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The map label for this gene is sdhA [H]

Identifier: 93004940

GI number: 93004940

Start: 125480

End: 127330

Strand: Direct

Name: sdhA [H]

Synonym: Pcryo_0109

Alternate gene names: 93004940

Gene position: 125480-127330 (Clockwise)

Preceding gene: 93004939

Following gene: 93004941

Centisome position: 4.1

GC content: 46.57

Gene sequence:

>1851_bases
ATGGCAACTAGACAAGACAATACCATTAGCAATATCAAAACCCTAAACTATGACGCGGTCATCGTTGGTGGTGGTGGTTC
AGGTATGCGTGCATCATTGCACTTAGCTGAAGCCGGCATGAAGGTTGCAGTCTTAACCAAAGTATTCCCAACCCGCTCGC
ACACTGTTGCAGCTCAGGGCGGTATCGGTGCAAGTCTCGGTAACATGAGCAACGATAACTGGCATTTCCACTTTTATGAT
ACCGTTAAAGGGTCAGACTGGTTGGGTGACCAAGACGCGATTGAGTACATGTGCCGTGAAGCGCCAAAAGTAGTATATGA
GCTTGAGCACATGGGCATGCCGTTTGACCGTAATGAAGATGGCACAATTTATCAGCGCCCATTTGGTGGTCATACCTCAA
ACTATGGCGAAAAAGCCGTACAACGTGCGTGTGCTGCTGCTGACCGTACCGGTCACGCGCTACTGCATACTCTATATCAA
AAAAACCTGCAGCAAGGTACTGAATTCTTTATTGAGTGGATTGCCCTTGATTTGATCAAAGATGAAGCCGGCAACATCAA
TGGCGTCATCGCTATTGAGCAAGAAACTGGTACTGTTGCGGTATTCCAGTCACCAATCACTGTGTTAGCGACAGGCGGCG
CAGGTCGTATCTTTGCTGCCTCTACCAACGCTTATATTAATACTGGTGACGGTATTGGCATGGCGGTTCGTGCTGGTATT
CCACTACAAGACATGGAATTTTGGCAGTTCCACCCAACCGGCGTTCATGGTGCCGGCGTACTATTGACCGAAGGTTGCCG
CGGTGAAGGCGCTATCTTACGTAATAAAGATGGCGAAGCCTTTATGGAGCGTTATGCTCCAACCGTAAAAGACTTGGCAC
CACGTGATTTAGTATCACGCTCTATGGACCAAGAAATCAAAGAAGGCCGTGGTTGTGGTCCAAATGCTGACCATATCGTG
ATGGATATGACCCATTTAGGTGTTGAAACCATCATGAAGCGTCTGCCATCAGTATTCGAGATTGGTAAGAACTTTGCCAA
CGTCGATATCACGAAAGAGCCAATTCCTGTTATTCCAACCATTCATTATATGATGGGCGGTATTCCAACCACGATTCATG
GTCAAGTGATTGTACCGGATCTAGAAGCAGGTACGGATGAAGATGGTCTATATGCAAAAGGCAACGTGGTTAAAGGTCTA
TATGCAATTGGCGAATGTGCGTGCGTCAGTGTTCACGGTGCCAACCGTTTAGGTACCAACTCATTGCTTGATTTATTGGT
ATTTGGTCGCGCTGCAGGTAAGCACATCGTCGATGAATTCCATCATGCGGATCATAACTATAAGCCACTTGATCCTCGCG
TCCTTGATTACACAGTCGGTCGTTTAGACAAGCTGCAACAGTCAACTTCAGGCTACAATGCGCAAGACGTTGCCGATGAG
ATTCGTGCAACTATGCAAACGCATGCCAGTGTATTCCGTACACAAGCGATGATGGATGAAGGCGTTGCAAAAATCCTAGC
GCTAGGCGAGAAGATTGATCAGATTCATTTGGCTGATAAATCACAAGTCTTTAACACTGCTCGTATTGAAGCCTTTGAAG
TGGGCAATCTTTACGAAGTAGCAAAAGCGACGATGATATCAGCGGCCCAGCGTCATGAAAGCCGCGGCGCGCACAGTGTC
TCTGACTATGATCGTCCTGAAGATGATGAATACGCACCAAACGGTCGTAACGATAATGATTGGATGAAGCATACCTTATG
GTATTCTGAAGGCAATAAGATTATCTATAAGCCGGTTCGTAAAATTCCATTAACGGTTGATTATATCGAGCCAAAGGTTC
GTGTCTACTAA

Upstream 100 bases:

>100_bases
TATCCGTGCTTTGAGTCGATGATTCAGCTCGGAGTGTATGACTGGTTAAGCAGTCCTTGTATTTACTTCGCAAGTATTAA
CAGGCATTAGGAAAACCGTA

Downstream 100 bases:

>100_bases
GTCAGACGCCTTGCGCCTGATGTGTATAGACAGCATAAACGTTTTATCCTTTATTCATTTATTAAAAAGGTGACCGCCAG
CTACAAGCTCATGCCAGCGC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MATRQDNTISNIKTLNYDAVIVGGGGSGMRASLHLAEAGMKVAVLTKVFPTRSHTVAAQGGIGASLGNMSNDNWHFHFYD
TVKGSDWLGDQDAIEYMCREAPKVVYELEHMGMPFDRNEDGTIYQRPFGGHTSNYGEKAVQRACAAADRTGHALLHTLYQ
KNLQQGTEFFIEWIALDLIKDEAGNINGVIAIEQETGTVAVFQSPITVLATGGAGRIFAASTNAYINTGDGIGMAVRAGI
PLQDMEFWQFHPTGVHGAGVLLTEGCRGEGAILRNKDGEAFMERYAPTVKDLAPRDLVSRSMDQEIKEGRGCGPNADHIV
MDMTHLGVETIMKRLPSVFEIGKNFANVDITKEPIPVIPTIHYMMGGIPTTIHGQVIVPDLEAGTDEDGLYAKGNVVKGL
YAIGECACVSVHGANRLGTNSLLDLLVFGRAAGKHIVDEFHHADHNYKPLDPRVLDYTVGRLDKLQQSTSGYNAQDVADE
IRATMQTHASVFRTQAMMDEGVAKILALGEKIDQIHLADKSQVFNTARIEAFEVGNLYEVAKATMISAAQRHESRGAHSV
SDYDRPEDDEYAPNGRNDNDWMKHTLWYSEGNKIIYKPVRKIPLTVDYIEPKVRVY

Sequences:

>Translated_616_residues
MATRQDNTISNIKTLNYDAVIVGGGGSGMRASLHLAEAGMKVAVLTKVFPTRSHTVAAQGGIGASLGNMSNDNWHFHFYD
TVKGSDWLGDQDAIEYMCREAPKVVYELEHMGMPFDRNEDGTIYQRPFGGHTSNYGEKAVQRACAAADRTGHALLHTLYQ
KNLQQGTEFFIEWIALDLIKDEAGNINGVIAIEQETGTVAVFQSPITVLATGGAGRIFAASTNAYINTGDGIGMAVRAGI
PLQDMEFWQFHPTGVHGAGVLLTEGCRGEGAILRNKDGEAFMERYAPTVKDLAPRDLVSRSMDQEIKEGRGCGPNADHIV
MDMTHLGVETIMKRLPSVFEIGKNFANVDITKEPIPVIPTIHYMMGGIPTTIHGQVIVPDLEAGTDEDGLYAKGNVVKGL
YAIGECACVSVHGANRLGTNSLLDLLVFGRAAGKHIVDEFHHADHNYKPLDPRVLDYTVGRLDKLQQSTSGYNAQDVADE
IRATMQTHASVFRTQAMMDEGVAKILALGEKIDQIHLADKSQVFNTARIEAFEVGNLYEVAKATMISAAQRHESRGAHSV
SDYDRPEDDEYAPNGRNDNDWMKHTLWYSEGNKIIYKPVRKIPLTVDYIEPKVRVY
>Mature_615_residues
ATRQDNTISNIKTLNYDAVIVGGGGSGMRASLHLAEAGMKVAVLTKVFPTRSHTVAAQGGIGASLGNMSNDNWHFHFYDT
VKGSDWLGDQDAIEYMCREAPKVVYELEHMGMPFDRNEDGTIYQRPFGGHTSNYGEKAVQRACAAADRTGHALLHTLYQK
NLQQGTEFFIEWIALDLIKDEAGNINGVIAIEQETGTVAVFQSPITVLATGGAGRIFAASTNAYINTGDGIGMAVRAGIP
LQDMEFWQFHPTGVHGAGVLLTEGCRGEGAILRNKDGEAFMERYAPTVKDLAPRDLVSRSMDQEIKEGRGCGPNADHIVM
DMTHLGVETIMKRLPSVFEIGKNFANVDITKEPIPVIPTIHYMMGGIPTTIHGQVIVPDLEAGTDEDGLYAKGNVVKGLY
AIGECACVSVHGANRLGTNSLLDLLVFGRAAGKHIVDEFHHADHNYKPLDPRVLDYTVGRLDKLQQSTSGYNAQDVADEI
RATMQTHASVFRTQAMMDEGVAKILALGEKIDQIHLADKSQVFNTARIEAFEVGNLYEVAKATMISAAQRHESRGAHSVS
DYDRPEDDEYAPNGRNDNDWMKHTLWYSEGNKIIYKPVRKIPLTVDYIEPKVRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=597, Percent_Identity=49.0787269681742, Blast_Score=560, Evalue=1e-159,
Organism=Escherichia coli, GI1786942, Length=601, Percent_Identity=52.0798668885191, Blast_Score=586, Evalue=1e-168,
Organism=Escherichia coli, GI1790597, Length=589, Percent_Identity=37.3514431239389, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1788928, Length=559, Percent_Identity=32.3792486583184, Blast_Score=230, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=597, Percent_Identity=49.9162479061977, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17505833, Length=598, Percent_Identity=48.6622073578595, Blast_Score=548, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322701, Length=623, Percent_Identity=50.8828250401284, Blast_Score=596, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6322416, Length=610, Percent_Identity=51.1475409836066, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI17137288, Length=614, Percent_Identity=49.8371335504886, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24655642, Length=614, Percent_Identity=49.8371335504886, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24655647, Length=614, Percent_Identity=49.8371335504886, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24663005, Length=619, Percent_Identity=45.3957996768982, Blast_Score=521, Evalue=1e-148,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 67553; Mature: 67422

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRQDNTISNIKTLNYDAVIVGGGGSGMRASLHLAEAGMKVAVLTKVFPTRSHTVAAQG
CCCCCCCCHHHEEEECCCEEEEECCCCCCEEEEEHHHCCCEEEEEEHHCCCCCCEEEECC
GIGASLGNMSNDNWHFHFYDTVKGSDWLGDQDAIEYMCREAPKVVYELEHMGMPFDRNED
CCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GTIYQRPFGGHTSNYGEKAVQRACAAADRTGHALLHTLYQKNLQQGTEFFIEWIALDLIK
CCEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEAGNINGVIAIEQETGTVAVFQSPITVLATGGAGRIFAASTNAYINTGDGIGMAVRAGI
HCCCCCCEEEEEEECCCEEEEEECCEEEEEECCCCEEEEEECCCEEECCCCCCEEEECCC
PLQDMEFWQFHPTGVHGAGVLLTEGCRGEGAILRNKDGEAFMERYAPTVKDLAPRDLVSR
CCCCCCCEEECCCCCCCCCEEEECCCCCCCCEEECCCCHHHHHHCCCHHHHCCHHHHHHH
SMDQEIKEGRGCGPNADHIVMDMTHLGVETIMKRLPSVFEIGKNFANVDITKEPIPVIPT
HHHHHHHHCCCCCCCCCEEEEEHHHHCHHHHHHHCHHHHHHCCCCCCCEECCCCCCCCCH
IHYMMGGIPTTIHGQVIVPDLEAGTDEDGLYAKGNVVKGLYAIGECACVSVHGANRLGTN
HHHHHCCCCCEECCEEEEECCCCCCCCCCEEECCCHHHHHHHHCCEEEEEECCCCCCCHH
SLLDLLVFGRAAGKHIVDEFHHADHNYKPLDPRVLDYTVGRLDKLQQSTSGYNAQDVADE
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
IRATMQTHASVFRTQAMMDEGVAKILALGEKIDQIHLADKSQVFNTARIEAFEVGNLYEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHEEEEEECCCHHHH
AKATMISAAQRHESRGAHSVSDYDRPEDDEYAPNGRNDNDWMKHTLWYSEGNKIIYKPVR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEECCCEEEEECHH
KIPLTVDYIEPKVRVY
HCCEEEEEECCCEEEC
>Mature Secondary Structure 
ATRQDNTISNIKTLNYDAVIVGGGGSGMRASLHLAEAGMKVAVLTKVFPTRSHTVAAQG
CCCCCCCHHHEEEECCCEEEEECCCCCCEEEEEHHHCCCEEEEEEHHCCCCCCEEEECC
GIGASLGNMSNDNWHFHFYDTVKGSDWLGDQDAIEYMCREAPKVVYELEHMGMPFDRNED
CCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GTIYQRPFGGHTSNYGEKAVQRACAAADRTGHALLHTLYQKNLQQGTEFFIEWIALDLIK
CCEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEAGNINGVIAIEQETGTVAVFQSPITVLATGGAGRIFAASTNAYINTGDGIGMAVRAGI
HCCCCCCEEEEEEECCCEEEEEECCEEEEEECCCCEEEEEECCCEEECCCCCCEEEECCC
PLQDMEFWQFHPTGVHGAGVLLTEGCRGEGAILRNKDGEAFMERYAPTVKDLAPRDLVSR
CCCCCCCEEECCCCCCCCCEEEECCCCCCCCEEECCCCHHHHHHCCCHHHHCCHHHHHHH
SMDQEIKEGRGCGPNADHIVMDMTHLGVETIMKRLPSVFEIGKNFANVDITKEPIPVIPT
HHHHHHHHCCCCCCCCCEEEEEHHHHCHHHHHHHCHHHHHHCCCCCCCEECCCCCCCCCH
IHYMMGGIPTTIHGQVIVPDLEAGTDEDGLYAKGNVVKGLYAIGECACVSVHGANRLGTN
HHHHHCCCCCEECCEEEEECCCCCCCCCCEEECCCHHHHHHHHCCEEEEEECCCCCCCHH
SLLDLLVFGRAAGKHIVDEFHHADHNYKPLDPRVLDYTVGRLDKLQQSTSGYNAQDVADE
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
IRATMQTHASVFRTQAMMDEGVAKILALGEKIDQIHLADKSQVFNTARIEAFEVGNLYEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHEEEEEECCCHHHH
AKATMISAAQRHESRGAHSVSDYDRPEDDEYAPNGRNDNDWMKHTLWYSEGNKIIYKPVR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEECCCEEEEECHH
KIPLTVDYIEPKVRVY
HCCEEEEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]