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The map label for this gene is phoR [H]

Identifier: 91788129

GI number: 91788129

Start: 2344495

End: 2345850

Strand: Direct

Name: phoR [H]

Synonym: Bpro_2258

Alternate gene names: 91788129

Gene position: 2344495-2345850 (Clockwise)

Preceding gene: 91788128

Following gene: 91788135

Centisome position: 45.08

GC content: 63.57

Gene sequence:

>1356_bases
ATGATCAACCGCTGGATCGCTTTTACCGCCTGCATGTTGGCCGGTGGCGCATTGGGATGGTTGACGACTGCGAAGGGTGG
ACCCGCATGGAGCCTGGGTGTGGGTCTTGGACTGGGCGCCTTGATATGGCTGATGATCGACAGCCTCTACCTGGCCCGGC
TCCTCCGGTGGCTGCGCGCCGAGCAGGGCCGCGAAGCGCCGGCCATGGTGTCCAGCCAGCTACCCCGCTTGCCCGGTGTA
TGGGAGGAAGTGGTCGACCGGACCCGCAGGCTGCTGAAGAACCGCGACCAGCAGTTGCAGGAAAGCCAGGCACGACTGGA
CGAGTTTCTGGCGGCCATGCAGGCTTCCCCGAGCGGGGTGGTGCTGCTGGATACGCAGGGGCGCATCGAGTGGTGCAATC
AGATGGCGACCCAGCATTTTGGTTTTGACGTGCAGCGCGATGTGATGCAGCATATTGCCAACCTGGTTCGCGAGCCTGCC
TTCAAGGCCTACCTGGCGTCGGGTAACTATTCGCATGACGTGGTGATTCCCGGCAGCCTCAGCACACCGGCGCGACCCGT
CAAGTTGTCAGTGCATGTGCATTCGTATGGCAAAGACCGCAAGTTGCTGCTGTCGCGGGACATCACCGCCGTCGAGCTGG
CGGAAGCCATGCGCCGGGATTTTGTGGCCAATGTGTCGCATGAGATCCGTACGCCGCTGACGGTGTTGTCCGGCTTCATC
GAGACGCTGCGAACCCTGCCTTTGGAGGAGCCCGAGCGCGCACGTTACCTGGCGCTGATGGCGCAGCAATCCCAGCGCAT
GCAGACGCTGGTGAATGACTTGCTGACACTGTCACGCCTGGAGGGAAGCCCGTTCCCCGGCGCCAATGACTGGATCACCA
CCAGTGCGCTGCTGGTGCAGTGCGAGCAGGAGGCCCGGGCCTTGTCGGCTGTGATTGCGCCGCGCGGGCATCGGCTGGAG
TTTGACGCCGGGCCGGCCAGCGAAATCGCAGGCGTGCAAACGGAGCTGTACAGCGCCATGTCCAACCTGGTGACCAATGC
GGTCCGCTATACACCGGAGACGGGCCTGGTCAGCGTCAGCTGGAAGCTGCTCAAGGATGGCCGCGGCCAGTTTGAGGTCA
GGGACACCGGACCGGGTATAGAGCCCGAACATTTGCCTCGCCTGACGGAGCGCTTTTATCGCATTGACCGCAGTCGCTCG
CGTGAAACTGGCGGAACGGGTTTGGGCCTGGCCATCGTCAAGCATGTCGCCCAGCGCCACGGTGCCGAACTGCATATCGA
CAGCCAGCCCGGGCACGGTTCGCGCTTTTCACTCATTTTCCCCGCGGCACGCATCCGCCCGGCTCACGCTGCCTGA

Upstream 100 bases:

>100_bases
CCGCCGGTACCATGGTTGAAACCGTTCGCGGGGCGGGTTACCGTCTGACTGCTGCGGCTGCCGCTACCACTCGGGTAACT
GCTGCGGCACAATCCGGCAC

Downstream 100 bases:

>100_bases
GTTTTCCCCGGGATGGCCCGCTGGCTCTGCCAAACCACGCGCCACAGCAACCCCAGGAGGCAGGCGGCTGCCAGTCCGAT
CGCGATGGTGCTGGCAGCCC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MINRWIAFTACMLAGGALGWLTTAKGGPAWSLGVGLGLGALIWLMIDSLYLARLLRWLRAEQGREAPAMVSSQLPRLPGV
WEEVVDRTRRLLKNRDQQLQESQARLDEFLAAMQASPSGVVLLDTQGRIEWCNQMATQHFGFDVQRDVMQHIANLVREPA
FKAYLASGNYSHDVVIPGSLSTPARPVKLSVHVHSYGKDRKLLLSRDITAVELAEAMRRDFVANVSHEIRTPLTVLSGFI
ETLRTLPLEEPERARYLALMAQQSQRMQTLVNDLLTLSRLEGSPFPGANDWITTSALLVQCEQEARALSAVIAPRGHRLE
FDAGPASEIAGVQTELYSAMSNLVTNAVRYTPETGLVSVSWKLLKDGRGQFEVRDTGPGIEPEHLPRLTERFYRIDRSRS
RETGGTGLGLAIVKHVAQRHGAELHIDSQPGHGSRFSLIFPAARIRPAHAA

Sequences:

