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The map label for this gene is ilvB [H]

Identifier: 89053897

GI number: 89053897

Start: 1374880

End: 1376571

Strand: Direct

Name: ilvB [H]

Synonym: Jann_1406

Alternate gene names: 89053897

Gene position: 1374880-1376571 (Clockwise)

Preceding gene: 89053894

Following gene: 89053899

Centisome position: 31.84

GC content: 65.6

Gene sequence:

>1692_bases
ATGGACAATCAGATGAACGGGGCGGACGCGCTGGTTGGTATGCTCAAGGCCCATGGCGTGCGGCATATCTTCGGCCTTTG
TGGCGATACCTCGCTGCCGTTCTACGATTCCATGCGCGCCCATGGCGGTAACATCACCCATGTGCTGACCCGCGATGAGC
GCTCCGCCACTTACATGGCGGACGGTTATTCCCGCGTCACAGGCCGCCCCGGCGTGGCGGAAGGGCCGTCGGGCGGCGGC
GCGACCTACATCCTTCCCGGCCTGATCGAAGCGTCGGAATCCTCCTACGCCGTCCTTGGCATCACAACGGATATCAGCGT
CGGCACCTACGGCAAATACCCCCTGACGGAGGTGGATCAAAACGCGCTGATGGCGCCCGTGACCAAATGGAACAGCGTCA
TCGTCCAGGCGGCCCACATCCCCCGCATGGTGCGCAAGGCGTTCCGTGCCATGACAACCGGGCGCGCGGGCGCGGCGCAT
CTGGGGCTGCCCTACGACATCCAGTATGACCCCGTGGACTCCAGTGATATCTGGGCCGATCCCAAACACGCGACGTACCC
GGCCTATCCCCAGGCGCCCGAGCCCGGCGCGGCGGAGGCAGCGGTGGACGCGATCTTAAGCGCAAAGAATCCGCTCATCG
TCTGCGGCGGCGGCGTGGTGATCGCAGGCGCGATGGAGGAGCTTGCGCGTCTGGCAAACCGCCTCGACATCCCCGTCGCG
ACGTCGATCAGCGGGCAGGGGAGCCTGGCGGATACGGACCCGATGTCCCTTGGCGTCGTGGGCTCCAACGGTGGCACGGA
TGAGACGTGGGAAGCGATGGAGGCCGCCGACCTGGTGATTTTTATGGGCGCGCGGGCAGGCTCCACCACCACGGCCCGGT
GGGAGGCCCCGAAACCCGGCGCGCGCGTGGTGCATTTTGACAGCGACCCAATGGTGATCGGTGCGAATTACCCGACGGAG
GTGGGCGTCGTGGGCGATCTGCGCCTCTCACTCCAGGCCGTGAACGCGGTCTTGGACGCGCGCGGACAGGGAGCCACGAC
GTTCGGCGGCGCGCAAGCTGTCGCTGACATCAAGGCGCGCAAATTCGCCCGCTTCAATGCCTTAGCAACCAGCGACGAGA
CCCCGATCCGGCCGGAGCGCGTCGTGGCCACCCTCAACCGCATTCTGCCCGAAGATGCCACCATCGTCTCGGACCCCGGC
ACATCCTGCCCGTATGTCTCGGCCTACTACCAGCATGCAAAGGCTGGCCGCTTCTTCATCACCAATCGCGCCCACGGGGC
ACTTGGCTATTCGCTGTCGGCATCGCTCGGCGCGTGGTTCGGGCGGCCCACGTCAAAGGTCGTGGCGCTGATGGGCGACG
GGTCCTTCGGGTTCACCTGCGGCGAGTTGGAGACGGTCACGCGGGCGCGCGCAAACATCACCTTCGTGGTGTTCTCCAAC
GCCAACTTCGGGTGGATCAAGGCCAGCCAGATGGCCGACAAGGGATCGCGTTACTACAACGTGGATTTCAACCGAGTGGA
TCACGCCGCGGTGGCCAGTGCTTATGGCGTGAAGGCGTGGCGGGTAGACGACCCCGGCGCATTGGAGGCGACGCTAACGG
AGGCGATTGATCATGACGGTCCGACCCTGGTGGACATCATCGCGCAGCCATTGGAAGAGGCGGCCGCCCCGGTGCGGCGT
TGGATGGGCTGA

Upstream 100 bases:

>100_bases
GCTTTCCGGTGTACTATCCATCCCGCGACCATGAAATCCGCGCTTGAGTTTTGCAAGGTATATTGCTCTGTATACAGCAC
GTAATGCAAGGAGGGGAATA

Downstream 100 bases:

>100_bases
CACGGCGTCTGTCGCTTTGGGCGATTCCTGTCAGCAGGAGGTCAAGGAAATCAAGCGCCAATGTGGACAGGGGCCGCGTG
GCCGATGTGATCACCATCAT

Product: acetolactate synthase, large subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 563; Mature: 563

Protein sequence:

>563_residues
MDNQMNGADALVGMLKAHGVRHIFGLCGDTSLPFYDSMRAHGGNITHVLTRDERSATYMADGYSRVTGRPGVAEGPSGGG
ATYILPGLIEASESSYAVLGITTDISVGTYGKYPLTEVDQNALMAPVTKWNSVIVQAAHIPRMVRKAFRAMTTGRAGAAH
LGLPYDIQYDPVDSSDIWADPKHATYPAYPQAPEPGAAEAAVDAILSAKNPLIVCGGGVVIAGAMEELARLANRLDIPVA
TSISGQGSLADTDPMSLGVVGSNGGTDETWEAMEAADLVIFMGARAGSTTTARWEAPKPGARVVHFDSDPMVIGANYPTE
VGVVGDLRLSLQAVNAVLDARGQGATTFGGAQAVADIKARKFARFNALATSDETPIRPERVVATLNRILPEDATIVSDPG
TSCPYVSAYYQHAKAGRFFITNRAHGALGYSLSASLGAWFGRPTSKVVALMGDGSFGFTCGELETVTRARANITFVVFSN
ANFGWIKASQMADKGSRYYNVDFNRVDHAAVASAYGVKAWRVDDPGALEATLTEAIDHDGPTLVDIIAQPLEEAAAPVRR
WMG

Sequences:

>Translated_563_residues
MDNQMNGADALVGMLKAHGVRHIFGLCGDTSLPFYDSMRAHGGNITHVLTRDERSATYMADGYSRVTGRPGVAEGPSGGG
ATYILPGLIEASESSYAVLGITTDISVGTYGKYPLTEVDQNALMAPVTKWNSVIVQAAHIPRMVRKAFRAMTTGRAGAAH
LGLPYDIQYDPVDSSDIWADPKHATYPAYPQAPEPGAAEAAVDAILSAKNPLIVCGGGVVIAGAMEELARLANRLDIPVA
TSISGQGSLADTDPMSLGVVGSNGGTDETWEAMEAADLVIFMGARAGSTTTARWEAPKPGARVVHFDSDPMVIGANYPTE
VGVVGDLRLSLQAVNAVLDARGQGATTFGGAQAVADIKARKFARFNALATSDETPIRPERVVATLNRILPEDATIVSDPG
TSCPYVSAYYQHAKAGRFFITNRAHGALGYSLSASLGAWFGRPTSKVVALMGDGSFGFTCGELETVTRARANITFVVFSN
ANFGWIKASQMADKGSRYYNVDFNRVDHAAVASAYGVKAWRVDDPGALEATLTEAIDHDGPTLVDIIAQPLEEAAAPVRR
WMG
>Mature_563_residues
MDNQMNGADALVGMLKAHGVRHIFGLCGDTSLPFYDSMRAHGGNITHVLTRDERSATYMADGYSRVTGRPGVAEGPSGGG
ATYILPGLIEASESSYAVLGITTDISVGTYGKYPLTEVDQNALMAPVTKWNSVIVQAAHIPRMVRKAFRAMTTGRAGAAH
LGLPYDIQYDPVDSSDIWADPKHATYPAYPQAPEPGAAEAAVDAILSAKNPLIVCGGGVVIAGAMEELARLANRLDIPVA
TSISGQGSLADTDPMSLGVVGSNGGTDETWEAMEAADLVIFMGARAGSTTTARWEAPKPGARVVHFDSDPMVIGANYPTE
VGVVGDLRLSLQAVNAVLDARGQGATTFGGAQAVADIKARKFARFNALATSDETPIRPERVVATLNRILPEDATIVSDPG
TSCPYVSAYYQHAKAGRFFITNRAHGALGYSLSASLGAWFGRPTSKVVALMGDGSFGFTCGELETVTRARANITFVVFSN
ANFGWIKASQMADKGSRYYNVDFNRVDHAAVASAYGVKAWRVDDPGALEATLTEAIDHDGPTLVDIIAQPLEEAAAPVRR
WMG

Specific function: Catalyzes The Condensation Of Two Molecules Of Glyoxylate To Give 2-Hydroxy-3-Oxopropanoate (Also Termed Tartronate Semialdehyde). [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=587, Percent_Identity=23.1686541737649, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI1786717, Length=562, Percent_Identity=30.2491103202847, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI87081685, Length=540, Percent_Identity=29.0740740740741, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1790104, Length=545, Percent_Identity=25.6880733944954, Blast_Score=189, Evalue=6e-49,
Organism=Escherichia coli, GI1787096, Length=550, Percent_Identity=25.4545454545455, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1788716, Length=567, Percent_Identity=23.2804232804233, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17531299, Length=583, Percent_Identity=24.3567753001715, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531301, Length=583, Percent_Identity=24.3567753001715, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17542570, Length=573, Percent_Identity=23.3856893542757, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323755, Length=571, Percent_Identity=26.6199649737303, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320816, Length=479, Percent_Identity=24.4258872651357, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321524, Length=527, Percent_Identity=24.2884250474383, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320123, Length=543, Percent_Identity=23.0202578268877, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323073, Length=531, Percent_Identity=24.4821092278719, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323163, Length=554, Percent_Identity=22.7436823104693, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922626, Length=491, Percent_Identity=26.6802443991853, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59404; Mature: 59404

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNQMNGADALVGMLKAHGVRHIFGLCGDTSLPFYDSMRAHGGNITHVLTRDERSATYMA
CCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEE
DGYSRVTGRPGVAEGPSGGGATYILPGLIEASESSYAVLGITTDISVGTYGKYPLTEVDQ
CCCHHCCCCCCCCCCCCCCCCEEEECCEEECCCCCEEEEEEEEECEECCCCCCCCCCCCC
NALMAPVTKWNSVIVQAAHIPRMVRKAFRAMTTGRAGAAHLGLPYDIQYDPVDSSDIWAD
CCEECCHHHHHHHEEEHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEECCCCCCCCCCC
PKHATYPAYPQAPEPGAAEAAVDAILSAKNPLIVCGGGVVIAGAMEELARLANRLDIPVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEEHHHHHHHHHHHHCCCCEE
TSISGQGSLADTDPMSLGVVGSNGGTDETWEAMEAADLVIFMGARAGSTTTARWEAPKPG
ECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCEEEEEECCCCCCCEEEECCCCCC
ARVVHFDSDPMVIGANYPTEVGVVGDLRLSLQAVNAVLDARGQGATTFGGAQAVADIKAR
CEEEEECCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
KFARFNALATSDETPIRPERVVATLNRILPEDATIVSDPGTSCPYVSAYYQHAKAGRFFI
HHHHHHEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEE
TNRAHGALGYSLSASLGAWFGRPTSKVVALMGDGSFGFTCGELETVTRARANITFVVFSN
ECCCCCCCCEEEHHHHHHHCCCCCCCEEEEEECCCCCEECCHHHHHHHHHCEEEEEEECC
ANFGWIKASQMADKGSRYYNVDFNRVDHAAVASAYGVKAWRVDDPGALEATLTEAIDHDG
CCCCEEEHHHHHCCCCEEEEECCCCCCHHHHHHHHCCEEEECCCCCCHHHHHHHHHCCCC
PTLVDIIAQPLEEAAAPVRRWMG
CHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDNQMNGADALVGMLKAHGVRHIFGLCGDTSLPFYDSMRAHGGNITHVLTRDERSATYMA
CCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEE
DGYSRVTGRPGVAEGPSGGGATYILPGLIEASESSYAVLGITTDISVGTYGKYPLTEVDQ
CCCHHCCCCCCCCCCCCCCCCEEEECCEEECCCCCEEEEEEEEECEECCCCCCCCCCCCC
NALMAPVTKWNSVIVQAAHIPRMVRKAFRAMTTGRAGAAHLGLPYDIQYDPVDSSDIWAD
CCEECCHHHHHHHEEEHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEECCCCCCCCCCC
PKHATYPAYPQAPEPGAAEAAVDAILSAKNPLIVCGGGVVIAGAMEELARLANRLDIPVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEEHHHHHHHHHHHHCCCCEE
TSISGQGSLADTDPMSLGVVGSNGGTDETWEAMEAADLVIFMGARAGSTTTARWEAPKPG
ECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCEEEEEECCCCCCCEEEECCCCCC
ARVVHFDSDPMVIGANYPTEVGVVGDLRLSLQAVNAVLDARGQGATTFGGAQAVADIKAR
CEEEEECCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
KFARFNALATSDETPIRPERVVATLNRILPEDATIVSDPGTSCPYVSAYYQHAKAGRFFI
HHHHHHEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEE
TNRAHGALGYSLSASLGAWFGRPTSKVVALMGDGSFGFTCGELETVTRARANITFVVFSN
ECCCCCCCCEEEHHHHHHHCCCCCCCEEEEEECCCCCEECCHHHHHHHHHCEEEEEEECC
ANFGWIKASQMADKGSRYYNVDFNRVDHAAVASAYGVKAWRVDDPGALEATLTEAIDHDG
CCCCEEEHHHHHCCCCEEEEECCCCCCHHHHHHHHCCEEEECCCCCCHHHHHHHHHCCCC
PTLVDIIAQPLEEAAAPVRRWMG
CHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9099862 [H]