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The map label for this gene is gor [H]

Identifier: 89054555

GI number: 89054555

Start: 2072959

End: 2074275

Strand: Direct

Name: gor [H]

Synonym: Jann_2064

Alternate gene names: 89054555

Gene position: 2072959-2074275 (Clockwise)

Preceding gene: 89054554

Following gene: 89054558

Centisome position: 48.01

GC content: 63.33

Gene sequence:

>1317_bases
ATGTCAGACACGTCTTTCGATGCCATCGTTATCGGTGCGGGATCAGGGGGGCTGTCGTTCGGCCAGACCGCCGCCAAACT
CGGCGCCCGGGTGGCAGTGATCGAGAAAGATCGGTTGGGCGGCACTTGCGTGAACCGCGGATGTGTTCCCAAAAAGCTGA
TGTGGACCCTGGCGCACGCGGTGAAGCAAAGCCGTGAACTGGCGACCCAAGGTATTCTGGAGGCCGCGCCAGCGATCAAT
ATGGCGACGTTTCGCACCAAGAGCGATGCCCACGTGAATGGGATCGTCGACAGCTTCAACGAGACGCTGGATGACGCGGG
TGTTGCCGTGTTTCGGGGCAGTGGTCTCATCTCCGCACCGGGTGAGATCACCCTGGGGGAGCAAATTCTTCGCGCGGACA
AGATCGTTGTGGCCACCGGCGGCCGACCCGCGCGGCCCGACATTGACGGCGCGGAGCTGTGCAAGGTGTCCGACGATATC
CTTGCCATGACAGATCTGCCGGACAGTATCGTGGTTGTCGGGGGCGGCTATATCGGGTGTGAGTTTGCCTCGATCCTTGC
GGGGCTTGGGGTGGACGTGACGCTGGTGTCCGATGGGGATGCGGTGCTGACGGAATTTTCCGCCCCTTTGCAGATTCTGG
CGGAGGCCAACCTGAAGGCGCAGGGATGCTCCGTCGTGCTGAACGCCCGTCCGCAGCGCGTGGAAAGGTCCGGCGACACC
TTGCGCGTCACGCTGGAGGATGGCTCAACGCTTGATGTCGCAGATGTCTTGCTGGCCACGGGCCGCGCCCCGAACCTGGA
TGTGCTGGGCGCACTGGCGGAGGACGTAAACTTGTCTGACAGCGGGCAAATCGACATCGACGACGGGTTTGCCACGTCTG
TGCCGAACCTGTTTGCCATCGGCGATTGCACAACCCGGCTGCCGTTGACGCCGGTCGCCACCGATGATGGGCGGGTGTTG
GCGCTCAACCTGTTTGGCGGCGGGGCTGATCCTGTCGCGACATCGCACATCGCCACGACCGCGTTCCTGATGCCGCCCCT
GGCGGAGGTCGGCGCAACGGATGATCTTGCAAAGGGCACCGATTTTCAATCGCTCAGCGAAGGGGTCCTGTCATCCGGGC
AGAAGCATGCCTGGCACGTCGCCCTTGACGGCGATCAGATCACCGGTCTCGCCTTCGCAGCCGACGGCGCGGGGGAGGCG
GCAGGCTTCATGGCGCAGATTGTGGCGGCTGAGATGCCGCGCAAGACCGCCACGCAGGCTTTGCCCGTCCATCCTTCCTC
CTCGGAAGAGATTTTCGACGCCCTCAAGACCGACTGA

Upstream 100 bases:

>100_bases
ATCAGGGTATTCTTGCGCGTCGAAGGGAACCTGCTTGAGGTCCGGGAAGTTGGTCCCGGGAAGCGCCAGATGCGCGCCCT
TCCAGCCAGTGAGATCTTCC

Downstream 100 bases:

>100_bases
TCCGCGCCGAAAGGGTATATCGGAGATCACACAGGTGACGGGGGGAGATCCCGTCCGCCCCGATTGTGACCGGTGGCGCG
GCAGATCTACGGCATGGGCT

Product: FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSDTSFDAIVIGAGSGGLSFGQTAAKLGARVAVIEKDRLGGTCVNRGCVPKKLMWTLAHAVKQSRELATQGILEAAPAIN
MATFRTKSDAHVNGIVDSFNETLDDAGVAVFRGSGLISAPGEITLGEQILRADKIVVATGGRPARPDIDGAELCKVSDDI
LAMTDLPDSIVVVGGGYIGCEFASILAGLGVDVTLVSDGDAVLTEFSAPLQILAEANLKAQGCSVVLNARPQRVERSGDT
LRVTLEDGSTLDVADVLLATGRAPNLDVLGALAEDVNLSDSGQIDIDDGFATSVPNLFAIGDCTTRLPLTPVATDDGRVL
ALNLFGGGADPVATSHIATTAFLMPPLAEVGATDDLAKGTDFQSLSEGVLSSGQKHAWHVALDGDQITGLAFAADGAGEA
AGFMAQIVAAEMPRKTATQALPVHPSSSEEIFDALKTD

Sequences:

>Translated_438_residues
MSDTSFDAIVIGAGSGGLSFGQTAAKLGARVAVIEKDRLGGTCVNRGCVPKKLMWTLAHAVKQSRELATQGILEAAPAIN
MATFRTKSDAHVNGIVDSFNETLDDAGVAVFRGSGLISAPGEITLGEQILRADKIVVATGGRPARPDIDGAELCKVSDDI
LAMTDLPDSIVVVGGGYIGCEFASILAGLGVDVTLVSDGDAVLTEFSAPLQILAEANLKAQGCSVVLNARPQRVERSGDT
LRVTLEDGSTLDVADVLLATGRAPNLDVLGALAEDVNLSDSGQIDIDDGFATSVPNLFAIGDCTTRLPLTPVATDDGRVL
ALNLFGGGADPVATSHIATTAFLMPPLAEVGATDDLAKGTDFQSLSEGVLSSGQKHAWHVALDGDQITGLAFAADGAGEA
AGFMAQIVAAEMPRKTATQALPVHPSSSEEIFDALKTD
>Mature_437_residues
SDTSFDAIVIGAGSGGLSFGQTAAKLGARVAVIEKDRLGGTCVNRGCVPKKLMWTLAHAVKQSRELATQGILEAAPAINM
ATFRTKSDAHVNGIVDSFNETLDDAGVAVFRGSGLISAPGEITLGEQILRADKIVVATGGRPARPDIDGAELCKVSDDIL
AMTDLPDSIVVVGGGYIGCEFASILAGLGVDVTLVSDGDAVLTEFSAPLQILAEANLKAQGCSVVLNARPQRVERSGDTL
RVTLEDGSTLDVADVLLATGRAPNLDVLGALAEDVNLSDSGQIDIDDGFATSVPNLFAIGDCTTRLPLTPVATDDGRVLA
LNLFGGGADPVATSHIATTAFLMPPLAEVGATDDLAKGTDFQSLSEGVLSSGQKHAWHVALDGDQITGLAFAADGAGEAA
GFMAQIVAAEMPRKTATQALPVHPSSSEEIFDALKTD

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=455, Percent_Identity=31.2087912087912, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI22035672, Length=465, Percent_Identity=29.8924731182796, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI33519430, Length=462, Percent_Identity=25.7575757575758, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI33519428, Length=462, Percent_Identity=25.7575757575758, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI33519426, Length=462, Percent_Identity=25.7575757575758, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI148277065, Length=462, Percent_Identity=25.7575757575758, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI148277071, Length=462, Percent_Identity=25.7575757575758, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI91199540, Length=382, Percent_Identity=28.2722513089005, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI291045266, Length=445, Percent_Identity=26.7415730337079, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI291045268, Length=430, Percent_Identity=26.7441860465116, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=31.322505800464, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87082354, Length=361, Percent_Identity=28.2548476454294, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081717, Length=449, Percent_Identity=27.3942093541203, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1786307, Length=388, Percent_Identity=26.2886597938144, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1789065, Length=288, Percent_Identity=26.0416666666667, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983429, Length=444, Percent_Identity=31.0810810810811, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71983419, Length=444, Percent_Identity=31.0810810810811, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=28.997867803838, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI32565766, Length=371, Percent_Identity=27.7628032345013, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=384, Percent_Identity=29.1666666666667, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=30.0429184549356, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321091, Length=386, Percent_Identity=28.2383419689119, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6325240, Length=375, Percent_Identity=25.3333333333333, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17737741, Length=485, Percent_Identity=32.1649484536082, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24640553, Length=485, Percent_Identity=30.9278350515464, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24640549, Length=485, Percent_Identity=30.9278350515464, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24640551, Length=485, Percent_Identity=30.9278350515464, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI21358499, Length=372, Percent_Identity=27.4193548387097, Blast_Score=129, Evalue=6e-30,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 44934; Mature: 44803

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTSFDAIVIGAGSGGLSFGQTAAKLGARVAVIEKDRLGGTCVNRGCVPKKLMWTLAHA
CCCCCCCEEEEECCCCCCCCCHHHHHHCCEEEEEECCCCCCCEECCCCCCHHHHHHHHHH
VKQSRELATQGILEAAPAINMATFRTKSDAHVNGIVDSFNETLDDAGVAVFRGSGLISAP
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEECCCEECCC
GEITLGEQILRADKIVVATGGRPARPDIDGAELCKVSDDILAMTDLPDSIVVVGGGYIGC
CCCCHHHHHHCCCEEEEEECCCCCCCCCCHHHHHCCCCCEEEEECCCCCEEEEECCCHHH
EFASILAGLGVDVTLVSDGDAVLTEFSAPLQILAEANLKAQGCSVVLNARPQRVERSGDT
HHHHHHHCCCCEEEEECCCCCEEHHHCCCCEEHHHCCCCCCCCEEEECCCCHHHHCCCCE
LRVTLEDGSTLDVADVLLATGRAPNLDVLGALAEDVNLSDSGQIDIDDGFATSVPNLFAI
EEEEECCCCEEHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCEEEE
GDCTTRLPLTPVATDDGRVLALNLFGGGADPVATSHIATTAFLMPPLAEVGATDDLAKGT
CCCCCCCCCCEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCC
DFQSLSEGVLSSGQKHAWHVALDGDQITGLAFAADGAGEAAGFMAQIVAAEMPRKTATQA
CHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHCCE
LPVHPSSSEEIFDALKTD
ECCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SDTSFDAIVIGAGSGGLSFGQTAAKLGARVAVIEKDRLGGTCVNRGCVPKKLMWTLAHA
CCCCCCEEEEECCCCCCCCCHHHHHHCCEEEEEECCCCCCCEECCCCCCHHHHHHHHHH
VKQSRELATQGILEAAPAINMATFRTKSDAHVNGIVDSFNETLDDAGVAVFRGSGLISAP
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEECCCEECCC
GEITLGEQILRADKIVVATGGRPARPDIDGAELCKVSDDILAMTDLPDSIVVVGGGYIGC
CCCCHHHHHHCCCEEEEEECCCCCCCCCCHHHHHCCCCCEEEEECCCCCEEEEECCCHHH
EFASILAGLGVDVTLVSDGDAVLTEFSAPLQILAEANLKAQGCSVVLNARPQRVERSGDT
HHHHHHHCCCCEEEEECCCCCEEHHHCCCCEEHHHCCCCCCCCEEEECCCCHHHHCCCCE
LRVTLEDGSTLDVADVLLATGRAPNLDVLGALAEDVNLSDSGQIDIDDGFATSVPNLFAI
EEEEECCCCEEHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCEEEE
GDCTTRLPLTPVATDDGRVLALNLFGGGADPVATSHIATTAFLMPPLAEVGATDDLAKGT
CCCCCCCCCCEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCC
DFQSLSEGVLSSGQKHAWHVALDGDQITGLAFAADGAGEAAGFMAQIVAAEMPRKTATQA
CHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHCCE
LPVHPSSSEEIFDALKTD
ECCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]