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The map label for this gene is rio1

Identifier: 15668620

GI number: 15668620

Start: 397734

End: 398606

Strand: Reverse

Name: rio1

Synonym: MJ0444

Alternate gene names: 15668620

Gene position: 398606-397734 (Counterclockwise)

Preceding gene: 15668621

Following gene: 15668619

Centisome position: 23.94

GC content: 31.04

Gene sequence:

>873_bases
GTGAGTTGTTATAAGGTGATGCCTATAGCTAAAAATATTGATGATGAACTCTATGAGTTAAATAAATTGCTTAGTGAAAA
AGAAGAGTTTCAATTGGATAGAGAATATCAAAAAGAAATTTTAGAGAAAGAGAGGAAGTTTTTAGAAGATTTAAAGACCG
CTAACGAAGTTTTTGATAAAAGAACCTTAATGACTTTATTTAGTCTATTAGCTGGAAAGCATTTAACTGAATATATAGGG
ATAGTTAATTCTGGAAAAGAGGCAGTAGTATTTAAAGCACGAAAGGGAAAGTTTTACAGAGCAGTTAAGGTTTATAGGGT
AGCCACTTGTGATTTTAAAACTATGAGTAAATATATCCAAGGAGACCCAAGATTTCATTTAAGGAAGAGTAGTAGAAGGC
AAATTATTCATGCATGGGTTGAGAAGGAATTTAGAAATCTAAGAAGGGCTTCTGAAATTATAAATGCCCCAAAGGCAAGA
TTAAGAAGAGAAAATGTCTTAGTTATGGATTTTGTTGGTTATAGAGGAATTCCAGCTCCAAAACTTAAAGATATGCAAGA
TTTAGATTGGGAGAAATATTTTAAAATTATAAAAGAGAGTATGAAAAAGCTTTATGAAGAAGGAGAGTTAGTTCATGGAG
ATTTGAGTGAATACAACATATTGGTTAAAGATGATGAGCCAGTATTTATTGATTTTTCTCAGAGCGTTATAACCCAACAT
CCTTTAGCTCATCCCTTACTTATTAGAGATTGCATAAATATATGCAATTTCTTTAGAAGGAAAAGGGTTGATTGCAATTA
CAAAGATTTATACAAATATATAACTGGAAAAGAGATAGACCCAATTGATGAAGCGATGATTAAGCAATTGTAA

Upstream 100 bases:

>100_bases
TTGACGCCTTTTAGGCGTCCATATCAATAAGGATACTTTCCTGTGAAAGTTCTGTGCCAATAGGGGGCGAAGCCCCCTAT
GGAAAGAAAAGGTTATTTAG

Downstream 100 bases:

>100_bases
ATTAGAATTCTTATTTCTAATTTTTATTTTATATGGTTTTTATATGGTGATAATTATGGTTTTTGGAAATATTGGACAAG
ATAAGAGCATTGAGATTTTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSCYKVMPIAKNIDDELYELNKLLSEKEEFQLDREYQKEILEKERKFLEDLKTANEVFDKRTLMTLFSLLAGKHLTEYIG
IVNSGKEAVVFKARKGKFYRAVKVYRVATCDFKTMSKYIQGDPRFHLRKSSRRQIIHAWVEKEFRNLRRASEIINAPKAR
LRRENVLVMDFVGYRGIPAPKLKDMQDLDWEKYFKIIKESMKKLYEEGELVHGDLSEYNILVKDDEPVFIDFSQSVITQH
PLAHPLLIRDCINICNFFRRKRVDCNYKDLYKYITGKEIDPIDEAMIKQL

Sequences:

>Translated_290_residues
MSCYKVMPIAKNIDDELYELNKLLSEKEEFQLDREYQKEILEKERKFLEDLKTANEVFDKRTLMTLFSLLAGKHLTEYIG
IVNSGKEAVVFKARKGKFYRAVKVYRVATCDFKTMSKYIQGDPRFHLRKSSRRQIIHAWVEKEFRNLRRASEIINAPKAR
LRRENVLVMDFVGYRGIPAPKLKDMQDLDWEKYFKIIKESMKKLYEEGELVHGDLSEYNILVKDDEPVFIDFSQSVITQH
PLAHPLLIRDCINICNFFRRKRVDCNYKDLYKYITGKEIDPIDEAMIKQL
>Mature_289_residues
SCYKVMPIAKNIDDELYELNKLLSEKEEFQLDREYQKEILEKERKFLEDLKTANEVFDKRTLMTLFSLLAGKHLTEYIGI
VNSGKEAVVFKARKGKFYRAVKVYRVATCDFKTMSKYIQGDPRFHLRKSSRRQIIHAWVEKEFRNLRRASEIINAPKARL
RRENVLVMDFVGYRGIPAPKLKDMQDLDWEKYFKIIKESMKKLYEEGELVHGDLSEYNILVKDDEPVFIDFSQSVITQHP
LAHPLLIRDCINICNFFRRKRVDCNYKDLYKYITGKEIDPIDEAMIKQL

Specific function: Unknown

COG id: COG1718

COG function: function code TD; Serine/threonine protein kinase involved in cell cycle control

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain

Homologues:

Organism=Homo sapiens, GI23510356, Length=238, Percent_Identity=37.3949579831933, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI22325377, Length=254, Percent_Identity=35.0393700787402, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI23510358, Length=150, Percent_Identity=38, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI115532073, Length=215, Percent_Identity=40.4651162790698, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17556977, Length=223, Percent_Identity=34.5291479820628, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71989043, Length=138, Percent_Identity=39.1304347826087, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324693, Length=238, Percent_Identity=34.0336134453782, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24662811, Length=239, Percent_Identity=40.1673640167364, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21356879, Length=239, Percent_Identity=40.1673640167364, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI19920700, Length=271, Percent_Identity=35.4243542435424, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIO1_METJA (Q57886)

Other databases:

- EMBL:   L77117
- PIR:   D64355
- RefSeq:   NP_247418.1
- ProteinModelPortal:   Q57886
- SMR:   Q57886
- GeneID:   1451304
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0444
- NMPDR:   fig|243232.1.peg.455
- TIGR:   MJ0444
- HOGENOM:   HBG746084
- OMA:   DPRFHLR
- ProtClustDB:   CLSK876191
- BioCyc:   MJAN243232:MJ_0444-MONOMER
- BRENDA:   2.7.11.1
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR000687
- InterPro:   IPR018935
- InterPro:   IPR008266
- SMART:   SM00090

Pfam domain/function: PF01163 RIO1; SSF56112 Kinase_like

EC number: =2.7.11.1

Molecular weight: Translated: 34470; Mature: 34338

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS50011 PROTEIN_KINASE_DOM; PS01245 RIO1; PS00109 PROTEIN_KINASE_TYR

Important sites: ACT_SITE 214-214 BINDING 103-103 BINDING 219-219 BINDING 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCYKVMPIAKNIDDELYELNKLLSEKEEFQLDREYQKEILEKERKFLEDLKTANEVFDK
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTLMTLFSLLAGKHLTEYIGIVNSGKEAVVFKARKGKFYRAVKVYRVATCDFKTMSKYIQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHC
GDPRFHLRKSSRRQIIHAWVEKEFRNLRRASEIINAPKARLRRENVLVMDFVGYRGIPAP
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCEEEEEECCCCCCCCC
KLKDMQDLDWEKYFKIIKESMKKLYEEGELVHGDLSEYNILVKDDEPVFIDFSQSVITQH
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCHHHCEEEEECCCCEEEECCHHHHHHC
PLAHPLLIRDCINICNFFRRKRVDCNYKDLYKYITGKEIDPIDEAMIKQL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SCYKVMPIAKNIDDELYELNKLLSEKEEFQLDREYQKEILEKERKFLEDLKTANEVFDK
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTLMTLFSLLAGKHLTEYIGIVNSGKEAVVFKARKGKFYRAVKVYRVATCDFKTMSKYIQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHC
GDPRFHLRKSSRRQIIHAWVEKEFRNLRRASEIINAPKARLRRENVLVMDFVGYRGIPAP
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCEEEEEECCCCCCCCC
KLKDMQDLDWEKYFKIIKESMKKLYEEGELVHGDLSEYNILVKDDEPVFIDFSQSVITQH
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCHHHCEEEEECCCCEEEECCHHHHHHC
PLAHPLLIRDCINICNFFRRKRVDCNYKDLYKYITGKEIDPIDEAMIKQL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087