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The map label for this gene is nqo13 [H]

Identifier: 89053686

GI number: 89053686

Start: 1154510

End: 1156054

Strand: Direct

Name: nqo13 [H]

Synonym: Jann_1195

Alternate gene names: 89053686

Gene position: 1154510-1156054 (Clockwise)

Preceding gene: 89053685

Following gene: 89053687

Centisome position: 26.74

GC content: 60.26

Gene sequence:

>1545_bases
ATGGATAACCTCATCTCCATCGTCACATTCCTGCCCCTGGTGGCCGCGATCATCATGGCCGTGTTCCTGCGCGGCGAGGA
TGAGGCCGCGCAGTTGAACGCCAAGCGTCTGGCCTTCGCCGCCACGGCTGCCACGTTCCTGGTGTCGATTTTCCTGTTGG
TGCAGTTCGATGCGTCCAACACTGACTTCCAGCTGGTGGAAGAGGCCCCGTGGCTCTTTGGGCTGACCTATAAGGTTGGC
GTGGACGGGATCTCCATCCTGTTCGTGATGCTGACCACGTTCCTGATGCCGATCACGATTGCCGCCTGCTGGAGTGTGAA
GACGCGCGTCAAGGAATACATGATCGCGCTTTTGATCCTTGAGACGCTGATGATCGGCGTTTTCGTAGCGCTCGACATGG
TGCTGTTCTACCTGTTCTTCGAGGCGGGCCTGATCCCGATGTTCCTGATCATCGGCATCTGGGGCGGGGCGAACCGGATC
TATGCATCGTTCAAGTTCTTCCTCTACACCTTCCTGGGCTCGGTCCTGATGCTGGTCGCTATGGTCGCGATGTATGTGGA
TGCGGGCACGACGGATATCCCGACGCTCCTGAACCACAATTTCGGCACGGAAACCTTCACCGTCGCGGGCTTCACCGTCG
TCGGCGGCCTCCAGACGATGCTGTTCCTCGCCTTCTTCGCGTCCTTCGCGGTGAAGATGCCGATGTGGCCCGTGCACACC
TGGCTGCCGGACGCGCACGTGCAGGCGCCCACGGCGGGGTCGGTGGTGCTGGCGGCGATCCTGTTGAAGATGGGTGGCTA
CGGGTTCCTGCGGTTCAGCCTGCCGATGTTCCCCGTGGCGTCTGATATCTTCGCACCGCTGATCCTGTGGCTGAGCGTCA
TCGCAATCATCTACACGTCGCTAGTGGCGATGGTGCAGGAGGACATGAAAAAGCTGATCGCCTACAGTTCCGTCGCGCAT
ATGGGCTTTGTGACCATGGGCATCTTTGCGGCCAACCAAAACGGCGTGGATGGCGCGATTTTCCAGATGATCTCCCACGG
GTTCATCTCGGGCGCGTTGTTCCTGTGCGTGGGCGTGATCTACGACCGGATGCACACCCGCGATATCGACGCCTATGGTG
GCCTTGTGGTCCGCATGCCTGCCTACGCGGCGATCTTTATGCTGTTCACCATGGCCAACGTGGGCCTTCCGGGCACCTCC
GGCTTTGTGGGGGAATTCCTGACGCTGATCGGGGTCTTTCAGGTCAATACATGGATCGGTCTTCTGGCCTGCACCGGCGT
GATCCTGTCAGCGTCCTATGCGCTGTGGCTCTACCGTCGGGTCGTCTTCGGCGACCTGATCAAGGAAAGCCTGAAGTCCA
TCACCGACATGACCCGCCGGGAGCGCGCGATCTTCGCGCCGCTGGTGGTCATGACGATCCTGCTGGGCGTCTATCCGAGC
CTTGTGACCGATATTATCGGCCCCTCGGTCGAGGCCCTCGTTACCAACTACGAACTTGCCGTGGCGGATTTCGCGTCCCA
CGCGCAAGTTGCCGCAAGCCACTAA

Upstream 100 bases:

>100_bases
CCGCGCGCAATCCGGCTACATTTTCCATTACGCGTTCGCGATGGTGCTGGGGCTTGTCGCCATCATCATCTTCGTCACGT
TGAGCGCGGGGTAAGGCATC

Downstream 100 bases:

>100_bases
TGCAGCTCGATAACCATCGAACGCACCTACTAAGGACCCGCGCCCATGATCTCCGCTGATCTTGCCATCCTGACGCCCGA
GATTGTCCTGTCGCTGTTCG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MDNLISIVTFLPLVAAIIMAVFLRGEDEAAQLNAKRLAFAATAATFLVSIFLLVQFDASNTDFQLVEEAPWLFGLTYKVG
VDGISILFVMLTTFLMPITIAACWSVKTRVKEYMIALLILETLMIGVFVALDMVLFYLFFEAGLIPMFLIIGIWGGANRI
YASFKFFLYTFLGSVLMLVAMVAMYVDAGTTDIPTLLNHNFGTETFTVAGFTVVGGLQTMLFLAFFASFAVKMPMWPVHT
WLPDAHVQAPTAGSVVLAAILLKMGGYGFLRFSLPMFPVASDIFAPLILWLSVIAIIYTSLVAMVQEDMKKLIAYSSVAH
MGFVTMGIFAANQNGVDGAIFQMISHGFISGALFLCVGVIYDRMHTRDIDAYGGLVVRMPAYAAIFMLFTMANVGLPGTS
GFVGEFLTLIGVFQVNTWIGLLACTGVILSASYALWLYRRVVFGDLIKESLKSITDMTRRERAIFAPLVVMTILLGVYPS
LVTDIIGPSVEALVTNYELAVADFASHAQVAASH

Sequences:

>Translated_514_residues
MDNLISIVTFLPLVAAIIMAVFLRGEDEAAQLNAKRLAFAATAATFLVSIFLLVQFDASNTDFQLVEEAPWLFGLTYKVG
VDGISILFVMLTTFLMPITIAACWSVKTRVKEYMIALLILETLMIGVFVALDMVLFYLFFEAGLIPMFLIIGIWGGANRI
YASFKFFLYTFLGSVLMLVAMVAMYVDAGTTDIPTLLNHNFGTETFTVAGFTVVGGLQTMLFLAFFASFAVKMPMWPVHT
WLPDAHVQAPTAGSVVLAAILLKMGGYGFLRFSLPMFPVASDIFAPLILWLSVIAIIYTSLVAMVQEDMKKLIAYSSVAH
MGFVTMGIFAANQNGVDGAIFQMISHGFISGALFLCVGVIYDRMHTRDIDAYGGLVVRMPAYAAIFMLFTMANVGLPGTS
GFVGEFLTLIGVFQVNTWIGLLACTGVILSASYALWLYRRVVFGDLIKESLKSITDMTRRERAIFAPLVVMTILLGVYPS
LVTDIIGPSVEALVTNYELAVADFASHAQVAASH
>Mature_514_residues
MDNLISIVTFLPLVAAIIMAVFLRGEDEAAQLNAKRLAFAATAATFLVSIFLLVQFDASNTDFQLVEEAPWLFGLTYKVG
VDGISILFVMLTTFLMPITIAACWSVKTRVKEYMIALLILETLMIGVFVALDMVLFYLFFEAGLIPMFLIIGIWGGANRI
YASFKFFLYTFLGSVLMLVAMVAMYVDAGTTDIPTLLNHNFGTETFTVAGFTVVGGLQTMLFLAFFASFAVKMPMWPVHT
WLPDAHVQAPTAGSVVLAAILLKMGGYGFLRFSLPMFPVASDIFAPLILWLSVIAIIYTSLVAMVQEDMKKLIAYSSVAH
MGFVTMGIFAANQNGVDGAIFQMISHGFISGALFLCVGVIYDRMHTRDIDAYGGLVVRMPAYAAIFMLFTMANVGLPGTS
GFVGEFLTLIGVFQVNTWIGLLACTGVILSASYALWLYRRVVFGDLIKESLKSITDMTRRERAIFAPLVVMTILLGVYPS
LVTDIIGPSVEALVTNYELAVADFASHAQVAASH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=377, Percent_Identity=33.9522546419098, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI251831117, Length=454, Percent_Identity=21.8061674008811, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1788613, Length=438, Percent_Identity=40.6392694063927, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1788827, Length=314, Percent_Identity=28.9808917197452, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1788831, Length=290, Percent_Identity=26.551724137931, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788829, Length=499, Percent_Identity=24.8496993987976, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI145693160, Length=426, Percent_Identity=23.943661971831, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788614, Length=417, Percent_Identity=24.9400479616307, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367154, Length=138, Percent_Identity=25.3623188405797, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 56119; Mature: 56119

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]