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The map label for this gene is nuoN

Identifier: 89053687

GI number: 89053687

Start: 1156100

End: 1157551

Strand: Direct

Name: nuoN

Synonym: Jann_1196

Alternate gene names: 89053687

Gene position: 1156100-1157551 (Clockwise)

Preceding gene: 89053686

Following gene: 89053688

Centisome position: 26.77

GC content: 61.98

Gene sequence:

>1452_bases
ATGATCTCCGCTGATCTTGCCATCCTGACGCCCGAGATTGTCCTGTCGCTGTTCGCGATGGCGGGGCTGTTGGGGGCGGT
CTACACGTCCAAGGACGCGCTCGCCTCGGCCATGTGCTGGGGCACGGCGGCCTTGTTCATCATCATGGCGTTCTACATCG
GCGTGACGGGCAACGGCGCGCGGGAGGCGTTTGACGGCATGATCATTGACGATGCCTTCTCTCGCTTTGCCAAGATCACC
ATCCTTCTGTCGGCCGCCGCAATCCTGATGATTTCGCAGGATTACATGGCCAAGGCGGATTTGTTACGGTTTGAGTTCCC
CGTGCTGATCATTCTGGCCGTTGTGGGCATGATGATCATGGTCTCCGCAGGTGATCTGATCGCGCTTTACATGGGGTTGG
AGCTGCAATCGCTGGCGCTCTACGTGGTCGCCGCCATGCGCCGCGACAGCGTGCGGTCCACGGAAGCGGGCCTGAAATAC
TTCGTGCTCGGCGCGCTGTCGTCGGGCCTTCTGCTTTACGGCTCCTCTCTGGCGTATGGGTTCGCGGGTACGACGCAATT
TGCGGGCATCATCGAAGCGGCGCAGGGCGGCGACATGCCTCTGGGGCTCCTGTTCGGCCTCGTCTTCATCACGGCGGGCC
TTGCCTTCAAGGTCTCTGCCGCGCCGTTTCATATGTGGACGCCGGATGTCTACGAAGGCTCCCCCACACCGATCACCGCG
CTTTTTGCCACCGCGCCGAAGGTCGCTGCGATGGCGCTGTTCGCGCGCGTGGTCCATGACGCGTTCGGTGGCGTGATCGG
CGATTGGCAGCAGATCGTGGCGTTTCTGGCCGTCGTCTCCATGTTCCTCGGTGCCATCGCGGCGATCGGGCAGACGGATA
TCAAGCGCCTGATGGCCTATTCCTCGATCTCCCACATGGGCTTTGCGCTGATGGGCCTTTCCGCAGGCACCGCGCAGGGC
GTGGAGGCGATGCTGATCTACATGGCGATCTACGTGGCGATGAACATCGGCACCTTCGCGTTTATCCTGACGATGGAGCG
GAACGGACGACATGTGACCGAGATCTCGTCGCTGTCCGCCTTCGCCTCCAAGGAGCCCACCAAGGCGCTGGCGATATTGG
TCATGATGTTCAGCCTTGCGGGCGTTCCGCCGCTTCTGGGGTTCTTCGGCAAATATGCCGTTCTGGTCGCCGCTGTCGAT
GCAGGTCTGGTGTGGCTGGCAATTGCGGGCGTCATCGCCTCGGTCATCGGCGCGTTCTACTACATCCGCATCGTCTATCT
AATGTATTTCGGGGAGGCGGATGAGGGCGCGTTGGACGGCAAGATGGGGCTGGTCCCCTATGTCGGCCTGATCGCCATGG
CGCTGGTCATCGGTCTCGGCTGGGTGCCCGGTGTGAATCTCTTCGGGATCGAGGCTCCGGCGGAAACGGCCGCCGCCATG
CTGATCCGCTAA

Upstream 100 bases:

>100_bases
CGAACTTGCCGTGGCGGATTTCGCGTCCCACGCGCAAGTTGCCGCAAGCCACTAATGCAGCTCGATAACCATCGAACGCA
CCTACTAAGGACCCGCGCCC

Downstream 100 bases:

>100_bases
ATGTCGGGTGGGGCCACAGGCGCTTGGCCCCTGGGTGTCTCCCGCCGTGTCCTTGCCACCACCGACAGCACGATGCTGGA
GGCCGCGCGCGCCGCGCCCA

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MISADLAILTPEIVLSLFAMAGLLGAVYTSKDALASAMCWGTAALFIIMAFYIGVTGNGAREAFDGMIIDDAFSRFAKIT
ILLSAAAILMISQDYMAKADLLRFEFPVLIILAVVGMMIMVSAGDLIALYMGLELQSLALYVVAAMRRDSVRSTEAGLKY
FVLGALSSGLLLYGSSLAYGFAGTTQFAGIIEAAQGGDMPLGLLFGLVFITAGLAFKVSAAPFHMWTPDVYEGSPTPITA
LFATAPKVAAMALFARVVHDAFGGVIGDWQQIVAFLAVVSMFLGAIAAIGQTDIKRLMAYSSISHMGFALMGLSAGTAQG
VEAMLIYMAIYVAMNIGTFAFILTMERNGRHVTEISSLSAFASKEPTKALAILVMMFSLAGVPPLLGFFGKYAVLVAAVD
AGLVWLAIAGVIASVIGAFYYIRIVYLMYFGEADEGALDGKMGLVPYVGLIAMALVIGLGWVPGVNLFGIEAPAETAAAM
LIR

Sequences:

>Translated_483_residues
MISADLAILTPEIVLSLFAMAGLLGAVYTSKDALASAMCWGTAALFIIMAFYIGVTGNGAREAFDGMIIDDAFSRFAKIT
ILLSAAAILMISQDYMAKADLLRFEFPVLIILAVVGMMIMVSAGDLIALYMGLELQSLALYVVAAMRRDSVRSTEAGLKY
FVLGALSSGLLLYGSSLAYGFAGTTQFAGIIEAAQGGDMPLGLLFGLVFITAGLAFKVSAAPFHMWTPDVYEGSPTPITA
LFATAPKVAAMALFARVVHDAFGGVIGDWQQIVAFLAVVSMFLGAIAAIGQTDIKRLMAYSSISHMGFALMGLSAGTAQG
VEAMLIYMAIYVAMNIGTFAFILTMERNGRHVTEISSLSAFASKEPTKALAILVMMFSLAGVPPLLGFFGKYAVLVAAVD
AGLVWLAIAGVIASVIGAFYYIRIVYLMYFGEADEGALDGKMGLVPYVGLIAMALVIGLGWVPGVNLFGIEAPAETAAAM
LIR
>Mature_483_residues
MISADLAILTPEIVLSLFAMAGLLGAVYTSKDALASAMCWGTAALFIIMAFYIGVTGNGAREAFDGMIIDDAFSRFAKIT
ILLSAAAILMISQDYMAKADLLRFEFPVLIILAVVGMMIMVSAGDLIALYMGLELQSLALYVVAAMRRDSVRSTEAGLKY
FVLGALSSGLLLYGSSLAYGFAGTTQFAGIIEAAQGGDMPLGLLFGLVFITAGLAFKVSAAPFHMWTPDVYEGSPTPITA
LFATAPKVAAMALFARVVHDAFGGVIGDWQQIVAFLAVVSMFLGAIAAIGQTDIKRLMAYSSISHMGFALMGLSAGTAQG
VEAMLIYMAIYVAMNIGTFAFILTMERNGRHVTEISSLSAFASKEPTKALAILVMMFSLAGVPPLLGFFGKYAVLVAAVD
AGLVWLAIAGVIASVIGAFYYIRIVYLMYFGEADEGALDGKMGLVPYVGLIAMALVIGLGWVPGVNLFGIEAPAETAAAM
LIR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=326, Percent_Identity=22.3926380368098, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI145693160, Length=379, Percent_Identity=34.8284960422164, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1788614, Length=360, Percent_Identity=25.2777777777778, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788613, Length=225, Percent_Identity=29.7777777777778, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788831, Length=224, Percent_Identity=25.4464285714286, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788827, Length=310, Percent_Identity=25.8064516129032, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788829, Length=332, Percent_Identity=26.2048192771084, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_JANSC (Q28T49)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509138.1
- STRING:   Q28T49
- GeneID:   3933640
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1196
- HOGENOM:   HBG747830
- OMA:   SIGHIGF
- PhylomeDB:   Q28T49
- ProtClustDB:   PRK05777
- BioCyc:   JSP290400:JANN_1196-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 50802; Mature: 50802

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf323ed4)-; HASH(0xf444f00)-; HASH(0xf313530)-; HASH(0xf424420)-; HASH(0xf313554)-; HASH(0xc271db8)-; HASH(0xf444c30)-; HASH(0xf4242f4)-; HASH(0xf42430c)-; HASH(0xe99add8)-; HASH(0xf30719c)-; HASH(0xf393940)-; HASH(0xf2a8410)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISADLAILTPEIVLSLFAMAGLLGAVYTSKDALASAMCWGTAALFIIMAFYIGVTGNGA
CCCCCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
REAFDGMIIDDAFSRFAKITILLSAAAILMISQDYMAKADLLRFEFPVLIILAVVGMMIM
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSAGDLIALYMGLELQSLALYVVAAMRRDSVRSTEAGLKYFVLGALSSGLLLYGSSLAYG
HCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHC
FAGTTQFAGIIEAAQGGDMPLGLLFGLVFITAGLAFKVSAAPFHMWTPDVYEGSPTPITA
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCCCCCCCCCCHHH
LFATAPKVAAMALFARVVHDAFGGVIGDWQQIVAFLAVVSMFLGAIAAIGQTDIKRLMAY
HHHCCHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
SSISHMGFALMGLSAGTAQGVEAMLIYMAIYVAMNIGTFAFILTMERNGRHVTEISSLSA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHH
FASKEPTKALAILVMMFSLAGVPPLLGFFGKYAVLVAAVDAGLVWLAIAGVIASVIGAFY
HHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YIRIVYLMYFGEADEGALDGKMGLVPYVGLIAMALVIGLGWVPGVNLFGIEAPAETAAAM
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHH
LIR
HCH
>Mature Secondary Structure
MISADLAILTPEIVLSLFAMAGLLGAVYTSKDALASAMCWGTAALFIIMAFYIGVTGNGA
CCCCCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
REAFDGMIIDDAFSRFAKITILLSAAAILMISQDYMAKADLLRFEFPVLIILAVVGMMIM
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSAGDLIALYMGLELQSLALYVVAAMRRDSVRSTEAGLKYFVLGALSSGLLLYGSSLAYG
HCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHC
FAGTTQFAGIIEAAQGGDMPLGLLFGLVFITAGLAFKVSAAPFHMWTPDVYEGSPTPITA
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCCCCCCCCCCHHH
LFATAPKVAAMALFARVVHDAFGGVIGDWQQIVAFLAVVSMFLGAIAAIGQTDIKRLMAY
HHHCCHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
SSISHMGFALMGLSAGTAQGVEAMLIYMAIYVAMNIGTFAFILTMERNGRHVTEISSLSA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHH
FASKEPTKALAILVMMFSLAGVPPLLGFFGKYAVLVAAVDAGLVWLAIAGVIASVIGAFY
HHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YIRIVYLMYFGEADEGALDGKMGLVPYVGLIAMALVIGLGWVPGVNLFGIEAPAETAAAM
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHH
LIR
HCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA