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The map label for this gene is lldD [H]

Identifier: 93006713

GI number: 93006713

Start: 2334514

End: 2335722

Strand: Direct

Name: lldD [H]

Synonym: Pcryo_1889

Alternate gene names: 93006713

Gene position: 2334514-2335722 (Clockwise)

Preceding gene: 93006712

Following gene: 93006714

Centisome position: 76.29

GC content: 48.22

Gene sequence:

>1209_bases
ATGAAAAATTTGAGCAAAATTACTGAAATTGAAGACTTACGACGGGTTGCTGAGCGCAAAGTGCCTCGCATGTTTTATGA
TTATGTCGACTCAGGCTCATGGACTGAGACCACCTATCGTAATAATGAAACTGACTTTGATCGTATCAAATTACGTCAGC
GGGTATTGGTCAATATGGAAGGACGCTCGCTTGCCACCGAAATGCTGGGCACGCCAGTAAAAATGCCAGTTGCGATTGCG
CCAACAGGCTTTACTGGCATGATGTGGGCAGACGGAGAAATCCTCGCGGCACAGGCAGCAGAAAATTTTGGCGTACCGTT
TTCCCTATCGACCATGAGTATTTGCTCTATCGAAGATGTCGCCACCCATACCAGCCAGCCATTTTGGTTTCAGCTATATA
TGATGCGCGATATGGACTTTATCGCCAATTTGATTCGCCGTGCCAAAGAAGCCAATTGCTCAGCGCTCATCCTGACCGCC
GATTTACAAGTACTCGGTCAACGTCATAAAGACATCAAAAATGGTCTATCTGCGCCGCCAAAACCAACGCTTGCCAATAT
CTTAAATCTGATGACCAAGCCAGAATGGTGTATGAATATGCTCCAAACCCGCCGCCGCACCTTTGGTAATATCGTCGGTC
ATGCTAAAAACGTCGAGGATATCTCATCGCTATCAGCATGGACAGCTGAGCAGTTCGATCCGGCGCTGAGCTGGGATGAT
GTCGCTCGTATTAAAGACATGTGGGGTGGCAAGCTGATTATCAAAGGCATTATGGAGCCAGAAGATGCCATCATGGCAGC
TCGTAGCGGTGCCGATGCGCTAGTGGTCTCCAATCATGGTGGACGCCAATTGGATGGTGCACCCTCTTCCATTTCATCTC
TATCCGATATTGTACAAGCCGTGCGTGCTGAAGACAGTCAGATTGAAGTTTGGCTCGATAGCGGTATTCGTTCTGGGCAA
GATGTACTCAAAGCGATGGCATTAGGAGCCAATGGCACGATGATTGGTCGCGCTTTTCTTTATGGTCTTGGCGCGTATGG
CGAAGATGGTGTCCGCCGAGCGCTTGAACTGATTTATAACGAATGTGATATCAGCATGGCGTTTTGCGGTCATACCGATA
TCAATGAAGTGCGCGATGATATCTTAGTCAAAGGTACCTACGAGCATCTCAAAACTGCCTTGCCTTACGTAGCGCCAATG
CGCTGGTAA

Upstream 100 bases:

>100_bases
ACGGTTAAGATAATATTTTCTGATAATTAACGACAAAAAATGAATGACCGCAGCATCATAATTAATAAACGGTTACCAAA
TAAGCAACAAGGAAGACCTT

Downstream 100 bases:

>100_bases
GTGTAGACGATATAACTACTTAGACTTGTTGGTCGCTTTCTTTATACTATCTATACCCTTTATACTGTACTGATAATTTT
TTATTGATAATTAGATGTTA

Product: L-lactate dehydrogenase (cytochrome)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKNLSKITEIEDLRRVAERKVPRMFYDYVDSGSWTETTYRNNETDFDRIKLRQRVLVNMEGRSLATEMLGTPVKMPVAIA
PTGFTGMMWADGEILAAQAAENFGVPFSLSTMSICSIEDVATHTSQPFWFQLYMMRDMDFIANLIRRAKEANCSALILTA
DLQVLGQRHKDIKNGLSAPPKPTLANILNLMTKPEWCMNMLQTRRRTFGNIVGHAKNVEDISSLSAWTAEQFDPALSWDD
VARIKDMWGGKLIIKGIMEPEDAIMAARSGADALVVSNHGGRQLDGAPSSISSLSDIVQAVRAEDSQIEVWLDSGIRSGQ
DVLKAMALGANGTMIGRAFLYGLGAYGEDGVRRALELIYNECDISMAFCGHTDINEVRDDILVKGTYEHLKTALPYVAPM
RW

Sequences:

>Translated_402_residues
MKNLSKITEIEDLRRVAERKVPRMFYDYVDSGSWTETTYRNNETDFDRIKLRQRVLVNMEGRSLATEMLGTPVKMPVAIA
PTGFTGMMWADGEILAAQAAENFGVPFSLSTMSICSIEDVATHTSQPFWFQLYMMRDMDFIANLIRRAKEANCSALILTA
DLQVLGQRHKDIKNGLSAPPKPTLANILNLMTKPEWCMNMLQTRRRTFGNIVGHAKNVEDISSLSAWTAEQFDPALSWDD
VARIKDMWGGKLIIKGIMEPEDAIMAARSGADALVVSNHGGRQLDGAPSSISSLSDIVQAVRAEDSQIEVWLDSGIRSGQ
DVLKAMALGANGTMIGRAFLYGLGAYGEDGVRRALELIYNECDISMAFCGHTDINEVRDDILVKGTYEHLKTALPYVAPM
RW
>Mature_402_residues
MKNLSKITEIEDLRRVAERKVPRMFYDYVDSGSWTETTYRNNETDFDRIKLRQRVLVNMEGRSLATEMLGTPVKMPVAIA
PTGFTGMMWADGEILAAQAAENFGVPFSLSTMSICSIEDVATHTSQPFWFQLYMMRDMDFIANLIRRAKEANCSALILTA
DLQVLGQRHKDIKNGLSAPPKPTLANILNLMTKPEWCMNMLQTRRRTFGNIVGHAKNVEDISSLSAWTAEQFDPALSWDD
VARIKDMWGGKLIIKGIMEPEDAIMAARSGADALVVSNHGGRQLDGAPSSISSLSDIVQAVRAEDSQIEVWLDSGIRSGQ
DVLKAMALGANGTMIGRAFLYGLGAYGEDGVRRALELIYNECDISMAFCGHTDINEVRDDILVKGTYEHLKTALPYVAPM
RW

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=382, Percent_Identity=34.2931937172775, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=32.3529411764706, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=32.3529411764706, Blast_Score=209, Evalue=2e-54,
Organism=Escherichia coli, GI1790033, Length=395, Percent_Identity=42.5316455696203, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI193208036, Length=375, Percent_Identity=34.1333333333333, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI32566217, Length=294, Percent_Identity=31.6326530612245, Blast_Score=146, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=400, Percent_Identity=30.25, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI78707188, Length=375, Percent_Identity=33.6, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI281363140, Length=375, Percent_Identity=33.6, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI78707190, Length=375, Percent_Identity=33.6, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 44713; Mature: 44713

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLSKITEIEDLRRVAERKVPRMFYDYVDSGSWTETTYRNNETDFDRIKLRQRVLVNME
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
GRSLATEMLGTPVKMPVAIAPTGFTGMMWADGEILAAQAAENFGVPFSLSTMSICSIEDV
CHHHHHHHHCCCCCCCEEECCCCCCEEEEECCCEEEEHHHHHCCCCEEECCEEECCHHHH
ATHTSQPFWFQLYMMRDMDFIANLIRRAKEANCSALILTADLQVLGQRHKDIKNGLSAPP
HHCCCCCHHEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCC
KPTLANILNLMTKPEWCMNMLQTRRRTFGNIVGHAKNVEDISSLSAWTAEQFDPALSWDD
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHH
VARIKDMWGGKLIIKGIMEPEDAIMAARSGADALVVSNHGGRQLDGAPSSISSLSDIVQA
HHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
VRAEDSQIEVWLDSGIRSGQDVLKAMALGANGTMIGRAFLYGLGAYGEDGVRRALELIYN
HHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ECDISMAFCGHTDINEVRDDILVKGTYEHLKTALPYVAPMRW
HCCCEEEECCCCCHHHHHHHHEECCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKNLSKITEIEDLRRVAERKVPRMFYDYVDSGSWTETTYRNNETDFDRIKLRQRVLVNME
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
GRSLATEMLGTPVKMPVAIAPTGFTGMMWADGEILAAQAAENFGVPFSLSTMSICSIEDV
CHHHHHHHHCCCCCCCEEECCCCCCEEEEECCCEEEEHHHHHCCCCEEECCEEECCHHHH
ATHTSQPFWFQLYMMRDMDFIANLIRRAKEANCSALILTADLQVLGQRHKDIKNGLSAPP
HHCCCCCHHEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCC
KPTLANILNLMTKPEWCMNMLQTRRRTFGNIVGHAKNVEDISSLSAWTAEQFDPALSWDD
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHH
VARIKDMWGGKLIIKGIMEPEDAIMAARSGADALVVSNHGGRQLDGAPSSISSLSDIVQA
HHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
VRAEDSQIEVWLDSGIRSGQDVLKAMALGANGTMIGRAFLYGLGAYGEDGVRRALELIYN
HHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ECDISMAFCGHTDINEVRDDILVKGTYEHLKTALPYVAPMRW
HCCCEEEECCCCCHHHHHHHHEECCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA