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The map label for this gene is pdhB [H]

Identifier: 91786665

GI number: 91786665

Start: 783323

End: 784315

Strand: Direct

Name: pdhB [H]

Synonym: Bpro_0763

Alternate gene names: 91786665

Gene position: 783323-784315 (Clockwise)

Preceding gene: 91786664

Following gene: 91786666

Centisome position: 15.06

GC content: 66.67

Gene sequence:

>993_bases
ATGGCCCGCCGCACCATCACATACCGGGAAGCCCTGCGTGAAGCGCTGCGCGAAGCCCTGTACGCCGACCCGCGTGTCTT
TCTGATGGGCGAGGACGTGGGCCGCTACGGCGGCACCTATGCTGTGTCCCGGGGGCTGCTTGACGAGTTCGGCCCTGAAC
GTATCCGCGACACACCGCTGTCCGAACTTGGATTTGTCGGTGCCGGCGTCGGCGCGGCGCTCGGTGGCATGCGTCCGATT
GTCGAGGTCATGACGGTCAACTTCAGCCTGCTGGCGCTCGACCCCATCGTCAACACCGCGGCCATGTTGCACCACATGTC
GGGCGGTCAGCTTTCCGTGCCCATCGTGATCCGCATGGCCACCGGTGCCGGGCGCCAGGTGGCGGCCCAGCACTCCAACA
GCTTTGAAAACTGGTATGCCCATGTGCCTGGACTCACGGTGCTGGCGCCAGCGACAGTGGAAGATGCCCGCGGCATGCTT
GCGGCTGCGCTGGCCGACCCGGACCCGGTGGTGATATTTGAGCATGCGCAGCTTTACAACATGGAAGGCGAGGTGCCGGA
CGGCGAATGGCCGGGTGTGGACATCCGCAGCGCCAGGGTGCGCCGCGCGGGCACGGATGTAAGCCTGATCACCCACGGCG
GCAGCCTGCCCAAGGCACTGCGGGCGGCGGAGGAACTGGAGCAGCAGGGTATTTCCGCCGAGGTCATCGACCTGCGCGTG
CTGCGCCCGCTCGACGATGCCACCCTGATGGCCTCAGTGCGGAAATGTCGCCGCGCCGTGGTCATTGACGAAGGCTGGCG
CTCAGGCAGCCTGGCGGCCGAGGTCATGGCGCGCATCATGGAGCAGGCCTTCTTTGACCTCGATGCCCCGCTGGCGCGCG
TGTGCAGCGAGGAGGTTCCGATTCCGTATGCCCGCCACATGGAAGAGGCCGCGTTGCCGCAAGTCCCGAAAATTGTCGCC
GCCGCGCGAGCGCTGTTGGGGAGCGCACCATGA

Upstream 100 bases:

>100_bases
AGGCAGAGGTCGATGCCGCCGCGGCCTTTGCCGAAGCCGGCACCTGGGAGCCGGTTGAAGACCTGCTGCGCGATGTCCAT
ACACGGGAGGGAGCAGCCTG

Downstream 100 bases:

>100_bases
TCGAATTCAAGTTGCCCGCGCTGGGCGCTGACATGGACGAGGGCACACTGCTCAAGTGGCATGTGCAACCGGGAGACGCC
GTCAAGCGTGGCCAGGTGGT

Product: transketolase, central region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MARRTITYREALREALREALYADPRVFLMGEDVGRYGGTYAVSRGLLDEFGPERIRDTPLSELGFVGAGVGAALGGMRPI
VEVMTVNFSLLALDPIVNTAAMLHHMSGGQLSVPIVIRMATGAGRQVAAQHSNSFENWYAHVPGLTVLAPATVEDARGML
AAALADPDPVVIFEHAQLYNMEGEVPDGEWPGVDIRSARVRRAGTDVSLITHGGSLPKALRAAEELEQQGISAEVIDLRV
LRPLDDATLMASVRKCRRAVVIDEGWRSGSLAAEVMARIMEQAFFDLDAPLARVCSEEVPIPYARHMEEAALPQVPKIVA
AARALLGSAP

Sequences:

>Translated_330_residues
MARRTITYREALREALREALYADPRVFLMGEDVGRYGGTYAVSRGLLDEFGPERIRDTPLSELGFVGAGVGAALGGMRPI
VEVMTVNFSLLALDPIVNTAAMLHHMSGGQLSVPIVIRMATGAGRQVAAQHSNSFENWYAHVPGLTVLAPATVEDARGML
AAALADPDPVVIFEHAQLYNMEGEVPDGEWPGVDIRSARVRRAGTDVSLITHGGSLPKALRAAEELEQQGISAEVIDLRV
LRPLDDATLMASVRKCRRAVVIDEGWRSGSLAAEVMARIMEQAFFDLDAPLARVCSEEVPIPYARHMEEAALPQVPKIVA
AARALLGSAP
>Mature_329_residues
ARRTITYREALREALREALYADPRVFLMGEDVGRYGGTYAVSRGLLDEFGPERIRDTPLSELGFVGAGVGAALGGMRPIV
EVMTVNFSLLALDPIVNTAAMLHHMSGGQLSVPIVIRMATGAGRQVAAQHSNSFENWYAHVPGLTVLAPATVEDARGMLA
AALADPDPVVIFEHAQLYNMEGEVPDGEWPGVDIRSARVRRAGTDVSLITHGGSLPKALRAAEELEQQGISAEVIDLRVL
RPLDDATLMASVRKCRRAVVIDEGWRSGSLAAEVMARIMEQAFFDLDAPLARVCSEEVPIPYARHMEEAALPQVPKIVAA
ARALLGSAP

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=43.558282208589, Blast_Score=285, Evalue=5e-77,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=41.1042944785276, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI4557353, Length=321, Percent_Identity=33.0218068535826, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI34101272, Length=321, Percent_Identity=33.0218068535826, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17538422, Length=332, Percent_Identity=45.1807228915663, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI17506935, Length=327, Percent_Identity=32.1100917431193, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319698, Length=334, Percent_Identity=44.9101796407186, Blast_Score=296, Evalue=3e-81,
Organism=Drosophila melanogaster, GI21358145, Length=331, Percent_Identity=48.3383685800604, Blast_Score=313, Evalue=8e-86,
Organism=Drosophila melanogaster, GI24650940, Length=331, Percent_Identity=48.3383685800604, Blast_Score=313, Evalue=8e-86,
Organism=Drosophila melanogaster, GI160714828, Length=314, Percent_Identity=32.484076433121, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI160714832, Length=320, Percent_Identity=31.875, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24650943, Length=94, Percent_Identity=50, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24650945, Length=94, Percent_Identity=50, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35525; Mature: 35394

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRTITYREALREALREALYADPRVFLMGEDVGRYGGTYAVSRGLLDEFGPERIRDTPL
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHCCCHHHHHHHHHHHCCHHHHCCCCH
SELGFVGAGVGAALGGMRPIVEVMTVNFSLLALDPIVNTAAMLHHMSGGQLSVPIVIRMA
HHHHHHHCCHHHHHCCHHHHHHHHHCCHHEEEHHHHHHHHHHHHHCCCCCEEEEEEEEEE
TGAGRQVAAQHSNSFENWYAHVPGLTVLAPATVEDARGMLAAALADPDPVVIFEHAQLYN
CCCCCHHHHHHCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEECCEEEC
MEGEVPDGEWPGVDIRSARVRRAGTDVSLITHGGSLPKALRAAEELEQQGISAEVIDLRV
CCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEE
LRPLDDATLMASVRKCRRAVVIDEGWRSGSLAAEVMARIMEQAFFDLDAPLARVCSEEVP
ECCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
IPYARHMEEAALPQVPKIVAAARALLGSAP
CCHHHHHHHHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ARRTITYREALREALREALYADPRVFLMGEDVGRYGGTYAVSRGLLDEFGPERIRDTPL
CCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHCCCHHHHHHHHHHHCCHHHHCCCCH
SELGFVGAGVGAALGGMRPIVEVMTVNFSLLALDPIVNTAAMLHHMSGGQLSVPIVIRMA
HHHHHHHCCHHHHHCCHHHHHHHHHCCHHEEEHHHHHHHHHHHHHCCCCCEEEEEEEEEE
TGAGRQVAAQHSNSFENWYAHVPGLTVLAPATVEDARGMLAAALADPDPVVIFEHAQLYN
CCCCCHHHHHHCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEECCEEEC
MEGEVPDGEWPGVDIRSARVRRAGTDVSLITHGGSLPKALRAAEELEQQGISAEVIDLRV
CCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEE
LRPLDDATLMASVRKCRRAVVIDEGWRSGSLAAEVMARIMEQAFFDLDAPLARVCSEEVP
ECCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
IPYARHMEEAALPQVPKIVAAARALLGSAP
CCHHHHHHHHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]