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The map label for this gene is helC [H]

Identifier: 99080842

GI number: 99080842

Start: 1072745

End: 1073479

Strand: Direct

Name: helC [H]

Synonym: TM1040_1001

Alternate gene names: 99080842

Gene position: 1072745-1073479 (Clockwise)

Preceding gene: 99080841

Following gene: 99080843

Centisome position: 33.51

GC content: 59.86

Gene sequence:

>735_bases
ATGTCGATCTGGGAATACGCCAATCCAAAGAAATTCCTGCGCACCAGTGAGCGTGTGCTGCCTGCCCTTTGGGGCATTTC
AGCTCTGCTCATCGTGAGCGGGCTGATCTGGGGGTTCTTTTTTACACCCGATGATTACCGCCAGGGTTCGACGGTCAAGA
TCATCTATCTGCATGTGCCTGCGGCGCTGATGGCGATCAACGCCTGGTTCATGATGCTGGTGGCCTCGCTGATCTGGGTG
ATCCGCCGACATCACGTAAGCGCACTGGCGGCGAAGGCAGCCGCGCCCGTGGGCGTTGTGATGACACTGATTGCCCTCGT
TACCGGCGCCATCTGGGGGCAACCGATGTGGGGCACCTGGTGGGCGTGGGACCCGCGGCTAACGTCCTTTCTGGTGCTGT
TCCTGTTCTACATTGGCTATATCGCGCTCTGGGAAGCGATCGAGAATGGCGATACCGCAGCGGATCTGGCGTCGATCCTC
TGCCTTGTGGGGTCTGTTTTTGCGGTGCTCTCGCGGTATGCGGTGAATTTCTGGAATCAGGGCCTGCACCAGGGGGCGTC
GCTGTCGCTCGACAAGGAAGAAAACGTCGCCGATGTCTTTGCCTTTCCGCTCTATACCTGCATGGCCGGGTTCGGGGCGC
TGTTTATCGCGCTGGTGCTCTATCGCACCGGTACCGAGATCCGCGCGCGCCGGATGTCGGCGCTGATCGCACGCGAAAGG
ATGATGGATGCCTGA

Upstream 100 bases:

>100_bases
CCATCGCCCTGTTGCCCTTTGCCTCCGCTGCCGTCCTGCGCGTCAATTTGCGCTAGGACAGGTGATTGTGATGACCAAGA
ACAAGAGCTAGATAGCCACC

Downstream 100 bases:

>100_bases
TTTGGGAAAATACGCAGAAACGGTTCTTTCGGCCTATGCTGTCTCGCTGGTGTTGCTGGTCGCGCTCCTGGTCGTGACCT
TCCTGCGCGGGGCCAAGGTG

Product: heme exporter protein CcmC

Products: NA

Alternate protein names: Cytochrome c-type biogenesis protein HelC [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSIWEYANPKKFLRTSERVLPALWGISALLIVSGLIWGFFFTPDDYRQGSTVKIIYLHVPAALMAINAWFMMLVASLIWV
IRRHHVSALAAKAAAPVGVVMTLIALVTGAIWGQPMWGTWWAWDPRLTSFLVLFLFYIGYIALWEAIENGDTAADLASIL
CLVGSVFAVLSRYAVNFWNQGLHQGASLSLDKEENVADVFAFPLYTCMAGFGALFIALVLYRTGTEIRARRMSALIARER
MMDA

Sequences:

>Translated_244_residues
MSIWEYANPKKFLRTSERVLPALWGISALLIVSGLIWGFFFTPDDYRQGSTVKIIYLHVPAALMAINAWFMMLVASLIWV
IRRHHVSALAAKAAAPVGVVMTLIALVTGAIWGQPMWGTWWAWDPRLTSFLVLFLFYIGYIALWEAIENGDTAADLASIL
CLVGSVFAVLSRYAVNFWNQGLHQGASLSLDKEENVADVFAFPLYTCMAGFGALFIALVLYRTGTEIRARRMSALIARER
MMDA
>Mature_243_residues
SIWEYANPKKFLRTSERVLPALWGISALLIVSGLIWGFFFTPDDYRQGSTVKIIYLHVPAALMAINAWFMMLVASLIWVI
RRHHVSALAAKAAAPVGVVMTLIALVTGAIWGQPMWGTWWAWDPRLTSFLVLFLFYIGYIALWEAIENGDTAADLASILC
LVGSVFAVLSRYAVNFWNQGLHQGASLSLDKEENVADVFAFPLYTCMAGFGALFIALVLYRTGTEIRARRMSALIARERM
MDA

Specific function: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes [H]

COG id: COG0755

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmC/CycZ/HelC family [H]

Homologues:

Organism=Escherichia coli, GI1788527, Length=236, Percent_Identity=40.6779661016949, Blast_Score=162, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002541
- InterPro:   IPR003557 [H]

Pfam domain/function: PF01578 Cytochrom_C_asm [H]

EC number: NA

Molecular weight: Translated: 27260; Mature: 27129

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIWEYANPKKFLRTSERVLPALWGISALLIVSGLIWGFFFTPDDYRQGSTVKIIYLHVP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHH
AALMAINAWFMMLVASLIWVIRRHHVSALAAKAAAPVGVVMTLIALVTGAIWGQPMWGTW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCC
WAWDPRLTSFLVLFLFYIGYIALWEAIENGDTAADLASILCLVGSVFAVLSRYAVNFWNQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLHQGASLSLDKEENVADVFAFPLYTCMAGFGALFIALVLYRTGTEIRARRMSALIARER
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
MMDA
HCCC
>Mature Secondary Structure 
SIWEYANPKKFLRTSERVLPALWGISALLIVSGLIWGFFFTPDDYRQGSTVKIIYLHVP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHH
AALMAINAWFMMLVASLIWVIRRHHVSALAAKAAAPVGVVMTLIALVTGAIWGQPMWGTW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCC
WAWDPRLTSFLVLFLFYIGYIALWEAIENGDTAADLASILCLVGSVFAVLSRYAVNFWNQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLHQGASLSLDKEENVADVFAFPLYTCMAGFGALFIALVLYRTGTEIRARRMSALIARER
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
MMDA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1310666 [H]