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The map label for this gene is yugH [H]

Identifier: 89054447

GI number: 89054447

Start: 1949481

End: 1950677

Strand: Reverse

Name: yugH [H]

Synonym: Jann_1956

Alternate gene names: 89054447

Gene position: 1950677-1949481 (Counterclockwise)

Preceding gene: 89054448

Following gene: 89054443

Centisome position: 45.18

GC content: 67.25

Gene sequence:

>1197_bases
ATGCCAGCCTTTTCCAAAAGAATTGCCGGATTGAACGGCGGAGGGGATGACGGCTGGGGCCTGTTCATCCGCGCGCGCCA
GATGAAGGATGCAGGCCAGCCGGTGCTGGAGCTGACCATCGGGGAGCATGACACGCGGACCGCACCCGACATTCTGGACG
CGATGATGACGTCGGCGCGGGGCGGGCATACGGGCTATGCCGCCGTGCCCGGCACCGATGCGCTGCGGGCGGCGGTGGCC
AAGCGATTGTCCACCTTCAGTGATCTGGCTTACGGCCCCGAGAACATCCTGATCACCCCCGGCGGCCAGTCGGCGCTGTT
TGCGGCCCATAGCCTGGCCTGCGATCCCGGTGACACCGCCCTTATGATCGACCCCCATTATGCCACCTATCCCGGCACGA
TCCGGGGTGTCAGTGCCGTGCCAAAGCCCGTCGTGGCCCACCCCGAGGACGGGTTTCAGCCGCGCGAGGCGGATCTGATG
GCGGCCAGTGAGGGGGCGAGAAGCCTGCTGATCAACACGCCCAACAATCCCACGGGGGCGGTCTATTCCGATGCCACGCT
GGATGGGATCGCGCGGGTCGCGGAGGCGCGTGATCTTTGGGTCATCTCTGACGAGGTCTATGACAGTCAGGTCTGGGACG
GGCGGCACCGGCCCTTCGCCAGCCTGCCCGGCATGTTCGCGCGGACGCTGAGTGTGGGGTCGCTGTCGAAAAGTCACGCG
ATGACGGGGTCGCGGCTGGGTTGGGTGGCGGGGCCTGCGCAGGCGATTGCGCATCTGATCAACCTGGCCACCAACACGAC
CTACGGCGTTCCGGGCTACATCCAGGATGCGGGCCTCTATGCCCTGTCGCTCGGGGCGGAGGCCGAGGCCGCTGTCGCCG
CCCCCTTCCGCCGTCGCCGCGATATGGTGCTGAGCCGTCTGGAGGGCCAACAGGCGATCGGCGCAATTCCACCGGCAGGC
GCGATGTACGTAATGCTGGATATCCGCGCTACGGGCCTGAGTGGGGAGGCCTTCGGCGAGGCGCTGCTGGACGAGGAACT
GGTGGCCGTCATGCCGGGAGAAAGTTTTGGGACGGCCGCCGCGGGCCATATCCGCGTGGCGCTGACCCTGCCCGATGACG
TGTTCGAAGTGGCGCTGGATCGCCTGTTCGCCTTTGCCGCCCGACGCATCGGCGCCGCGGCGGAGGCGACAGGTTAA

Upstream 100 bases:

>100_bases
GGCAATACGGGCGTGAGCTGATCGCCGAGCAAATGGGGTTGCGTCCGGTGTCCGACCCCCGCAACGTCGCGCCAGATATG
TCTGTTTCGGAGCCTGCCCC

Downstream 100 bases:

>100_bases
CGGCGTTAACGTTTGGCCGTTTCAACAGGTCGCCATGGCCAACGCCCTGGACCTTTGCATAAAAAAGGCCCGCCCCCAGG
TGCAGGGAGCGGGCCGATCA

Product: aminotransferase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MPAFSKRIAGLNGGGDDGWGLFIRARQMKDAGQPVLELTIGEHDTRTAPDILDAMMTSARGGHTGYAAVPGTDALRAAVA
KRLSTFSDLAYGPENILITPGGQSALFAAHSLACDPGDTALMIDPHYATYPGTIRGVSAVPKPVVAHPEDGFQPREADLM
AASEGARSLLINTPNNPTGAVYSDATLDGIARVAEARDLWVISDEVYDSQVWDGRHRPFASLPGMFARTLSVGSLSKSHA
MTGSRLGWVAGPAQAIAHLINLATNTTYGVPGYIQDAGLYALSLGAEAEAAVAAPFRRRRDMVLSRLEGQQAIGAIPPAG
AMYVMLDIRATGLSGEAFGEALLDEELVAVMPGESFGTAAAGHIRVALTLPDDVFEVALDRLFAFAARRIGAAAEATG

Sequences:

