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The map label for this gene is dppC

Identifier: 16273108

GI number: 16273108

Start: 1251729

End: 1252616

Strand: Reverse

Name: dppC

Synonym: HI1186

Alternate gene names: 16273108

Gene position: 1252616-1251729 (Counterclockwise)

Preceding gene: 30995430

Following gene: 16273107

Centisome position: 68.44

GC content: 41.44

Gene sequence:

>888_bases
ATGTCTGACACGCCTTTAACTTTCGCGCCAAAAACACCCTTACAAGAATTTTGGTTTTACTTTAAACAAAATCGTGGTGC
GCTAATTGGTTTAATTTTTATTTTGATTGTTGCCTTAATCAGCATTCTCGCGCCTTATATTGCACCTTTTGATCCAACAG
AACAAAATCGTACCGCACTTTTACTGCCACCCGCTTGGTATGAGGGCGGTAATCCTGCTTATTTACTCGGCACAGACGAT
ATTGGGCGAGATATTCTTTCGCGTATTATTTATGGAACGCGAATTTCCGTCTTTGCGGGATTTATCATCGTATTACTATC
TTGCGCCTTTGGTACCAGCCTTGGCTTGATTTCTGGCTATTATGGCGGCGTGCTAGATACAATTATCATTCGCCTAATTG
ATATTATGCTCGCAATTCCAAACTTACTTTTGACGATTGTAGTCGTCTCTATTTTAGAGCCATCACTCGCCAATGCCACT
TTAGCGATCGCCGTGGTATCGATTCCTAGCTATGTGCGTTTAACTCGAGCAGCGATGATGAATGAAAAAAATCGTGATTA
TGTGACTTCATCTAAAGTGGCAGGGGCAGGTATTTTACGCCTCATGTTTATTGTGATTTTACCAAACTGTTTAGCCCCTT
TAATTGTGCAAATGACTATGGGAATATCCAATGCTATCTTAGAACTCGCGACACTTGGTTTCTTAGGCATTGGTGCAAAA
CCACCAACACCTGAACTTGGCACAATGCTTTCAGAAGCACGTGGTTTTATGCAAGCGGCAAACTGGTTAGTTACAATTCC
TGGCTTAGTGATTTTATCTTTGGTATTAGCTTTCAACTTAATGGGCGATGGCTTGCGTGATGCCCTTGATCCAAAACTCA
AACAATAG

Upstream 100 bases:

>100_bases
TACTGATTATTGCGACGATTATTATTGTGGTAAATTTAACCGTCGATTTACTTTACGGCGTGGTCAATCCGCGTATCCGT
CATTAATTGTAGGAGAAATT

Downstream 100 bases:

>100_bases
GAAAACAGAATGGCATTATTAGACGTAAAAGAACTTTCTGTTCACTTTGGCGATAAAAAAACGCCATTTAAAGCAGTGGA
TCGCATTAGCTATCAAGTCG

Product: dipeptide ABC transporter permease

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSDTPLTFAPKTPLQEFWFYFKQNRGALIGLIFILIVALISILAPYIAPFDPTEQNRTALLLPPAWYEGGNPAYLLGTDD
IGRDILSRIIYGTRISVFAGFIIVLLSCAFGTSLGLISGYYGGVLDTIIIRLIDIMLAIPNLLLTIVVVSILEPSLANAT
LAIAVVSIPSYVRLTRAAMMNEKNRDYVTSSKVAGAGILRLMFIVILPNCLAPLIVQMTMGISNAILELATLGFLGIGAK
PPTPELGTMLSEARGFMQAANWLVTIPGLVILSLVLAFNLMGDGLRDALDPKLKQ

Sequences:

>Translated_295_residues
MSDTPLTFAPKTPLQEFWFYFKQNRGALIGLIFILIVALISILAPYIAPFDPTEQNRTALLLPPAWYEGGNPAYLLGTDD
IGRDILSRIIYGTRISVFAGFIIVLLSCAFGTSLGLISGYYGGVLDTIIIRLIDIMLAIPNLLLTIVVVSILEPSLANAT
LAIAVVSIPSYVRLTRAAMMNEKNRDYVTSSKVAGAGILRLMFIVILPNCLAPLIVQMTMGISNAILELATLGFLGIGAK
PPTPELGTMLSEARGFMQAANWLVTIPGLVILSLVLAFNLMGDGLRDALDPKLKQ
>Mature_294_residues
SDTPLTFAPKTPLQEFWFYFKQNRGALIGLIFILIVALISILAPYIAPFDPTEQNRTALLLPPAWYEGGNPAYLLGTDDI
GRDILSRIIYGTRISVFAGFIIVLLSCAFGTSLGLISGYYGGVLDTIIIRLIDIMLAIPNLLLTIVVVSILEPSLANATL
AIAVVSIPSYVRLTRAAMMNEKNRDYVTSSKVAGAGILRLMFIVILPNCLAPLIVQMTMGISNAILELATLGFLGIGAKP
PTPELGTMLSEARGFMQAANWLVTIPGLVILSLVLAFNLMGDGLRDALDPKLKQ

Specific function: Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain

Homologues:

Organism=Escherichia coli, GI1789964, Length=286, Percent_Identity=64.3356643356643, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1787054, Length=284, Percent_Identity=40.4929577464789, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1787760, Length=261, Percent_Identity=43.6781609195402, Blast_Score=214, Evalue=5e-57,
Organism=Escherichia coli, GI1787549, Length=280, Percent_Identity=36.0714285714286, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789889, Length=251, Percent_Identity=33.8645418326693, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1787498, Length=272, Percent_Identity=31.6176470588235, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1788505, Length=218, Percent_Identity=33.4862385321101, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPPC_HAEIN (P51000)

Other databases:

- EMBL:   L42023
- EMBL:   U17295
- RefSeq:   NP_439342.1
- ProteinModelPortal:   P51000
- GeneID:   950114
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1186
- TIGR:   HI_1186
- HOGENOM:   HBG729429
- OMA:   GNWKFIL
- ProtClustDB:   CLSK870020
- BioCyc:   HINF71421:HI_1186-MONOMER
- InterPro:   IPR000515

Pfam domain/function: PF00528 BPD_transp_1

EC number: NA

Molecular weight: Translated: 31841; Mature: 31709

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xdff87f4)-; HASH(0xe2c2a94)-; HASH(0xd7ee140)-; HASH(0xde90074)-; HASH(0xe23f93c)-; HASH(0xe2acb08)-; HASH(0xe2a6f54)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTPLTFAPKTPLQEFWFYFKQNRGALIGLIFILIVALISILAPYIAPFDPTEQNRTAL
CCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LLPPAWYEGGNPAYLLGTDDIGRDILSRIIYGTRISVFAGFIIVLLSCAFGTSLGLISGY
EECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGGVLDTIIIRLIDIMLAIPNLLLTIVVVSILEPSLANATLAIAVVSIPSYVRLTRAAMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NEKNRDYVTSSKVAGAGILRLMFIVILPNCLAPLIVQMTMGISNAILELATLGFLGIGAK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PPTPELGTMLSEARGFMQAANWLVTIPGLVILSLVLAFNLMGDGLRDALDPKLKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCH
>Mature Secondary Structure 
SDTPLTFAPKTPLQEFWFYFKQNRGALIGLIFILIVALISILAPYIAPFDPTEQNRTAL
CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LLPPAWYEGGNPAYLLGTDDIGRDILSRIIYGTRISVFAGFIIVLLSCAFGTSLGLISGY
EECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGGVLDTIIIRLIDIMLAIPNLLLTIVVVSILEPSLANATLAIAVVSIPSYVRLTRAAMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NEKNRDYVTSSKVAGAGILRLMFIVILPNCLAPLIVQMTMGISNAILELATLGFLGIGAK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PPTPELGTMLSEARGFMQAANWLVTIPGLVILSLVLAFNLMGDGLRDALDPKLKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800; 8550458