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The map label for this gene is hemH [H]

Identifier: 16273084

GI number: 16273084

Start: 1229539

End: 1230510

Strand: Reverse

Name: hemH [H]

Synonym: HI1160

Alternate gene names: 16273084

Gene position: 1230510-1229539 (Counterclockwise)

Preceding gene: 16273085

Following gene: 16273083

Centisome position: 67.24

GC content: 37.96

Gene sequence:

>972_bases
ATGACAAAACCAGCAAAAATCGGCGTATTACTTGCCAATCTAGGCACGCCAGATAGCCCAACGCCAAAGTCAATTAGCCG
TTATTTATGGCAATTCTTAACGGATCCTCGCGTGGTCGATTTACCCCGTTGCAAATGGTATCCTCTACTCAAAGCCATTA
TTTTGCCATTGCGTTCAAAACGTATCGCCAAAAATTATCAAGCCATTTGGACAGAGCAAGGATCGCCTTTACTTGCTATT
TCACGACAACAAAAAGACGCATTACAAGCCTATTTAGATAATCAAAATATCGATACTCAAGTAGAAATTGCCATGACTTA
TGGCAATCCATCAATGCAAAGTGCGGTGAAAAATTTGCTTAAAAATCAAGTTGAGCGAATTATTGTCTTGCCTCTTTATC
CGCAATACTCTAGCTCAACTACAGGCGCAGTATTTGATGCTTTCGCTAACGCTCTTAAAGAAGAACGAGGATTACTGCCT
TTTGATTTCATCCATTCTTATCATATTGATGAAAATTACATTAATGCCTTAGCCGACTCCATAAAAGTGCGGTTAAAATC
CGATGAGTTTTTGTTATTTTCTTATCACGGTATTCCTCTGCGTTACGAAAAAATGGGCGATTATTATCGTGAACATTGTA
AACAAACGACTATTGCAGTTGTTAATAAGCTGGGCTTAACAGAAAACCAATGGAGAATGACGTTTCAATCTCGCTTTGGC
CGTGAAGAATGGCTGCAACCTTATACCGATAAATTTTTAGAATCTGCTGCAGCACAGAACATTCAAAAAATTGCCGTTAT
TTGCCCGGGTTTCTCCGTAGATTGTTTAGAAACCATTGAAGAAATTGACGAAGAAAATCGAGAAAATTTCCTAAACAATG
GCGGACAATCTTATCAATATATTCCTGCACTTAATGTAGAGCATGCACATATTGAAATGATGGGAAAATTGATCCTAGAA
AAACTTACTTAA

Upstream 100 bases:

>100_bases
TTAATTTGGGCAGAAATATCCAAGTTTGGCAAATTGACATCCGCACAGAAGAGAATAAACTTTGTTGTGTTTCTAGATTA
ACCCTTTCCGTAATCAATTT

Downstream 100 bases:

>100_bases
TAATAGAAATGGTAAAACGTTTCTAAAATCTTCCGCACTTTGCTAAAATCAGCCATTATTTTTTTCACAAGGATAAAACA
TGGCTGATTTTCCTTTTATC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTKPAKIGVLLANLGTPDSPTPKSISRYLWQFLTDPRVVDLPRCKWYPLLKAIILPLRSKRIAKNYQAIWTEQGSPLLAI
SRQQKDALQAYLDNQNIDTQVEIAMTYGNPSMQSAVKNLLKNQVERIIVLPLYPQYSSSTTGAVFDAFANALKEERGLLP
FDFIHSYHIDENYINALADSIKVRLKSDEFLLFSYHGIPLRYEKMGDYYREHCKQTTIAVVNKLGLTENQWRMTFQSRFG
REEWLQPYTDKFLESAAAQNIQKIAVICPGFSVDCLETIEEIDEENRENFLNNGGQSYQYIPALNVEHAHIEMMGKLILE
KLT

Sequences:

>Translated_323_residues
MTKPAKIGVLLANLGTPDSPTPKSISRYLWQFLTDPRVVDLPRCKWYPLLKAIILPLRSKRIAKNYQAIWTEQGSPLLAI
SRQQKDALQAYLDNQNIDTQVEIAMTYGNPSMQSAVKNLLKNQVERIIVLPLYPQYSSSTTGAVFDAFANALKEERGLLP
FDFIHSYHIDENYINALADSIKVRLKSDEFLLFSYHGIPLRYEKMGDYYREHCKQTTIAVVNKLGLTENQWRMTFQSRFG
REEWLQPYTDKFLESAAAQNIQKIAVICPGFSVDCLETIEEIDEENRENFLNNGGQSYQYIPALNVEHAHIEMMGKLILE
KLT
>Mature_322_residues
TKPAKIGVLLANLGTPDSPTPKSISRYLWQFLTDPRVVDLPRCKWYPLLKAIILPLRSKRIAKNYQAIWTEQGSPLLAIS
RQQKDALQAYLDNQNIDTQVEIAMTYGNPSMQSAVKNLLKNQVERIIVLPLYPQYSSSTTGAVFDAFANALKEERGLLPF
DFIHSYHIDENYINALADSIKVRLKSDEFLLFSYHGIPLRYEKMGDYYREHCKQTTIAVVNKLGLTENQWRMTFQSRFGR
EEWLQPYTDKFLESAAAQNIQKIAVICPGFSVDCLETIEEIDEENRENFLNNGGQSYQYIPALNVEHAHIEMMGKLILEK
LT

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=292, Percent_Identity=26.3698630136986, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI60499021, Length=292, Percent_Identity=26.3698630136986, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1786681, Length=316, Percent_Identity=51.5822784810127, Blast_Score=326, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=25.7396449704142, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17864156, Length=294, Percent_Identity=25.8503401360544, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24651774, Length=259, Percent_Identity=26.6409266409266, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 37089; Mature: 36958

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPAKIGVLLANLGTPDSPTPKSISRYLWQFLTDPRVVDLPRCKWYPLLKAIILPLRSK
CCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHH
RIAKNYQAIWTEQGSPLLAISRQQKDALQAYLDNQNIDTQVEIAMTYGNPSMQSAVKNLL
HHHHHHHHHEECCCCEEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHH
KNQVERIIVLPLYPQYSSSTTGAVFDAFANALKEERGLLPFDFIHSYHIDENYINALADS
HHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHH
IKVRLKSDEFLLFSYHGIPLRYEKMGDYYREHCKQTTIAVVNKLGLTENQWRMTFQSRFG
HEEEECCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
REEWLQPYTDKFLESAAAQNIQKIAVICPGFSVDCLETIEEIDEENRENFLNNGGQSYQY
HHHHCCHHHHHHHHHHHHHCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IPALNVEHAHIEMMGKLILEKLT
ECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKPAKIGVLLANLGTPDSPTPKSISRYLWQFLTDPRVVDLPRCKWYPLLKAIILPLRSK
CCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHH
RIAKNYQAIWTEQGSPLLAISRQQKDALQAYLDNQNIDTQVEIAMTYGNPSMQSAVKNLL
HHHHHHHHHEECCCCEEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHH
KNQVERIIVLPLYPQYSSSTTGAVFDAFANALKEERGLLPFDFIHSYHIDENYINALADS
HHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHH
IKVRLKSDEFLLFSYHGIPLRYEKMGDYYREHCKQTTIAVVNKLGLTENQWRMTFQSRFG
HEEEECCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
REEWLQPYTDKFLESAAAQNIQKIAVICPGFSVDCLETIEEIDEENRENFLNNGGQSYQY
HHHHCCHHHHHHHHHHHHHCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IPALNVEHAHIEMMGKLILEKLT
ECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA