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The map label for this gene is tyrS [H]

Identifier: 89054283

GI number: 89054283

Start: 1778873

End: 1779667

Strand: Reverse

Name: tyrS [H]

Synonym: Jann_1792

Alternate gene names: 89054283

Gene position: 1779667-1778873 (Counterclockwise)

Preceding gene: 89054285

Following gene: 89054282

Centisome position: 41.22

GC content: 61.51

Gene sequence:

>795_bases
TTGCTGGCGTTCGATAGTGTGAAATCACGGCTGGACCGCGAGCAGGCGCTGAGTTTTATCGAGTTCAACTACATGCTGTT
GCAGGCCTACGATTACCTTGAATTGTACCGCCGCCATGGCTGCGTGTTGCAGATGGGCGGCTCCGACCAATGGGGCAACA
TCGTCTCCGGCGCAGACCTGATCCGGCGCGTGGATGCGGGGGAGGCTTTCGGGCTGACAACTCCGCTGGTGACCCGCGCG
GACGGGAAGAAAATGGGCAAGTCTGCGGATGGCGCTGTCTGGTTGAACGAAGACCGGATGTCCTCCTACGAGTTCTGGCA
ATGGTGGCGCAATGTGGACGACGCGGATGTCGCCAAGCTCCTGAAATTGTTCACCGAACTGGATGTGGCGGAGTGTGACC
GTTTGGGGGCGCTGGAAGGGTCTGACATCAACTCCGCCAAGATCATTCTCGCCAACGAAGTGACCACGCTGTGCCACGGG
GCGGAGGCTGCCGCAGCGGCGGAGGCCACCGCGCGCGAGGTGTTTGAGAAGGGCGGCACGGGTGACGATTTGCCAACGCT
GGAACTGAACACGGAGGAGGTCGGTGATGGCATCTCCATCGTGCAGCTGATCACGCGCTCGGGCCTTGCGAAATCCGGCA
AGGACGCCAAGCGTTTGATTGCTGAAGGGGGCGCGCGGTTGAATGACGAGGCCATTGCAGAGGCCGGTTTGATGGTCGGC
GCCAGCGATCTGGGCGCGCCGATCAAGCTGAGCGCGGGCAAAAAGCGCCATGCGCTGGTGGTGCTGAAGGACTAG

Upstream 100 bases:

>100_bases
ACCCACGGACAGCCCATTGGTCAACAACGCCGAATGGCTCGACAAACTGGGTTACATCGATTTCCTGCGCGATATCGGAA
AACATTTTACGATCAATCGC

Downstream 100 bases:

>100_bases
GCTGGTTTTCGGCGGCGTTAACCATTGCTTCATCGAATCGGGATCAATGTTCCCCCTATGTTCGATGCCCTGCCCGAGTT
TCATCGCCCACCTTCCCTGC

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MLAFDSVKSRLDREQALSFIEFNYMLLQAYDYLELYRRHGCVLQMGGSDQWGNIVSGADLIRRVDAGEAFGLTTPLVTRA
DGKKMGKSADGAVWLNEDRMSSYEFWQWWRNVDDADVAKLLKLFTELDVAECDRLGALEGSDINSAKIILANEVTTLCHG
AEAAAAAEATAREVFEKGGTGDDLPTLELNTEEVGDGISIVQLITRSGLAKSGKDAKRLIAEGGARLNDEAIAEAGLMVG
ASDLGAPIKLSAGKKRHALVVLKD

Sequences:

>Translated_264_residues
MLAFDSVKSRLDREQALSFIEFNYMLLQAYDYLELYRRHGCVLQMGGSDQWGNIVSGADLIRRVDAGEAFGLTTPLVTRA
DGKKMGKSADGAVWLNEDRMSSYEFWQWWRNVDDADVAKLLKLFTELDVAECDRLGALEGSDINSAKIILANEVTTLCHG
AEAAAAAEATAREVFEKGGTGDDLPTLELNTEEVGDGISIVQLITRSGLAKSGKDAKRLIAEGGARLNDEAIAEAGLMVG
ASDLGAPIKLSAGKKRHALVVLKD
>Mature_264_residues
MLAFDSVKSRLDREQALSFIEFNYMLLQAYDYLELYRRHGCVLQMGGSDQWGNIVSGADLIRRVDAGEAFGLTTPLVTRA
DGKKMGKSADGAVWLNEDRMSSYEFWQWWRNVDDADVAKLLKLFTELDVAECDRLGALEGSDINSAKIILANEVTTLCHG
AEAAAAAEATAREVFEKGGTGDDLPTLELNTEEVGDGISIVQLITRSGLAKSGKDAKRLIAEGGARLNDEAIAEAGLMVG
ASDLGAPIKLSAGKKRHALVVLKD

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=280, Percent_Identity=32.5, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI1787925, Length=282, Percent_Identity=39.0070921985816, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25145802, Length=180, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25145805, Length=180, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6325160, Length=181, Percent_Identity=40.3314917127072, Blast_Score=149, Evalue=4e-37,
Organism=Drosophila melanogaster, GI20130383, Length=279, Percent_Identity=37.6344086021505, Blast_Score=168, Evalue=3e-42,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 28540; Mature: 28540

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAFDSVKSRLDREQALSFIEFNYMLLQAYDYLELYRRHGCVLQMGGSDQWGNIVSGADL
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHH
IRRVDAGEAFGLTTPLVTRADGKKMGKSADGAVWLNEDRMSSYEFWQWWRNVDDADVAKL
HHHHCCCCCCCCCCCCEECCCCHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHH
LKLFTELDVAECDRLGALEGSDINSAKIILANEVTTLCHGAEAAAAAEATAREVFEKGGT
HHHHHHCCHHHHHHCCCCCCCCCCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHCCCC
GDDLPTLELNTEEVGDGISIVQLITRSGLAKSGKDAKRLIAEGGARLNDEAIAEAGLMVG
CCCCCEEEECHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHEEC
ASDLGAPIKLSAGKKRHALVVLKD
HHHCCCCEEECCCCCEEEEEEEEC
>Mature Secondary Structure
MLAFDSVKSRLDREQALSFIEFNYMLLQAYDYLELYRRHGCVLQMGGSDQWGNIVSGADL
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHH
IRRVDAGEAFGLTTPLVTRADGKKMGKSADGAVWLNEDRMSSYEFWQWWRNVDDADVAKL
HHHHCCCCCCCCCCCCEECCCCHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHH
LKLFTELDVAECDRLGALEGSDINSAKIILANEVTTLCHGAEAAAAAEATAREVFEKGGT
HHHHHHCCHHHHHHCCCCCCCCCCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHCCCC
GDDLPTLELNTEEVGDGISIVQLITRSGLAKSGKDAKRLIAEGGARLNDEAIAEAGLMVG
CCCCCEEEECHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHEEC
ASDLGAPIKLSAGKKRHALVVLKD
HHHCCCCEEECCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA