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The map label for this gene is glcD [H]

Identifier: 89054428

GI number: 89054428

Start: 1927282

End: 1928736

Strand: Direct

Name: glcD [H]

Synonym: Jann_1937

Alternate gene names: 89054428

Gene position: 1927282-1928736 (Clockwise)

Preceding gene: 89054427

Following gene: 89054429

Centisome position: 44.63

GC content: 64.47

Gene sequence:

>1455_bases
ATGGCACTGCTTGCAGATCTGCCGCGCAATGAGGATGGAATTGCCGCAACTTTGGGCATTTTGACCCAGATGTTCGGCCC
GCGGGTGGAACAGGGTCAGGCGCTGCGGGATCAGCACGGGCACACAACGACCTGGCTGCGCAATCAGCCGCCCGATGCGG
TGATCTTTCCCGAGACGACGCAGGAGGTGCAGGAGATCGTGCGGGTCTGCGCCACCCATCGCGTGCCGATTATCCCCTTC
GGCACCGGCACGTCCCTTGAGGGGCATGTGAATGCGCCTGCCGGTGGAATATCCATCGATTTCAGTCAGATGGACGCCAT
TCTTGATGTGCATGCGGAAGATATGGACGTGGTGATCCAGCCCGGCGTCACCCGCAAGGCGCTCAACACCCACCTCCGCG
ACACGGGCCTGTTTTTCCCGATTGATCCCGGGGCCGATGCGTCGCTTGGCGGGATGGCGGCCACGCGGGCCAGCGGCACC
TGCGCGGTGCGTTACGGGACCATGAAGGACAATGTTCTGGCGCTGAAGGCGGTGATGCCGTCGGGCGAGGTGATCCAGAC
GGCGGCGCGGGCGCGCAAGACATCGGCCGGGTATGATCTGACCCGGCTGATGGTGGGCTCGGAAGGGACGCTTGGCCTGA
TCACCGAGTTGACCTTGAAGCTGCACGGCATTCCGGAGGCGACGTCTGCGGCGACCTGTTCCTTCCCCAGCGTGGAGGCC
GCATGCACCGCCGTCATCGCCTGTTTCCAATATGGCCTGCCGCTGGCGCGGATTGAGCTGCTCAACGCCCTGCAAGTGCG
CGCCTGCAATGCCTATTCCAACCTCTCCCTGCCCGAAACACCCCTTCTGTTGCTGGAATTCCACGGGTCCGAGACCGGCG
TGACCGAACAGGCCGAGGCCTTCGGAGACATCGCCGGCGATTGCGGCGGGACCGGCTTCACCTTCACCACGCGGGAGGAG
GAGCGGACCAAGCTGTGGCAGGCCCGCCACGATGCCTATTGGGCCGCGCTGCAACTGCGTCCCGGGGCGCGCGGCATCTC
CACTGACGTCTGCGTTCCGATCAGCCGCCTGGCCGATTGCGTCACCCGGACGGAGGCGAAACTGGCCGAATTGGACTTCA
CCGCCCCCATCGTGGGCCATGCGGGCGACGGCAATTTTCACACGCTGCTGCTGGTGGATATGGAGAACCCCGAAGAGATC
GCCAGGGCGGAGGGCTATGTGGGCTGGCTGGCGGATCTGGCGATTTCGATGGACGGGACCTGCACTGGCGAACATGGTAT
CGGTCAGGGCAAGGCCAAGTATCTGGAGCGGGAGATTGGCCCCGGCGCGATGGATGTGATGGCCGCAATCAAGCGCGGCA
TTGACCCGCACAACATCTTCAATCCAGGAAAGATGAACCTGCCGCCCCTTGGGGACACGGACCTGTCGTCCCCCCAGGGC
AAGGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
GAGGTTGGATGTGCGTTTCTTGGGCAAGATGAAAGACGGGCGTTGAGGCGTCCGCGCGGGCTTTGTACGGTGAGGGCACG
CGACCTGGGAGGGACCGACC

Downstream 100 bases:

>100_bases
CCCATGGTGCGCCCCACGGCCTCCAACGTCCCCTCCGCCCATGCCGAGCCGCATCTGTCCGGCCGGGCGGGCTGGCTGCG
GGCGGCGGTCATGGGGGCCA

Product: D-lactate dehydrogenase (cytochrome)

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MALLADLPRNEDGIAATLGILTQMFGPRVEQGQALRDQHGHTTTWLRNQPPDAVIFPETTQEVQEIVRVCATHRVPIIPF
GTGTSLEGHVNAPAGGISIDFSQMDAILDVHAEDMDVVIQPGVTRKALNTHLRDTGLFFPIDPGADASLGGMAATRASGT
CAVRYGTMKDNVLALKAVMPSGEVIQTAARARKTSAGYDLTRLMVGSEGTLGLITELTLKLHGIPEATSAATCSFPSVEA
ACTAVIACFQYGLPLARIELLNALQVRACNAYSNLSLPETPLLLLEFHGSETGVTEQAEAFGDIAGDCGGTGFTFTTREE
ERTKLWQARHDAYWAALQLRPGARGISTDVCVPISRLADCVTRTEAKLAELDFTAPIVGHAGDGNFHTLLLVDMENPEEI
ARAEGYVGWLADLAISMDGTCTGEHGIGQGKAKYLEREIGPGAMDVMAAIKRGIDPHNIFNPGKMNLPPLGDTDLSSPQG
KAAR

Sequences:

>Translated_484_residues
MALLADLPRNEDGIAATLGILTQMFGPRVEQGQALRDQHGHTTTWLRNQPPDAVIFPETTQEVQEIVRVCATHRVPIIPF
GTGTSLEGHVNAPAGGISIDFSQMDAILDVHAEDMDVVIQPGVTRKALNTHLRDTGLFFPIDPGADASLGGMAATRASGT
CAVRYGTMKDNVLALKAVMPSGEVIQTAARARKTSAGYDLTRLMVGSEGTLGLITELTLKLHGIPEATSAATCSFPSVEA
ACTAVIACFQYGLPLARIELLNALQVRACNAYSNLSLPETPLLLLEFHGSETGVTEQAEAFGDIAGDCGGTGFTFTTREE
ERTKLWQARHDAYWAALQLRPGARGISTDVCVPISRLADCVTRTEAKLAELDFTAPIVGHAGDGNFHTLLLVDMENPEEI
ARAEGYVGWLADLAISMDGTCTGEHGIGQGKAKYLEREIGPGAMDVMAAIKRGIDPHNIFNPGKMNLPPLGDTDLSSPQG
KAAR
>Mature_483_residues
ALLADLPRNEDGIAATLGILTQMFGPRVEQGQALRDQHGHTTTWLRNQPPDAVIFPETTQEVQEIVRVCATHRVPIIPFG
TGTSLEGHVNAPAGGISIDFSQMDAILDVHAEDMDVVIQPGVTRKALNTHLRDTGLFFPIDPGADASLGGMAATRASGTC
AVRYGTMKDNVLALKAVMPSGEVIQTAARARKTSAGYDLTRLMVGSEGTLGLITELTLKLHGIPEATSAATCSFPSVEAA
CTAVIACFQYGLPLARIELLNALQVRACNAYSNLSLPETPLLLLEFHGSETGVTEQAEAFGDIAGDCGGTGFTFTTREEE
RTKLWQARHDAYWAALQLRPGARGISTDVCVPISRLADCVTRTEAKLAELDFTAPIVGHAGDGNFHTLLLVDMENPEEIA
RAEGYVGWLADLAISMDGTCTGEHGIGQGKAKYLEREIGPGAMDVMAAIKRGIDPHNIFNPGKMNLPPLGDTDLSSPQGK
AAR

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=443, Percent_Identity=51.2415349887133, Blast_Score=464, Evalue=1e-130,
Organism=Homo sapiens, GI37595754, Length=466, Percent_Identity=48.7124463519313, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI119964728, Length=433, Percent_Identity=29.5612009237875, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI4501993, Length=468, Percent_Identity=26.0683760683761, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1789351, Length=424, Percent_Identity=31.3679245283019, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1787977, Length=514, Percent_Identity=27.0428015564202, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI48994907, Length=174, Percent_Identity=29.8850574712644, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI48994914, Length=214, Percent_Identity=25.2336448598131, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71992373, Length=465, Percent_Identity=45.1612903225806, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71992381, Length=465, Percent_Identity=43.6559139784946, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71992392, Length=380, Percent_Identity=48.6842105263158, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17556096, Length=483, Percent_Identity=25.0517598343685, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17534361, Length=446, Percent_Identity=26.6816143497758, Blast_Score=126, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320027, Length=463, Percent_Identity=36.2850971922246, Blast_Score=295, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6320023, Length=449, Percent_Identity=27.8396436525612, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320764, Length=472, Percent_Identity=24.364406779661, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI18921117, Length=448, Percent_Identity=27.2321428571429, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24639277, Length=448, Percent_Identity=27.2321428571429, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24639275, Length=448, Percent_Identity=27.2321428571429, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24653753, Length=490, Percent_Identity=26.1224489795918, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 51493; Mature: 51362

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLADLPRNEDGIAATLGILTQMFGPRVEQGQALRDQHGHTTTWLRNQPPDAVIFPETT
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCEEECCCCH
QEVQEIVRVCATHRVPIIPFGTGTSLEGHVNAPAGGISIDFSQMDAILDVHAEDMDVVIQ
HHHHHHHHHHHHCCCEEEECCCCCCCCCEECCCCCCEEEEHHHHHHHHHCCCCCCEEEEC
PGVTRKALNTHLRDTGLFFPIDPGADASLGGMAATRASGTCAVRYGTMKDNVLALKAVMP
CCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCEEECCCCEEEEEECCCCCCEEEEEEECC
SGEVIQTAARARKTSAGYDLTRLMVGSEGTLGLITELTLKLHGIPEATSAATCSFPSVEA
CCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEHHEEEEEEECCCCCCCCCCCCCCCCHHH
ACTAVIACFQYGLPLARIELLNALQVRACNAYSNLSLPETPLLLLEFHGSETGVTEQAEA
HHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEECCCCCCCCHHHHH
FGDIAGDCGGTGFTFTTREEERTKLWQARHDAYWAALQLRPGARGISTDVCVPISRLADC
HHHHCCCCCCCCCEEECCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHH
VTRTEAKLAELDFTAPIVGHAGDGNFHTLLLVDMENPEEIARAEGYVGWLADLAISMDGT
HHHHHHHHHHCCCCCCEEECCCCCCEEEEEEEECCCHHHHHHHCCCHHHHHHHHEECCCC
CTGEHGIGQGKAKYLEREIGPGAMDVMAAIKRGIDPHNIFNPGKMNLPPLGDTDLSSPQG
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KAAR
CCCC
>Mature Secondary Structure 
ALLADLPRNEDGIAATLGILTQMFGPRVEQGQALRDQHGHTTTWLRNQPPDAVIFPETT
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCEEECCCCH
QEVQEIVRVCATHRVPIIPFGTGTSLEGHVNAPAGGISIDFSQMDAILDVHAEDMDVVIQ
HHHHHHHHHHHHCCCEEEECCCCCCCCCEECCCCCCEEEEHHHHHHHHHCCCCCCEEEEC
PGVTRKALNTHLRDTGLFFPIDPGADASLGGMAATRASGTCAVRYGTMKDNVLALKAVMP
CCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCEEECCCCEEEEEECCCCCCEEEEEEECC
SGEVIQTAARARKTSAGYDLTRLMVGSEGTLGLITELTLKLHGIPEATSAATCSFPSVEA
CCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEHHEEEEEEECCCCCCCCCCCCCCCCHHH
ACTAVIACFQYGLPLARIELLNALQVRACNAYSNLSLPETPLLLLEFHGSETGVTEQAEA
HHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEECCCCCCCCHHHHH
FGDIAGDCGGTGFTFTTREEERTKLWQARHDAYWAALQLRPGARGISTDVCVPISRLADC
HHHHCCCCCCCCCEEECCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHH
VTRTEAKLAELDFTAPIVGHAGDGNFHTLLLVDMENPEEIARAEGYVGWLADLAISMDGT
HHHHHHHHHHCCCCCCEEECCCCCCEEEEEEEECCCHHHHHHHCCCHHHHHHHHEECCCC
CTGEHGIGQGKAKYLEREIGPGAMDVMAAIKRGIDPHNIFNPGKMNLPPLGDTDLSSPQG
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KAAR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]