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The map label for this gene is pbuX [H]

Identifier: 94312657

GI number: 94312657

Start: 267171

End: 268508

Strand: Direct

Name: pbuX [H]

Synonym: Rmet_3725

Alternate gene names: 94312657

Gene position: 267171-268508 (Clockwise)

Preceding gene: 94312656

Following gene: 94312659

Centisome position: 10.36

GC content: 63.9

Gene sequence:

>1338_bases
ATGGAGACGTTGCTTTATAAGGTCGAGGATCGTCCACCGATCCTGACGACCGTGCTGCTTGCCGCACAACATCTGCTCGC
CGCGCTTGGCGGCATCATCGCCGTACCGCTCGTTCTGGGCGGCGCGCTCAAACTTCCCCCAGATCAGATCGTCGCGCTTG
TGAATGCCGCGTTGCTTGGCTCCGGCATCGTCACGATCATCCAATGCAAGGGTGTCGGTCCCGTCGGCATTCGACTGCCC
TGCGTCATGGGCACCAGCTTCACGTTTGTTGGCGCCGGCATCAGTGTTGGCCTCGAGCATGGTGTGCCAGGCATTCTCGG
CGCATCGCTGGCCGGATCGTTGGTGATGATTGTGGGCAGCTTCTTCATGCCGACAATTCGCAAGCTGTTTCCGCACACGG
TGACAGGTGTCGTCGTCACAATGATCGGCCTGTCGTTGACACCGGTTGCAATCGATTGGGCAGCGGGTGGCGCGGGTAGC
GCCAACTACGCGGCGCCCGGCTCACTGGCGATTGCAGGCATCGTGCTGTTGCTCGTGATCGGCTTCGTGCAATGGGGCAA
GGGCATCGTTTCGGCGTCGGCCGTGGTGCTCGGCATCATGATCGGGTACCTCATCTGCCTGGCGCTTGGCATGGTGGACT
TCTCGCAGCTTCATGATGCGCCGGTCTTCGCGCTGCCGCAGCCCGCGAGCTTCGGCATGAAGTTCCCGATTTCCGGTATC
GCCGCGATGTCCCTGGCGTTCCTGGTCACCATCGTTGAAACGACTGGCACGTTCATGGCGCTAGGTTCGGCGACGCGCAC
GCCGATGCCTGGCAAGACGCTGGCGCGCGGCATTCTTTGCGATGGTGTCGGCTCCGCTTTCGCGGCGCTGCTGTCTAGCC
CCCCCGTCTCGACGTTCGCGCAGAACGTGGGCGTGGTCTCGCTGACCGGTGTCGCCAGCCGCCATGTGGTGGCGTTGACG
GGCGGGATGCTGGTGCTTGCGGGGCTGTTCCCGGTGCTCGGCGCGCTGGTGGTGACGATTCCGCAGCCCGTGCTTGGTGG
CGCGGGCCTGATGATGTTCGCGATGATCGTGTCGGCCGGCATCCGCATGCTGGGCCATTCCGCACCGACCAAGCGCAACA
GCCTGATCATCGCCGTGTCGATCGGCTGCGGTCTGGCCGTGACGATCCGTCCAGATCTGCTCGCCAAGCTGCCCGCGTTC
GTGAAGGAAGTATTCGGTTCCGGGATCACCGTCGGCGCGCTGGTGGCCGTGGTGCTCAACCTGTGCCTGCCGGGCCGCGA
GGTCGATGCGATAGACGAGGAAGTCGAAGGCGAGACGCTGGTGCAGGAGCTTGCCTGA

Upstream 100 bases:

>100_bases
ATTTGTATTACAAAAATTGTATGCAAAAGCGACAGGTTCTGTGATAAAAACCCGAGGACAAATTCGGCTATGACCGGATC
AACCGAGGAGACCCTGAAGC

Downstream 100 bases:

>100_bases
GGTGATCAGCGGAAGATAATCGTGCTTGATCGGCGCCCCGGAGCAGCGATGCTTCGGGGCGTTTGACTTGTGGGATCAGC
ACTCAAGTGCCCCCTGTCGG

Product: uracil-xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
METLLYKVEDRPPILTTVLLAAQHLLAALGGIIAVPLVLGGALKLPPDQIVALVNAALLGSGIVTIIQCKGVGPVGIRLP
CVMGTSFTFVGAGISVGLEHGVPGILGASLAGSLVMIVGSFFMPTIRKLFPHTVTGVVVTMIGLSLTPVAIDWAAGGAGS
ANYAAPGSLAIAGIVLLLVIGFVQWGKGIVSASAVVLGIMIGYLICLALGMVDFSQLHDAPVFALPQPASFGMKFPISGI
AAMSLAFLVTIVETTGTFMALGSATRTPMPGKTLARGILCDGVGSAFAALLSSPPVSTFAQNVGVVSLTGVASRHVVALT
GGMLVLAGLFPVLGALVVTIPQPVLGGAGLMMFAMIVSAGIRMLGHSAPTKRNSLIIAVSIGCGLAVTIRPDLLAKLPAF
VKEVFGSGITVGALVAVVLNLCLPGREVDAIDEEVEGETLVQELA

Sequences:

>Translated_445_residues
METLLYKVEDRPPILTTVLLAAQHLLAALGGIIAVPLVLGGALKLPPDQIVALVNAALLGSGIVTIIQCKGVGPVGIRLP
CVMGTSFTFVGAGISVGLEHGVPGILGASLAGSLVMIVGSFFMPTIRKLFPHTVTGVVVTMIGLSLTPVAIDWAAGGAGS
ANYAAPGSLAIAGIVLLLVIGFVQWGKGIVSASAVVLGIMIGYLICLALGMVDFSQLHDAPVFALPQPASFGMKFPISGI
AAMSLAFLVTIVETTGTFMALGSATRTPMPGKTLARGILCDGVGSAFAALLSSPPVSTFAQNVGVVSLTGVASRHVVALT
GGMLVLAGLFPVLGALVVTIPQPVLGGAGLMMFAMIVSAGIRMLGHSAPTKRNSLIIAVSIGCGLAVTIRPDLLAKLPAF
VKEVFGSGITVGALVAVVLNLCLPGREVDAIDEEVEGETLVQELA
>Mature_445_residues
METLLYKVEDRPPILTTVLLAAQHLLAALGGIIAVPLVLGGALKLPPDQIVALVNAALLGSGIVTIIQCKGVGPVGIRLP
CVMGTSFTFVGAGISVGLEHGVPGILGASLAGSLVMIVGSFFMPTIRKLFPHTVTGVVVTMIGLSLTPVAIDWAAGGAGS
ANYAAPGSLAIAGIVLLLVIGFVQWGKGIVSASAVVLGIMIGYLICLALGMVDFSQLHDAPVFALPQPASFGMKFPISGI
AAMSLAFLVTIVETTGTFMALGSATRTPMPGKTLARGILCDGVGSAFAALLSSPPVSTFAQNVGVVSLTGVASRHVVALT
GGMLVLAGLFPVLGALVVTIPQPVLGGAGLMMFAMIVSAGIRMLGHSAPTKRNSLIIAVSIGCGLAVTIRPDLLAKLPAF
VKEVFGSGITVGALVAVVLNLCLPGREVDAIDEEVEGETLVQELA

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680143, Length=502, Percent_Identity=26.6932270916335, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI44680145, Length=506, Percent_Identity=27.4703557312253, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI44680148, Length=493, Percent_Identity=23.1237322515213, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI40316845, Length=493, Percent_Identity=23.1237322515213, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI87082181, Length=449, Percent_Identity=39.1982182628062, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI87082178, Length=440, Percent_Identity=35.9090909090909, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1790087, Length=442, Percent_Identity=36.1990950226244, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI1788843, Length=391, Percent_Identity=29.4117647058824, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI87081818, Length=457, Percent_Identity=27.5711159737418, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17558856, Length=499, Percent_Identity=24.6492985971944, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17541904, Length=510, Percent_Identity=23.5294117647059, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71993493, Length=283, Percent_Identity=25.7950530035336, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17542260, Length=276, Percent_Identity=25, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17542262, Length=263, Percent_Identity=27.3764258555133, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356175, Length=175, Percent_Identity=30.8571428571429, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44918; Mature: 44918

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLLYKVEDRPPILTTVLLAAQHLLAALGGIIAVPLVLGGALKLPPDQIVALVNAALLG
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
SGIVTIIQCKGVGPVGIRLPCVMGTSFTFVGAGISVGLEHGVPGILGASLAGSLVMIVGS
CCCEEEEEECCCCCCCEEEEEEECCCEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
FFMPTIRKLFPHTVTGVVVTMIGLSLTPVAIDWAAGGAGSANYAAPGSLAIAGIVLLLVI
HHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
GFVQWGKGIVSASAVVLGIMIGYLICLALGMVDFSQLHDAPVFALPQPASFGMKFPISGI
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHH
AAMSLAFLVTIVETTGTFMALGSATRTPMPGKTLARGILCDGVGSAFAALLSSPPVSTFA
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHH
QNVGVVSLTGVASRHVVALTGGMLVLAGLFPVLGALVVTIPQPVLGGAGLMMFAMIVSAG
HCCCCEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHH
IRMLGHSAPTKRNSLIIAVSIGCGLAVTIRPDLLAKLPAFVKEVFGSGITVGALVAVVLN
HHHHCCCCCCCCCCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LCLPGREVDAIDEEVEGETLVQELA
HHCCCCCCHHHHHHCCHHHHHHHHC
>Mature Secondary Structure
METLLYKVEDRPPILTTVLLAAQHLLAALGGIIAVPLVLGGALKLPPDQIVALVNAALLG
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
SGIVTIIQCKGVGPVGIRLPCVMGTSFTFVGAGISVGLEHGVPGILGASLAGSLVMIVGS
CCCEEEEEECCCCCCCEEEEEEECCCEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
FFMPTIRKLFPHTVTGVVVTMIGLSLTPVAIDWAAGGAGSANYAAPGSLAIAGIVLLLVI
HHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
GFVQWGKGIVSASAVVLGIMIGYLICLALGMVDFSQLHDAPVFALPQPASFGMKFPISGI
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHH
AAMSLAFLVTIVETTGTFMALGSATRTPMPGKTLARGILCDGVGSAFAALLSSPPVSTFA
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHH
QNVGVVSLTGVASRHVVALTGGMLVLAGLFPVLGALVVTIPQPVLGGAGLMMFAMIVSAG
HCCCCEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHH
IRMLGHSAPTKRNSLIIAVSIGCGLAVTIRPDLLAKLPAFVKEVFGSGITVGALVAVVLN
HHHHCCCCCCCCCCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LCLPGREVDAIDEEVEGETLVQELA
HHCCCCCCHHHHHHCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]