BacMap

Definition	Francisella tularensis subsp. holarctica LVS chromosome, complete genome.
Accession	NC_007880
Length	1,895,994

Click here to switch to the map view.

The map label for this gene is bacC [H]

Identifier: 89256411

GI number: 89256411

Start: 1028678

End: 1029403

Strand: Direct

Name: bacC [H]

Synonym: FTL_1076

Alternate gene names: 89256411

Gene position: 1028678-1029403 (Clockwise)

Preceding gene: 89256409

Following gene: 89256412

Centisome position: 54.26

GC content: 29.89

Gene sequence:

>726_bases
ATGGCAAATTACCTAGTTACAGGTGGTTCAAAAGGGATTGGTAAAGCAGTTGTCGAGCTACTTTTACAAAATAAAAATCA
TACTGTTATTAATATAGATATACAACAAAGTTTTAGTGCTGAAAACCTAAAATTTATCAAAGCTGATTTGACTAAACAAC
AAGATATTACTAATGTTTTAGATATTATCAAAAATGTTAGCTTTGATGGAATTTTCTTGAATGCAGGAATTTTGATAAAA
GGTTCAATTTTTGATATTGATATTGAAAGTATTAAAAAAGTATTAGATTTGAATGTTTGGTCAAGTATTTACTTTATCAA
AGGTCTAGAAAATAACCTCAAAGTCGGAGCATCAATAGTATTTAATGGTTCTGATCAATGCTTTATCGCCAAGCCAAATA
GTTTTGCTTATACTCTAAGTAAAGGAGCTATTGCACAAATGACTAAATCACTAGCGCTAGATCTAGCTAAATATCAAATT
AGAGTCAATACAGTTTGTCCAGGTACTGTTGATACAGATTTATATCGAAATTTGATACAAAAATATGCAAATAATGTTGG
AATATCATTTGATGAAGCACAAAAACAGGAAGAAAAAGAATTTCCGCTAAATAGAATCGCACAGCCTCAAGAAATTGCTG
AATTAGTAATTTTTTTACTCAGTGATAAAAGTAAATTTATGACTGGTGGCTTAATTCCTATAGATGGTGGCTATACAGCG
CAATAG

Upstream 100 bases:

>100_bases
ATCAATCTAGATTTCATAATTAGATTTTAGACAAAATATTTGTCTTTTTCAAAGCTTATCATATATTATTTATTAGATGA
TGAGAATTAGTTTATAAACT

Downstream 100 bases:

>100_bases
TATTGTCAACATATAAGATAAAAATGTTATAATTATTAGCAAATTTTATTATAAAACTACAGTATGATCGAAACAGATAG
AATAATCTCAGCTAATACAG

Product: short chain dehydrogenase family protein

Products: 2,3-Dihydroxybenzoate; H+; Nicotinamide adenine dinucleotide - reduced [C]

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MANYLVTGGSKGIGKAVVELLLQNKNHTVINIDIQQSFSAENLKFIKADLTKQQDITNVLDIIKNVSFDGIFLNAGILIK
GSIFDIDIESIKKVLDLNVWSSIYFIKGLENNLKVGASIVFNGSDQCFIAKPNSFAYTLSKGAIAQMTKSLALDLAKYQI
RVNTVCPGTVDTDLYRNLIQKYANNVGISFDEAQKQEEKEFPLNRIAQPQEIAELVIFLLSDKSKFMTGGLIPIDGGYTA
Q

Sequences:

>Translated_241_residues
MANYLVTGGSKGIGKAVVELLLQNKNHTVINIDIQQSFSAENLKFIKADLTKQQDITNVLDIIKNVSFDGIFLNAGILIK
GSIFDIDIESIKKVLDLNVWSSIYFIKGLENNLKVGASIVFNGSDQCFIAKPNSFAYTLSKGAIAQMTKSLALDLAKYQI
RVNTVCPGTVDTDLYRNLIQKYANNVGISFDEAQKQEEKEFPLNRIAQPQEIAELVIFLLSDKSKFMTGGLIPIDGGYTA
Q
>Mature_240_residues
ANYLVTGGSKGIGKAVVELLLQNKNHTVINIDIQQSFSAENLKFIKADLTKQQDITNVLDIIKNVSFDGIFLNAGILIKG
SIFDIDIESIKKVLDLNVWSSIYFIKGLENNLKVGASIVFNGSDQCFIAKPNSFAYTLSKGAIAQMTKSLALDLAKYQIR
VNTVCPGTVDTDLYRNLIQKYANNVGISFDEAQKQEEKEFPLNRIAQPQEIAELVIFLLSDKSKFMTGGLIPIDGGYTAQ

Specific function: Part of the bacABCDE operon responsible for the biosynthesis of bacilysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=28.4615384615385, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI66933014, Length=225, Percent_Identity=31.5555555555556, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=28.8065843621399, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=27.4131274131274, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=26.8292682926829, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4758504, Length=260, Percent_Identity=27.3076923076923, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=24.8091603053435, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI59889578, Length=197, Percent_Identity=28.4263959390863, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=30.1587301587302, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI2367175, Length=262, Percent_Identity=30.5343511450382, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI87082100, Length=248, Percent_Identity=28.6290322580645, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI2367365, Length=246, Percent_Identity=26.4227642276423, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=27.0491803278689, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788459, Length=169, Percent_Identity=27.2189349112426, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=25.6, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=23.2931726907631, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789057, Length=256, Percent_Identity=26.953125, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=24.4979919678715, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=25.2, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=30.952380952381, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=31.25, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=30.4, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=29.5275590551181, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=29.0196078431373, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=30.5343511450382, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=29.3233082706767, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=27.8810408921933, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=29.811320754717, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=24.3027888446215, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=28.1368821292776, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=29.0697674418605, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=269, Percent_Identity=29.368029739777, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=258, Percent_Identity=28.2945736434109, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=25.5725190839695, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=24.904214559387, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=124, Percent_Identity=34.6774193548387, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=258, Percent_Identity=26.3565891472868, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322226, Length=203, Percent_Identity=28.0788177339901, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=33.8775510204082, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24644337, Length=204, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=31.3492063492063, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24643142, Length=248, Percent_Identity=32.6612903225806, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=31.496062992126, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=28.515625, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=25.3968253968254, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355319, Length=256, Percent_Identity=28.125, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.3.1.28 [C]

Molecular weight: Translated: 26563; Mature: 26432

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYLVTGGSKGIGKAVVELLLQNKNHTVINIDIQQSFSAENLKFIKADLTKQQDITNVL
CCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEHHCCCHHHHHHHH
DIIKNVSFDGIFLNAGILIKGSIFDIDIESIKKVLDLNVWSSIYFIKGLENNLKVGASIV
HHHHCCCCCEEEEECCEEEECCEEECCHHHHHHHHHHHHHHHEEEEECCCCCCEECEEEE
FNGSDQCFIAKPNSFAYTLSKGAIAQMTKSLALDLAKYQIRVNTVCPGTVDTDLYRNLIQ
ECCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHEEEEEEEEEECCCCCCHHHHHHHHH
KYANNVGISFDEAQKQEEKEFPLNRIAQPQEIAELVIFLLSDKSKFMTGGLIPIDGGYTA
HHHHHCCCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCC
Q
C
>Mature Secondary Structure 
ANYLVTGGSKGIGKAVVELLLQNKNHTVINIDIQQSFSAENLKFIKADLTKQQDITNVL
CCEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEHHCCCHHHHHHHH
DIIKNVSFDGIFLNAGILIKGSIFDIDIESIKKVLDLNVWSSIYFIKGLENNLKVGASIV
HHHHCCCCCEEEEECCEEEECCEEECCHHHHHHHHHHHHHHHEEEEECCCCCCEECEEEE
FNGSDQCFIAKPNSFAYTLSKGAIAQMTKSLALDLAKYQIRVNTVCPGTVDTDLYRNLIQ
ECCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHEEEEEEEEEECCCCCCHHHHHHHHH
KYANNVGISFDEAQKQEEKEFPLNRIAQPQEIAELVIFLLSDKSKFMTGGLIPIDGGYTA
HHHHHCCCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): 5550 [C]

Specific activity: 66

Km value (mM): 0.26 {methyl-2,3-dehydro-3-hydroxybenzoate}} 0.2 {3-oxocyclohexane-1-carboxylic} 0.3 {2,3-dihydro-2,3-dihydroxybenzoate}} [C]

Substrates: 2,3-Dihydro-2,3-dihydroxybenzoate; Nicotinamide adenine dinucleotide [C]

Specific reaction: 2,3-Dihydro-2,3-dihydroxybenzoate + Nicotinamide adenine dinucleotide <==> 2,3-Dihydroxybenzoate + H+ + Nicotinamide adenine dinucleotide - reduced [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA