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The map label for this gene is dppB

Identifier: 30995430

GI number: 30995430

Start: 1252631

End: 1253602

Strand: Reverse

Name: dppB

Synonym: HI1187

Alternate gene names: 30995430

Gene position: 1253602-1252631 (Counterclockwise)

Preceding gene: 16273110

Following gene: 16273108

Centisome position: 68.5

GC content: 41.05

Gene sequence:

>972_bases
ATGGTGATCCCTACTTTTATTGCCATTACTCTTATTACCTTTGCCCTTGTGCATTTTATTCCCGGTGATCCTGTGGAAAT
TATGATGGGGGAACGTGGCTTAACGGCAGAAGTACATCAACAAATGATGCACCAATTGGGTTTAGATTTACCTCTTTATC
AGCAATATTTCCACTATATTGGCAATGTAATTCAAGGGGATTTCGGTGCATCGTTCCGCACTCAACAACCTGTCCTTACT
GAATTTTTTACGCTTTTCCCTGCTACCGCTGAATTAGCTTTTTTTGCGTTATTTTGGTCATTATTAGGTGGAATAATTTT
AGGCACGATTGCCGCAGTAAAAAAAGACAGTTGGATTTCTCACACCGTTACAGCTGCATCGCTCACAGGTTATTCTATGC
CGATTTTCTGGTGGGGTTTAATTTTAATTTTATATGTTTCGCCACAACTCGGTTTGCCACAAGGTGGGCGTTTAGATAAT
GAATTTTGGATCGATACACCAACAGGATTTATGCTTATTGATAGCTGGCTTTCAGGTGTTTCTGGTGCCTTCGAAAATGC
GGTGAAATCCTTAATTCTTCCTGCAATAGTCCTAGGCACAGTTCCTCTCGCCATTATTACGCGTATGACACGATCTGCAA
TGCTGGAAGTATTAGGCGAAGATTACATTCGCACGGCAAAAGCAAAAGGTTTAAGCTATACTCGAATTGTTATTGTTCAC
GCATTGCGTAATGCGTTAATTCCTGTTGTCACTGTGGTCGGGTTAATTGTAGCTCAATTGCTTTCTGGTGCAGTTCTCAC
AGAAACTATTTTCTCTTGGCCGGGGATTGGAAAATGGATTATTGATGCCATTCAAGCCCGTGATTATCCAGTGTTGCAAG
GTTCTGTACTGATTATTGCGACGATTATTATTGTGGTAAATTTAACCGTCGATTTACTTTACGGCGTGGTCAATCCGCGT
ATCCGTCATTAA

Upstream 100 bases:

>100_bases
TTTTACCGATTAATTTCTTTGAAGAGTGCGGTGAATTTTTACCGCACTTTTATTATCTACGAGTGATGGAATGTTTAAAT
TTGTATTCAAACGAATCTTA

Downstream 100 bases:

>100_bases
TTGTAGGAGAAATTATGTCTGACACGCCTTTAACTTTCGCGCCAAAAACACCCTTACAAGAATTTTGGTTTTACTTTAAA
CAAAATCGTGGTGCGCTAAT

Product: dipeptide ABC transporter permease

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MVIPTFIAITLITFALVHFIPGDPVEIMMGERGLTAEVHQQMMHQLGLDLPLYQQYFHYIGNVIQGDFGASFRTQQPVLT
EFFTLFPATAELAFFALFWSLLGGIILGTIAAVKKDSWISHTVTAASLTGYSMPIFWWGLILILYVSPQLGLPQGGRLDN
EFWIDTPTGFMLIDSWLSGVSGAFENAVKSLILPAIVLGTVPLAIITRMTRSAMLEVLGEDYIRTAKAKGLSYTRIVIVH
ALRNALIPVVTVVGLIVAQLLSGAVLTETIFSWPGIGKWIIDAIQARDYPVLQGSVLIIATIIIVVNLTVDLLYGVVNPR
IRH

Sequences:

>Translated_323_residues
MVIPTFIAITLITFALVHFIPGDPVEIMMGERGLTAEVHQQMMHQLGLDLPLYQQYFHYIGNVIQGDFGASFRTQQPVLT
EFFTLFPATAELAFFALFWSLLGGIILGTIAAVKKDSWISHTVTAASLTGYSMPIFWWGLILILYVSPQLGLPQGGRLDN
EFWIDTPTGFMLIDSWLSGVSGAFENAVKSLILPAIVLGTVPLAIITRMTRSAMLEVLGEDYIRTAKAKGLSYTRIVIVH
ALRNALIPVVTVVGLIVAQLLSGAVLTETIFSWPGIGKWIIDAIQARDYPVLQGSVLIIATIIIVVNLTVDLLYGVVNPR
IRH
>Mature_323_residues
MVIPTFIAITLITFALVHFIPGDPVEIMMGERGLTAEVHQQMMHQLGLDLPLYQQYFHYIGNVIQGDFGASFRTQQPVLT
EFFTLFPATAELAFFALFWSLLGGIILGTIAAVKKDSWISHTVTAASLTGYSMPIFWWGLILILYVSPQLGLPQGGRLDN
EFWIDTPTGFMLIDSWLSGVSGAFENAVKSLILPAIVLGTVPLAIITRMTRSAMLEVLGEDYIRTAKAKGLSYTRIVIVH
ALRNALIPVVTVVGLIVAQLLSGAVLTETIFSWPGIGKWIIDAIQARDYPVLQGSVLIIATIIIVVNLTVDLLYGVVNPR
IRH

Specific function: Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane

COG id: COG0601

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain

Homologues:

Organism=Escherichia coli, GI1789965, Length=327, Percent_Identity=61.1620795107034, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1787761, Length=318, Percent_Identity=48.7421383647799, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1787053, Length=322, Percent_Identity=38.5093167701863, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1787550, Length=276, Percent_Identity=36.5942028985507, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789888, Length=326, Percent_Identity=34.0490797546012, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1787497, Length=322, Percent_Identity=32.6086956521739, Blast_Score=174, Evalue=5e-45,
Organism=Escherichia coli, GI1788504, Length=367, Percent_Identity=26.7029972752044, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPPB_HAEIN (P45096)

Other databases:

- EMBL:   L42023
- EMBL:   U17295
- PIR:   G64188
- RefSeq:   NP_439343.2
- ProteinModelPortal:   P45096
- GeneID:   950100
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1187
- NMPDR:   fig|71421.1.peg.1134
- TIGR:   HI_1187
- HOGENOM:   HBG724229
- OMA:   MLVSVQL
- ProtClustDB:   CLSK870019
- BioCyc:   HINF71421:HI_1187-MONOMER
- InterPro:   IPR000515

Pfam domain/function: PF00528 BPD_transp_1

EC number: NA

Molecular weight: Translated: 35478; Mature: 35478

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xdc53ed8)-; HASH(0xdf7cae0)-; HASH(0xdad5538)-; HASH(0xd1a6708)-; HASH(0xd44f620)-; HASH(0xc5ad848)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIPTFIAITLITFALVHFIPGDPVEIMMGERGLTAEVHQQMMHQLGLDLPLYQQYFHYI
CCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
GNVIQGDFGASFRTQQPVLTEFFTLFPATAELAFFALFWSLLGGIILGTIAAVKKDSWIS
HHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
HTVTAASLTGYSMPIFWWGLILILYVSPQLGLPQGGRLDNEFWIDTPTGFMLIDSWLSGV
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHH
SGAFENAVKSLILPAIVLGTVPLAIITRMTRSAMLEVLGEDYIRTAKAKGLSYTRIVIVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ALRNALIPVVTVVGLIVAQLLSGAVLTETIFSWPGIGKWIIDAIQARDYPVLQGSVLIIA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
TIIIVVNLTVDLLYGVVNPRIRH
HHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MVIPTFIAITLITFALVHFIPGDPVEIMMGERGLTAEVHQQMMHQLGLDLPLYQQYFHYI
CCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
GNVIQGDFGASFRTQQPVLTEFFTLFPATAELAFFALFWSLLGGIILGTIAAVKKDSWIS
HHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
HTVTAASLTGYSMPIFWWGLILILYVSPQLGLPQGGRLDNEFWIDTPTGFMLIDSWLSGV
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHH
SGAFENAVKSLILPAIVLGTVPLAIITRMTRSAMLEVLGEDYIRTAKAKGLSYTRIVIVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ALRNALIPVVTVVGLIVAQLLSGAVLTETIFSWPGIGKWIIDAIQARDYPVLQGSVLIIA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
TIIIVVNLTVDLLYGVVNPRIRH
HHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800; 8550458