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The map label for this gene is hutH [H]

Identifier: 94972197

GI number: 94972197

Start: 296721

End: 298220

Strand: Direct

Name: hutH [H]

Synonym: Dgeo_2730

Alternate gene names: 94972197

Gene position: 296721-298220 (Clockwise)

Preceding gene: 94972198

Following gene: 94972195

Centisome position: 51.68

GC content: 68.87

Gene sequence:

>1500_bases
GTGATCCTAGACCGGCAATTGACGCTTGACGACTTTATCCGCGTGGTGCGTGGCGGCGAGGAGGTGACCCTTGCTGATGC
GGCGCGGACACGGATGGGACGAGCGCGGGCGGTGATCGAGCGCATCGTCGATGGCCCCGAAGCCGTGTACGGCGTGAACA
CGGGCTTTGGCAAGTTCGCCTCGGTCCGCGTGGCGCGCGAGGAGCTGAAGCAGCTCCAGCACAACCTGATTGTGTCGCAT
GCAATCGGGGTAGGTGCAGGTTTGCCTGCCGAAGTCGTGCGCGGAATGCTGCTGCTGCGGGCCCAGTCGCTCGCTCTTGG
GCATTCGGGGGTGCGGCCGGAGGTGGTCGAACTCCTGCTCGCGCTGCTCAACGCGGGAGCCTGCCCGGTCGTGCCTGCCC
AAGGCAGCGTGGGGGCGAGCGGCGACCTGGCCCCGCTCGCGCACCTCGCGTTGGCCCTGATCGGAGGGGGCGAATTGGAA
TACGGCGGTCAGGTGCGGCCCGCTGCCGACGTGCTGGCCGAACTGGGTCTCCAGCCGCTCACGCTGGAGGCAAAGGAGGG
GCTGGCCCTCATCAACGGCACACAGCTGATGGGCAGCCTGCTGGCCCTCGCGCTGCACGACGCCCGGACACTGCTGCACA
CGGCGAACCTGGCCGCTGCAATGACGGTGGAGGCGCTGTCCGGCAGTCACCGGCCTTTCAGTGAGGGCGTGGTGAGCTTA
CGGCCCCACCCCGGCGCGCTGGAGGTCGCCGCCGACCTGCGCGCCTTCCTGCACGGTTCGGACATCGCACCGGCCCACGC
CCACTGCGGCAAGGTGCAGGATGCCTACAGTCTGCGGGCGGTGCCCCAGGTCCACGGCGCTTCCCTCGACGCACTAATGC
AAGCGGGGCGCGTGCTGGAGGTGGAATTTGCCAGCGTGACCGACAATCCGCTGATCTTCCCCGAGACGGGCGAGGTGATC
TCGGGCGGCAATTTCCACGGGCAGCCCCTTGCCCTGGCGGCCGATGCCCTGAAGGTGGCGGTGGCCGAACTGGCGAACAT
CAGCGAACGCCGCAGCGAGCAACTGCTGAATCCGGCCCTGTCGGGGCTACCGGGGTTCCTGACGCCGGAAGGGGGCTTAA
GCAGCGGCTTCATGATCGCGCAGTACACCGCCGCCGCCCTGGTCAGCGAGAACAAGGTGCTGGCCCACCCCGCCAGCGTG
GACTCGATTCCGACGAGCGCCAATCAGGAAGACCATGTCAGCATGGGCGCGCATGGAGCACGGCAGCTGCGGCAGATCCT
GGAAAACGCGCAGAGCGTCATCAGCATCGAGCTGCTGTGCGCCGCGCAGGCCCTGGACTTCCAGTCGCTGCGCGCTGGGC
GAGGCGTGCAGGCCGCCTACGAGCGCATCCGGCAGGAGGTCGCACCGCTCGGCCAGGACCGCTACTACCGGCCCGACCTC
CTGCGGGTGCGCGAGCTGGTGACCAGCGGCGAGCTGCTGCGGGCCGCCCGGGAGGCTTGA

Upstream 100 bases:

>100_bases
ACTGGCGCGACCTGGCCTACACGCTGGGCGCAAACCCTGTCCGCGACGTGTTCGTGGGCGGGCAAAACATCAAGGAGACT
CTGAGCAAGGAGAAGGCCCT

Downstream 100 bases:

>100_bases
CCCTCAGGCGGCTGGCTGGCCCAGGACCTTTCTCAGCTCCTCAAGCACCTCGGCGGCATGGGTCTTGGGGATCACCTCGG
TCCAGTGCCGCACGACCCGG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MILDRQLTLDDFIRVVRGGEEVTLADAARTRMGRARAVIERIVDGPEAVYGVNTGFGKFASVRVAREELKQLQHNLIVSH
AIGVGAGLPAEVVRGMLLLRAQSLALGHSGVRPEVVELLLALLNAGACPVVPAQGSVGASGDLAPLAHLALALIGGGELE
YGGQVRPAADVLAELGLQPLTLEAKEGLALINGTQLMGSLLALALHDARTLLHTANLAAAMTVEALSGSHRPFSEGVVSL
RPHPGALEVAADLRAFLHGSDIAPAHAHCGKVQDAYSLRAVPQVHGASLDALMQAGRVLEVEFASVTDNPLIFPETGEVI
SGGNFHGQPLALAADALKVAVAELANISERRSEQLLNPALSGLPGFLTPEGGLSSGFMIAQYTAAALVSENKVLAHPASV
DSIPTSANQEDHVSMGAHGARQLRQILENAQSVISIELLCAAQALDFQSLRAGRGVQAAYERIRQEVAPLGQDRYYRPDL
LRVRELVTSGELLRAAREA

Sequences:

>Translated_499_residues
MILDRQLTLDDFIRVVRGGEEVTLADAARTRMGRARAVIERIVDGPEAVYGVNTGFGKFASVRVAREELKQLQHNLIVSH
AIGVGAGLPAEVVRGMLLLRAQSLALGHSGVRPEVVELLLALLNAGACPVVPAQGSVGASGDLAPLAHLALALIGGGELE
YGGQVRPAADVLAELGLQPLTLEAKEGLALINGTQLMGSLLALALHDARTLLHTANLAAAMTVEALSGSHRPFSEGVVSL
RPHPGALEVAADLRAFLHGSDIAPAHAHCGKVQDAYSLRAVPQVHGASLDALMQAGRVLEVEFASVTDNPLIFPETGEVI
SGGNFHGQPLALAADALKVAVAELANISERRSEQLLNPALSGLPGFLTPEGGLSSGFMIAQYTAAALVSENKVLAHPASV
DSIPTSANQEDHVSMGAHGARQLRQILENAQSVISIELLCAAQALDFQSLRAGRGVQAAYERIRQEVAPLGQDRYYRPDL
LRVRELVTSGELLRAAREA
>Mature_499_residues
MILDRQLTLDDFIRVVRGGEEVTLADAARTRMGRARAVIERIVDGPEAVYGVNTGFGKFASVRVAREELKQLQHNLIVSH
AIGVGAGLPAEVVRGMLLLRAQSLALGHSGVRPEVVELLLALLNAGACPVVPAQGSVGASGDLAPLAHLALALIGGGELE
YGGQVRPAADVLAELGLQPLTLEAKEGLALINGTQLMGSLLALALHDARTLLHTANLAAAMTVEALSGSHRPFSEGVVSL
RPHPGALEVAADLRAFLHGSDIAPAHAHCGKVQDAYSLRAVPQVHGASLDALMQAGRVLEVEFASVTDNPLIFPETGEVI
SGGNFHGQPLALAADALKVAVAELANISERRSEQLLNPALSGLPGFLTPEGGLSSGFMIAQYTAAALVSENKVLAHPASV
DSIPTSANQEDHVSMGAHGARQLRQILENAQSVISIELLCAAQALDFQSLRAGRGVQAAYERIRQEVAPLGQDRYYRPDL
LRVRELVTSGELLRAAREA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=481, Percent_Identity=45.7380457380457, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567831, Length=504, Percent_Identity=46.6269841269841, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 52369; Mature: 52369

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDRQLTLDDFIRVVRGGEEVTLADAARTRMGRARAVIERIVDGPEAVYGVNTGFGKFA
CCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHH
SVRVAREELKQLQHNLIVSHAIGVGAGLPAEVVRGMLLLRAQSLALGHSGVRPEVVELLL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALLNAGACPVVPAQGSVGASGDLAPLAHLALALIGGGELEYGGQVRPAADVLAELGLQPL
HHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCE
TLEAKEGLALINGTQLMGSLLALALHDARTLLHTANLAAAMTVEALSGSHRPFSEGVVSL
EEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEE
RPHPGALEVAADLRAFLHGSDIAPAHAHCGKVQDAYSLRAVPQVHGASLDALMQAGRVLE
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHCCCEEE
VEFASVTDNPLIFPETGEVISGGNFHGQPLALAADALKVAVAELANISERRSEQLLNPAL
EEEEECCCCCEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLPGFLTPEGGLSSGFMIAQYTAAALVSENKVLAHPASVDSIPTSANQEDHVSMGAHGA
HCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHCCHHH
RQLRQILENAQSVISIELLCAAQALDFQSLRAGRGVQAAYERIRQEVAPLGQDRYYRPDL
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
LRVRELVTSGELLRAAREA
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MILDRQLTLDDFIRVVRGGEEVTLADAARTRMGRARAVIERIVDGPEAVYGVNTGFGKFA
CCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHH
SVRVAREELKQLQHNLIVSHAIGVGAGLPAEVVRGMLLLRAQSLALGHSGVRPEVVELLL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALLNAGACPVVPAQGSVGASGDLAPLAHLALALIGGGELEYGGQVRPAADVLAELGLQPL
HHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCE
TLEAKEGLALINGTQLMGSLLALALHDARTLLHTANLAAAMTVEALSGSHRPFSEGVVSL
EEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEE
RPHPGALEVAADLRAFLHGSDIAPAHAHCGKVQDAYSLRAVPQVHGASLDALMQAGRVLE
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHCCCEEE
VEFASVTDNPLIFPETGEVISGGNFHGQPLALAADALKVAVAELANISERRSEQLLNPAL
EEEEECCCCCEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLPGFLTPEGGLSSGFMIAQYTAAALVSENKVLAHPASVDSIPTSANQEDHVSMGAHGA
HCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHCCHHH
RQLRQILENAQSVISIELLCAAQALDFQSLRAGRGVQAAYERIRQEVAPLGQDRYYRPDL
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
LRVRELVTSGELLRAAREA
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA