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The map label for this gene is hutU [H]

Identifier: 93006754

GI number: 93006754

Start: 2380829

End: 2382547

Strand: Direct

Name: hutU [H]

Synonym: Pcryo_1930

Alternate gene names: 93006754

Gene position: 2380829-2382547 (Clockwise)

Preceding gene: 93006749

Following gene: 93006755

Centisome position: 77.81

GC content: 48.4

Gene sequence:

>1719_bases
ATGACTACTGATAATGGATTGAACAAAACTTCTGCATATACTCGCCGTGACGAGAGTCGCAATATCGCGGCGCCAACTGG
CAGTACGCTACACTGTAAAAGCTGGCTGACCGAAGCCCCTTATCGTATGTTACAAAACAACCTACATCCTGATGTGGCTG
AAAATCCAAAAAGCTTGGTCGTTTATGGCGGTATCGGACGCGCAGCCCGTAATTGGGAAAGCTATGATCAAATTTTAGCG
TCACTTAAAGAATTAGAGGACGATGAAACCTTATTGGTGCAATCTGGCAAACCAGTTGGCGTTTTTCAAACCCATGAAAA
TGCGCCGCGCGTATTGATTGCCAACTCCAACCTTGTCCCGCGCTGGGCAACATGGGAGCATTTCAACGAGCTCGATCGTA
AAGACTTGTTCATGTACGGTCAAATGACTGCGGGCAGCTGGATTTATATCGGCACCCAAGGCATCGTTCAAGGCACTTAT
GAAACCTTTGTCGAAGCTGGTCGTCAGCATTACGACGGTAGCTGGGCAGGACGTTGGATTTTGACTGCTGGCCTTGGTGG
TATGGGCGGCGCGCAGCCATTGGCAGCGACCTTTGCTGGAGCCACCTCTTTAAATATAGAGTGTCAGCAGTCTAGTATTG
ATTTCCGTTTGCGTACGGGCTACGTCGATAAACAAGCTGACAATCTTGATCATGCCTATGAGCTGATTAAGCAACATACT
GCAGCTGGTGAAGCCGTCTCAATCGCCCTACTTGGTAATGCAGCAGACATCTTGCCTGAGATGGTAAAGCGTGCCAATGC
AGGCGAAATCAAACCTGATTTGGTCACCGATCAAACCTCCGCCCATGATTTGATTAATGGCTATCTACCAAGTGGTTGGA
CAGTTAAAGAATGGAAAGCCGCTCAAGAAAACCCAGAGCAACACGCTGATCTAACCAAAGCCGCTGCTCAGTCTTGTGCG
GTACACGTACAGGCAATGCTAGATTTACAAGAGATGGACATCCCAACGACCGATTATGGCAATAACATCCGTCAGGTGGC
GTTTGATGAAGGCGTAAAAAATGCCTTTAATTTCCCAGGTTTTGTCCCTGCGTATATTCGTCCGCTGTTTTGCCAAGGCA
AAGGCCCATTCCGCTGGGTAGCGTTATCAGGTGATCCAGAAGATATCTATAAGACCGATCAAAAAATCAAAGAGCTATTC
CCTGAAAATCAGCACATTCATCGCTGGCTCGATATGGCAAAAGAGCGCATTCAGTTCCAAGGTCTGCCAGCACGTATCTG
TTGGTTAGGTCTAGGTGAGCGTGATAAAGCAGGTCTTGCCTTCAATGAGATGGTCAAAAACGGCGAGCTTAAAGGTCCTA
TCGTCATTGGTCGTGACCATTTAGATACTGGCTCTGTTGCCAGCCCAAACCGCGAAACAGAAAGTATGAAAGATGGCTCA
GATGCGGTATCGGATTGGGCATTATTAAACGGTATGCTGAATGTCGCAGGCGGCGCCACGTGGGTATCATTACATCATGG
CGGCGGTGTTGGTATGGGCTACTCGCAGCACTCTGGCATGGTTATCGTCGCTGACGGTACGGACGCTGCAGCCAAGCGCT
TAGCTCGGGTACTGGTCAACGATTGTGGTTCTGGCGTTATGCGTCATGCCGATGCTGGCTATGAGTTGGCGATTAAAACT
GCTAAGGATTACGGTCTAAATCTTCCTATGATTAAGTAA

Upstream 100 bases:

>100_bases
TATACAACTTTACGGCAGTATTAGTAAATTTAGCAAACTGACCGTATAAGACTCACTTTGATTGCCATATTGCCTCAACA
GATATCATAAGGATAGGATC

Downstream 100 bases:

>100_bases
TTCTCCATAGACACATAGATTACATGATTTTATCAAGGAAGATAATATGACCAAGCAAGATACCCTACAACTAGAGAAAA
CTGAGCAAGTTGTTAACACC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MTTDNGLNKTSAYTRRDESRNIAAPTGSTLHCKSWLTEAPYRMLQNNLHPDVAENPKSLVVYGGIGRAARNWESYDQILA
SLKELEDDETLLVQSGKPVGVFQTHENAPRVLIANSNLVPRWATWEHFNELDRKDLFMYGQMTAGSWIYIGTQGIVQGTY
ETFVEAGRQHYDGSWAGRWILTAGLGGMGGAQPLAATFAGATSLNIECQQSSIDFRLRTGYVDKQADNLDHAYELIKQHT
AAGEAVSIALLGNAADILPEMVKRANAGEIKPDLVTDQTSAHDLINGYLPSGWTVKEWKAAQENPEQHADLTKAAAQSCA
VHVQAMLDLQEMDIPTTDYGNNIRQVAFDEGVKNAFNFPGFVPAYIRPLFCQGKGPFRWVALSGDPEDIYKTDQKIKELF
PENQHIHRWLDMAKERIQFQGLPARICWLGLGERDKAGLAFNEMVKNGELKGPIVIGRDHLDTGSVASPNRETESMKDGS
DAVSDWALLNGMLNVAGGATWVSLHHGGGVGMGYSQHSGMVIVADGTDAAAKRLARVLVNDCGSGVMRHADAGYELAIKT
AKDYGLNLPMIK

Sequences:

>Translated_572_residues
MTTDNGLNKTSAYTRRDESRNIAAPTGSTLHCKSWLTEAPYRMLQNNLHPDVAENPKSLVVYGGIGRAARNWESYDQILA
SLKELEDDETLLVQSGKPVGVFQTHENAPRVLIANSNLVPRWATWEHFNELDRKDLFMYGQMTAGSWIYIGTQGIVQGTY
ETFVEAGRQHYDGSWAGRWILTAGLGGMGGAQPLAATFAGATSLNIECQQSSIDFRLRTGYVDKQADNLDHAYELIKQHT
AAGEAVSIALLGNAADILPEMVKRANAGEIKPDLVTDQTSAHDLINGYLPSGWTVKEWKAAQENPEQHADLTKAAAQSCA
VHVQAMLDLQEMDIPTTDYGNNIRQVAFDEGVKNAFNFPGFVPAYIRPLFCQGKGPFRWVALSGDPEDIYKTDQKIKELF
PENQHIHRWLDMAKERIQFQGLPARICWLGLGERDKAGLAFNEMVKNGELKGPIVIGRDHLDTGSVASPNRETESMKDGS
DAVSDWALLNGMLNVAGGATWVSLHHGGGVGMGYSQHSGMVIVADGTDAAAKRLARVLVNDCGSGVMRHADAGYELAIKT
AKDYGLNLPMIK
>Mature_571_residues
TTDNGLNKTSAYTRRDESRNIAAPTGSTLHCKSWLTEAPYRMLQNNLHPDVAENPKSLVVYGGIGRAARNWESYDQILAS
LKELEDDETLLVQSGKPVGVFQTHENAPRVLIANSNLVPRWATWEHFNELDRKDLFMYGQMTAGSWIYIGTQGIVQGTYE
TFVEAGRQHYDGSWAGRWILTAGLGGMGGAQPLAATFAGATSLNIECQQSSIDFRLRTGYVDKQADNLDHAYELIKQHTA
AGEAVSIALLGNAADILPEMVKRANAGEIKPDLVTDQTSAHDLINGYLPSGWTVKEWKAAQENPEQHADLTKAAAQSCAV
HVQAMLDLQEMDIPTTDYGNNIRQVAFDEGVKNAFNFPGFVPAYIRPLFCQGKGPFRWVALSGDPEDIYKTDQKIKELFP
ENQHIHRWLDMAKERIQFQGLPARICWLGLGERDKAGLAFNEMVKNGELKGPIVIGRDHLDTGSVASPNRETESMKDGSD
AVSDWALLNGMLNVAGGATWVSLHHGGGVGMGYSQHSGMVIVADGTDAAAKRLARVLVNDCGSGVMRHADAGYELAIKTA
KDYGLNLPMIK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=561, Percent_Identity=33.3333333333333, Blast_Score=291, Evalue=8e-79,
Organism=Homo sapiens, GI260306182, Length=207, Percent_Identity=36.231884057971, Blast_Score=149, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71997891, Length=561, Percent_Identity=34.7593582887701, Blast_Score=295, Evalue=5e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 62643; Mature: 62512

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDNGLNKTSAYTRRDESRNIAAPTGSTLHCKSWLTEAPYRMLQNNLHPDVAENPKSLV
CCCCCCCCCCHHHHCCCCCCCEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
VYGGIGRAARNWESYDQILASLKELEDDETLLVQSGKPVGVFQTHENAPRVLIANSNLVP
EECCCCHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCC
RWATWEHFNELDRKDLFMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQHYDGSWAGRWI
CCCCHHHHHHCCHHHEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEE
LTAGLGGMGGAQPLAATFAGATSLNIECQQSSIDFRLRTGYVDKQADNLDHAYELIKQHT
EEECCCCCCCCCHHHHHHCCCEEEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHC
AAGEAVSIALLGNAADILPEMVKRANAGEIKPDLVTDQTSAHDLINGYLPSGWTVKEWKA
CCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHH
AQENPEQHADLTKAAAQSCAVHVQAMLDLQEMDIPTTDYGNNIRQVAFDEGVKNAFNFPG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
FVPAYIRPLFCQGKGPFRWVALSGDPEDIYKTDQKIKELFPENQHIHRWLDMAKERIQFQ
CCHHHHCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GLPARICWLGLGERDKAGLAFNEMVKNGELKGPIVIGRDHLDTGSVASPNRETESMKDGS
CCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCH
DAVSDWALLNGMLNVAGGATWVSLHHGGGVGMGYSQHSGMVIVADGTDAAAKRLARVLVN
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
DCGSGVMRHADAGYELAIKTAKDYGLNLPMIK
HHCCHHHHHCCCCEEEEEEEHHHCCCCCCCCC
>Mature Secondary Structure 
TTDNGLNKTSAYTRRDESRNIAAPTGSTLHCKSWLTEAPYRMLQNNLHPDVAENPKSLV
CCCCCCCCCHHHHCCCCCCCEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
VYGGIGRAARNWESYDQILASLKELEDDETLLVQSGKPVGVFQTHENAPRVLIANSNLVP
EECCCCHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCC
RWATWEHFNELDRKDLFMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQHYDGSWAGRWI
CCCCHHHHHHCCHHHEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEE
LTAGLGGMGGAQPLAATFAGATSLNIECQQSSIDFRLRTGYVDKQADNLDHAYELIKQHT
EEECCCCCCCCCHHHHHHCCCEEEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHC
AAGEAVSIALLGNAADILPEMVKRANAGEIKPDLVTDQTSAHDLINGYLPSGWTVKEWKA
CCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHH
AQENPEQHADLTKAAAQSCAVHVQAMLDLQEMDIPTTDYGNNIRQVAFDEGVKNAFNFPG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
FVPAYIRPLFCQGKGPFRWVALSGDPEDIYKTDQKIKELFPENQHIHRWLDMAKERIQFQ
CCHHHHCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GLPARICWLGLGERDKAGLAFNEMVKNGELKGPIVIGRDHLDTGSVASPNRETESMKDGS
CCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCH
DAVSDWALLNGMLNVAGGATWVSLHHGGGVGMGYSQHSGMVIVADGTDAAAKRLARVLVN
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
DCGSGVMRHADAGYELAIKTAKDYGLNLPMIK
HHCCHHHHHCCCCEEEEEEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]