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The map label for this gene is ytbQ [H]

Identifier: 91788969

GI number: 91788969

Start: 3281823

End: 3282632

Strand: Reverse

Name: ytbQ [H]

Synonym: Bpro_3109

Alternate gene names: 91788969

Gene position: 3282632-3281823 (Counterclockwise)

Preceding gene: 91788981

Following gene: 91788968

Centisome position: 63.12

GC content: 61.6

Gene sequence:

>810_bases
ATGACAATCAAAGTTCATGAAAAACTCTTGCTGACCGGTGCTGCCGGCGGTCTGGGAAAAGCCTTGCGCGAGCGCCTGAA
GGCCAATTGCTCGGTGCTTCGCTTGTCCGATGTCCAGCCGTTTGGCGATGCTGCTGTGGGCGAGGAAGTGGTGCTGGCCG
ACCTGGCCGATGCGGCTGCCGTCAACGAGATGGTCAAGGGGATGGATGCCATCATCCACCTGGGTGGCGTTTCGGTCGAA
GGGCCGTTCGGGCCCATCCTGCAGGCCAACATCCTTGGCGCCTACAACCTTTATGAGGCTGCGCGCAAACACGGCGTCAA
GCGTGTGGTGTTTGCCAGTTCCAACCACGTCACCGGCTTTTACCGCCAGGACCAGACGATCACTGCGGATCATCCGCCAC
GGCCCGACGGCTTTTATGGCTTGAGCAAGGCGTTTGGGGAAGACCTGGCGCGGCTCTACTTTGACCGCTACGGCATAGAA
ACCGCCTGCGTGCGCATCGGCTCTTCATTTCCCGAGCCCAGGGACCGCCGCATGCTGGCCACCTGGCTGAGCTATGACGA
CCTGCACCGCCTCATCACCGCCTGCCTGACGACGCCGGTGCTGGGCCACAGCATCATTTTTGGCATGTCTGACAACGCCG
TGACCTGGTGGGACAACAGCCGCGCTCGCCACATCGGCTATGTGCCGAAAGACAGCTCGGATGTTTTCCGCGATGCGGTG
TATGCGCGCACCCCCCAGCCGGATCTGAATGATCCGGTGGTTCAATACCAGGGCGGCGGTTTTGTCGTGGCCGGCCCCTT
CGGCGACTGA

Upstream 100 bases:

>100_bases
TCCCAGTCATCAGACAACCTATGACTGACGACTTGTTTGACTTTAACAAACTTCATGAAAAAGTCCAGTTCCAATTCGCA
ATCCGACCAGGATGCCCAAA

Downstream 100 bases:

>100_bases
CCGCATGAGCACCCTCACGGACGCGACGCGGGCCGAGCTGCTGCTCGATGCGCGCAATGCCACGGGCGAAAGCCCGGTCT
GGCATGCCGCCGAGCAGGCG

Product: NAD-dependent epimerase/dehydratase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTIKVHEKLLLTGAAGGLGKALRERLKANCSVLRLSDVQPFGDAAVGEEVVLADLADAAAVNEMVKGMDAIIHLGGVSVE
GPFGPILQANILGAYNLYEAARKHGVKRVVFASSNHVTGFYRQDQTITADHPPRPDGFYGLSKAFGEDLARLYFDRYGIE
TACVRIGSSFPEPRDRRMLATWLSYDDLHRLITACLTTPVLGHSIIFGMSDNAVTWWDNSRARHIGYVPKDSSDVFRDAV
YARTPQPDLNDPVVQYQGGGFVVAGPFGD

Sequences:

>Translated_269_residues
MTIKVHEKLLLTGAAGGLGKALRERLKANCSVLRLSDVQPFGDAAVGEEVVLADLADAAAVNEMVKGMDAIIHLGGVSVE
GPFGPILQANILGAYNLYEAARKHGVKRVVFASSNHVTGFYRQDQTITADHPPRPDGFYGLSKAFGEDLARLYFDRYGIE
TACVRIGSSFPEPRDRRMLATWLSYDDLHRLITACLTTPVLGHSIIFGMSDNAVTWWDNSRARHIGYVPKDSSDVFRDAV
YARTPQPDLNDPVVQYQGGGFVVAGPFGD
>Mature_268_residues
TIKVHEKLLLTGAAGGLGKALRERLKANCSVLRLSDVQPFGDAAVGEEVVLADLADAAAVNEMVKGMDAIIHLGGVSVEG
PFGPILQANILGAYNLYEAARKHGVKRVVFASSNHVTGFYRQDQTITADHPPRPDGFYGLSKAFGEDLARLYFDRYGIET
ACVRIGSSFPEPRDRRMLATWLSYDDLHRLITACLTTPVLGHSIIFGMSDNAVTWWDNSRARHIGYVPKDSSDVFRDAVY
ARTPQPDLNDPVVQYQGGGFVVAGPFGD

Specific function: INVOLVED IN THE SYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN (ECA) AND REQUIRED FOR SYNTHESIS OF LIPOPOLYSACCHARIDE O-SIDE CHAINS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 29296; Mature: 29164

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKVHEKLLLTGAAGGLGKALRERLKANCSVLRLSDVQPFGDAAVGEEVVLADLADAAA
CEEEEEEEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
VNEMVKGMDAIIHLGGVSVEGPFGPILQANILGAYNLYEAARKHGVKRVVFASSNHVTGF
HHHHHHHHHHHEEECCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEE
YRQDQTITADHPPRPDGFYGLSKAFGEDLARLYFDRYGIETACVRIGSSFPEPRDRRMLA
EECCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHH
TWLSYDDLHRLITACLTTPVLGHSIIFGMSDNAVTWWDNSRARHIGYVPKDSSDVFRDAV
HHHCHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCEECCCCCCCHHHHHHHH
YARTPQPDLNDPVVQYQGGGFVVAGPFGD
HHCCCCCCCCCCEEEECCCCEEEECCCCC
>Mature Secondary Structure 
TIKVHEKLLLTGAAGGLGKALRERLKANCSVLRLSDVQPFGDAAVGEEVVLADLADAAA
EEEEEEEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
VNEMVKGMDAIIHLGGVSVEGPFGPILQANILGAYNLYEAARKHGVKRVVFASSNHVTGF
HHHHHHHHHHHEEECCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEE
YRQDQTITADHPPRPDGFYGLSKAFGEDLARLYFDRYGIETACVRIGSSFPEPRDRRMLA
EECCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHH
TWLSYDDLHRLITACLTTPVLGHSIIFGMSDNAVTWWDNSRARHIGYVPKDSSDVFRDAV
HHHCHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCEECCCCCCCHHHHHHHH
YARTPQPDLNDPVVQYQGGGFVVAGPFGD
HHCCCCCCCCCCEEEECCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]