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The map label for this gene is uvrD

Identifier: 16273110

GI number: 16273110

Start: 1253722

End: 1255905

Strand: Reverse

Name: uvrD

Synonym: HI1188

Alternate gene names: 16273110

Gene position: 1255905-1253722 (Counterclockwise)

Preceding gene: 16273111

Following gene: 30995430

Centisome position: 68.62

GC content: 39.93

Gene sequence:

>2184_bases
ATGATGGATATTTCTGAATTACTTGACGGACTCAACGATAAACAACGCGAACGCGTAGCTGCTCCTCTTGGTAATCACTT
AGTGCTAGCTGGTGCAGGCTCGGGCAAAACGCGTGTATTGACGCACCGTATTGCTTGGTTAATTGCGGTCGAAAATATTT
CTGAAGGCAGCATTATGGCGGTGACGTTTACCAATAAAGCCGCAGCAGAAATGCGTCATCGTATTCAATCTACCCTTGCC
AAACACGCACAACATCAATTATTTGGTATGTGGATTGGCACCTTCCATAGCATTGCTCATCGTTTGTTGCGAGCTCATCA
TTTAGATGTGGGATTGCCACAAGATTTCCAAATTTTAGATTCAGAAGATCAACTTCGTTTAATTAAACGATTATTAAAAT
TACATAATTTTGATGAAAAAGCTTTTCCGCCTAAACAGGCTTGTTGGTACATCAATAACAAAAAAGATGAAGGCTTGCGA
CCAAATGATATTGAAGATTTTAATGATCGCCAAGAACGTGAATGGATTAAAATTTATCAGATCTATCAAGACACTTGCGA
TCGCGCAGGGTTGGTCGATTTTGCTGAATTATTAATTCGGGTCTATGAATTATTTGAGAAAAAACCATTAATTTTGCAAC
GTTATCAACAACGTTTTCAGCATATTTTGGTGGATGAATTTCAAGACACCAATAAAATCCAATATAAATGGATCAAAATT
CTTGCTGGAAAAACAGGCCAAGTCATGATTGTGGGCGATGATGATCAATCTATATACGGTTGGCGTGGTGCACAAATAGA
AAATATCCAAAAATTCTTGAAAGATTTCAAAGCCGAAACAATTCGCCTTGAACAAAACTATCGTTCTACCGCCAATATCC
TAAACAGCGCAAATGAATTAATTGCAAACAATAGTGATCGTCTTGGTAAAAATTTATGGACAGAGGGTGAGAAAGGCGAT
CCTGTGGGCATCTATTCTGCCTTTAATGAATTAGATGAAGCAAAATTTGTCGCTTCACAAATTCAGGATTGGGTAGAACA
TGGCGGAAAACTTGATGATTGCGCTGTACTTTATCGTAGTAATAGCCAATCACGGGTTATTGAAGAAGCTTTAATTCGTT
GTCAAATTCCATACCGTATTTATGGCGGTATGCGTTTCTTCGAACGTCAAGAAATTAAAGATGCGTTAGCCTATCTTCGT
TTGATTAATAATCGTCAAGATGATGCGGCTTTTGAGCGTGTAATTAATACGCCAACCCGTGGCATTGGCGACCGCACTTT
AGATATATTGCGTAACTTAACACGCGAACGCCAAATTACCTTATGGCAAGCAGTACAAGTCGCAACACAAGAAAATATGT
TGGCAGGGCGAGCCTCAACAGCCTTATTACGTTTCCAAGAATTAATTAATTCACTACAACTTGATACCGCAGAAATGCCG
CTTTTCGCACAAACTGATTTTGTGATTAAACATTCGGGCTTATATGAAATGTATCAACAAGAAAAAGGCGAAAAAGGCGA
AGTGCGTATTGAAAACTTGGAAGAATTAGTTACCGCAACCCGTGAATTTATCAAACCTGATAATGCGGAAGAAATGACCG
AACTCACTGCCTTTTTAACGCACGCTTCCTTAGAAGCTGGCGAAGAACAAGCCTCGCCGCATCAATCTTGTGTAGAAATG
ATGACGTTGCACTCTGCGAAAGGCTTAGAATTTCCTCGTGTATTTATGGTGGGCGTAGAAGAAGGATTATTCCCAAGTTT
TCGTTCTTTTGAAGAACCCGGACGTTTAGAAGAAGAGCGTCGTTTAGCTTATGTCGGTATTACTCGCGCGAAGAAAAAAC
TGACCATCTCTTATGCGGAAAGCCGTCGATTATATGCCAAAGAAGAACGCCATTTGCCATCACGGTTTATCGCAGAATTA
CCGAGAGAATGTATCCAAGAAATTCGTTTACGAGGGACAGTCACTCGTGCGATGAACCTAGCAAAAGTCGGTTCATTGTC
GAATACCAGTGCGGTCGAAAATGAATGGAAAATGGGTCAAAAAGTTAAACACGAAAAATTTGGTTTCGGCACAGTGATTA
ATGTGGAAGGTTCTGAAAATAACACACGTTTACAAATAGCATTCCAAGCGCAAGGCATTAAATGGTTGATTGCGCATTTG
GCAAAATTGGAAAAAGTGCGGTAG

Upstream 100 bases:

>100_bases
AAATGTTCTACCCTACTTTTGATATACTCACAAATCTTATTGTTTCACAAGATAGATGGGACTATAATAACTGTAAATTT
AAACAGATTAAAGATAGTTT

Downstream 100 bases:

>100_bases
AATTCAAGAGTATTATATTTTTTACCGATTAATTTCTTTGAAGAGTGCGGTGAATTTTTACCGCACTTTTATTATCTACG
AGTGATGGAATGTTTAAATT

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 727; Mature: 727

Protein sequence:

>727_residues
MMDISELLDGLNDKQRERVAAPLGNHLVLAGAGSGKTRVLTHRIAWLIAVENISEGSIMAVTFTNKAAAEMRHRIQSTLA
KHAQHQLFGMWIGTFHSIAHRLLRAHHLDVGLPQDFQILDSEDQLRLIKRLLKLHNFDEKAFPPKQACWYINNKKDEGLR
PNDIEDFNDRQEREWIKIYQIYQDTCDRAGLVDFAELLIRVYELFEKKPLILQRYQQRFQHILVDEFQDTNKIQYKWIKI
LAGKTGQVMIVGDDDQSIYGWRGAQIENIQKFLKDFKAETIRLEQNYRSTANILNSANELIANNSDRLGKNLWTEGEKGD
PVGIYSAFNELDEAKFVASQIQDWVEHGGKLDDCAVLYRSNSQSRVIEEALIRCQIPYRIYGGMRFFERQEIKDALAYLR
LINNRQDDAAFERVINTPTRGIGDRTLDILRNLTRERQITLWQAVQVATQENMLAGRASTALLRFQELINSLQLDTAEMP
LFAQTDFVIKHSGLYEMYQQEKGEKGEVRIENLEELVTATREFIKPDNAEEMTELTAFLTHASLEAGEEQASPHQSCVEM
MTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERRLAYVGITRAKKKLTISYAESRRLYAKEERHLPSRFIAEL
PRECIQEIRLRGTVTRAMNLAKVGSLSNTSAVENEWKMGQKVKHEKFGFGTVINVEGSENNTRLQIAFQAQGIKWLIAHL
AKLEKVR

Sequences:

>Translated_727_residues
MMDISELLDGLNDKQRERVAAPLGNHLVLAGAGSGKTRVLTHRIAWLIAVENISEGSIMAVTFTNKAAAEMRHRIQSTLA
KHAQHQLFGMWIGTFHSIAHRLLRAHHLDVGLPQDFQILDSEDQLRLIKRLLKLHNFDEKAFPPKQACWYINNKKDEGLR
PNDIEDFNDRQEREWIKIYQIYQDTCDRAGLVDFAELLIRVYELFEKKPLILQRYQQRFQHILVDEFQDTNKIQYKWIKI
LAGKTGQVMIVGDDDQSIYGWRGAQIENIQKFLKDFKAETIRLEQNYRSTANILNSANELIANNSDRLGKNLWTEGEKGD
PVGIYSAFNELDEAKFVASQIQDWVEHGGKLDDCAVLYRSNSQSRVIEEALIRCQIPYRIYGGMRFFERQEIKDALAYLR
LINNRQDDAAFERVINTPTRGIGDRTLDILRNLTRERQITLWQAVQVATQENMLAGRASTALLRFQELINSLQLDTAEMP
LFAQTDFVIKHSGLYEMYQQEKGEKGEVRIENLEELVTATREFIKPDNAEEMTELTAFLTHASLEAGEEQASPHQSCVEM
MTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERRLAYVGITRAKKKLTISYAESRRLYAKEERHLPSRFIAEL
PRECIQEIRLRGTVTRAMNLAKVGSLSNTSAVENEWKMGQKVKHEKFGFGTVINVEGSENNTRLQIAFQAQGIKWLIAHL
AKLEKVR
>Mature_727_residues
MMDISELLDGLNDKQRERVAAPLGNHLVLAGAGSGKTRVLTHRIAWLIAVENISEGSIMAVTFTNKAAAEMRHRIQSTLA
KHAQHQLFGMWIGTFHSIAHRLLRAHHLDVGLPQDFQILDSEDQLRLIKRLLKLHNFDEKAFPPKQACWYINNKKDEGLR
PNDIEDFNDRQEREWIKIYQIYQDTCDRAGLVDFAELLIRVYELFEKKPLILQRYQQRFQHILVDEFQDTNKIQYKWIKI
LAGKTGQVMIVGDDDQSIYGWRGAQIENIQKFLKDFKAETIRLEQNYRSTANILNSANELIANNSDRLGKNLWTEGEKGD
PVGIYSAFNELDEAKFVASQIQDWVEHGGKLDDCAVLYRSNSQSRVIEEALIRCQIPYRIYGGMRFFERQEIKDALAYLR
LINNRQDDAAFERVINTPTRGIGDRTLDILRNLTRERQITLWQAVQVATQENMLAGRASTALLRFQELINSLQLDTAEMP
LFAQTDFVIKHSGLYEMYQQEKGEKGEVRIENLEELVTATREFIKPDNAEEMTELTAFLTHASLEAGEEQASPHQSCVEM
MTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERRLAYVGITRAKKKLTISYAESRRLYAKEERHLPSRFIAEL
PRECIQEIRLRGTVTRAMNLAKVGSLSNTSAVENEWKMGQKVKHEKFGFGTVINVEGSENNTRLQIAFQAQGIKWLIAHL
AKLEKVR

Specific function: May process damage occurring in non-replicating regions of DNA to produce recombinational intermediates for sister strand recombinational exchange

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain

Homologues:

Organism=Escherichia coli, GI2367296, Length=728, Percent_Identity=67.1703296703297, Blast_Score=1019, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=643, Percent_Identity=39.1912908242613, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1789183, Length=518, Percent_Identity=23.5521235521236, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1787196, Length=183, Percent_Identity=28.9617486338798, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322369, Length=734, Percent_Identity=28.8828337874659, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324477, Length=668, Percent_Identity=21.7065868263473, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): UVRD_HAEIN (Q02322)

Other databases:

- EMBL:   M99049
- EMBL:   L42023
- PIR:   H64188
- RefSeq:   NP_439344.1
- ProteinModelPortal:   Q02322
- SMR:   Q02322
- GeneID:   950076
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1188
- NMPDR:   fig|71421.1.peg.1135
- TIGR:   HI_1188
- HOGENOM:   HBG467281
- OMA:   GIKWLIA
- ProtClustDB:   PRK11773
- BioCyc:   HINF71421:HI_1188-MONOMER
- GO:   GO:0005737
- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016
- Gene3D:   G3DSA:1.10.10.160
- PANTHER:   PTHR11070
- TIGRFAMs:   TIGR01075

Pfam domain/function: PF00580 UvrD-helicase

EC number: =3.6.4.12

Molecular weight: Translated: 83714; Mature: 83714

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS51198 UVRD_HELICASE_ATP_BIND; PS51217 UVRD_HELICASE_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDISELLDGLNDKQRERVAAPLGNHLVLAGAGSGKTRVLTHRIAWLIAVENISEGSIMA
CCCHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHEECCCCCCCEEE
VTFTNKAAAEMRHRIQSTLAKHAQHQLFGMWIGTFHSIAHRLLRAHHLDVGLPQDFQILD
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECC
SEDQLRLIKRLLKLHNFDEKAFPPKQACWYINNKKDEGLRPNDIEDFNDRQEREWIKIYQ
CCHHHHHHHHHHHHCCCCCCCCCCCHHEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
IYQDTCDRAGLVDFAELLIRVYELFEKKPLILQRYQQRFQHILVDEFQDTNKIQYKWIKI
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEE
LAGKTGQVMIVGDDDQSIYGWRGAQIENIQKFLKDFKAETIRLEQNYRSTANILNSANEL
EECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHH
IANNSDRLGKNLWTEGEKGDPVGIYSAFNELDEAKFVASQIQDWVEHGGKLDDCAVLYRS
HCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEC
NSQSRVIEEALIRCQIPYRIYGGMRFFERQEIKDALAYLRLINNRQDDAAFERVINTPTR
CCHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
GIGDRTLDILRNLTRERQITLWQAVQVATQENMLAGRASTALLRFQELINSLQLDTAEMP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LFAQTDFVIKHSGLYEMYQQEKGEKGEVRIENLEELVTATREFIKPDNAEEMTELTAFLT
EEECCCEEEECCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
HASLEAGEEQASPHQSCVEMMTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEER
HHHHHCCHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCHHH
RLAYVGITRAKKKLTISYAESRRLYAKEERHLPSRFIAELPRECIQEIRLRGTVTRAMNL
CEEEEEHHHHCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKVGSLSNTSAVENEWKMGQKVKHEKFGFGTVINVEGSENNTRLQIAFQAQGIKWLIAHL
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCHHHHHHHH
AKLEKVR
HHHHCCC
>Mature Secondary Structure
MMDISELLDGLNDKQRERVAAPLGNHLVLAGAGSGKTRVLTHRIAWLIAVENISEGSIMA
CCCHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHEECCCCCCCEEE
VTFTNKAAAEMRHRIQSTLAKHAQHQLFGMWIGTFHSIAHRLLRAHHLDVGLPQDFQILD
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECC
SEDQLRLIKRLLKLHNFDEKAFPPKQACWYINNKKDEGLRPNDIEDFNDRQEREWIKIYQ
CCHHHHHHHHHHHHCCCCCCCCCCCHHEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
IYQDTCDRAGLVDFAELLIRVYELFEKKPLILQRYQQRFQHILVDEFQDTNKIQYKWIKI
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEE
LAGKTGQVMIVGDDDQSIYGWRGAQIENIQKFLKDFKAETIRLEQNYRSTANILNSANEL
EECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHH
IANNSDRLGKNLWTEGEKGDPVGIYSAFNELDEAKFVASQIQDWVEHGGKLDDCAVLYRS
HCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEC
NSQSRVIEEALIRCQIPYRIYGGMRFFERQEIKDALAYLRLINNRQDDAAFERVINTPTR
CCHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
GIGDRTLDILRNLTRERQITLWQAVQVATQENMLAGRASTALLRFQELINSLQLDTAEMP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LFAQTDFVIKHSGLYEMYQQEKGEKGEVRIENLEELVTATREFIKPDNAEEMTELTAFLT
EEECCCEEEECCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
HASLEAGEEQASPHQSCVEMMTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEER
HHHHHCCHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCHHH
RLAYVGITRAKKKLTISYAESRRLYAKEERHLPSRFIAELPRECIQEIRLRGTVTRAMNL
CEEEEEHHHHCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKVGSLSNTSAVENEWKMGQKVKHEKFGFGTVINVEGSENNTRLQIAFQAQGIKWLIAHL
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCHHHHHHHH
AKLEKVR
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8294031; 7542800; 3259573