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The map label for this gene is yisK [H]

Identifier: 89054530

GI number: 89054530

Start: 2044603

End: 2045520

Strand: Direct

Name: yisK [H]

Synonym: Jann_2039

Alternate gene names: 89054530

Gene position: 2044603-2045520 (Clockwise)

Preceding gene: 89054529

Following gene: 89054531

Centisome position: 47.35

GC content: 60.57

Gene sequence:

>918_bases
ATGAAGATCGGTACGATCCACTTTCAGGGCCGGGACAGGTTGGTGGCCCGCCTGGACGATGACCAGGTTCTCGACCTGCT
GGAGGCCTCAGGCGGCGACGTCCATTTCGTCAACACGGTCGCGATGATTGAAGCGGGACCCGCCGCATTGGACAAAGCGC
GTGCGGTGCTGGAGGATCCCCCGACGCGCGCAGTGATCGCCCTGTCGCAGGCCGAGCACCGCGTGCCGCTGCGCCCCGTG
CAGTATCGCGATTGCCTTGTGTTTGAGCAGCATCTGATCAACGGGTTCAAGCAGGCCGAGAAGATGACGGGGCGCCCCTT
CGCCATTCCGCCGGTCTGGTACGAGCAGCCGATCTACTACAAGGGCAATCGGATGTCCTTCATTGGCCACGGCCAGACGG
TGCGATGGCCCGCCTACTCAGACTATCTGGATCTGGAGCTGGAACTGGCGATCATCATCGGGAAGGAGGGCGCTGATATC
CCGCGCGAGACGGCCCATGAGCATATCTGGGGCTATACCATCCTTAATGATGTTTCCGCCCGGGATGCGCAGATGCGGGA
GATGGCGGGACAGCTGGGGCCTGCAAAGGGCAAGGATTTTGATACAGGCAATATCCTCGGGCCTTGGATCGTGACCGCCG
ATGAAGTGTCGCATCCGGCCGTTTTGAACATGGATGTGAGCGTGAACGGTGAGCGGTGGGGTGGTGGCACGTCCGCCGAT
ATGCAGTTCGATTTCGCGCAGATCATCGCACATATCTCCGCGTCTGAGCGGCTATTTCCCGGTGAAGTGATCGGCTCCGG
CACGGTCGGCACTGGCTGTGGGCTGGAGATCGGCAAGCGGCTCAGCGACGGCGATATGATGGATTTGACGATTGAGAAGA
TCGGAACCCTGACCAACACAATCAAGAAAGGGGCCTGA

Upstream 100 bases:

>100_bases
CCCTTCCCGCGACCGGATTCACGATTTCCTGCTTTCCGATCAAGATCAAGCGCGCCTCAGCCGGGTTCACGCGCGCAGTC
GCAATTCTGGAGGATGAGAC

Downstream 100 bases:

>100_bases
CATGGCGCTTACCCCAGATCAGATGCCTGACCGCGCCGAAGTGGTCTTCACCTGCAATGGCAAGGCGGTGGGCAAGATGC
GGAACGAGTTGGACGTGGCC

Product: fumarylacetoacetate (FAA) hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKIGTIHFQGRDRLVARLDDDQVLDLLEASGGDVHFVNTVAMIEAGPAALDKARAVLEDPPTRAVIALSQAEHRVPLRPV
QYRDCLVFEQHLINGFKQAEKMTGRPFAIPPVWYEQPIYYKGNRMSFIGHGQTVRWPAYSDYLDLELELAIIIGKEGADI
PRETAHEHIWGYTILNDVSARDAQMREMAGQLGPAKGKDFDTGNILGPWIVTADEVSHPAVLNMDVSVNGERWGGGTSAD
MQFDFAQIIAHISASERLFPGEVIGSGTVGTGCGLEIGKRLSDGDMMDLTIEKIGTLTNTIKKGA

Sequences:

>Translated_305_residues
MKIGTIHFQGRDRLVARLDDDQVLDLLEASGGDVHFVNTVAMIEAGPAALDKARAVLEDPPTRAVIALSQAEHRVPLRPV
QYRDCLVFEQHLINGFKQAEKMTGRPFAIPPVWYEQPIYYKGNRMSFIGHGQTVRWPAYSDYLDLELELAIIIGKEGADI
PRETAHEHIWGYTILNDVSARDAQMREMAGQLGPAKGKDFDTGNILGPWIVTADEVSHPAVLNMDVSVNGERWGGGTSAD
MQFDFAQIIAHISASERLFPGEVIGSGTVGTGCGLEIGKRLSDGDMMDLTIEKIGTLTNTIKKGA
>Mature_305_residues
MKIGTIHFQGRDRLVARLDDDQVLDLLEASGGDVHFVNTVAMIEAGPAALDKARAVLEDPPTRAVIALSQAEHRVPLRPV
QYRDCLVFEQHLINGFKQAEKMTGRPFAIPPVWYEQPIYYKGNRMSFIGHGQTVRWPAYSDYLDLELELAIIIGKEGADI
PRETAHEHIWGYTILNDVSARDAQMREMAGQLGPAKGKDFDTGNILGPWIVTADEVSHPAVLNMDVSVNGERWGGGTSAD
MQFDFAQIIAHISASERLFPGEVIGSGTVGTGCGLEIGKRLSDGDMMDLTIEKIGTLTNTIKKGA

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=188, Percent_Identity=37.2340425531915, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI40786394, Length=188, Percent_Identity=35.6382978723404, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557587, Length=255, Percent_Identity=28.2352941176471, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI215422413, Length=153, Percent_Identity=28.1045751633987, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI66348062, Length=153, Percent_Identity=28.1045751633987, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI13654274, Length=153, Percent_Identity=28.1045751633987, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787428, Length=156, Percent_Identity=30.7692307692308, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17568863, Length=300, Percent_Identity=26, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI28572127, Length=188, Percent_Identity=30.8510638297872, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24663695, Length=188, Percent_Identity=26.063829787234, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 33409; Mature: 33409

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGTIHFQGRDRLVARLDDDQVLDLLEASGGDVHFVNTVAMIEAGPAALDKARAVLEDP
CCEEEEEECCCCEEEEECCCHHHHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHCCC
PTRAVIALSQAEHRVPLRPVQYRDCLVFEQHLINGFKQAEKMTGRPFAIPPVWYEQPIYY
CCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEE
KGNRMSFIGHGQTVRWPAYSDYLDLELELAIIIGKEGADIPRETAHEHIWGYTILNDVSA
ECCEEEEEECCCEEECCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHCEEEEECCCCC
RDAQMREMAGQLGPAKGKDFDTGNILGPWIVTADEVSHPAVLNMDVSVNGERWGGGTSAD
HHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCC
MQFDFAQIIAHISASERLFPGEVIGSGTVGTGCGLEIGKRLSDGDMMDLTIEKIGTLTNT
CEECHHHHHHHHCCCCCCCCCCEECCCCCCCCCCHHHHCCCCCCCEEEEEHHHHHHHHHH
IKKGA
HHCCC
>Mature Secondary Structure
MKIGTIHFQGRDRLVARLDDDQVLDLLEASGGDVHFVNTVAMIEAGPAALDKARAVLEDP
CCEEEEEECCCCEEEEECCCHHHHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHCCC
PTRAVIALSQAEHRVPLRPVQYRDCLVFEQHLINGFKQAEKMTGRPFAIPPVWYEQPIYY
CCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEE
KGNRMSFIGHGQTVRWPAYSDYLDLELELAIIIGKEGADIPRETAHEHIWGYTILNDVSA
ECCEEEEEECCCEEECCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHCEEEEECCCCC
RDAQMREMAGQLGPAKGKDFDTGNILGPWIVTADEVSHPAVLNMDVSVNGERWGGGTSAD
HHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCC
MQFDFAQIIAHISASERLFPGEVIGSGTVGTGCGLEIGKRLSDGDMMDLTIEKIGTLTNT
CEECHHHHHHHHCCCCCCCCCCEECCCCCCCCCCHHHHCCCCCCCEEEEEHHHHHHHHHH
IKKGA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]