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The map label for this gene is hisB [H]

Identifier: 93007267

GI number: 93007267

Start: 3017829

End: 3018503

Strand: Reverse

Name: hisB [H]

Synonym: Pcryo_2443

Alternate gene names: 93007267

Gene position: 3018503-3017829 (Counterclockwise)

Preceding gene: 93007271

Following gene: 93007266

Centisome position: 98.65

GC content: 44.15

Gene sequence:

>675_bases
ATGACCGCCAATTTAACGACGACAGCCAATATACCCAATACAGCTGAGCAAGATCCTACGCAAAAACTAAATTTACATGG
TCGCCCTGAACGTATCGCGACTGTTGAGCGTATTACTGCTGAGACCCAAGTGACCTGTACGGTCAATCTTGATGGTACAG
GGCAAGGTACTGTGGACACTGGCGTCCCGTTTTTGGATCATATGATTGACCAAATCAAGCGTCACGGTTTGTTTGACTTA
GACATCAAATGTACCGGTGATACTTTCATCGATGATCACCACAGTGTTGAAGATACAGGCATTACGCTTGGTCAAGCATT
TAACAAAGCATTAGGTGATAAAAAAGGTATCCGTCGTTATGGGCATTTTTACGCGCCACTAGACGAAGCATTGACGCGTG
CGGTTGTTGATTTATCTGGTCGTCCAGGTCTGCATATGGATATTCCCTTTACGCGCTCGCATGTCGGCACTTTTGATGTC
GATTTATTTAGCGAATTCTTCTATGGTTTTGTGAATCATTCGTGGATGACCGTGCATTTAGATAATCTAAAAGGCAAAAA
CAGTCATCATCAAATCGAATCTACCTTTAAAGCCTTTGCTCGTGCGCTACGTATGGCGTGTGAATACGATGAACGTGCGC
TAAATACCTTGCCATCGACCAAAGAGGCGTTTTAG

Upstream 100 bases:

>100_bases
TAGCCTGATTGTTTTATTATCTATTTTAGACGCTAGTAAGAATATATTGGGCATTTTTCGCCCTATTTTATTGACCGCTT
TTCATTTATAGAGAGTAGCC

Downstream 100 bases:

>100_bases
ATGAGTCGTGCCACAAAAATTGCACTATTAGATTATGGTATGGGTAACTTGCACTCAGCCAGCAAAGCATTATCAGCGGT
CGGGGCAGAAGTCTCTATCA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MTANLTTTANIPNTAEQDPTQKLNLHGRPERIATVERITAETQVTCTVNLDGTGQGTVDTGVPFLDHMIDQIKRHGLFDL
DIKCTGDTFIDDHHSVEDTGITLGQAFNKALGDKKGIRRYGHFYAPLDEALTRAVVDLSGRPGLHMDIPFTRSHVGTFDV
DLFSEFFYGFVNHSWMTVHLDNLKGKNSHHQIESTFKAFARALRMACEYDERALNTLPSTKEAF

Sequences:

>Translated_224_residues
MTANLTTTANIPNTAEQDPTQKLNLHGRPERIATVERITAETQVTCTVNLDGTGQGTVDTGVPFLDHMIDQIKRHGLFDL
DIKCTGDTFIDDHHSVEDTGITLGQAFNKALGDKKGIRRYGHFYAPLDEALTRAVVDLSGRPGLHMDIPFTRSHVGTFDV
DLFSEFFYGFVNHSWMTVHLDNLKGKNSHHQIESTFKAFARALRMACEYDERALNTLPSTKEAF
>Mature_223_residues
TANLTTTANIPNTAEQDPTQKLNLHGRPERIATVERITAETQVTCTVNLDGTGQGTVDTGVPFLDHMIDQIKRHGLFDLD
IKCTGDTFIDDHHSVEDTGITLGQAFNKALGDKKGIRRYGHFYAPLDEALTRAVVDLSGRPGLHMDIPFTRSHVGTFDVD
LFSEFFYGFVNHSWMTVHLDNLKGKNSHHQIESTFKAFARALRMACEYDERALNTLPSTKEAF

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=214, Percent_Identity=45.7943925233645, Blast_Score=173, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=42.1296296296296, Blast_Score=166, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 25022; Mature: 24891

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANLTTTANIPNTAEQDPTQKLNLHGRPERIATVERITAETQVTCTVNLDGTGQGTVDT
CCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEEEECCCCCCCCCC
GVPFLDHMIDQIKRHGLFDLDIKCTGDTFIDDHHSVEDTGITLGQAFNKALGDKKGIRRY
CCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
GHFYAPLDEALTRAVVDLSGRPGLHMDIPFTRSHVGTFDVDLFSEFFYGFVNHSWMTVHL
CCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEE
DNLKGKNSHHQIESTFKAFARALRMACEYDERALNTLPSTKEAF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TANLTTTANIPNTAEQDPTQKLNLHGRPERIATVERITAETQVTCTVNLDGTGQGTVDT
CCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEEEECCCCCCCCCC
GVPFLDHMIDQIKRHGLFDLDIKCTGDTFIDDHHSVEDTGITLGQAFNKALGDKKGIRRY
CCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
GHFYAPLDEALTRAVVDLSGRPGLHMDIPFTRSHVGTFDVDLFSEFFYGFVNHSWMTVHL
CCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEE
DNLKGKNSHHQIESTFKAFARALRMACEYDERALNTLPSTKEAF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA