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The map label for this gene is murE [H]

Identifier: 91786968

GI number: 91786968

Start: 1100565

End: 1102070

Strand: Direct

Name: murE [H]

Synonym: Bpro_1070

Alternate gene names: 91786968

Gene position: 1100565-1102070 (Clockwise)

Preceding gene: 91786967

Following gene: 91786969

Centisome position: 21.16

GC content: 64.67

Gene sequence:

>1506_bases
TTGACAACCCAGCTCCATACCCCCGAGCAGGCGGCCCGCTGGTTGCGTGAGCGCGTGACCGGCAGCCTGCGGACGGACAG
CCGCATGGTGGGCGGCGGTGACGGATTCATTGCGTGGCCTGGCGCCGCGACGGACGGCCGGAAGTATCTCGGTGATGCAC
TGGCTTCGGGCGCCCGCGCCTGCCTGGTGGAGTTGCAGGGTTTTGAGCCCCGCGGCCCGGATGACGAAAGGGTGGCCGCT
TACGCAGGACTCAAGGCGGCAACCGGCCCCATCGCCGCTGCCTATTTTGATGAGCCAAGCCGGCATTTGCAGGTCGCGGC
CGTCACCGGCACCAATGGCAAGACATCGACAACATGGTGGCTGGCCCAGGCGCTGGGCAGGCTGGGGCGCAAATGCGGTG
TCGTGGGAACCCTGGGCATCGGGGCGCCCGGTGCGGTGGTTTTCACGGGGTTGACCACCCCTGATCCTGTGCTGCTCCAG
CAGCAAATGCGCCGTTTTGTGGATGAGGGCTTCGCCACCTGCGCCCTGGAGGCTTCCTCGATAGGGCTGGTGGAGCGGCG
GCTGGACGCCACCACCATACAGGTCGCGATCTTCACCAACTTCACGCAGGACCATCTCGACTACCACCCGTCCATGCAGG
ACTATTGGGAGGCCAAGAAAATGCTGTTCAGCTGGCCAGGCCTGAAGGCAGCAGTCATCAATGTGGACGATGGCAAAGGC
CTTGAGCTGAGCGCGTCACTGGCCGGCTCGGACCTGGATGTCTGGACATTGTCCTGCACAGGGCCGGCCCGAATTCATGC
ACAAAAAATTCACCACGGCGTGAATGGCGTGAGTTTTGATGTTGTCGAAGGCGCGGAGCAGCACCGAGTTTCCAGCAAGC
TGGTCGGCCAGTACAACGTGTACAACCTGCTGGGCGTCATCGCGGCCCTGCGTGCCATGGGCATACCGCTGGTCGATGCC
GTGGCTGCTTGCGCCGACCTGCTGCCGGTGCCGGGGCGCATGGACACGCTGGCGGAAGAAGGCCTGCCCCTGGTCGTCAT
CGATTACGCGCACACGCCTGACGCCCTGGAAAAAGTACTCACAGCGCTTCAGCCGGTCGCGCGCAGCCGCGGTGGCCAGC
TCTGGTGCGTCTTTGGCTGTGGCGGAGACCGCGATGCCGGCAAACGCCCGCTGATGGCAGCGGTGGCGGAAAAAAATGCC
GACCGGGTGGTGGTCACCAGCGACAACCCGCGCAGTGAGAATCCGCTGGCCATCATCGACCAGGTGCTGAGGGGGTTGAA
TCACCGCGATGCCGTGCACGTGCAGGCAGACCGGGCCATGGCGATTACGCATGCGCTGAGTTTGGCGCAAGCCCATGATG
TGGTGCTGCTGGCGGGCAAGGGGCATGAAAGTTATCAAGAGGTCCAGGGCGTGAAGCTTCCTTTTTCCGACAGGACGCAG
GCGCAAGCCGCTCTCGCCCTGAATGCGGCGCGCGTGGCACGCCAGGCCGGGGGAGGCTCCGCATGA

Upstream 100 bases:

>100_bases
TATTCAGCGAAGTGGTGCAGCAGACGTTGCGCATGATGGGCGTGCAGCCGGACGTGAGCGTCAAGCCGCAAATCGTGACG
CAGGCTGTCGAGGAGTCGTT

Downstream 100 bases:

>100_bases
TGACCTTGCAACAAGCCCTGGGCTGGTTGCCGTCGGCCCGGCTAGTGGGTGATGGCAGCGTGAAGCCTCTGCGCGTGCAC
ACCGATACCCGCAGCCTGCA

Product: UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase

Products: NA

Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTTQLHTPEQAARWLRERVTGSLRTDSRMVGGGDGFIAWPGAATDGRKYLGDALASGARACLVELQGFEPRGPDDERVAA
YAGLKAATGPIAAAYFDEPSRHLQVAAVTGTNGKTSTTWWLAQALGRLGRKCGVVGTLGIGAPGAVVFTGLTTPDPVLLQ
QQMRRFVDEGFATCALEASSIGLVERRLDATTIQVAIFTNFTQDHLDYHPSMQDYWEAKKMLFSWPGLKAAVINVDDGKG
LELSASLAGSDLDVWTLSCTGPARIHAQKIHHGVNGVSFDVVEGAEQHRVSSKLVGQYNVYNLLGVIAALRAMGIPLVDA
VAACADLLPVPGRMDTLAEEGLPLVVIDYAHTPDALEKVLTALQPVARSRGGQLWCVFGCGGDRDAGKRPLMAAVAEKNA
DRVVVTSDNPRSENPLAIIDQVLRGLNHRDAVHVQADRAMAITHALSLAQAHDVVLLAGKGHESYQEVQGVKLPFSDRTQ
AQAALALNAARVARQAGGGSA

Sequences:

>Translated_501_residues
MTTQLHTPEQAARWLRERVTGSLRTDSRMVGGGDGFIAWPGAATDGRKYLGDALASGARACLVELQGFEPRGPDDERVAA
YAGLKAATGPIAAAYFDEPSRHLQVAAVTGTNGKTSTTWWLAQALGRLGRKCGVVGTLGIGAPGAVVFTGLTTPDPVLLQ
QQMRRFVDEGFATCALEASSIGLVERRLDATTIQVAIFTNFTQDHLDYHPSMQDYWEAKKMLFSWPGLKAAVINVDDGKG
LELSASLAGSDLDVWTLSCTGPARIHAQKIHHGVNGVSFDVVEGAEQHRVSSKLVGQYNVYNLLGVIAALRAMGIPLVDA
VAACADLLPVPGRMDTLAEEGLPLVVIDYAHTPDALEKVLTALQPVARSRGGQLWCVFGCGGDRDAGKRPLMAAVAEKNA
DRVVVTSDNPRSENPLAIIDQVLRGLNHRDAVHVQADRAMAITHALSLAQAHDVVLLAGKGHESYQEVQGVKLPFSDRTQ
AQAALALNAARVARQAGGGSA
>Mature_500_residues
TTQLHTPEQAARWLRERVTGSLRTDSRMVGGGDGFIAWPGAATDGRKYLGDALASGARACLVELQGFEPRGPDDERVAAY
AGLKAATGPIAAAYFDEPSRHLQVAAVTGTNGKTSTTWWLAQALGRLGRKCGVVGTLGIGAPGAVVFTGLTTPDPVLLQQ
QMRRFVDEGFATCALEASSIGLVERRLDATTIQVAIFTNFTQDHLDYHPSMQDYWEAKKMLFSWPGLKAAVINVDDGKGL
ELSASLAGSDLDVWTLSCTGPARIHAQKIHHGVNGVSFDVVEGAEQHRVSSKLVGQYNVYNLLGVIAALRAMGIPLVDAV
AACADLLPVPGRMDTLAEEGLPLVVIDYAHTPDALEKVLTALQPVARSRGGQLWCVFGCGGDRDAGKRPLMAAVAEKNAD
RVVVTSDNPRSENPLAIIDQVLRGLNHRDAVHVQADRAMAITHALSLAQAHDVVLLAGKGHESYQEVQGVKLPFSDRTQA
QAALALNAARVARQAGGGSA

Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]

COG id: COG0769

COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family. MurE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786273, Length=481, Percent_Identity=41.995841995842, Blast_Score=293, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR005761 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.13 [H]

Molecular weight: Translated: 53152; Mature: 53021

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQLHTPEQAARWLRERVTGSLRTDSRMVGGGDGFIAWPGAATDGRKYLGDALASGARA
CCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCCCCHHHHHHHHHCCCCE
CLVELQGFEPRGPDDERVAAYAGLKAATGPIAAAYFDEPSRHLQVAAVTGTNGKTSTTWW
EEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCHHHH
LAQALGRLGRKCGVVGTLGIGAPGAVVFTGLTTPDPVLLQQQMRRFVDEGFATCALEASS
HHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
IGLVERRLDATTIQVAIFTNFTQDHLDYHPSMQDYWEAKKMLFSWPGLKAAVINVDDGKG
CHHHHHHCCCEEEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
LELSASLAGSDLDVWTLSCTGPARIHAQKIHHGVNGVSFDVVEGAEQHRVSSKLVGQYNV
CEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEHHHCCHHHHHHHHHHHCCHHH
YNLLGVIAALRAMGIPLVDAVAACADLLPVPGRMDTLAEEGLPLVVIDYAHTPDALEKVL
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCHHHHHHHH
TALQPVARSRGGQLWCVFGCGGDRDAGKRPLMAAVAEKNADRVVVTSDNPRSENPLAIID
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCHHHHH
QVLRGLNHRDAVHVQADRAMAITHALSLAQAHDVVLLAGKGHESYQEVQGVKLPFSDRTQ
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCCCCHH
AQAALALNAARVARQAGGGSA
HHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTQLHTPEQAARWLRERVTGSLRTDSRMVGGGDGFIAWPGAATDGRKYLGDALASGARA
CCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCCCCHHHHHHHHHCCCCE
CLVELQGFEPRGPDDERVAAYAGLKAATGPIAAAYFDEPSRHLQVAAVTGTNGKTSTTWW
EEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCHHHH
LAQALGRLGRKCGVVGTLGIGAPGAVVFTGLTTPDPVLLQQQMRRFVDEGFATCALEASS
HHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
IGLVERRLDATTIQVAIFTNFTQDHLDYHPSMQDYWEAKKMLFSWPGLKAAVINVDDGKG
CHHHHHHCCCEEEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
LELSASLAGSDLDVWTLSCTGPARIHAQKIHHGVNGVSFDVVEGAEQHRVSSKLVGQYNV
CEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEHHHCCHHHHHHHHHHHCCHHH
YNLLGVIAALRAMGIPLVDAVAACADLLPVPGRMDTLAEEGLPLVVIDYAHTPDALEKVL
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCHHHHHHHH
TALQPVARSRGGQLWCVFGCGGDRDAGKRPLMAAVAEKNADRVVVTSDNPRSENPLAIID
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCHHHHH
QVLRGLNHRDAVHVQADRAMAITHALSLAQAHDVVLLAGKGHESYQEVQGVKLPFSDRTQ
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCCCCHH
AQAALALNAARVARQAGGGSA
HHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA