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The map label for this gene is penA [H]

Identifier: 91786967

GI number: 91786967

Start: 1098835

End: 1100568

Strand: Direct

Name: penA [H]

Synonym: Bpro_1069

Alternate gene names: 91786967

Gene position: 1098835-1100568 (Clockwise)

Preceding gene: 91786966

Following gene: 91786968

Centisome position: 21.13

GC content: 61.76

Gene sequence:

>1734_bases
ATGAGTAGGAGCGTTCTCTACAGCTCCAGCCCCTTGCTGGCCAGCAAGACGCCGGTCTGGCGCAGCAAATTTATTGTGGC
GGCCATTGCCCTGGCTTTTGTGGGGCTGGCGGGGCGGGCCGCGTACATCCAGGTTTTCGGCAATGAATTTTTCCAGCGCC
AGGGTGAAGTCCGCTTTGCCCGGACGCTGGAGCTGCCGGCCAATCGCGGCCGTATTCTCGATCGCAATGGCCTGATTTTG
GCTTCCAGCGTGCCTGCTCCCAGTATCTGGGCCATCCCGGAAGACGTCGAAGCGAGCAAGGCCCAGCTTGCAGAACTCGC
CAAGCTGCTGGAAATGCCGCAGGCCGATCTGAAGAAAAAACTGGGTAACGAGGATAAAACTTTTGTCTGGCTCAAGCGCC
AGGTCGACGAGCCGATAGCCCAGCAAATCCATGCGATGGGCATCAAGGGGATCTATGCGCGCCGGGAATACAAGCGCAAG
TACCCTGAAGGCGAGGCGGCTGCCCATGTGGTCGGTTTCACCAACGTCGAAGACAACGGCCAGGAAGGCATCGAACTCAC
GTTCAACAAGGAGCTCGCCGGAAAGGCGGGCTCACGGCGTGTCATCAAGGACCGGCTCGGTCGCGTGGTTGAAGGCGTTG
GTGAGCAGGTGCCGCCGATCGAGGGCAAAGACATCCAGTTAAGCGTTGACAGCAAGGTGCAGTTCTTCGCTTACCAGAAG
CTGCGCGACGCCGTGACCGCGCGCAAGGCCAAGGCCGGCAGCGTGGTGGTGCTTGATGCGATCACCGGCGAGGTGCTGGC
GCTCGCCAACTACCCGAGCTACGTGCCCGACAAGCGGCAGAACCTCACTGGCGAGCAACTGCGCAACCGCGCGCTGACTG
ACACCTTCGAGCCCGGTTCAACGATGAAGCCGATCACGGTCGCCATGGCGCTGGAAGCCGGCCGGGTCAAACCGCAGACC
CTTGTCGAAACCGGGCCTGGCCGCTTCAGCATCGGCGGCTTTACCATCAGCGATACCCACAATTACGGTACGCTGACCGT
CGAGGGCGTGATCCAGAAGTCGAGCAACGTCGGTGCATTGAAAATCGCGCAGAAGATGAGTCCGCACGAGATGTGGGATA
CCTACACCGCGCTCGGTTACGGGCAGAAGCCCCAGATCCAGTTTCCCGGCGCCGTCACAGGCCGGCTGCGACCCTGGAAA
AGCTGGCGGCCTGTTGAGCAGGCGACCATGGCTTATGGCTACGGGCTCTCGGCCTCGCTGTTCCAGATGGCGCATTCCTA
TACCTCGTTTGCGCACGATGGGCAGATCATTCCGGTTACGATGCTCAAGAGCACTGAGCCCGCCGTCGGCGTCAGGGTGT
TTTCTGCCGAGAACGCGCATGCGGTGCGAAGGATGCTCCAGATGGCCGCGGCACCGGGTGGCACCGGTCAACTGGCACAG
ACGGTCGGCTATTCGGTTGGCGGCAAGTCGGGCACGGCGCACAAGCAGGTCGGCAAGGGCTATGCGAGCAATAAATACCG
TGCCTGGTTCACCGGCATGGCGCCGATTGAGGCGCCGCGCATCATCGTCGCGGTGATGATCGACGAGCCGAGCGATGGCC
AGTATTTCGGCGGCGTTGCGGCGGCGCCGGTATTCAGCGAAGTGGTGCAGCAGACGTTGCGCATGATGGGCGTGCAGCCG
GACGTGAGCGTCAAGCCGCAAATCGTGACGCAGGCTGTCGAGGAGTCGTTTTGA

Upstream 100 bases:

>100_bases
GTTGAGAAACTCGCCAGGGATCGCCTGCAGATGCGCACGGCAACGCCGGCCATCACGCAGTATGTGACCTACCAGGAGGC
CGCGGTTGCCGGGGTGCCGC

Downstream 100 bases:

>100_bases
CAACCCAGCTCCATACCCCCGAGCAGGCGGCCCGCTGGTTGCGTGAGCGCGTGACCGGCAGCCTGCGGACGGACAGCCGC
ATGGTGGGCGGCGGTGACGG

Product: peptidoglycan synthetase FtsI

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MSRSVLYSSSPLLASKTPVWRSKFIVAAIALAFVGLAGRAAYIQVFGNEFFQRQGEVRFARTLELPANRGRILDRNGLIL
ASSVPAPSIWAIPEDVEASKAQLAELAKLLEMPQADLKKKLGNEDKTFVWLKRQVDEPIAQQIHAMGIKGIYARREYKRK
YPEGEAAAHVVGFTNVEDNGQEGIELTFNKELAGKAGSRRVIKDRLGRVVEGVGEQVPPIEGKDIQLSVDSKVQFFAYQK
LRDAVTARKAKAGSVVVLDAITGEVLALANYPSYVPDKRQNLTGEQLRNRALTDTFEPGSTMKPITVAMALEAGRVKPQT
LVETGPGRFSIGGFTISDTHNYGTLTVEGVIQKSSNVGALKIAQKMSPHEMWDTYTALGYGQKPQIQFPGAVTGRLRPWK
SWRPVEQATMAYGYGLSASLFQMAHSYTSFAHDGQIIPVTMLKSTEPAVGVRVFSAENAHAVRRMLQMAAAPGGTGQLAQ
TVGYSVGGKSGTAHKQVGKGYASNKYRAWFTGMAPIEAPRIIVAVMIDEPSDGQYFGGVAAAPVFSEVVQQTLRMMGVQP
DVSVKPQIVTQAVEESF

Sequences:

>Translated_577_residues
MSRSVLYSSSPLLASKTPVWRSKFIVAAIALAFVGLAGRAAYIQVFGNEFFQRQGEVRFARTLELPANRGRILDRNGLIL
ASSVPAPSIWAIPEDVEASKAQLAELAKLLEMPQADLKKKLGNEDKTFVWLKRQVDEPIAQQIHAMGIKGIYARREYKRK
YPEGEAAAHVVGFTNVEDNGQEGIELTFNKELAGKAGSRRVIKDRLGRVVEGVGEQVPPIEGKDIQLSVDSKVQFFAYQK
LRDAVTARKAKAGSVVVLDAITGEVLALANYPSYVPDKRQNLTGEQLRNRALTDTFEPGSTMKPITVAMALEAGRVKPQT
LVETGPGRFSIGGFTISDTHNYGTLTVEGVIQKSSNVGALKIAQKMSPHEMWDTYTALGYGQKPQIQFPGAVTGRLRPWK
SWRPVEQATMAYGYGLSASLFQMAHSYTSFAHDGQIIPVTMLKSTEPAVGVRVFSAENAHAVRRMLQMAAAPGGTGQLAQ
TVGYSVGGKSGTAHKQVGKGYASNKYRAWFTGMAPIEAPRIIVAVMIDEPSDGQYFGGVAAAPVFSEVVQQTLRMMGVQP
DVSVKPQIVTQAVEESF
>Mature_576_residues
SRSVLYSSSPLLASKTPVWRSKFIVAAIALAFVGLAGRAAYIQVFGNEFFQRQGEVRFARTLELPANRGRILDRNGLILA
SSVPAPSIWAIPEDVEASKAQLAELAKLLEMPQADLKKKLGNEDKTFVWLKRQVDEPIAQQIHAMGIKGIYARREYKRKY
PEGEAAAHVVGFTNVEDNGQEGIELTFNKELAGKAGSRRVIKDRLGRVVEGVGEQVPPIEGKDIQLSVDSKVQFFAYQKL
RDAVTARKAKAGSVVVLDAITGEVLALANYPSYVPDKRQNLTGEQLRNRALTDTFEPGSTMKPITVAMALEAGRVKPQTL
VETGPGRFSIGGFTISDTHNYGTLTVEGVIQKSSNVGALKIAQKMSPHEMWDTYTALGYGQKPQIQFPGAVTGRLRPWKS
WRPVEQATMAYGYGLSASLFQMAHSYTSFAHDGQIIPVTMLKSTEPAVGVRVFSAENAHAVRRMLQMAAAPGGTGQLAQT
VGYSVGGKSGTAHKQVGKGYASNKYRAWFTGMAPIEAPRIIVAVMIDEPSDGQYFGGVAAAPVFSEVVQQTLRMMGVQPD
VSVKPQIVTQAVEESF

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=548, Percent_Identity=38.3211678832117, Blast_Score=384, Evalue=1e-107,
Organism=Escherichia coli, GI1786854, Length=584, Percent_Identity=26.027397260274, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 62722; Mature: 62591

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSVLYSSSPLLASKTPVWRSKFIVAAIALAFVGLAGRAAYIQVFGNEFFQRQGEVRFA
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCEEEE
RTLELPANRGRILDRNGLILASSVPAPSIWAIPEDVEASKAQLAELAKLLEMPQADLKKK
EEEECCCCCCEEEECCCEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
LGNEDKTFVWLKRQVDEPIAQQIHAMGIKGIYARREYKRKYPEGEAAAHVVGFTNVEDNG
HCCCCCEEEEEEHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
QEGIELTFNKELAGKAGSRRVIKDRLGRVVEGVGEQVPPIEGKDIQLSVDSKVQFFAYQK
CCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHH
LRDAVTARKAKAGSVVVLDAITGEVLALANYPSYVPDKRQNLTGEQLRNRALTDTFEPGS
HHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCHHCCCCHHHHHCCCCCCCCCCCC
TMKPITVAMALEAGRVKPQTLVETGPGRFSIGGFTISDTHNYGTLTVEGVIQKSSNVGAL
CCCCEEEEEEECCCCCCCHHHHCCCCCEEEECCEEEECCCCCCEEEEEEEEECCCCCCHH
KIAQKMSPHEMWDTYTALGYGQKPQIQFPGAVTGRLRPWKSWRPVEQATMAYGYGLSASL
HHHHHCCHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHH
FQMAHSYTSFAHDGQIIPVTMLKSTEPAVGVRVFSAENAHAVRRMLQMAAAPGGTGQLAQ
HHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHH
TVGYSVGGKSGTAHKQVGKGYASNKYRAWFTGMAPIEAPRIIVAVMIDEPSDGQYFGGVA
HHCCCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCH
AAPVFSEVVQQTLRMMGVQPDVSVKPQIVTQAVEESF
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SRSVLYSSSPLLASKTPVWRSKFIVAAIALAFVGLAGRAAYIQVFGNEFFQRQGEVRFA
CCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCEEEE
RTLELPANRGRILDRNGLILASSVPAPSIWAIPEDVEASKAQLAELAKLLEMPQADLKKK
EEEECCCCCCEEEECCCEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
LGNEDKTFVWLKRQVDEPIAQQIHAMGIKGIYARREYKRKYPEGEAAAHVVGFTNVEDNG
HCCCCCEEEEEEHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
QEGIELTFNKELAGKAGSRRVIKDRLGRVVEGVGEQVPPIEGKDIQLSVDSKVQFFAYQK
CCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHH
LRDAVTARKAKAGSVVVLDAITGEVLALANYPSYVPDKRQNLTGEQLRNRALTDTFEPGS
HHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCHHCCCCHHHHHCCCCCCCCCCCC
TMKPITVAMALEAGRVKPQTLVETGPGRFSIGGFTISDTHNYGTLTVEGVIQKSSNVGAL
CCCCEEEEEEECCCCCCCHHHHCCCCCEEEECCEEEECCCCCCEEEEEEEEECCCCCCHH
KIAQKMSPHEMWDTYTALGYGQKPQIQFPGAVTGRLRPWKSWRPVEQATMAYGYGLSASL
HHHHHCCHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHH
FQMAHSYTSFAHDGQIIPVTMLKSTEPAVGVRVFSAENAHAVRRMLQMAAAPGGTGQLAQ
HHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHH
TVGYSVGGKSGTAHKQVGKGYASNKYRAWFTGMAPIEAPRIIVAVMIDEPSDGQYFGGVA
HHCCCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCH
AAPVFSEVVQQTLRMMGVQPDVSVKPQIVTQAVEESF
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]