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The map label for this gene is hmvC [H]

Identifier: 94312766

GI number: 94312766

Start: 377957

End: 379294

Strand: Direct

Name: hmvC [H]

Synonym: Rmet_3836

Alternate gene names: 94312766

Gene position: 377957-379294 (Clockwise)

Preceding gene: 94312765

Following gene: 94312767

Centisome position: 14.65

GC content: 69.28

Gene sequence:

>1338_bases
ATGGCCTCCGTGGGCTCCATTGCCGCCTCGGCCGGGCAAGCCGCCAGCGGACCCATGCCTCCAGATGGCCCCTGCATGCC
GCCTCCGGCAAAGGCCGCGCTGACCCTGGCGCAGGCACGCCTTGACGCGCTGCGCTGCAACCGCGACATCATCTCGGCCC
GTCGCGGCGAGGAAGCCAGCCAGGCCGACATCCAGATTGCCTCCCAACGCCCGAACCCGGTCCTGAGCCTGGGTGTGGCC
AATATCAACCCGCATCTTGGCGTGGGCGCCGGGAACTGGCGCAGCAAGACCGTGGACTCGACGGTACGCGTCGACCAGGT
GATCGAGACCGCGAACAAGGGCAACCTTCGCACCGACGCGGCCCGCAAGGCCAGCGCCGCCGCCGGCGAGCAGACGCAGG
CCGTGGTGGCCCAGCAGGTCGGCGCCGTGGAGCAGGCGTGGTATGACGCGGTAGCCAGCCAGAGCCGGGTAGAGGTGCTG
ACAGAAACCGTCGGTCTCTATGGCAAGACTCAGCAAGCGAACGAGGCCCGGCTCAAGGCTGGCGACGTGGCACGCGCCGA
TGTGACCAAGCTCCAGCTCGAAACGCTGCGGGCCCAGAGTGACCTGCGCTCCGCCCAGTCGGACTATGCCACCAGCAAGG
CAGCACTGGCCGCCACGATCGGTCTTCCGGGCACGCTGTTGGACAACCGGCTCGTGCCGGACTGGCCTGCGCTCGATGCC
CCGGTGCCGTCAGTCGATCCCGAAGTGCTGCAGCGCCGCCCGGATGTGACGGCTGCCGAAGCCCGGCTGGCCGCCGCGGC
CTCCGCGCGTGACCTGGCGCGTGCCGGCCGTGTGCCCGACGTGACCGTCGGCGCCCAGTACGAGCACTATCCGGTTTCCG
AGGCCAATACCACCGGCAGCGGCAACAGCTACGGCGTGTTCATCTCGATTCCGCTGTTCGTGCGCCACAGCTTCGGCGGT
GAAGCGCGCCGCGCCGAGGTGGACTACTACGCGGCGCTCGACGACCGTAATCGTATCCTGCTGGCCGCGCAGAACGACAT
CGAACGGCTGCGCAGCCAGCTCGAATCGGCGCGCGCGTCGCTGCAGCAGATGCAGACCGCCGTGCTGCCGGCGGCGGAGA
CCGTCGCGCAGAGCGCCGAATTCGCCTATACGAAGGGTGCCACCGGCGTGCTCGACCTGCTCGACGCGCGCCGCGCGCTG
CGTCAGACGCGCCTGGACGCCGTCGACGTGCAGGGCAACTTCGCCAAGGCCATGGCCGCCTACCGCGCCGCCCTGCAGGC
CACCACTTCCGATATCAACAAGCTTCCCCAGGTTCGAACCGATGCATCGCATCCCTGA

Upstream 100 bases:

>100_bases
GTTTGGCGGACATGATCGTTAACTTCCGATCAAGTCGAAACGAGCCAGACTGACCGTGCATTCTTATGTTTCCCGAGTCG
CCGTGGCGACGTTGCTGGCC

Downstream 100 bases:

>100_bases
TATGCCGCTCATCTCCCGCGATTCCCGCTTCACCCGTGCCGGCGCCGCGCGTCTGGCGGCCGTGCTGTCACTGTGCGTCC
TTACGCTGGGCGCCTGCGGC

Product: heavy metal cation tricomponent efflux outer membrane porin HmvC

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MASVGSIAASAGQAASGPMPPDGPCMPPPAKAALTLAQARLDALRCNRDIISARRGEEASQADIQIASQRPNPVLSLGVA
NINPHLGVGAGNWRSKTVDSTVRVDQVIETANKGNLRTDAARKASAAAGEQTQAVVAQQVGAVEQAWYDAVASQSRVEVL
TETVGLYGKTQQANEARLKAGDVARADVTKLQLETLRAQSDLRSAQSDYATSKAALAATIGLPGTLLDNRLVPDWPALDA
PVPSVDPEVLQRRPDVTAAEARLAAAASARDLARAGRVPDVTVGAQYEHYPVSEANTTGSGNSYGVFISIPLFVRHSFGG
EARRAEVDYYAALDDRNRILLAAQNDIERLRSQLESARASLQQMQTAVLPAAETVAQSAEFAYTKGATGVLDLLDARRAL
RQTRLDAVDVQGNFAKAMAAYRAALQATTSDINKLPQVRTDASHP

Sequences:

>Translated_445_residues
MASVGSIAASAGQAASGPMPPDGPCMPPPAKAALTLAQARLDALRCNRDIISARRGEEASQADIQIASQRPNPVLSLGVA
NINPHLGVGAGNWRSKTVDSTVRVDQVIETANKGNLRTDAARKASAAAGEQTQAVVAQQVGAVEQAWYDAVASQSRVEVL
TETVGLYGKTQQANEARLKAGDVARADVTKLQLETLRAQSDLRSAQSDYATSKAALAATIGLPGTLLDNRLVPDWPALDA
PVPSVDPEVLQRRPDVTAAEARLAAAASARDLARAGRVPDVTVGAQYEHYPVSEANTTGSGNSYGVFISIPLFVRHSFGG
EARRAEVDYYAALDDRNRILLAAQNDIERLRSQLESARASLQQMQTAVLPAAETVAQSAEFAYTKGATGVLDLLDARRAL
RQTRLDAVDVQGNFAKAMAAYRAALQATTSDINKLPQVRTDASHP
>Mature_444_residues
ASVGSIAASAGQAASGPMPPDGPCMPPPAKAALTLAQARLDALRCNRDIISARRGEEASQADIQIASQRPNPVLSLGVAN
INPHLGVGAGNWRSKTVDSTVRVDQVIETANKGNLRTDAARKASAAAGEQTQAVVAQQVGAVEQAWYDAVASQSRVEVLT
ETVGLYGKTQQANEARLKAGDVARADVTKLQLETLRAQSDLRSAQSDYATSKAALAATIGLPGTLLDNRLVPDWPALDAP
VPSVDPEVLQRRPDVTAAEARLAAAASARDLARAGRVPDVTVGAQYEHYPVSEANTTGSGNSYGVFISIPLFVRHSFGGE
ARRAEVDYYAALDDRNRILLAAQNDIERLRSQLESARASLQQMQTAVLPAAETVAQSAEFAYTKGATGVLDLLDARRALR
QTRLDAVDVQGNFAKAMAAYRAALQATTSDINKLPQVRTDASHP

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 46974; Mature: 46843

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVGSIAASAGQAASGPMPPDGPCMPPPAKAALTLAQARLDALRCNRDIISARRGEEAS
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCC
QADIQIASQRPNPVLSLGVANINPHLGVGAGNWRSKTVDSTVRVDQVIETANKGNLRTDA
CCCEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHH
ARKASAAAGEQTQAVVAQQVGAVEQAWYDAVASQSRVEVLTETVGLYGKTQQANEARLKA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHCC
GDVARADVTKLQLETLRAQSDLRSAQSDYATSKAALAATIGLPGTLLDNRLVPDWPALDA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCCCCCCCCCC
PVPSVDPEVLQRRPDVTAAEARLAAAASARDLARAGRVPDVTVGAQYEHYPVSEANTTGS
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCC
GNSYGVFISIPLFVRHSFGGEARRAEVDYYAALDDRNRILLAAQNDIERLRSQLESARAS
CCCEEEEEEEEEHEEECCCCCCCEECEEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHH
LQQMQTAVLPAAETVAQSAEFAYTKGATGVLDLLDARRALRQTRLDAVDVQGNFAKAMAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHH
YRAALQATTSDINKLPQVRTDASHP
HHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ASVGSIAASAGQAASGPMPPDGPCMPPPAKAALTLAQARLDALRCNRDIISARRGEEAS
CCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCC
QADIQIASQRPNPVLSLGVANINPHLGVGAGNWRSKTVDSTVRVDQVIETANKGNLRTDA
CCCEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHH
ARKASAAAGEQTQAVVAQQVGAVEQAWYDAVASQSRVEVLTETVGLYGKTQQANEARLKA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHCC
GDVARADVTKLQLETLRAQSDLRSAQSDYATSKAALAATIGLPGTLLDNRLVPDWPALDA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCCCCCCCCCC
PVPSVDPEVLQRRPDVTAAEARLAAAASARDLARAGRVPDVTVGAQYEHYPVSEANTTGS
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCC
GNSYGVFISIPLFVRHSFGGEARRAEVDYYAALDDRNRILLAAQNDIERLRSQLESARAS
CCCEEEEEEEEEHEEECCCCCCCEECEEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHH
LQQMQTAVLPAAETVAQSAEFAYTKGATGVLDLLDARRALRQTRLDAVDVQGNFAKAMAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHH
YRAALQATTSDINKLPQVRTDASHP
HHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]