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The map label for this gene is gcvT [H]

Identifier: 92113938

GI number: 92113938

Start: 2063688

End: 2064827

Strand: Direct

Name: gcvT [H]

Synonym: Csal_1815

Alternate gene names: 92113938

Gene position: 2063688-2064827 (Clockwise)

Preceding gene: 92113937

Following gene: 92113944

Centisome position: 55.83

GC content: 65.18

Gene sequence:

>1140_bases
ATGCACCTTTGCGAGGAAGCGACCATGGACGACGATCTGCACCAGACACCGCTGCATGACTTGCATCTCTCTCTCGGCGC
CAAGATGGTGCCTTTCGCCGGCTACAGCATGCCGGTGCAGTATGCGCTTGGCGTCAAGAAAGAGCATGAGCACACCCGCA
ACGCGTGCGGCCTGTTCGATGTCTCGCACATGGGACAGCTCTTGATTTCGGGACCGACGCCGGCGCAGGCCATCGAGACG
CTGGTGCCGGCGGATATCGTCGACTTGCCGGCGGGCATGCAGCGTTATGCGCTCTTCACCGGCAACGAAGGCGGCATTCT
CGATGACCTGATGATCGTCAATCGAGGCGACGACCTCTATGTGGTGGTCAACGCGGCCTGCAAGGACCAGGACGTGACGC
ATCTGCGCACCGGCCTCGATGCCGCGCATCAGGTGGAAGTGCTCGACCGTTCGCTTCTGGCGCTGCAGGGGCCGCAAGCC
AAGGATGTCATGGCGCGCCTGTGCCCCGCGGCATGCGATCTGGTCTTCATGCGCCATGGGCAGTTCGATGCCCTGGGCAC
CACGCTATGGATCAGTCGCAGTGGCTATACCGGCGAAGATGGTTTCGAAATTTCGGTGTCCAGGGACGCGGCCGAGACAT
TGGCCCGGTGGCTCGTGGAGCAGCCCGAGGTCGAGCCGATCGGCCTCGGCGCACGCGATTCGTTGCGGCTGGAAGCGGGG
CTTTGCCTGTATGGCCATGATCTGGATGCACACACCACGCCGGCGGAGGCCAGCTTGATCTGGGCCGTGGGCAAGGCGCG
CCGCATTGGGGGGGAACGCGAAGGCGGGTTCCCGGGCGCGGACGTCATCCTGCCGCAGATCGACACCAAGCGCATCGTGC
GCAAGCGTGTCGGCCTGGTGGGCGAGGGCCGGGCCCCTGTGCGCGAAGGCACCCGACTCTACGACGACGCCGATCGACAT
GTCGGCCAAGTGACCTCCGGCAGCTTCGGGCCGACGCTGGGCAAGCCCGTGGCCATGGCCTACGTGGATGTCGAGTGGGC
CGGCGTGGAGACGACGCTGTACGCGGACGTACGCGGCAAGCGCCTGCCGATGCGGGTGACCCGCATGCCCTTCGTGCCTG
CCAACTATTATCGCGGATAG

Upstream 100 bases:

>100_bases
GCTCACGCGTGATCACTTCGAGGGCAAGACCGTCCTGCCGGGCGAAGATCTCAACGACAAGCACTGAAACCAAGCCGGGC
GCGGTCCAGCCGCTCCCGGC

Downstream 100 bases:

>100_bases
CATTCGCTGAGCAGTCCAGGCGTTATACCGTTATCTAGACATCTTTGAAACCTCGAGCAAACCTCGAAGTTTTTTTCATG
GCAAACAGCAAGGAAGGAAA

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MHLCEEATMDDDLHQTPLHDLHLSLGAKMVPFAGYSMPVQYALGVKKEHEHTRNACGLFDVSHMGQLLISGPTPAQAIET
LVPADIVDLPAGMQRYALFTGNEGGILDDLMIVNRGDDLYVVVNAACKDQDVTHLRTGLDAAHQVEVLDRSLLALQGPQA
KDVMARLCPAACDLVFMRHGQFDALGTTLWISRSGYTGEDGFEISVSRDAAETLARWLVEQPEVEPIGLGARDSLRLEAG
LCLYGHDLDAHTTPAEASLIWAVGKARRIGGEREGGFPGADVILPQIDTKRIVRKRVGLVGEGRAPVREGTRLYDDADRH
VGQVTSGSFGPTLGKPVAMAYVDVEWAGVETTLYADVRGKRLPMRVTRMPFVPANYYRG

Sequences:

>Translated_379_residues
MHLCEEATMDDDLHQTPLHDLHLSLGAKMVPFAGYSMPVQYALGVKKEHEHTRNACGLFDVSHMGQLLISGPTPAQAIET
LVPADIVDLPAGMQRYALFTGNEGGILDDLMIVNRGDDLYVVVNAACKDQDVTHLRTGLDAAHQVEVLDRSLLALQGPQA
KDVMARLCPAACDLVFMRHGQFDALGTTLWISRSGYTGEDGFEISVSRDAAETLARWLVEQPEVEPIGLGARDSLRLEAG
LCLYGHDLDAHTTPAEASLIWAVGKARRIGGEREGGFPGADVILPQIDTKRIVRKRVGLVGEGRAPVREGTRLYDDADRH
VGQVTSGSFGPTLGKPVAMAYVDVEWAGVETTLYADVRGKRLPMRVTRMPFVPANYYRG
>Mature_379_residues
MHLCEEATMDDDLHQTPLHDLHLSLGAKMVPFAGYSMPVQYALGVKKEHEHTRNACGLFDVSHMGQLLISGPTPAQAIET
LVPADIVDLPAGMQRYALFTGNEGGILDDLMIVNRGDDLYVVVNAACKDQDVTHLRTGLDAAHQVEVLDRSLLALQGPQA
KDVMARLCPAACDLVFMRHGQFDALGTTLWISRSGYTGEDGFEISVSRDAAETLARWLVEQPEVEPIGLGARDSLRLEAG
LCLYGHDLDAHTTPAEASLIWAVGKARRIGGEREGGFPGADVILPQIDTKRIVRKRVGLVGEGRAPVREGTRLYDDADRH
VGQVTSGSFGPTLGKPVAMAYVDVEWAGVETTLYADVRGKRLPMRVTRMPFVPANYYRG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=374, Percent_Identity=46.2566844919786, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI257796258, Length=354, Percent_Identity=45.4802259887006, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI257796254, Length=378, Percent_Identity=42.8571428571429, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI257796256, Length=321, Percent_Identity=44.2367601246106, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI197927446, Length=323, Percent_Identity=23.5294117647059, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI21361378, Length=323, Percent_Identity=23.5294117647059, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=33.4239130434783, Blast_Score=171, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17560118, Length=395, Percent_Identity=41.7721518987342, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6320222, Length=389, Percent_Identity=41.9023136246787, Blast_Score=279, Evalue=4e-76,
Organism=Drosophila melanogaster, GI20129441, Length=382, Percent_Identity=43.1937172774869, Blast_Score=267, Evalue=1e-71,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41264; Mature: 41264

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLCEEATMDDDLHQTPLHDLHLSLGAKMVPFAGYSMPVQYALGVKKEHEHTRNACGLFD
CCCCCCCCCCCCHHHCCHHHHHHHCCCEECCCCCCCCCCHHHCCCCHHHHHHHHHCCEEE
VSHMGQLLISGPTPAQAIETLVPADIVDLPAGMQRYALFTGNEGGILDDLMIVNRGDDLY
HHHCCCEEECCCCHHHHHHHHCCCHHHHCCCCCEEEEEEECCCCCCEEEEEEEECCCCEE
VVVNAACKDQDVTHLRTGLDAAHQVEVLDRSLLALQGPQAKDVMARLCPAACDLVFMRHG
EEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
QFDALGTTLWISRSGYTGEDGFEISVSRDAAETLARWLVEQPEVEPIGLGARDSLRLEAG
CCCCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCEECCCCCCCEEEECC
LCLYGHDLDAHTTPAEASLIWAVGKARRIGGEREGGFPGADVILPQIDTKRIVRKRVGLV
EEEEECCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCC
GEGRAPVREGTRLYDDADRHVGQVTSGSFGPTLGKPVAMAYVDVEWAGVETTLYADVRGK
CCCCCCHHCCCCHHCCHHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCC
RLPMRVTRMPFVPANYYRG
CCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MHLCEEATMDDDLHQTPLHDLHLSLGAKMVPFAGYSMPVQYALGVKKEHEHTRNACGLFD
CCCCCCCCCCCCHHHCCHHHHHHHCCCEECCCCCCCCCCHHHCCCCHHHHHHHHHCCEEE
VSHMGQLLISGPTPAQAIETLVPADIVDLPAGMQRYALFTGNEGGILDDLMIVNRGDDLY
HHHCCCEEECCCCHHHHHHHHCCCHHHHCCCCCEEEEEEECCCCCCEEEEEEEECCCCEE
VVVNAACKDQDVTHLRTGLDAAHQVEVLDRSLLALQGPQAKDVMARLCPAACDLVFMRHG
EEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
QFDALGTTLWISRSGYTGEDGFEISVSRDAAETLARWLVEQPEVEPIGLGARDSLRLEAG
CCCCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCEECCCCCCCEEEECC
LCLYGHDLDAHTTPAEASLIWAVGKARRIGGEREGGFPGADVILPQIDTKRIVRKRVGLV
EEEEECCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCC
GEGRAPVREGTRLYDDADRHVGQVTSGSFGPTLGKPVAMAYVDVEWAGVETTLYADVRGK
CCCCCCHHCCCCHHCCHHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCC
RLPMRVTRMPFVPANYYRG
CCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA