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The map label for this gene is trxB

Identifier: 16273083

GI number: 16273083

Start: 1227571

End: 1228527

Strand: Reverse

Name: trxB

Synonym: HI1158

Alternate gene names: 16273083

Gene position: 1228527-1227571 (Counterclockwise)

Preceding gene: 16273084

Following gene: 16273082

Centisome position: 67.13

GC content: 43.16

Gene sequence:

>957_bases
ATGTCAGATATCAAACACGCAAAACTTTTAATTTTAGGCTCAGGCCCTGCTGGTTATACAGCAGCCATTTATGCGGCACG
TGCAAACTTAAAACCAGTATTGGTGACTGGTTTGCAACAAGGTGGGCAGCTGACCACTACAGATGAAATTGAGAACTGGC
CGGGCGATTTTGAGATGACTACTGGTTCAGGTTTAATGCAACGTATGTTGCAACATGCAGAAAAATTTGAGACAGAAATC
GTTTTCGATCATATCAATCGCGTCGATTTATCTTCTCGCCCATTCAAACTTTTTGGCGATGTGCAAAATTTCACTTGTGA
TGCGTTAATTATCGCAACAGGTGCCTCTGCACGCTATATTGGCTTACCTTCAGAAGAAAACTACAAAGGTCGTGGCGTTT
CTGCTTGTGCAACCTGTGATGGTTTCTTTTATCGTAATAAGCCTGTTGGTGTCATTGGTGGAGGAAATACAGCGGTGGAA
GAAGCCCTTTACTTAGCCAATATTGCAAGTACAGTGCATTTAATCCACCGTCGCGATAGCTTCCGTGCGGAAAAAATCCT
TATCGATCGTTTATACAAAAAAGTGGAAGAAGGGAAAATCGTTCTTCATACTGACCGCACTTTAGATGAAGTATTGGGCG
ATAATATGGGCGTAACTGGATTACGTTTAGCCAACACAAAAACTGGGGAGAAAGAAGAACTCAAATTAGATGGCTTATTC
GTGGCGATTGGTCATTCGCCAAATACGGAAATTTTCCAAGGGCAACTAGAATTGAATAATGGCTATATCGTTGTAAAATC
TGGTCTTGACGGCAATGCAACTGCCACTTCTGTGGAAGGCGTGTTCGCAGCAGGCGATGTCATGGATCACAATTATCGCC
AAGCCATTACCTCCGCAGGAACTGGTTGTATGGCAGCCTTGGATGCAGAACGCTATTTAGATGCTCAAGAAGCATAA

Upstream 100 bases:

>100_bases
CGATTGCTTTATTCGCTGCTTTACTAAGCAAAAAGTTTATAATCAGTAAAATGCAACTTATTGCATTATATTATTACTTA
ACTACAAACAAGGATTCTTT

Downstream 100 bases:

>100_bases
ATCTTCTAACCAATTCCCCTCTTTTAACTCTTTTAAAGAGGGGAACTTTTTCTATAATCACGACCAAAACAATGAATAAA
CTTCGCCAAAAATATTTACA

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQLTTTDEIENWPGDFEMTTGSGLMQRMLQHAEKFETEI
VFDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYIGLPSEENYKGRGVSACATCDGFFYRNKPVGVIGGGNTAVE
EALYLANIASTVHLIHRRDSFRAEKILIDRLYKKVEEGKIVLHTDRTLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLF
VAIGHSPNTEIFQGQLELNNGYIVVKSGLDGNATATSVEGVFAAGDVMDHNYRQAITSAGTGCMAALDAERYLDAQEA

Sequences:

>Translated_318_residues
MSDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQLTTTDEIENWPGDFEMTTGSGLMQRMLQHAEKFETEI
VFDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYIGLPSEENYKGRGVSACATCDGFFYRNKPVGVIGGGNTAVE
EALYLANIASTVHLIHRRDSFRAEKILIDRLYKKVEEGKIVLHTDRTLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLF
VAIGHSPNTEIFQGQLELNNGYIVVKSGLDGNATATSVEGVFAAGDVMDHNYRQAITSAGTGCMAALDAERYLDAQEA
>Mature_317_residues
SDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQLTTTDEIENWPGDFEMTTGSGLMQRMLQHAEKFETEIV
FDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYIGLPSEENYKGRGVSACATCDGFFYRNKPVGVIGGGNTAVEE
ALYLANIASTVHLIHRRDSFRAEKILIDRLYKKVEEGKIVLHTDRTLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLFV
AIGHSPNTEIFQGQLELNNGYIVVKSGLDGNATATSVEGVFAAGDVMDHNYRQAITSAGTGCMAALDAERYLDAQEA

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family

Homologues:

Organism=Escherichia coli, GI1787114, Length=315, Percent_Identity=76.1904761904762, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI87081763, Length=314, Percent_Identity=35.031847133758, Blast_Score=140, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6321898, Length=329, Percent_Identity=50.1519756838906, Blast_Score=298, Evalue=9e-82,
Organism=Saccharomyces cerevisiae, GI6320560, Length=326, Percent_Identity=50, Blast_Score=292, Evalue=5e-80,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRXB_HAEIN (P43788)

Other databases:

- EMBL:   L42023
- PIR:   G64186
- RefSeq:   NP_439316.1
- ProteinModelPortal:   P43788
- SMR:   P43788
- GeneID:   950118
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1158
- NMPDR:   fig|71421.1.peg.1111
- TIGR:   HI_1158
- HOGENOM:   HBG669726
- OMA:   PSCGPCH
- ProtClustDB:   CLSK870161
- BioCyc:   HINF71421:HI_1158-MONOMER
- BRENDA:   1.8.1.9
- GO:   GO:0005737
- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982
- PRINTS:   PR00368
- PRINTS:   PR00469
- TIGRFAMs:   TIGR01292

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2

EC number: =1.8.1.9

Molecular weight: Translated: 34395; Mature: 34264

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQLTTTDEIENWPGDFEMT
CCCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEHHHHHCCCCCEEEE
TGSGLMQRMLQHAEKFETEIVFDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEE
GLPSEENYKGRGVSACATCDGFFYRNKPVGVIGGGNTAVEEALYLANIASTVHLIHRRDS
ECCCCCCCCCCCCEEEEECCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
FRAEKILIDRLYKKVEEGKIVLHTDRTLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLF
HHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCCEEEEECCCCCCHHEEEEEEEE
VAIGHSPNTEIFQGQLELNNGYIVVKSGLDGNATATSVEGVFAAGDVMDHNYRQAITSAG
EEECCCCCCCEEEEEEEECCCEEEEECCCCCCCCEEEECCEEEECCHHCCHHHHHHHHCC
TGCMAALDAERYLDAQEA
CCCEEECCHHHHCCCCCC
>Mature Secondary Structure 
SDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQLTTTDEIENWPGDFEMT
CCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEHHHHHCCCCCEEEE
TGSGLMQRMLQHAEKFETEIVFDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEE
GLPSEENYKGRGVSACATCDGFFYRNKPVGVIGGGNTAVEEALYLANIASTVHLIHRRDS
ECCCCCCCCCCCCEEEEECCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
FRAEKILIDRLYKKVEEGKIVLHTDRTLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLF
HHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCCEEEEECCCCCCHHEEEEEEEE
VAIGHSPNTEIFQGQLELNNGYIVVKSGLDGNATATSVEGVFAAGDVMDHNYRQAITSAG
EEECCCCCCCEEEEEEEECCCEEEEECCCCCCCCEEEECCEEEECCHHCCHHHHHHHHCC
TGCMAALDAERYLDAQEA
CCCEEECCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800