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The map label for this gene is lysS

Identifier: 15668719

GI number: 15668719

Start: 474829

End: 476421

Strand: Reverse

Name: lysS

Synonym: MJ0539

Alternate gene names: 15668719

Gene position: 476421-474829 (Counterclockwise)

Preceding gene: 15668720

Following gene: 15668718

Centisome position: 28.61

GC content: 33.27

Gene sequence:

>1593_bases
ATGCATTGGGCTGATGTAATTGCTGAAAAATTGATTGAAGAGAGAAAAGCAGATAAATATATCGTTGCGAGTGGAATAAC
ACCTTCAGGACATATCCACGTAGGAAATGCAAGGGAAACACTGACAGCAGATGCAATCTATAAGGGATTAATAAATAAAG
GAGTTGAAGCAGAGTTAATTTTTATAGCAGATACCTACGACCCATTAAGGAAGTTATATCCATTCTTACCAAAAGAGTTT
GAGCAGTATATTGGGATGCCTTTAAGCGAGATACCATGTCCAGAGGGTTGCTGTGAAAGTTATGCTGAACACTTTTTAAG
ACCTTACTTAGAGAGTTTAGATGATTTAGGAGTAGAGCTAACAACATATAGAGCTGATGAAAACTACAAAAAAGGACTTT
ATGATGAAAAGATAAAGATTGCCTTAGACAATAGAGAAAAAATTATGGAGATTTTGAATAAATTTAGAGCTAATCCTTTA
CCAGATGACTGGTGGCCAATAAACATAGTTTGTGAAAACTGTGGAAAGTTAAAGACAAAGGTTATAAAATATGATAGTGA
GAAAGAGGAAATAACCTATAGATGTGAGATTTGTGGATTTGAAAACACTGTAAAACCATATAAAGGAAGAGCTAAGCTTC
CATGGAGAGTAGATTGGCCGGCGAGATGGAGTATATTTAATGTAACTATTGAGCCAATGGGTAAAGACCATGCAGCAGCA
GGGGGAAGTTACGATACAGGAGTTTTAATTGCAAAAGAGATTTATAACTATATACCACCAAAAAAGGTTGTTTATGAATG
GATTCAATTAAAAGTTGGGGATAAAGCAATTCCTATGAGTTCTTCAAAAGGTGTTGTGTTTGCTGTAAAGGATTGGACTA
ATATAGCCCACCCAGAGATTTTAAGATTCTTATTGTTGAGAAGTAAGCCAACAAAGCATATAGACTTTGATTTGAAGAAA
ATTCCTGACTTAGTGGATGAATATGATAGATTAGAGGATTTCTACTTTAACAACAAAGATAAAGATGAGTTAAGTGAAGA
AGAACAAGAAAAGATAAGAATTTATGAGTTATCAACACCAAAAATCCCTGAAACTAAGCCGTTTGTTATACCATATAGAT
TCTGTTCAATCATTGCTCAGCTAACTTATGATGAAGAGAAGGAAGATATTAATATGGAGAGAGTATTTGAAATATTAAGA
AGAAATAACTATAGTATAGATGATATTGATGAGTTCAGCATGAAAAAATTGAAAGATAGATTGTTAATGGCAAGAAACTG
GGCTTTGAAGTATGGAGAAAAGTTGGTTATAATTAGTGAGGATGAGGCAAAAGAGATATATGAAAAATTGAAGGATAAAC
AAAAAGAATGGATTAAATACTTCGCTGAAAAATTAAAAACAGCAGAGTTTGATGCTTTAAACTTGCATGAGTTGATTTAT
CAAACAGCAAAAGAACTTGGCTTAAATCCAAGAGATGCCTTCCAAGCATCGTATATGATACTCTTAGGTAAAAAGTACGG
GCCAAAGTTAGGAGCTTTCTTAGCAACTCTTGGAAAAGATTTTGTTATAAGAAGATATTCATTATTTGAATAA

Upstream 100 bases:

>100_bases
CAAATTATTATGTAACCTAAAGAAATTTGGATTTTTTGATTTTTATATTTTAAATAATATAGACAATAAAATAGAAGAAA
CAAAAATTTTGAGGGAAATT

Downstream 100 bases:

>100_bases
TTTTTTACTTTTTTTGGTGGTAAGATGATAAAAATACACGCATTAGAGGAAGTTAAAGGAAATTCTAAAGAAATTGTTGA
AAAAGAATTTGAAAATTTGG

Product: tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MHWADVIAEKLIEERKADKYIVASGITPSGHIHVGNARETLTADAIYKGLINKGVEAELIFIADTYDPLRKLYPFLPKEF
EQYIGMPLSEIPCPEGCCESYAEHFLRPYLESLDDLGVELTTYRADENYKKGLYDEKIKIALDNREKIMEILNKFRANPL
PDDWWPINIVCENCGKLKTKVIKYDSEKEEITYRCEICGFENTVKPYKGRAKLPWRVDWPARWSIFNVTIEPMGKDHAAA
GGSYDTGVLIAKEIYNYIPPKKVVYEWIQLKVGDKAIPMSSSKGVVFAVKDWTNIAHPEILRFLLLRSKPTKHIDFDLKK
IPDLVDEYDRLEDFYFNNKDKDELSEEEQEKIRIYELSTPKIPETKPFVIPYRFCSIIAQLTYDEEKEDINMERVFEILR
RNNYSIDDIDEFSMKKLKDRLLMARNWALKYGEKLVIISEDEAKEIYEKLKDKQKEWIKYFAEKLKTAEFDALNLHELIY
QTAKELGLNPRDAFQASYMILLGKKYGPKLGAFLATLGKDFVIRRYSLFE

Sequences:

>Translated_530_residues
MHWADVIAEKLIEERKADKYIVASGITPSGHIHVGNARETLTADAIYKGLINKGVEAELIFIADTYDPLRKLYPFLPKEF
EQYIGMPLSEIPCPEGCCESYAEHFLRPYLESLDDLGVELTTYRADENYKKGLYDEKIKIALDNREKIMEILNKFRANPL
PDDWWPINIVCENCGKLKTKVIKYDSEKEEITYRCEICGFENTVKPYKGRAKLPWRVDWPARWSIFNVTIEPMGKDHAAA
GGSYDTGVLIAKEIYNYIPPKKVVYEWIQLKVGDKAIPMSSSKGVVFAVKDWTNIAHPEILRFLLLRSKPTKHIDFDLKK
IPDLVDEYDRLEDFYFNNKDKDELSEEEQEKIRIYELSTPKIPETKPFVIPYRFCSIIAQLTYDEEKEDINMERVFEILR
RNNYSIDDIDEFSMKKLKDRLLMARNWALKYGEKLVIISEDEAKEIYEKLKDKQKEWIKYFAEKLKTAEFDALNLHELIY
QTAKELGLNPRDAFQASYMILLGKKYGPKLGAFLATLGKDFVIRRYSLFE
>Mature_530_residues
MHWADVIAEKLIEERKADKYIVASGITPSGHIHVGNARETLTADAIYKGLINKGVEAELIFIADTYDPLRKLYPFLPKEF
EQYIGMPLSEIPCPEGCCESYAEHFLRPYLESLDDLGVELTTYRADENYKKGLYDEKIKIALDNREKIMEILNKFRANPL
PDDWWPINIVCENCGKLKTKVIKYDSEKEEITYRCEICGFENTVKPYKGRAKLPWRVDWPARWSIFNVTIEPMGKDHAAA
GGSYDTGVLIAKEIYNYIPPKKVVYEWIQLKVGDKAIPMSSSKGVVFAVKDWTNIAHPEILRFLLLRSKPTKHIDFDLKK
IPDLVDEYDRLEDFYFNNKDKDELSEEEQEKIRIYELSTPKIPETKPFVIPYRFCSIIAQLTYDEEKEDINMERVFEILR
RNNYSIDDIDEFSMKKLKDRLLMARNWALKYGEKLVIISEDEAKEIYEKLKDKQKEWIKYFAEKLKTAEFDALNLHELIY
QTAKELGLNPRDAFQASYMILLGKKYGPKLGAFLATLGKDFVIRRYSLFE

Specific function: Unknown

COG id: COG1384

COG function: function code J; Lysyl-tRNA synthetase (class I)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_METJA (Q57959)

Other databases:

- EMBL:   L77117
- RefSeq:   NP_247518.1
- ProteinModelPortal:   Q57959
- SMR:   Q57959
- GeneID:   1451404
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0539
- NMPDR:   fig|243232.1.peg.555
- TIGR:   MJ0539
- HOGENOM:   HBG297306
- OMA:   VFAVKDW
- ProtClustDB:   PRK00750
- BioCyc:   MJAN243232:MJ_0539-MONOMER
- BRENDA:   6.1.1.6
- GO:   GO:0005737
- HAMAP:   MF_00177
- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR002904
- InterPro:   IPR020754
- InterPro:   IPR020756
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- Gene3D:   G3DSA:1.10.10.350
- TIGRFAMs:   TIGR00467

Pfam domain/function: PF01921 tRNA-synt_1f; SSF48163 tRNA-synt_bind

EC number: =6.1.1.6

Molecular weight: Translated: 61922; Mature: 61922

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHWADVIAEKLIEERKADKYIVASGITPSGHIHVGNARETLTADAIYKGLINKGVEAELI
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEE
FIADTYDPLRKLYPFLPKEFEQYIGMPLSEIPCPEGCCESYAEHFLRPYLESLDDLGVEL
EEECCHHHHHHHHHCCCHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
TTYRADENYKKGLYDEKIKIALDNREKIMEILNKFRANPLPDDWWPINIVCENCGKLKTK
EEEECCCCHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHH
VIKYDSEKEEITYRCEICGFENTVKPYKGRAKLPWRVDWPARWSIFNVTIEPMGKDHAAA
HEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCCCCC
GGSYDTGVLIAKEIYNYIPPKKVVYEWIQLKVGDKAIPMSSSKGVVFAVKDWTNIAHPEI
CCCCCCHHEEHHHHHHHCCCHHHHHHHHHHEECCCCCCCCCCCCEEEEEECCCCCCCHHH
LRFLLLRSKPTKHIDFDLKKIPDLVDEYDRLEDFYFNNKDKDELSEEEQEKIRIYELSTP
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCEEEEECCCC
KIPETKPFVIPYRFCSIIAQLTYDEEKEDINMERVFEILRRNNYSIDDIDEFSMKKLKDR
CCCCCCCCEEHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LLMARNWALKYGEKLVIISEDEAKEIYEKLKDKQKEWIKYFAEKLKTAEFDALNLHELIY
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QTAKELGLNPRDAFQASYMILLGKKYGPKLGAFLATLGKDFVIRRYSLFE
HHHHHHCCCCHHHHHHEEEEEEECCCCCHHHHHHHHHCHHHHHHHHHCCC
>Mature Secondary Structure
MHWADVIAEKLIEERKADKYIVASGITPSGHIHVGNARETLTADAIYKGLINKGVEAELI
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEE
FIADTYDPLRKLYPFLPKEFEQYIGMPLSEIPCPEGCCESYAEHFLRPYLESLDDLGVEL
EEECCHHHHHHHHHCCCHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
TTYRADENYKKGLYDEKIKIALDNREKIMEILNKFRANPLPDDWWPINIVCENCGKLKTK
EEEECCCCHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHH
VIKYDSEKEEITYRCEICGFENTVKPYKGRAKLPWRVDWPARWSIFNVTIEPMGKDHAAA
HEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCCCCC
GGSYDTGVLIAKEIYNYIPPKKVVYEWIQLKVGDKAIPMSSSKGVVFAVKDWTNIAHPEI
CCCCCCHHEEHHHHHHHCCCHHHHHHHHHHEECCCCCCCCCCCCEEEEEECCCCCCCHHH
LRFLLLRSKPTKHIDFDLKKIPDLVDEYDRLEDFYFNNKDKDELSEEEQEKIRIYELSTP
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCEEEEECCCC
KIPETKPFVIPYRFCSIIAQLTYDEEKEDINMERVFEILRRNNYSIDDIDEFSMKKLKDR
CCCCCCCCEEHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LLMARNWALKYGEKLVIISEDEAKEIYEKLKDKQKEWIKYFAEKLKTAEFDALNLHELIY
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QTAKELGLNPRDAFQASYMILLGKKYGPKLGAFLATLGKDFVIRRYSLFE
HHHHHHCCCCHHHHHHEEEEEEECCCCCHHHHHHHHHCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087