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The map label for this gene is ttcA1 [H]

Identifier: 89256143

GI number: 89256143

Start: 750859

End: 751614

Strand: Reverse

Name: ttcA1 [H]

Synonym: FTL_0760

Alternate gene names: 89256143

Gene position: 751614-750859 (Counterclockwise)

Preceding gene: 89256144

Following gene: 89256142

Centisome position: 39.64

GC content: 33.47

Gene sequence:

>756_bases
ATGACAAAGACCGAGAAAAAACTACGCCACTATATCACCAAGGCTATTGCAGACTATAAGCTTCTTGATAAAGGTGATAA
AGCTATGCTATGCCTATCTGGTGGTAAAGATTCTTTTGGACTTCTAAAAGTCTTACATGGTTTAATTGAAGATAAAACCT
ATGATATTGACCTTCATGTATATACACTAGATCAGTCTCAACCAGGTTGGGATGATAGTCAACTTAGAAAATATCTTGAT
GATCTCGGTGTATCTTATGAAATTGAGACAAAAAACACTTATGGTGTAGTCATAGACAAAGTTCCAGAGGGTAAAACCTA
TTGCTCACTATGTTCTAGGCTACGTCGTGGTAACATCTATAGATATGCAAAAGAGCATAAAATGGATAAAATAATTCTGG
GACATCATCGTGATGATTTAATTCAATCATTATTAATGTCTATACTTTACCAAGGTCAGATTAAATCTATGCCACCTAAG
TTTGTTACTCAAGATGGTGAAAATACTGTAATCCGCCCAATGGTGTTAGTACAAGAACGCGACTTAATAGAATTTGCTAA
GGAAGAGAATTTCCCGATAATCCCATGCAATCTATGTGGTTCACAGGAAAACCTAAAAAGAAAGAAAGTTAAAAAACTTA
TCCAAGATTTAGCTCTTGAAAATCCAAAAGTACCTAGTAATATTTTGAATTCACTATCAAATGTATTGCCTAGTCATTTG
ATGGATAAAAATTTACTTAACTCCTTAGAAAATTAA

Upstream 100 bases:

>100_bases
ATTAGCTCAAGGTAAAAAAGTTCATGATAAGCGCCAAGCACAAAAAGACAAAGACTGGGCACGCGAAAAAGATAGATTAT
TTAAAAAGGCTTATAAATAA

Downstream 100 bases:

>100_bases
ATTAGTATAGGTATGAAATATTATTTATATCTTTTTAGAACTTAAAACTGCATATCAAAGTAAAAGGTAAATAGAAATAT
ACAAAAAATAACTACTGTAA

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTKTEKKLRHYITKAIADYKLLDKGDKAMLCLSGGKDSFGLLKVLHGLIEDKTYDIDLHVYTLDQSQPGWDDSQLRKYLD
DLGVSYEIETKNTYGVVIDKVPEGKTYCSLCSRLRRGNIYRYAKEHKMDKIILGHHRDDLIQSLLMSILYQGQIKSMPPK
FVTQDGENTVIRPMVLVQERDLIEFAKEENFPIIPCNLCGSQENLKRKKVKKLIQDLALENPKVPSNILNSLSNVLPSHL
MDKNLLNSLEN

Sequences:

>Translated_251_residues
MTKTEKKLRHYITKAIADYKLLDKGDKAMLCLSGGKDSFGLLKVLHGLIEDKTYDIDLHVYTLDQSQPGWDDSQLRKYLD
DLGVSYEIETKNTYGVVIDKVPEGKTYCSLCSRLRRGNIYRYAKEHKMDKIILGHHRDDLIQSLLMSILYQGQIKSMPPK
FVTQDGENTVIRPMVLVQERDLIEFAKEENFPIIPCNLCGSQENLKRKKVKKLIQDLALENPKVPSNILNSLSNVLPSHL
MDKNLLNSLEN
>Mature_250_residues
TKTEKKLRHYITKAIADYKLLDKGDKAMLCLSGGKDSFGLLKVLHGLIEDKTYDIDLHVYTLDQSQPGWDDSQLRKYLDD
LGVSYEIETKNTYGVVIDKVPEGKTYCSLCSRLRRGNIYRYAKEHKMDKIILGHHRDDLIQSLLMSILYQGQIKSMPPKF
VTQDGENTVIRPMVLVQERDLIEFAKEENFPIIPCNLCGSQENLKRKKVKKLIQDLALENPKVPSNILNSLSNVLPSHLM
DKNLLNSLEN

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=247, Percent_Identity=46.9635627530364, Blast_Score=257, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI193211090, Length=238, Percent_Identity=31.0924369747899, Blast_Score=123, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17540090, Length=234, Percent_Identity=26.4957264957265, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24651972, Length=231, Percent_Identity=26.8398268398268, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 28766; Mature: 28635

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTEKKLRHYITKAIADYKLLDKGDKAMLCLSGGKDSFGLLKVLHGLIEDKTYDIDLHV
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEE
YTLDQSQPGWDDSQLRKYLDDLGVSYEIETKNTYGVVIDKVPEGKTYCSLCSRLRRGNIY
EEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCH
RYAKEHKMDKIILGHHRDDLIQSLLMSILYQGQIKSMPPKFVTQDGENTVIRPMVLVQER
HHHHHHCCCHHEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEEHHHHHHHHH
DLIEFAKEENFPIIPCNLCGSQENLKRKKVKKLIQDLALENPKVPSNILNSLSNVLPSHL
HHHHHHHCCCCCEEEHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
MDKNLLNSLEN
HHHHHHHHHCC
>Mature Secondary Structure 
TKTEKKLRHYITKAIADYKLLDKGDKAMLCLSGGKDSFGLLKVLHGLIEDKTYDIDLHV
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEE
YTLDQSQPGWDDSQLRKYLDDLGVSYEIETKNTYGVVIDKVPEGKTYCSLCSRLRRGNIY
EEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCH
RYAKEHKMDKIILGHHRDDLIQSLLMSILYQGQIKSMPPKFVTQDGENTVIRPMVLVQER
HHHHHHCCCHHEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEEHHHHHHHHH
DLIEFAKEENFPIIPCNLCGSQENLKRKKVKKLIQDLALENPKVPSNILNSLSNVLPSHL
HHHHHHHCCCCCEEEHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
MDKNLLNSLEN
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA