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The map label for this gene is pdhA [H]

Identifier: 89054182

GI number: 89054182

Start: 1673781

End: 1674824

Strand: Reverse

Name: pdhA [H]

Synonym: Jann_1691

Alternate gene names: 89054182

Gene position: 1674824-1673781 (Counterclockwise)

Preceding gene: 89054183

Following gene: 89054181

Centisome position: 38.79

GC content: 61.59

Gene sequence:

>1044_bases
ATGGCTGCACGCAAGACGACCGCCAAAGAGGCTGCCGATGACCAGACAGGGCCATCGAATGTCTCAGCAGATGAGCTGAA
AACCTACTACCGGGAGATGCTCTTGATCCGCCGGTTCGAAGAGAAGGCGGGCCAGCTTTATGGCATGGGCCTGATCGGCG
GGTTTTGCCACCTCTACATCGGACAGGAAGCGGTCGTTGTGGGCCTTGAGGCTGCGGCAGAAGAGGGCGACAAGCGCGTC
ACCTCCTACCGCGACCACGGTCATATGCTCGCCTGCGGCATGGACCCCAAGGGCGTCATGGCCGAGTTGACGGGCCGTGA
GGGGGGCTATTCCAAGGGCAAGGGCGGGAGCATGCATATGTTCTCCAAGGAAAAGCACTTCTACGGCGGGCACGGCATCG
TCGCCGCGCAGGTCCCCATCGGGGCGGGTCTGGCCTTTGCGGACAAATACCTGGGCAATGACCGCGTGACCTTCACCTAT
TTCGGCGACGGCGCGGCCAACCAGGGCCAGGTCTATGAGGCCTACAACATGGCCGAAATCTGGGGCCTGCCCTGCATTTT
CGTCATTGAAAACAACCAATACGCCATGGGCACCTCCACCAAACGCTCCACCCATTCGCCGTCCTACTGGGAGCGTGGGG
CCGCTTACGGCATCCCGGGCGAAGAGGTCGACGGCATGGATGTGCTGGCCGTGAAGGCCGCCGGTGAGAAGGCCGTTGCC
CACTGCCGCGCGGGCAAGGGGCCGTATATCCTTGAGATCAAGACCTACCGCTACCGGGGCCATTCCATGTCCGATCCGGC
GAAATACCGGACCCGCGAGGAAGTGCAGGAGATGCGGGAGAAACGCGACGCGATTGAACATGTCCGCCAGATGCTGCTGA
CCGGCGGCCACGCGTCCGAGGATGACCTCAAGGCCATCGACAAAGAGATCAAGGAAATCGTCAACGCCTCCGCCGAGTTC
GCCAAGGAAAGCCCGGAGCCCGCGTTAGAAGAGCTGTGGACCGACATCTACGCAAAAGAAATCCCGCAGGGGGAGGCTGT
ATAA

Upstream 100 bases:

>100_bases
TGCCCCTGCGTCAGCTTTACCGGAAGACTCTTTGCGCTAGCTCTGCTAAATGATTGTTCAACGTTAAACTATTCCAATAC
CGGAAGGGGAGTGGCGCAGA

Downstream 100 bases:

>100_bases
ATGGCTGTAGAAATTCTGATGCCCGCCCTGTCCCCCACGATGGAAGAGGGCACCCTGGCCAAGTGGCTGGTCAAGGAAGG
CGACACCGTTCAGTCCGGCG

Product: pyruvate dehydrogenase (lipoamide)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MAARKTTAKEAADDQTGPSNVSADELKTYYREMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLEAAAEEGDKRV
TSYRDHGHMLACGMDPKGVMAELTGREGGYSKGKGGSMHMFSKEKHFYGGHGIVAAQVPIGAGLAFADKYLGNDRVTFTY
FGDGAANQGQVYEAYNMAEIWGLPCIFVIENNQYAMGTSTKRSTHSPSYWERGAAYGIPGEEVDGMDVLAVKAAGEKAVA
HCRAGKGPYILEIKTYRYRGHSMSDPAKYRTREEVQEMREKRDAIEHVRQMLLTGGHASEDDLKAIDKEIKEIVNASAEF
AKESPEPALEELWTDIYAKEIPQGEAV

Sequences:

>Translated_347_residues
MAARKTTAKEAADDQTGPSNVSADELKTYYREMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLEAAAEEGDKRV
TSYRDHGHMLACGMDPKGVMAELTGREGGYSKGKGGSMHMFSKEKHFYGGHGIVAAQVPIGAGLAFADKYLGNDRVTFTY
FGDGAANQGQVYEAYNMAEIWGLPCIFVIENNQYAMGTSTKRSTHSPSYWERGAAYGIPGEEVDGMDVLAVKAAGEKAVA
HCRAGKGPYILEIKTYRYRGHSMSDPAKYRTREEVQEMREKRDAIEHVRQMLLTGGHASEDDLKAIDKEIKEIVNASAEF
AKESPEPALEELWTDIYAKEIPQGEAV
>Mature_346_residues
AARKTTAKEAADDQTGPSNVSADELKTYYREMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLEAAAEEGDKRVT
SYRDHGHMLACGMDPKGVMAELTGREGGYSKGKGGSMHMFSKEKHFYGGHGIVAAQVPIGAGLAFADKYLGNDRVTFTYF
GDGAANQGQVYEAYNMAEIWGLPCIFVIENNQYAMGTSTKRSTHSPSYWERGAAYGIPGEEVDGMDVLAVKAAGEKAVAH
CRAGKGPYILEIKTYRYRGHSMSDPAKYRTREEVQEMREKRDAIEHVRQMLLTGGHASEDDLKAIDKEIKEIVNASAEFA
KESPEPALEELWTDIYAKEIPQGEAV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=313, Percent_Identity=54.3130990415335, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI291084742, Length=320, Percent_Identity=54.375, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI4505685, Length=320, Percent_Identity=54.375, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI291084744, Length=327, Percent_Identity=53.2110091743119, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI291084757, Length=320, Percent_Identity=48.125, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI11386135, Length=314, Percent_Identity=31.8471337579618, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI258645172, Length=314, Percent_Identity=31.8471337579618, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=315, Percent_Identity=52.0634920634921, Blast_Score=314, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI17536047, Length=315, Percent_Identity=52.0634920634921, Blast_Score=314, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI86563355, Length=291, Percent_Identity=31.6151202749141, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI86563357, Length=291, Percent_Identity=31.6151202749141, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321026, Length=365, Percent_Identity=46.027397260274, Blast_Score=309, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24639744, Length=329, Percent_Identity=49.8480243161094, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI28571106, Length=329, Percent_Identity=49.8480243161094, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24639740, Length=329, Percent_Identity=49.8480243161094, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24639746, Length=310, Percent_Identity=51.2903225806452, Blast_Score=320, Evalue=8e-88,
Organism=Drosophila melanogaster, GI24639748, Length=333, Percent_Identity=48.048048048048, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI21355903, Length=332, Percent_Identity=27.1084337349398, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38119; Mature: 37988

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARKTTAKEAADDQTGPSNVSADELKTYYREMLLIRRFEEKAGQLYGMGLIGGFCHLYI
CCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHC
GQEAVVVGLEAAAEEGDKRVTSYRDHGHMLACGMDPKGVMAELTGREGGYSKGKGGSMHM
CCCEEEEEHHHHHHCCHHHHHHHCCCCCEEEECCCCCCHHHEECCCCCCCCCCCCCCEEE
FSKEKHFYGGHGIVAAQVPIGAGLAFADKYLGNDRVTFTYFGDGAANQGQVYEAYNMAEI
EECCCCEECCCEEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCEEEHHCHHHH
WGLPCIFVIENNQYAMGTSTKRSTHSPSYWERGAAYGIPGEEVDGMDVLAVKAAGEKAVA
HCCCEEEEEECCEEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHH
HCRAGKGPYILEIKTYRYRGHSMSDPAKYRTREEVQEMREKRDAIEHVRQMLLTGGHASE
HHCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DDLKAIDKEIKEIVNASAEFAKESPEPALEELWTDIYAKEIPQGEAV
HHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AARKTTAKEAADDQTGPSNVSADELKTYYREMLLIRRFEEKAGQLYGMGLIGGFCHLYI
CCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHC
GQEAVVVGLEAAAEEGDKRVTSYRDHGHMLACGMDPKGVMAELTGREGGYSKGKGGSMHM
CCCEEEEEHHHHHHCCHHHHHHHCCCCCEEEECCCCCCHHHEECCCCCCCCCCCCCCEEE
FSKEKHFYGGHGIVAAQVPIGAGLAFADKYLGNDRVTFTYFGDGAANQGQVYEAYNMAEI
EECCCCEECCCEEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCEEEHHCHHHH
WGLPCIFVIENNQYAMGTSTKRSTHSPSYWERGAAYGIPGEEVDGMDVLAVKAAGEKAVA
HCCCEEEEEECCEEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHH
HCRAGKGPYILEIKTYRYRGHSMSDPAKYRTREEVQEMREKRDAIEHVRQMLLTGGHASE
HHCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DDLKAIDKEIKEIVNASAEFAKESPEPALEELWTDIYAKEIPQGEAV
HHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]