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The map label for this gene is nuoM [H]

Identifier: 91789104

GI number: 91789104

Start: 3433692

End: 3435167

Strand: Reverse

Name: nuoM [H]

Synonym: Bpro_3244

Alternate gene names: 91789104

Gene position: 3435167-3433692 (Counterclockwise)

Preceding gene: 91789105

Following gene: 91789103

Centisome position: 66.06

GC content: 57.86

Gene sequence:

>1476_bases
ATGGGTTTGTTGAGCCTTGCCATCTGGACGCCGATTATTTTCGGTGCCGTGTTGTTGGCGCTGGGTCGTGACGAGCAGGC
ACGCAGTGTGCGCTGGATCGCACTGATAGGCGCTGTCGTCAGCTTTCTGGTGACCCTGCCGCTGTATGACGGCTTTCAGC
TGGGTACATCGGCCATGCAGTTCGTCGAGAAGGGAAGCTGGATCCAGCGCTTCAATGTCAGCTACCACGTGGGTGTGGAC
GGTATTTCGCTCTGGTTCGTCCTGCTGACCGCCTTCATCAATGTCGTGGTGATCATCGCCAGCTGGGAGGCGATTACGAC
TCGCGTCAGCCAGTACATGGCCGCCTTCATGATGCTCAGCGGTCTGATGATCGGGGTGTTTTCCGCGCTGGACGGCATTT
TGTTTTACGTCTTCTTCGAGGCAACCCTCATTCCGATGTACCTGATCATCGGTATCTGGGGCGGACCGAACAAGATCTAT
GCGGCATTCAAGTTTTTCCTGTACACACTGCTCGGCTCTTTGCTGCTGCTGGTGGCGCTGATCTACCTGTATAACAAGTC
GGGTGGCAGTTTTGACATCCTGACATGGCACAAGCTGCCGCTCGGCAGTGCGGTGCAGACCGTGCTGTTCTTTGCCTTCT
TTGCTGCGTTCGCCGTGAAGGTGCCGATGTGGCCGGTTCACACCTGGCTGCCGGACGTGCACGTTGAGGCGCCCACCGGC
GGCTCTGCCGTGCTGGCGGCCATCATGCTCAAGCTCGGGGCCTACGGTTTTCTCCGTTTCTCGATGCCTATTGCACCGGA
TGCTTCGCGGGAATGGGCCTGGGTGATGATCGCGCTGTCCGTGATCGCCGTCATTTATGTGGGATTGGTCGCCCTGGTGC
AGCAGGACATGAAAAAACTGGTGGCGTATTCGTCCGTCGCTCACATGGGTTTTGTCACGCTGGGCTTTTTCATCTTCAAC
GACATCGGCGTGTCCGGCGGCATTGTGCAGATGATTGCGCACGGCTTTGTGTCGGGCGCCATGTTCCTGTGCATTGGTGT
GCTGTACGACCGGGTTCACTCGCGCGAAATTGCCAGCTACGGCGGTGTGGTCAACACCATGCCGAAGTTCGCAGCGTTTG
CCCTGCTGTTTGCCATGGCCAACTGCGGCCTGCCAGGCACCGCAGGTTTTGTTGGCGAGTGGATGGTCATTCTGGGCGCG
GTCAAGTCCAACTTCTGGCTGGGTGCCGCCGCGGCGACAGCATTGATCTTTGGTGCGGCCTACACGCTGTGGATGTTCAA
GCGCGTGTATCTCGGACCGGTCGCCAACGATGACGTCAAGGCTCTGACGGATATCAACAGCCGTGAATTCCTGATGCTCT
CCATGCTGGCTATCGCCGTGTTGTACATGGGCATTTATCCCAAGCCGTTTACCGATGTGATGAACCCGTCGGTGGCCGAC
CTGCTCAAGCATGTCGCGGCATCGAAACTGAACTAG

Upstream 100 bases:

>100_bases
ACCACTACGCTTTTGGCATGATCATCGGCGTCTTTTTATTGATGACGTATTTCGTTTGGCTGAACCAATAACACGCGAAT
AATAAGAAGGAAAAACGAGA

Downstream 100 bases:

>100_bases
GCAAAGAATTCAGATGATTGACAAACTCTCCTGGATCACGGTTTATCCTGAAATCGTCCTCGTGATCATGGCCTGCGTGA
TCGCGCTGCTGGATCTCGGG

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MGLLSLAIWTPIIFGAVLLALGRDEQARSVRWIALIGAVVSFLVTLPLYDGFQLGTSAMQFVEKGSWIQRFNVSYHVGVD
GISLWFVLLTAFINVVVIIASWEAITTRVSQYMAAFMMLSGLMIGVFSALDGILFYVFFEATLIPMYLIIGIWGGPNKIY
AAFKFFLYTLLGSLLLLVALIYLYNKSGGSFDILTWHKLPLGSAVQTVLFFAFFAAFAVKVPMWPVHTWLPDVHVEAPTG
GSAVLAAIMLKLGAYGFLRFSMPIAPDASREWAWVMIALSVIAVIYVGLVALVQQDMKKLVAYSSVAHMGFVTLGFFIFN
DIGVSGGIVQMIAHGFVSGAMFLCIGVLYDRVHSREIASYGGVVNTMPKFAAFALLFAMANCGLPGTAGFVGEWMVILGA
VKSNFWLGAAAATALIFGAAYTLWMFKRVYLGPVANDDVKALTDINSREFLMLSMLAIAVLYMGIYPKPFTDVMNPSVAD
LLKHVAASKLN

Sequences:

>Translated_491_residues
MGLLSLAIWTPIIFGAVLLALGRDEQARSVRWIALIGAVVSFLVTLPLYDGFQLGTSAMQFVEKGSWIQRFNVSYHVGVD
GISLWFVLLTAFINVVVIIASWEAITTRVSQYMAAFMMLSGLMIGVFSALDGILFYVFFEATLIPMYLIIGIWGGPNKIY
AAFKFFLYTLLGSLLLLVALIYLYNKSGGSFDILTWHKLPLGSAVQTVLFFAFFAAFAVKVPMWPVHTWLPDVHVEAPTG
GSAVLAAIMLKLGAYGFLRFSMPIAPDASREWAWVMIALSVIAVIYVGLVALVQQDMKKLVAYSSVAHMGFVTLGFFIFN
DIGVSGGIVQMIAHGFVSGAMFLCIGVLYDRVHSREIASYGGVVNTMPKFAAFALLFAMANCGLPGTAGFVGEWMVILGA
VKSNFWLGAAAATALIFGAAYTLWMFKRVYLGPVANDDVKALTDINSREFLMLSMLAIAVLYMGIYPKPFTDVMNPSVAD
LLKHVAASKLN
>Mature_490_residues
GLLSLAIWTPIIFGAVLLALGRDEQARSVRWIALIGAVVSFLVTLPLYDGFQLGTSAMQFVEKGSWIQRFNVSYHVGVDG
ISLWFVLLTAFINVVVIIASWEAITTRVSQYMAAFMMLSGLMIGVFSALDGILFYVFFEATLIPMYLIIGIWGGPNKIYA
AFKFFLYTLLGSLLLLVALIYLYNKSGGSFDILTWHKLPLGSAVQTVLFFAFFAAFAVKVPMWPVHTWLPDVHVEAPTGG
SAVLAAIMLKLGAYGFLRFSMPIAPDASREWAWVMIALSVIAVIYVGLVALVQQDMKKLVAYSSVAHMGFVTLGFFIFND
IGVSGGIVQMIAHGFVSGAMFLCIGVLYDRVHSREIASYGGVVNTMPKFAAFALLFAMANCGLPGTAGFVGEWMVILGAV
KSNFWLGAAAATALIFGAAYTLWMFKRVYLGPVANDDVKALTDINSREFLMLSMLAIAVLYMGIYPKPFTDVMNPSVADL
LKHVAASKLN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=357, Percent_Identity=36.6946778711485, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI251831117, Length=236, Percent_Identity=26.271186440678, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1788613, Length=470, Percent_Identity=37.6595744680851, Blast_Score=311, Evalue=8e-86,
Organism=Escherichia coli, GI1788827, Length=273, Percent_Identity=27.4725274725275, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788831, Length=316, Percent_Identity=24.3670886075949, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788829, Length=330, Percent_Identity=29.3939393939394, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788614, Length=438, Percent_Identity=26.7123287671233, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI145693160, Length=356, Percent_Identity=24.438202247191, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367154, Length=243, Percent_Identity=27.9835390946502, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53519; Mature: 53388

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLSLAIWTPIIFGAVLLALGRDEQARSVRWIALIGAVVSFLVTLPLYDGFQLGTSAMQ
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FVEKGSWIQRFNVSYHVGVDGISLWFVLLTAFINVVVIIASWEAITTRVSQYMAAFMMLS
HHHCCCHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLMIGVFSALDGILFYVFFEATLIPMYLIIGIWGGPNKIYAAFKFFLYTLLGSLLLLVAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYLYNKSGGSFDILTWHKLPLGSAVQTVLFFAFFAAFAVKVPMWPVHTWLPDVHVEAPTG
HHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEECCCC
GSAVLAAIMLKLGAYGFLRFSMPIAPDASREWAWVMIALSVIAVIYVGLVALVQQDMKKL
HHHHHHHHHHHHCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAYSSVAHMGFVTLGFFIFNDIGVSGGIVQMIAHGFVSGAMFLCIGVLYDRVHSREIASY
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGVVNTMPKFAAFALLFAMANCGLPGTAGFVGEWMVILGAVKSNFWLGAAAATALIFGAA
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YTLWMFKRVYLGPVANDDVKALTDINSREFLMLSMLAIAVLYMGIYPKPFTDVMNPSVAD
HHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHH
LLKHVAASKLN
HHHHHHHHCCC
>Mature Secondary Structure 
GLLSLAIWTPIIFGAVLLALGRDEQARSVRWIALIGAVVSFLVTLPLYDGFQLGTSAMQ
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH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HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]