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The map label for this gene is pdhA [H]

Identifier: 91786664

GI number: 91786664

Start: 782310

End: 783323

Strand: Direct

Name: pdhA [H]

Synonym: Bpro_0762

Alternate gene names: 91786664

Gene position: 782310-783323 (Clockwise)

Preceding gene: 91786663

Following gene: 91786665

Centisome position: 15.04

GC content: 65.78

Gene sequence:

>1014_bases
ATGAGTCACCTGCCGGTACCCCCGCCACCGAGTGGCCCGGTGCCTTGGGACAAGGCCTTTGCGCTGGCGGTGCTGGCCGG
CATGCTGCGCATCCGCCGCATGGAAGAGAAGTGTGCCCAGCTCTACGGCGAGCAGAAGATCCGCGGCTTTCTGCATCTGT
ACATCGGCGAGGAGGCCGTGGCTGTCGGCGCGCTGCGCGCTCTCCAGCCGCAAGACAACGTGGTGGCTACCTACCGCGAG
CACGGTCATGCGCTGCTGCGCGGCTTGGCCATGAACGGCATCATGGCCGAAATGTACGGCAAGCGCGAGGGCTGTTCGCG
CGGGCGCGGCGGCTCCATGCATTTGTTCGACCGTGCGACCCGTTTTTATGGCGGCAATGCGATTGTGGGTGGTGGCCTGC
CATTGGCTGCAGGACTGGCGCTGGCCGACAAAATGGCGGGGCGCCAGGCACTCACCGCCTGTTTTTTTGGTGAGGGTGCG
ATCGCCGAGGGGGCCTTTCATGAAGCGGCCAACCTTGCCGCGCTCTGGCAGCTGCCGGTACTGTTTTGCTGCGAGAACAA
TCTATATGCCATGGGCACGGCGCTGGCGCGCTCCGAGGCGCAGACCGATCTGTGCATGAAGGCGGCGTCGTACGGCATGG
CCACCGTGCAGGCTGACGGCATGGATGTGGTGGCCGTATTTGACGCTGTGCAGCGCAGCGCGCAGCAGGTGCGCAGCCAG
GGCCGCCCGGTGTTTGTGGAACTGAAGACCTACCGCTTTCGCGCGCACTCGATGTTCGACCCCGAGCTGTACCGCGACAA
GGCCGAGGTGCAAGCCTGGAAGACGCGTGGCCCCATCCACACATTCACCGCGCGCCTGAAGGCGCAGGGCAGCCTGACGG
AGGACGAGTTCCTGGTGCTTGATGCGGCGGCGCAGGCAGAGGTCGATGCCGCCGCGGCCTTTGCCGAAGCCGGCACCTGG
GAGCCGGTTGAAGACCTGCTGCGCGATGTCCATACACGGGAGGGAGCAGCCTGA

Upstream 100 bases:

>100_bases
TATTGCCGCGCACGCGCAGCGGCAAGATCATGCGCCGCCTGCTCAAGGCCCGCGAGCTCGGCCTGCCTGAGGGCGACATC
TCGACGCTGGAGGGTGGAGC

Downstream 100 bases:

>100_bases
TGGCCCGCCGCACCATCACATACCGGGAAGCCCTGCGTGAAGCGCTGCGCGAAGCCCTGTACGCCGACCCGCGTGTCTTT
CTGATGGGCGAGGACGTGGG

Product: pyruvate dehydrogenase (lipoamide)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSHLPVPPPPSGPVPWDKAFALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAVAVGALRALQPQDNVVATYRE
HGHALLRGLAMNGIMAEMYGKREGCSRGRGGSMHLFDRATRFYGGNAIVGGGLPLAAGLALADKMAGRQALTACFFGEGA
IAEGAFHEAANLAALWQLPVLFCCENNLYAMGTALARSEAQTDLCMKAASYGMATVQADGMDVVAVFDAVQRSAQQVRSQ
GRPVFVELKTYRFRAHSMFDPELYRDKAEVQAWKTRGPIHTFTARLKAQGSLTEDEFLVLDAAAQAEVDAAAAFAEAGTW
EPVEDLLRDVHTREGAA

Sequences:

