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The map label for this gene is nhaR [H]

Identifier: 99080672

GI number: 99080672

Start: 872933

End: 873844

Strand: Reverse

Name: nhaR [H]

Synonym: TM1040_0831

Alternate gene names: 99080672

Gene position: 873844-872933 (Counterclockwise)

Preceding gene: 99080675

Following gene: 99080671

Centisome position: 27.3

GC content: 58.77

Gene sequence:

>912_bases
ATGCCCCTGAACTATCATCACTTGCGTTATTTCTGGGCCGTCGCCCATGACGGCAACCTCACGCGCACCGCGCAGCGATT
GAACCTGTCGCAATCGGCGCTGTCGGTGCAGATCAAAAACCTTGAGGAGCGCCTTGGTCACGCGCTCTTTGAACGCCGCG
GCCGTCAGTTGCATCTTACTGAAGCCGGTCGGATCACGCTCGATCATGCGGATGCGATTTTCTCGACAGGACAAGAACTT
GTGGCGACGCTCACCGGCGCTGTCCAAGAGCGAAAGGCCCTGCGCGTGGGCGCGCTGGCAACCTTGTCCCGCAACTTCCA
GATCGAGTTCCTACGCCCCATGCTGGCACGGCAGGACGTGGAAATCATCCTGCGATCCGGCAGCCCAACCGAGCTCCTAG
AGGGGCTCTCGACCCTCAATCTCGATATGGTTCTGATGAACAAACCTCCGCCAAATGACAGTTTGACGCGCTACGACACC
CATCAGATCGGGGAACAACATGTCAGTATCGTCGGCACCCCGGCCCGACTGGATCCGACCAAATCGCTTCGCGATCTTTT
GGCAGAACAGCCCTTTATCGTGCCGACAATGGACAACAGCGTGCGCACGGCCTTTGATTCCCTGGCCAGCCGTATGTCGG
TGCGCCCTCAGATCGCCGCAGAGGTCGATGACATGGCGATGATGCGCCTGCTTGCCCGCGAGGACATCGGGCTCTCCTTG
GTGGCACCGATCGTGGTGAAGGATGAACTAACCTCGGGGCTTCTGAACGAGGCCAAGGACCATTTGCAGATCAAAGAAAC
CTTCTACGCGGTCACGTTGCGCCGACGTTTCCCCAATCCGCTTGTCCAGGATCTGATCAAGATCACTGCTGATCTCGCCC
CCTTTGGCCGAGGAGACTCGGAGCCATCCTAA

Upstream 100 bases:

>100_bases
TTAGAATTTCGGGTCAACGACCTGAGGAGATCAACTAGGTCAAAACTCGTGACCATAAAAATTCATTGTTTGGATGCTTT
CGTTCGCTTAAATAGAACGC

Downstream 100 bases:

>100_bases
CGCGACCGAAGCACGGCGCCCAAAATGGCTTGCGCGAGGGAGGCGATATGCAAAAACGTCCACCAAATTCACAGCCCAAG
GCCCCACACTGGCCTGCTGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Na(+)/H(+) antiporter regulatory protein [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MPLNYHHLRYFWAVAHDGNLTRTAQRLNLSQSALSVQIKNLEERLGHALFERRGRQLHLTEAGRITLDHADAIFSTGQEL
VATLTGAVQERKALRVGALATLSRNFQIEFLRPMLARQDVEIILRSGSPTELLEGLSTLNLDMVLMNKPPPNDSLTRYDT
HQIGEQHVSIVGTPARLDPTKSLRDLLAEQPFIVPTMDNSVRTAFDSLASRMSVRPQIAAEVDDMAMMRLLAREDIGLSL
VAPIVVKDELTSGLLNEAKDHLQIKETFYAVTLRRRFPNPLVQDLIKITADLAPFGRGDSEPS

Sequences:

>Translated_303_residues
MPLNYHHLRYFWAVAHDGNLTRTAQRLNLSQSALSVQIKNLEERLGHALFERRGRQLHLTEAGRITLDHADAIFSTGQEL
VATLTGAVQERKALRVGALATLSRNFQIEFLRPMLARQDVEIILRSGSPTELLEGLSTLNLDMVLMNKPPPNDSLTRYDT
HQIGEQHVSIVGTPARLDPTKSLRDLLAEQPFIVPTMDNSVRTAFDSLASRMSVRPQIAAEVDDMAMMRLLAREDIGLSL
VAPIVVKDELTSGLLNEAKDHLQIKETFYAVTLRRRFPNPLVQDLIKITADLAPFGRGDSEPS
>Mature_302_residues
PLNYHHLRYFWAVAHDGNLTRTAQRLNLSQSALSVQIKNLEERLGHALFERRGRQLHLTEAGRITLDHADAIFSTGQELV
ATLTGAVQERKALRVGALATLSRNFQIEFLRPMLARQDVEIILRSGSPTELLEGLSTLNLDMVLMNKPPPNDSLTRYDTH
QIGEQHVSIVGTPARLDPTKSLRDLLAEQPFIVPTMDNSVRTAFDSLASRMSVRPQIAAEVDDMAMMRLLAREDIGLSLV
APIVVKDELTSGLLNEAKDHLQIKETFYAVTLRRRFPNPLVQDLIKITADLAPFGRGDSEPS

Specific function: Plays a role in the positive regulation of nhaA (Probable) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786202, Length=286, Percent_Identity=26.2237762237762, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788887, Length=162, Percent_Identity=35.8024691358025, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI157672245, Length=252, Percent_Identity=26.984126984127, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI2367136, Length=253, Percent_Identity=28.0632411067194, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789204, Length=257, Percent_Identity=28.0155642023346, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787530, Length=254, Percent_Identity=26.3779527559055, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33856; Mature: 33725

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNYHHLRYFWAVAHDGNLTRTAQRLNLSQSALSVQIKNLEERLGHALFERRGRQLHLT
CCCCCEEEEEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
EAGRITLDHADAIFSTGQELVATLTGAVQERKALRVGALATLSRNFQIEFLRPMLARQDV
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCE
EIILRSGSPTELLEGLSTLNLDMVLMNKPPPNDSLTRYDTHQIGEQHVSIVGTPARLDPT
EEEEECCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHEEEEECCCCCCHH
KSLRDLLAEQPFIVPTMDNSVRTAFDSLASRMSVRPQIAAEVDDMAMMRLLAREDIGLSL
HHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHH
VAPIVVKDELTSGLLNEAKDHLQIKETFYAVTLRRRFPNPLVQDLIKITADLAPFGRGDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
EPS
CCC
>Mature Secondary Structure 
PLNYHHLRYFWAVAHDGNLTRTAQRLNLSQSALSVQIKNLEERLGHALFERRGRQLHLT
CCCCEEEEEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
EAGRITLDHADAIFSTGQELVATLTGAVQERKALRVGALATLSRNFQIEFLRPMLARQDV
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCE
EIILRSGSPTELLEGLSTLNLDMVLMNKPPPNDSLTRYDTHQIGEQHVSIVGTPARLDPT
EEEEECCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHEEEEECCCCCCHH
KSLRDLLAEQPFIVPTMDNSVRTAFDSLASRMSVRPQIAAEVDDMAMMRLLAREDIGLSL
HHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHH
VAPIVVKDELTSGLLNEAKDHLQIKETFYAVTLRRRFPNPLVQDLIKITADLAPFGRGDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
EPS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8231807; 9457888; 10952301 [H]