>Translated_451_residues
MINRWIAFTACMLAGGALGWLTTAKGGPAWSLGVGLGLGALIWLMIDSLYLARLLRWLRAEQGREAPAMVSSQLPRLPGV
WEEVVDRTRRLLKNRDQQLQESQARLDEFLAAMQASPSGVVLLDTQGRIEWCNQMATQHFGFDVQRDVMQHIANLVREPA
FKAYLASGNYSHDVVIPGSLSTPARPVKLSVHVHSYGKDRKLLLSRDITAVELAEAMRRDFVANVSHEIRTPLTVLSGFI
ETLRTLPLEEPERARYLALMAQQSQRMQTLVNDLLTLSRLEGSPFPGANDWITTSALLVQCEQEARALSAVIAPRGHRLE
FDAGPASEIAGVQTELYSAMSNLVTNAVRYTPETGLVSVSWKLLKDGRGQFEVRDTGPGIEPEHLPRLTERFYRIDRSRS
RETGGTGLGLAIVKHVAQRHGAELHIDSQPGHGSRFSLIFPAARIRPAHAA
>Mature_451_residues
MINRWIAFTACMLAGGALGWLTTAKGGPAWSLGVGLGLGALIWLMIDSLYLARLLRWLRAEQGREAPAMVSSQLPRLPGV
WEEVVDRTRRLLKNRDQQLQESQARLDEFLAAMQASPSGVVLLDTQGRIEWCNQMATQHFGFDVQRDVMQHIANLVREPA
FKAYLASGNYSHDVVIPGSLSTPARPVKLSVHVHSYGKDRKLLLSRDITAVELAEAMRRDFVANVSHEIRTPLTVLSGFI
ETLRTLPLEEPERARYLALMAQQSQRMQTLVNDLLTLSRLEGSPFPGANDWITTSALLVQCEQEARALSAVIAPRGHRLE
FDAGPASEIAGVQTELYSAMSNLVTNAVRYTPETGLVSVSWKLLKDGRGQFEVRDTGPGIEPEHLPRLTERFYRIDRSRS
RETGGTGLGLAIVKHVAQRHGAELHIDSQPGHGSRFSLIFPAARIRPAHAA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=425, Percent_Identity=38.3529411764706, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=33.1983805668016, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788393, Length=237, Percent_Identity=30.8016877637131, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=32.9059829059829, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789149, Length=257, Percent_Identity=31.1284046692607, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=31.0344827586207, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=27.5590551181102, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=25.531914893617, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788549, Length=395, Percent_Identity=23.5443037974684, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=30.4526748971193, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789403, Length=217, Percent_Identity=31.3364055299539, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=31.7535545023697, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=31.3559322033898, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790436, Length=287, Percent_Identity=26.8292682926829, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=29.1845493562232, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790300, Length=235, Percent_Identity=29.7872340425532, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=230, Percent_Identity=30, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=234, Percent_Identity=26.4957264957265, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788279, Length=202, Percent_Identity=26.7326732673267, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49924; Mature: 49924

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINRWIAFTACMLAGGALGWLTTAKGGPAWSLGVGLGLGALIWLMIDSLYLARLLRWLRA
CCCHHHHHHHHHHHCCCHHHHEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQGREAPAMVSSQLPRLPGVWEEVVDRTRRLLKNRDQQLQESQARLDEFLAAMQASPSGV
HCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VLLDTQGRIEWCNQMATQHFGFDVQRDVMQHIANLVREPAFKAYLASGNYSHDVVIPGSL
EEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCEEECCCC
STPARPVKLSVHVHSYGKDRKLLLSRDITAVELAEAMRRDFVANVSHEIRTPLTVLSGFI
CCCCCCEEEEEEEECCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLRTLPLEEPERARYLALMAQQSQRMQTLVNDLLTLSRLEGSPFPGANDWITTSALLVQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
CEQEARALSAVIAPRGHRLEFDAGPASEIAGVQTELYSAMSNLVTNAVRYTPETGLVSVS
HHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
WKLLKDGRGQFEVRDTGPGIEPEHLPRLTERFYRIDRSRSRETGGTGLGLAIVKHVAQRH
HHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
GAELHIDSQPGHGSRFSLIFPAARIRPAHAA
CCEEEECCCCCCCCEEEEEECHHHCCCCCCC
>Mature Secondary Structure
MINRWIAFTACMLAGGALGWLTTAKGGPAWSLGVGLGLGALIWLMIDSLYLARLLRWLRA
CCCHHHHHHHHHHHCCCHHHHEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQGREAPAMVSSQLPRLPGVWEEVVDRTRRLLKNRDQQLQESQARLDEFLAAMQASPSGV
HCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VLLDTQGRIEWCNQMATQHFGFDVQRDVMQHIANLVREPAFKAYLASGNYSHDVVIPGSL
EEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCEEECCCC
STPARPVKLSVHVHSYGKDRKLLLSRDITAVELAEAMRRDFVANVSHEIRTPLTVLSGFI
CCCCCCEEEEEEEECCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLRTLPLEEPERARYLALMAQQSQRMQTLVNDLLTLSRLEGSPFPGANDWITTSALLVQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
CEQEARALSAVIAPRGHRLEFDAGPASEIAGVQTELYSAMSNLVTNAVRYTPETGLVSVS
HHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
WKLLKDGRGQFEVRDTGPGIEPEHLPRLTERFYRIDRSRSRETGGTGLGLAIVKHVAQRH
HHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
GAELHIDSQPGHGSRFSLIFPAARIRPAHAA
CCEEEECCCCCCCCEEEEEECHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]