>Translated_398_residues
MPAFSKRIAGLNGGGDDGWGLFIRARQMKDAGQPVLELTIGEHDTRTAPDILDAMMTSARGGHTGYAAVPGTDALRAAVA
KRLSTFSDLAYGPENILITPGGQSALFAAHSLACDPGDTALMIDPHYATYPGTIRGVSAVPKPVVAHPEDGFQPREADLM
AASEGARSLLINTPNNPTGAVYSDATLDGIARVAEARDLWVISDEVYDSQVWDGRHRPFASLPGMFARTLSVGSLSKSHA
MTGSRLGWVAGPAQAIAHLINLATNTTYGVPGYIQDAGLYALSLGAEAEAAVAAPFRRRRDMVLSRLEGQQAIGAIPPAG
AMYVMLDIRATGLSGEAFGEALLDEELVAVMPGESFGTAAAGHIRVALTLPDDVFEVALDRLFAFAARRIGAAAEATG
>Mature_397_residues
PAFSKRIAGLNGGGDDGWGLFIRARQMKDAGQPVLELTIGEHDTRTAPDILDAMMTSARGGHTGYAAVPGTDALRAAVAK
RLSTFSDLAYGPENILITPGGQSALFAAHSLACDPGDTALMIDPHYATYPGTIRGVSAVPKPVVAHPEDGFQPREADLMA
ASEGARSLLINTPNNPTGAVYSDATLDGIARVAEARDLWVISDEVYDSQVWDGRHRPFASLPGMFARTLSVGSLSKSHAM
TGSRLGWVAGPAQAIAHLINLATNTTYGVPGYIQDAGLYALSLGAEAEAAVAAPFRRRRDMVLSRLEGQQAIGAIPPAGA
MYVMLDIRATGLSGEAFGEALLDEELVAVMPGESFGTAAAGHIRVALTLPDDVFEVALDRLFAFAARRIGAAAEATG

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=255, Percent_Identity=32.9411764705882, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI169881279, Length=255, Percent_Identity=32.9411764705882, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI56713254, Length=262, Percent_Identity=30.5343511450382, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI56713256, Length=262, Percent_Identity=30.5343511450382, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI169881281, Length=173, Percent_Identity=35.2601156069364, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4507369, Length=396, Percent_Identity=23.2323232323232, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1788722, Length=355, Percent_Identity=26.7605633802817, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786816, Length=330, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788627, Length=383, Percent_Identity=25.8485639686684, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787909, Length=352, Percent_Identity=25, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994472, Length=345, Percent_Identity=31.0144927536232, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71994476, Length=345, Percent_Identity=31.0144927536232, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17567369, Length=195, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17567663, Length=347, Percent_Identity=26.2247838616715, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322401, Length=397, Percent_Identity=22.4181360201511, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28573069, Length=341, Percent_Identity=27.8592375366569, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24646114, Length=341, Percent_Identity=27.8592375366569, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI28573067, Length=341, Percent_Identity=27.8592375366569, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI28573065, Length=341, Percent_Identity=27.8592375366569, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI18859735, Length=384, Percent_Identity=26.8229166666667, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 41594; Mature: 41463

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAFSKRIAGLNGGGDDGWGLFIRARQMKDAGQPVLELTIGEHDTRTAPDILDAMMTSAR
CCCHHHHHCCCCCCCCCCCEEEEEEEHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCC
GGHTGYAAVPGTDALRAAVAKRLSTFSDLAYGPENILITPGGQSALFAAHSLACDPGDTA
CCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCEE
LMIDPHYATYPGTIRGVSAVPKPVVAHPEDGFQPREADLMAASEGARSLLINTPNNPTGA
EEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCC
VYSDATLDGIARVAEARDLWVISDEVYDSQVWDGRHRPFASLPGMFARTLSVGSLSKSHA
EECCCHHHHHHHHHHCCCEEEEECHHHCCHHCCCCCCCHHHCCHHHHHHHHHCCCCHHHC
MTGSRLGWVAGPAQAIAHLINLATNTTYGVPGYIQDAGLYALSLGAEAEAAVAAPFRRRR
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHH
DMVLSRLEGQQAIGAIPPAGAMYVMLDIRATGLSGEAFGEALLDEELVAVMPGESFGTAA
HHHHHHHCCCHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCCC
AGHIRVALTLPDDVFEVALDRLFAFAARRIGAAAEATG
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure 
PAFSKRIAGLNGGGDDGWGLFIRARQMKDAGQPVLELTIGEHDTRTAPDILDAMMTSAR
CCHHHHHCCCCCCCCCCCEEEEEEEHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCC
GGHTGYAAVPGTDALRAAVAKRLSTFSDLAYGPENILITPGGQSALFAAHSLACDPGDTA
CCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCEE
LMIDPHYATYPGTIRGVSAVPKPVVAHPEDGFQPREADLMAASEGARSLLINTPNNPTGA
EEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCC
VYSDATLDGIARVAEARDLWVISDEVYDSQVWDGRHRPFASLPGMFARTLSVGSLSKSHA
EECCCHHHHHHHHHHCCCEEEEECHHHCCHHCCCCCCCHHHCCHHHHHHHHHCCCCHHHC
MTGSRLGWVAGPAQAIAHLINLATNTTYGVPGYIQDAGLYALSLGAEAEAAVAAPFRRRR
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHH
DMVLSRLEGQQAIGAIPPAGAMYVMLDIRATGLSGEAFGEALLDEELVAVMPGESFGTAA
HHHHHHHCCCHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCCC
AGHIRVALTLPDDVFEVALDRLFAFAARRIGAAAEATG
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]