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The map label for this gene is lytS [H]

Identifier: 93005594

GI number: 93005594

Start: 899499

End: 901247

Strand: Direct

Name: lytS [H]

Synonym: Pcryo_0764

Alternate gene names: 93005594

Gene position: 899499-901247 (Clockwise)

Preceding gene: 93005593

Following gene: 93005595

Centisome position: 29.4

GC content: 36.36

Gene sequence:

>1749_bases
ATGTGGGAAATATTATCGCAGATGCTATCAAGAATGAGTATCATCATTACGATTGCTTATTTAATCACTAGACTGCCTAT
ATTTAGAAAAATGATTTCCCAGCGAGTCGGAATAGGTGGTTTATTTGTTTTGATAATAATATTTGGTATGTTTGGAGTCA
TTGGTAATTATACGGCGCTTGTTGTAGAGCCGGGTAACCAAAAAGTCATATCCAATATATGGAATCCTACACTTCAATCA
AACAATGCAGTAGCGGATACAAGAAATATCGGTATCATCATCGGTGGCTTTTTTGGTGGTCCAATAGTTGGCATAGGTGC
TTCAGTTATTGCCGGTGCCCATCGTTTGCTGATGGGTGGTTTTATCAGTGGAGCCACTTTCTGGGTATCTATCTTAGGTG
GCTGCTTTGCAGGATGGTTTGGATATAAATGGCGCGGAATGGGTCTAATTAAGCCAAGATATATGTTTCTTACCAGCATT
ATCATTTTAACGATTCAAATTTTAGCTATTCCAGTCTTAACTACCGATCATACTACGGCACTCAAATTAATTGCTTTTAC
AGGCCCACCCATTATCATCATCAACAGTGTTGGTATATGGATTTGTGCGATGATTTTTTATAATGTAGTAGTAGAAGAGG
ATAGAACAAGAGCAAGTCAAACGGTCAAAACATTTTCAATTGCTGATCAAACCTTCTCGTTATTCCGATCGGGTCTCAAT
GAAAACTCAGCTAAAAAAAGTACAAAAATTATTAAAAAATTAACTGCTGTAGAGCATGTAGCGATTACTAGAGGTATTCG
TGAATTAGCTTATACTGGAACATTGAATAATCAAAAGAGAAATGAAGAAGAAGACCTTGCATCACGTAAGCTGGCTTTAT
CAACGGGAAAATCAGTATTAAATGAGCCAAAGTCAAAATGGCTGTTTTCAAAGAAATCAAATAGTAGAGCTTCTGTAGTA
GTGCCATTTTGTGTTCAGAATAAAACGATTGGAACCATTACTTTTTATTATGCAAGCTCATTACATATTACTGTCGTTGA
AAAAGAACTGATTGAAGGTTTAGGCAAGCTTTTCTCAAATCAATTAGAGCTTGGTGAGATTGAACGTCATAATCAACTAT
TACAAAACGCAAAAATTGAGGCGTTACAATCGCAAATTCAACCCCATTTTTTATTTAATGCATTAAATACCATTGTAGCT
TTATGTAGAATCGATCCAATGCTAGCGCGAGATTTATTGCTACACTTATCTACTTATTTGCGAAATAACTTGTCAGGCAT
TGCTGATTTTTTGGTACCGGTATACAAGGAAATGGAGAATGTACAAGCTTATTTGGCCATTGAACAAGCTCGTTTTCCAG
ATAAGTTTGTAGTCAATATAGAAGTAGCTCCTGATTTGATTGAGTGTCTTATTCCTCCATTTATCATTCAGCCTTTGGTC
GAGAACGCAATAAAGCACGGTGGATTTAAAAAGATAGAAGCTAAAGGTGCAGTTCATATCGAGATTAAAAAAATATCAGA
ACTCTTAATTTTGATTAAAGTTTCTGATAATGGGATTGGCGTTGAGCTAAATCGAATAGTAGATCTAGGGGAACGTGTTG
TAAAATCCTCTAAAGATGGAAGTGGCACCGCGTTATTCAATATAAAAGAGCGACTTACGGCACTGTACAGCCAAGATGTA
CGCTTTAATATAGACAGTGATGTTGGCAAAGGGACTTGTGTGTCGATTATATTGCCGGTTAAAACTTAG

Upstream 100 bases:

>100_bases
TGCTGAAGTCTTAAACTAGTGATGGTTTGAAAAACCGTTACTAGTTTAGTTATTGGCGCCAAGACAAAGCTGATATTCAC
CATCAAAATGAGATATTTCA

Downstream 100 bases:

>100_bases
GGAAGGGTTTGGATGAATGTTTATGTTGTTGAAGACGAAGTGTTAGCTAGACAAGAGTTGATTTATCTTTTGAAAGACAC
AGGAAAAATTAACGTAGTTG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 582

Protein sequence:

>582_residues
MWEILSQMLSRMSIIITIAYLITRLPIFRKMISQRVGIGGLFVLIIIFGMFGVIGNYTALVVEPGNQKVISNIWNPTLQS
NNAVADTRNIGIIIGGFFGGPIVGIGASVIAGAHRLLMGGFISGATFWVSILGGCFAGWFGYKWRGMGLIKPRYMFLTSI
IILTIQILAIPVLTTDHTTALKLIAFTGPPIIIINSVGIWICAMIFYNVVVEEDRTRASQTVKTFSIADQTFSLFRSGLN
ENSAKKSTKIIKKLTAVEHVAITRGIRELAYTGTLNNQKRNEEEDLASRKLALSTGKSVLNEPKSKWLFSKKSNSRASVV
VPFCVQNKTIGTITFYYASSLHITVVEKELIEGLGKLFSNQLELGEIERHNQLLQNAKIEALQSQIQPHFLFNALNTIVA
LCRIDPMLARDLLLHLSTYLRNNLSGIADFLVPVYKEMENVQAYLAIEQARFPDKFVVNIEVAPDLIECLIPPFIIQPLV
ENAIKHGGFKKIEAKGAVHIEIKKISELLILIKVSDNGIGVELNRIVDLGERVVKSSKDGSGTALFNIKERLTALYSQDV
RFNIDSDVGKGTCVSIILPVKT

Sequences:

>Translated_582_residues
MWEILSQMLSRMSIIITIAYLITRLPIFRKMISQRVGIGGLFVLIIIFGMFGVIGNYTALVVEPGNQKVISNIWNPTLQS
NNAVADTRNIGIIIGGFFGGPIVGIGASVIAGAHRLLMGGFISGATFWVSILGGCFAGWFGYKWRGMGLIKPRYMFLTSI
IILTIQILAIPVLTTDHTTALKLIAFTGPPIIIINSVGIWICAMIFYNVVVEEDRTRASQTVKTFSIADQTFSLFRSGLN
ENSAKKSTKIIKKLTAVEHVAITRGIRELAYTGTLNNQKRNEEEDLASRKLALSTGKSVLNEPKSKWLFSKKSNSRASVV
VPFCVQNKTIGTITFYYASSLHITVVEKELIEGLGKLFSNQLELGEIERHNQLLQNAKIEALQSQIQPHFLFNALNTIVA
LCRIDPMLARDLLLHLSTYLRNNLSGIADFLVPVYKEMENVQAYLAIEQARFPDKFVVNIEVAPDLIECLIPPFIIQPLV
ENAIKHGGFKKIEAKGAVHIEIKKISELLILIKVSDNGIGVELNRIVDLGERVVKSSKDGSGTALFNIKERLTALYSQDV
RFNIDSDVGKGTCVSIILPVKT
>Mature_582_residues
MWEILSQMLSRMSIIITIAYLITRLPIFRKMISQRVGIGGLFVLIIIFGMFGVIGNYTALVVEPGNQKVISNIWNPTLQS
NNAVADTRNIGIIIGGFFGGPIVGIGASVIAGAHRLLMGGFISGATFWVSILGGCFAGWFGYKWRGMGLIKPRYMFLTSI
IILTIQILAIPVLTTDHTTALKLIAFTGPPIIIINSVGIWICAMIFYNVVVEEDRTRASQTVKTFSIADQTFSLFRSGLN
ENSAKKSTKIIKKLTAVEHVAITRGIRELAYTGTLNNQKRNEEEDLASRKLALSTGKSVLNEPKSKWLFSKKSNSRASVV
VPFCVQNKTIGTITFYYASSLHITVVEKELIEGLGKLFSNQLELGEIERHNQLLQNAKIEALQSQIQPHFLFNALNTIVA
LCRIDPMLARDLLLHLSTYLRNNLSGIADFLVPVYKEMENVQAYLAIEQARFPDKFVVNIEVAPDLIECLIPPFIIQPLV
ENAIKHGGFKKIEAKGAVHIEIKKISELLILIKVSDNGIGVELNRIVDLGERVVKSSKDGSGTALFNIKERLTALYSQDV
RFNIDSDVGKGTCVSIILPVKT

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=571, Percent_Identity=29.9474605954466, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1788446, Length=581, Percent_Identity=26.8502581755594, Blast_Score=199, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64323; Mature: 64323

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWEILSQMLSRMSIIITIAYLITRLPIFRKMISQRVGIGGLFVLIIIFGMFGVIGNYTAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEE
VVEPGNQKVISNIWNPTLQSNNAVADTRNIGIIIGGFFGGPIVGIGASVIAGAHRLLMGG
EEECCCHHHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
FISGATFWVSILGGCFAGWFGYKWRGMGLIKPRYMFLTSIIILTIQILAIPVLTTDHTTA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHE
LKLIAFTGPPIIIINSVGIWICAMIFYNVVVEEDRTRASQTVKTFSIADQTFSLFRSGLN
EEEEEECCCCEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ENSAKKSTKIIKKLTAVEHVAITRGIRELAYTGTLNNQKRNEEEDLASRKLALSTGKSVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHH
NEPKSKWLFSKKSNSRASVVVPFCVQNKTIGTITFYYASSLHITVVEKELIEGLGKLFSN
CCCHHHCEEECCCCCCCEEEEEEEECCCCEEEEEEEEECCEEEEEHHHHHHHHHHHHHHC
QLELGEIERHNQLLQNAKIEALQSQIQPHFLFNALNTIVALCRIDPMLARDLLLHLSTYL
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RNNLSGIADFLVPVYKEMENVQAYLAIEQARFPDKFVVNIEVAPDLIECLIPPFIIQPLV
HHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCEEEEEEEECHHHHHHHCCHHHHHHHH
ENAIKHGGFKKIEAKGAVHIEIKKISELLILIKVSDNGIGVELNRIVDLGERVVKSSKDG
HHHHHCCCCEEEECCCEEEEEHEECCEEEEEEEECCCCCCEEHHHHHHHHHHHHHCCCCC
SGTALFNIKERLTALYSQDVRFNIDSDVGKGTCVSIILPVKT
CCEEEEEHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MWEILSQMLSRMSIIITIAYLITRLPIFRKMISQRVGIGGLFVLIIIFGMFGVIGNYTAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEE
VVEPGNQKVISNIWNPTLQSNNAVADTRNIGIIIGGFFGGPIVGIGASVIAGAHRLLMGG
EEECCCHHHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
FISGATFWVSILGGCFAGWFGYKWRGMGLIKPRYMFLTSIIILTIQILAIPVLTTDHTTA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHE
LKLIAFTGPPIIIINSVGIWICAMIFYNVVVEEDRTRASQTVKTFSIADQTFSLFRSGLN
EEEEEECCCCEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ENSAKKSTKIIKKLTAVEHVAITRGIRELAYTGTLNNQKRNEEEDLASRKLALSTGKSVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHH
NEPKSKWLFSKKSNSRASVVVPFCVQNKTIGTITFYYASSLHITVVEKELIEGLGKLFSN
CCCHHHCEEECCCCCCCEEEEEEEECCCCEEEEEEEEECCEEEEEHHHHHHHHHHHHHHC
QLELGEIERHNQLLQNAKIEALQSQIQPHFLFNALNTIVALCRIDPMLARDLLLHLSTYL
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RNNLSGIADFLVPVYKEMENVQAYLAIEQARFPDKFVVNIEVAPDLIECLIPPFIIQPLV
HHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCEEEEEEEECHHHHHHHCCHHHHHHHH
ENAIKHGGFKKIEAKGAVHIEIKKISELLILIKVSDNGIGVELNRIVDLGERVVKSSKDG
HHHHHCCCCEEEECCCEEEEEHEECCEEEEEEEECCCCCCEEHHHHHHHHHHHHHCCCCC
SGTALFNIKERLTALYSQDVRFNIDSDVGKGTCVSIILPVKT
CCEEEEEHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]