVVSWRAVPVLPIEIVLLPIWSPFHLYKISYWARTTI
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHEEEHHHHHHHH
VPLMVLAVLKPRAKNPKGVGIEELFLQDTKSVGMNPKAPHQSWGWFLLFRGIDGILRVIE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHC
PHLPKKLRERAIASALAFTEERLNGEDGMGAIYPSMANIVMMYDALGKDDHFPPRAIARR
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AIDKLLVIGEEEAYCQPCLSPVWDTALTCHALQEVGGANAVAKAKQGLDWLKPRQVLDVK
HHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHCCCCCEEECC
GDWAVKAPNIRPGGWPFQYNNAHYPDLDDTAVVVMAMDRAQRHAGSKEYATAIARGREWI
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHHHHHHHH
EGMQSRDGGWAAFDVNNLEYYLNNLPFADHGALLDPPTEDVTARCVSMLAQVGEFTQRSK
HHHHCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVAEGIAYLRRTQHAEGSWYGRWGLNYIYGTWSVLCALNAAGIDHQDPMIRKAVEWLVSI
HHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
QSWDGGWGEDAISYRLDYSGYEQAPSTSSQTAWALLGLMAAGEVEHPAVARGVNYLKNAQ
HCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
TENGLWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYRNLRSTNV
CCCCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424