>Translated_337_residues
MSHLPVPPPPSGPVPWDKAFALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAVAVGALRALQPQDNVVATYRE
HGHALLRGLAMNGIMAEMYGKREGCSRGRGGSMHLFDRATRFYGGNAIVGGGLPLAAGLALADKMAGRQALTACFFGEGA
IAEGAFHEAANLAALWQLPVLFCCENNLYAMGTALARSEAQTDLCMKAASYGMATVQADGMDVVAVFDAVQRSAQQVRSQ
GRPVFVELKTYRFRAHSMFDPELYRDKAEVQAWKTRGPIHTFTARLKAQGSLTEDEFLVLDAAAQAEVDAAAAFAEAGTW
EPVEDLLRDVHTREGAA
>Mature_336_residues
SHLPVPPPPSGPVPWDKAFALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAVAVGALRALQPQDNVVATYREH
GHALLRGLAMNGIMAEMYGKREGCSRGRGGSMHLFDRATRFYGGNAIVGGGLPLAAGLALADKMAGRQALTACFFGEGAI
AEGAFHEAANLAALWQLPVLFCCENNLYAMGTALARSEAQTDLCMKAASYGMATVQADGMDVVAVFDAVQRSAQQVRSQG
RPVFVELKTYRFRAHSMFDPELYRDKAEVQAWKTRGPIHTFTARLKAQGSLTEDEFLVLDAAAQAEVDAAAAFAEAGTWE
PVEDLLRDVHTREGAA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=330, Percent_Identity=40.3030303030303, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4505685, Length=309, Percent_Identity=40.1294498381877, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI291084742, Length=309, Percent_Identity=40.1294498381877, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI291084744, Length=316, Percent_Identity=39.2405063291139, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI291084757, Length=301, Percent_Identity=37.5415282392027, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI11386135, Length=281, Percent_Identity=30.9608540925267, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI258645172, Length=281, Percent_Identity=31.3167259786477, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17536047, Length=324, Percent_Identity=40.1234567901235, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI32564172, Length=324, Percent_Identity=40.1234567901235, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI86563357, Length=322, Percent_Identity=31.6770186335404, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI86563355, Length=322, Percent_Identity=31.6770186335404, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321026, Length=311, Percent_Identity=41.1575562700965, Blast_Score=234, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24639744, Length=327, Percent_Identity=40.9785932721713, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI28571106, Length=327, Percent_Identity=40.9785932721713, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI24639740, Length=327, Percent_Identity=40.9785932721713, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24639746, Length=309, Percent_Identity=41.747572815534, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24639748, Length=327, Percent_Identity=38.2262996941896, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI21355903, Length=285, Percent_Identity=28.4210526315789, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36460; Mature: 36329

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLPVPPPPSGPVPWDKAFALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEEEECCHHH
AVGALRALQPQDNVVATYREHGHALLRGLAMNGIMAEMYGKREGCSRGRGGSMHLFDRAT
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHH
RFYGGNAIVGGGLPLAAGLALADKMAGRQALTACFFGEGAIAEGAFHEAANLAALWQLPV
HHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCE
LFCCENNLYAMGTALARSEAQTDLCMKAASYGMATVQADGMDVVAVFDAVQRSAQQVRSQ
EEEECCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHC
GRPVFVELKTYRFRAHSMFDPELYRDKAEVQAWKTRGPIHTFTARLKAQGSLTEDEFLVL
CCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEE
DAAAQAEVDAAAAFAEAGTWEPVEDLLRDVHTREGAA
ECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SHLPVPPPPSGPVPWDKAFALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEEEECCHHH
AVGALRALQPQDNVVATYREHGHALLRGLAMNGIMAEMYGKREGCSRGRGGSMHLFDRAT
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHH
RFYGGNAIVGGGLPLAAGLALADKMAGRQALTACFFGEGAIAEGAFHEAANLAALWQLPV
HHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCE
LFCCENNLYAMGTALARSEAQTDLCMKAASYGMATVQADGMDVVAVFDAVQRSAQQVRSQ
EEEECCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHC
GRPVFVELKTYRFRAHSMFDPELYRDKAEVQAWKTRGPIHTFTARLKAQGSLTEDEFLVL
CCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEE
DAAAQAEVDAAAAFAEAGTWEPVEDLLRDVHTREGAA
ECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA