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The map label for this gene is hisB [H]

Identifier: 91786708

GI number: 91786708

Start: 832473

End: 833093

Strand: Direct

Name: hisB [H]

Synonym: Bpro_0806

Alternate gene names: 91786708

Gene position: 832473-833093 (Clockwise)

Preceding gene: 91786707

Following gene: 91786709

Centisome position: 16.01

GC content: 63.29

Gene sequence:

>621_bases
ATGACCACCCCTTCCACTGCTCCGACCCCGGCCCCGCGCAAGGCGGAAGTCTCGCGCAACACCGCCGAGACCCAGATCAC
CGTCAAGCTCAACCTGGACGGCACGGGCAAAGCCAGCCTGTCGACGGGCATCGGCTTTTTCGACCACATGCTGGACCAGA
TCGCCCGCCACGGCCTGATCGACCTGGACATCCAGGCCAAGGGCGACCTGCACATTGATGGCCACCACACGGTGGAAGAC
GTCGGCATCACCTTCGGACAGGCCGTGGCCCAGGCCGTCGGCGACAAAAAAGGCCTGCGCCGCTATGGCCACGCCTATGT
GCCGCTGGACGAGGCCCTATCGCGCGTGGTGATCGATTTCTCGGGCCGCCCCGGCCTGGAAATGCATGTGCCCTTCAAGA
GCGGCATGATAGGTACCTTTGACAGCCAGCTCGCCTATGAATTCTTCCAGGGTTTTGCCAACCATGCGTTTGTGACGCTG
CACATTGACAACCTGCGTGGCGACAACGCCCATCATCAGGCCGAAACCGTGTTCAAGGCGTTTGCGCGGGCGCTGCGCAT
GGCGCTGGAAATCGACCCGCGGTCGGCAGGCGTGATTCCGTCGACCAAGGGCTCGCTGTAG

Upstream 100 bases:

>100_bases
ACGTTTCTAAAATGCATCCATTGCTGGCCAATTGTTTGCGCCTGACCGTCGGCACCGCGGACGAGAATACGCAAATGCTG
GCGGCGCTTGAAAAATCCCT

Downstream 100 bases:

>100_bases
GTGCCGGTGCGCCATGGATGGACCGTTCCCCGTTTTGGGTTTTCTGCCCCGCTAGAATGGACGTCAATAGCTCCTGAGTC
CGTAGCAAATATCGATGAAT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTTPSTAPTPAPRKAEVSRNTAETQITVKLNLDGTGKASLSTGIGFFDHMLDQIARHGLIDLDIQAKGDLHIDGHHTVED
VGITFGQAVAQAVGDKKGLRRYGHAYVPLDEALSRVVIDFSGRPGLEMHVPFKSGMIGTFDSQLAYEFFQGFANHAFVTL
HIDNLRGDNAHHQAETVFKAFARALRMALEIDPRSAGVIPSTKGSL

Sequences:

>Translated_206_residues
MTTPSTAPTPAPRKAEVSRNTAETQITVKLNLDGTGKASLSTGIGFFDHMLDQIARHGLIDLDIQAKGDLHIDGHHTVED
VGITFGQAVAQAVGDKKGLRRYGHAYVPLDEALSRVVIDFSGRPGLEMHVPFKSGMIGTFDSQLAYEFFQGFANHAFVTL
HIDNLRGDNAHHQAETVFKAFARALRMALEIDPRSAGVIPSTKGSL
>Mature_205_residues
TTPSTAPTPAPRKAEVSRNTAETQITVKLNLDGTGKASLSTGIGFFDHMLDQIARHGLIDLDIQAKGDLHIDGHHTVEDV
GITFGQAVAQAVGDKKGLRRYGHAYVPLDEALSRVVIDFSGRPGLEMHVPFKSGMIGTFDSQLAYEFFQGFANHAFVTLH
IDNLRGDNAHHQAETVFKAFARALRMALEIDPRSAGVIPSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=198, Percent_Identity=45.959595959596, Blast_Score=180, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=38.9908256880734, Blast_Score=158, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22289; Mature: 22157

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPSTAPTPAPRKAEVSRNTAETQITVKLNLDGTGKASLSTGIGFFDHMLDQIARHGLI
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEE
DLDIQAKGDLHIDGHHTVEDVGITFGQAVAQAVGDKKGLRRYGHAYVPLDEALSRVVIDF
EEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHEEEEEE
SGRPGLEMHVPFKSGMIGTFDSQLAYEFFQGFANHAFVTLHIDNLRGDNAHHQAETVFKA
CCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHH
FARALRMALEIDPRSAGVIPSTKGSL
HHHHHHHHHEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTPSTAPTPAPRKAEVSRNTAETQITVKLNLDGTGKASLSTGIGFFDHMLDQIARHGLI
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEE
DLDIQAKGDLHIDGHHTVEDVGITFGQAVAQAVGDKKGLRRYGHAYVPLDEALSRVVIDF
EEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHEEEEEE
SGRPGLEMHVPFKSGMIGTFDSQLAYEFFQGFANHAFVTLHIDNLRGDNAHHQAETVFKA
CCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHH
FARALRMALEIDPRSAGVIPSTKGSL
HHHHHHHHHEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA