Click here to switch to the map view.

The map label for this gene is meaA [H]

Identifier: 89053288

GI number: 89053288

Start: 758266

End: 760230

Strand: Direct

Name: meaA [H]

Synonym: Jann_0797

Alternate gene names: 89053288

Gene position: 758266-760230 (Clockwise)

Preceding gene: 89053287

Following gene: 89053289

Centisome position: 17.56

GC content: 60.46

Gene sequence:

>1965_bases
ATGACGCAAGCCCAGAAAGATCGCCCCTGGTTGATCCGCACCTATGCCGGGCACTCGACGGCGGAGGCGTCCAACGCGCT
TTACCGGGGCAATCTGGCAAAGGGGCAGACGGGTCTTTCAGTGGCCTTCGATCTGCCGACCCAGACGGGCTATGACAGTG
ATCACGTTCTGGCGCGGGGCGAGGTTGGCAAGGTGGGCGTGCCGGTCAGTCATCTGGGCGATATGCGCACGCTGTTCAAG
GATATCCCGCTGGAGCAGATGAATACGTCGATGACGATCAATGCCACCGCGCCGTGGCTGCTATCGCTGTATATCGCTGT
GGCCGAGGAGCAGGGGGCCGATGTCGCCAAGCTGCAAGGCACGGTCCAGAACGATCTGATGAAGGAATACCTGTCGCGGG
GCACCTATATCTGCCCGCCGAAACCCTCCATGGCGATGATCGCGGATGTGGCCGAATATTGCTACAAAGAGGTTCCGAAA
TGGAACCCGATGAACGTGTGCTCGTACCATTTGCAGGAAGCGGGTGCGACGCCGGAGCAGGAATTGGCTTTCGCGCTGGC
CACCGCCATTTCGGTTCTGGACGAATTGCGCCCCCGCGTGCCGGAGGCGGATTTCCCGGTGCTGGTCGGCCGCATTTCCT
TCTTCGTGAATGCGGGTATTCGGTTCGTGACCGAGATGTGCAAAATGCGTGCGTTTGTGGATCTGTGGGACGAGATTTGC
GAAACCCGCTATGGCGTGTCTGACCCAAAAATGCGGCGGTTCCGCTATGGCGTGCAGGTCAATTCCCTGGGCCTGACCGA
GCAGCAGCCGGAAAACAACGTCTACCGCATTCTGATTGAAATGCTGGCCGTGACGCTGTCAAAAAAGGCCCGCGCCCGCG
CCGTGCAATTGCCCGCCTGGAATGAGGCGCTGGGCCTGCCGCGCCCCTGGGATCAGCAATGGTCGATGCGGATGCAGCAG
ATCATGGCGTTCGAGACCGATCTGTTGGAATACGGCGATTTGTTTGACGGTAATCCCGTGGTGGATGGCAAGGTTGCTGA
ATTGAAAGAGGGCGCGCGGGCGGAATTGGCCAATCTGGAGGGCATGGGCGGCGCCATTTCAGCGATTGATTACATGAAGG
GCCGTTTGGTGGAAAGCAACGCGGACCGGGTGAACCGGATTGAGCGCGGCGAAACGGTGGTTGTGGGGGTGAACAAATAT
ACGGCGTCCGAGCCGTCTCCGCTATTGGGGGAGGATGGCGGGATCATGGTCGTCGATCCGGCGGTGGAGCAGGACCAGAT
CGCGCGGCTGGAGGCGTGGCGGGGCAGCCGTGATGCGGACGCGGTGCGCGCGACGTTGGACGCCTTGGCCGACGCGGCGC
GCGATGGGCGCAATGTCATGCCGGCCTCCATCCAGGCCGCGAAAGCGGGGGTTACGACGGGCGAATGGGCGGGCGTGATG
CGCGGCGTCCACGGGGAATATCGGGGGCCAACCGGTGTCTCGGGCGCTGTGTCGAACAAAACCGAAGGATTGGATGAGAT
CCGAGATGCGGTTGATCTGGTCAGCGACAAATTGGGTCGCCGCCTGAAATTCCTGGTCGGCAAACCGGGCCTTGACGGCC
ATTCCAACGGGGCCGAACAAATCGCATTCCGCGCGCGCGATTGCGGCATGGATATCAGCTATGAAGGGATCCGGCTGACG
CCGTCTGAAATTGTCGCCGCGGCGAAGGCGGAAGAGGCCCATGTGATTGGCCTGTCCATTCTATCCGGCAGCCATGTTCC
GCTGATCAAGGAGGTGATGGAATTGATCCGGGCCGAGGGTCTTTCCATTCCCGTGATGGTTGGCGGTATCATTCCCGACG
ACGACCGCTCCACGCTTTTGGGATACGGTGTGGCCCGGGTTTATACGCCCAAGGATTTCGAATTAAACCGGATCATGATG
GATATCGTGACGCTGGTTGACCCTACGGAAATTGCTGCTGAATAA

Upstream 100 bases:

>100_bases
GGGCAGACATGCCGCGATGCAGCGAATTGACAGGGTATTATTATTCCGAATAGATGCGGCTTGACGAAATGATATTGCTG
TAGACGAGTCGGAGTGGCCC

Downstream 100 bases:

>100_bases
GTGTCAGCCCTTTCGCGCTCAAAAAAGAACATGTCTAAAAGTTTGCTTGCCATTGGTAGGTCTTTTCTGCATGTGCCTGT
TTATTAGCAGCCATTACGAA

Product: methylmalonyl-CoA mutase

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MTQAQKDRPWLIRTYAGHSTAEASNALYRGNLAKGQTGLSVAFDLPTQTGYDSDHVLARGEVGKVGVPVSHLGDMRTLFK
DIPLEQMNTSMTINATAPWLLSLYIAVAEEQGADVAKLQGTVQNDLMKEYLSRGTYICPPKPSMAMIADVAEYCYKEVPK
WNPMNVCSYHLQEAGATPEQELAFALATAISVLDELRPRVPEADFPVLVGRISFFVNAGIRFVTEMCKMRAFVDLWDEIC
ETRYGVSDPKMRRFRYGVQVNSLGLTEQQPENNVYRILIEMLAVTLSKKARARAVQLPAWNEALGLPRPWDQQWSMRMQQ
IMAFETDLLEYGDLFDGNPVVDGKVAELKEGARAELANLEGMGGAISAIDYMKGRLVESNADRVNRIERGETVVVGVNKY
TASEPSPLLGEDGGIMVVDPAVEQDQIARLEAWRGSRDADAVRATLDALADAARDGRNVMPASIQAAKAGVTTGEWAGVM
RGVHGEYRGPTGVSGAVSNKTEGLDEIRDAVDLVSDKLGRRLKFLVGKPGLDGHSNGAEQIAFRARDCGMDISYEGIRLT
PSEIVAAAKAEEAHVIGLSILSGSHVPLIKEVMELIRAEGLSIPVMVGGIIPDDDRSTLLGYGVARVYTPKDFELNRIMM
DIVTLVDPTEIAAE

Sequences:

>Translated_654_residues
MTQAQKDRPWLIRTYAGHSTAEASNALYRGNLAKGQTGLSVAFDLPTQTGYDSDHVLARGEVGKVGVPVSHLGDMRTLFK
DIPLEQMNTSMTINATAPWLLSLYIAVAEEQGADVAKLQGTVQNDLMKEYLSRGTYICPPKPSMAMIADVAEYCYKEVPK
WNPMNVCSYHLQEAGATPEQELAFALATAISVLDELRPRVPEADFPVLVGRISFFVNAGIRFVTEMCKMRAFVDLWDEIC
ETRYGVSDPKMRRFRYGVQVNSLGLTEQQPENNVYRILIEMLAVTLSKKARARAVQLPAWNEALGLPRPWDQQWSMRMQQ
IMAFETDLLEYGDLFDGNPVVDGKVAELKEGARAELANLEGMGGAISAIDYMKGRLVESNADRVNRIERGETVVVGVNKY
TASEPSPLLGEDGGIMVVDPAVEQDQIARLEAWRGSRDADAVRATLDALADAARDGRNVMPASIQAAKAGVTTGEWAGVM
RGVHGEYRGPTGVSGAVSNKTEGLDEIRDAVDLVSDKLGRRLKFLVGKPGLDGHSNGAEQIAFRARDCGMDISYEGIRLT
PSEIVAAAKAEEAHVIGLSILSGSHVPLIKEVMELIRAEGLSIPVMVGGIIPDDDRSTLLGYGVARVYTPKDFELNRIMM
DIVTLVDPTEIAAE
>Mature_653_residues
TQAQKDRPWLIRTYAGHSTAEASNALYRGNLAKGQTGLSVAFDLPTQTGYDSDHVLARGEVGKVGVPVSHLGDMRTLFKD
IPLEQMNTSMTINATAPWLLSLYIAVAEEQGADVAKLQGTVQNDLMKEYLSRGTYICPPKPSMAMIADVAEYCYKEVPKW
NPMNVCSYHLQEAGATPEQELAFALATAISVLDELRPRVPEADFPVLVGRISFFVNAGIRFVTEMCKMRAFVDLWDEICE
TRYGVSDPKMRRFRYGVQVNSLGLTEQQPENNVYRILIEMLAVTLSKKARARAVQLPAWNEALGLPRPWDQQWSMRMQQI
MAFETDLLEYGDLFDGNPVVDGKVAELKEGARAELANLEGMGGAISAIDYMKGRLVESNADRVNRIERGETVVVGVNKYT
ASEPSPLLGEDGGIMVVDPAVEQDQIARLEAWRGSRDADAVRATLDALADAARDGRNVMPASIQAAKAGVTTGEWAGVMR
GVHGEYRGPTGVSGAVSNKTEGLDEIRDAVDLVSDKLGRRLKFLVGKPGLDGHSNGAEQIAFRARDCGMDISYEGIRLTP
SEIVAAAKAEEAHVIGLSILSGSHVPLIKEVMELIRAEGLSIPVMVGGIIPDDDRSTLLGYGVARVYTPKDFELNRIMMD
IVTLVDPTEIAAE

Specific function: Required for the assimilation of methanol and ethanol [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=643, Percent_Identity=36.0808709175739, Blast_Score=366, Evalue=1e-101,
Organism=Escherichia coli, GI1789284, Length=652, Percent_Identity=37.5766871165644, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI25144500, Length=631, Percent_Identity=35.9746434231379, Blast_Score=367, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 71422; Mature: 71291

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAQKDRPWLIRTYAGHSTAEASNALYRGNLAKGQTGLSVAFDLPTQTGYDSDHVLARG
CCCCCCCCCEEEEEECCCCHHHHCCCEEECCCCCCCCCCEEEEECCCCCCCCCCCEEECC
EVGKVGVPVSHLGDMRTLFKDIPLEQMNTSMTINATAPWLLSLYIAVAEEQGADVAKLQG
CCCCCCCCHHHHHHHHHHHHHCCHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHH
TVQNDLMKEYLSRGTYICPPKPSMAMIADVAEYCYKEVPKWNPMNVCSYHLQEAGATPEQ
HHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHH
ELAFALATAISVLDELRPRVPEADFPVLVGRISFFVNAGIRFVTEMCKMRAFVDLWDEIC
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETRYGVSDPKMRRFRYGVQVNSLGLTEQQPENNVYRILIEMLAVTLSKKARARAVQLPAW
HHHCCCCCHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEECCCC
NEALGLPRPWDQQWSMRMQQIMAFETDLLEYGDLFDGNPVVDGKVAELKEGARAELANLE
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHCCC
GMGGAISAIDYMKGRLVESNADRVNRIERGETVVVGVNKYTASEPSPLLGEDGGIMVVDP
CCCCHHHHHHHHHCEEECCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECC
AVEQDQIARLEAWRGSRDADAVRATLDALADAARDGRNVMPASIQAAKAGVTTGEWAGVM
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHH
RGVHGEYRGPTGVSGAVSNKTEGLDEIRDAVDLVSDKLGRRLKFLVGKPGLDGHSNGAEQ
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEHHCCCCCCCCCCCCHHH
IAFRARDCGMDISYEGIRLTPSEIVAAAKAEEAHVIGLSILSGSHVPLIKEVMELIRAEG
HHHHHHHCCCCCCCCCEEECHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCC
LSIPVMVGGIIPDDDRSTLLGYGVARVYTPKDFELNRIMMDIVTLVDPTEIAAE
CCCEEEECCCCCCCCCCHHHHCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TQAQKDRPWLIRTYAGHSTAEASNALYRGNLAKGQTGLSVAFDLPTQTGYDSDHVLARG
CCCCCCCCEEEEEECCCCHHHHCCCEEECCCCCCCCCCEEEEECCCCCCCCCCCEEECC
EVGKVGVPVSHLGDMRTLFKDIPLEQMNTSMTINATAPWLLSLYIAVAEEQGADVAKLQG
CCCCCCCCHHHHHHHHHHHHHCCHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHH
TVQNDLMKEYLSRGTYICPPKPSMAMIADVAEYCYKEVPKWNPMNVCSYHLQEAGATPEQ
HHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHH
ELAFALATAISVLDELRPRVPEADFPVLVGRISFFVNAGIRFVTEMCKMRAFVDLWDEIC
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETRYGVSDPKMRRFRYGVQVNSLGLTEQQPENNVYRILIEMLAVTLSKKARARAVQLPAW
HHHCCCCCHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEECCCC
NEALGLPRPWDQQWSMRMQQIMAFETDLLEYGDLFDGNPVVDGKVAELKEGARAELANLE
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHCCC
GMGGAISAIDYMKGRLVESNADRVNRIERGETVVVGVNKYTASEPSPLLGEDGGIMVVDP
CCCCHHHHHHHHHCEEECCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECC
AVEQDQIARLEAWRGSRDADAVRATLDALADAARDGRNVMPASIQAAKAGVTTGEWAGVM
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHH
RGVHGEYRGPTGVSGAVSNKTEGLDEIRDAVDLVSDKLGRRLKFLVGKPGLDGHSNGAEQ
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEHHCCCCCCCCCCCCHHH
IAFRARDCGMDISYEGIRLTPSEIVAAAKAEEAHVIGLSILSGSHVPLIKEVMELIRAEG
HHHHHHHCCCCCCCCCEEECHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCC
LSIPVMVGGIIPDDDRSTLLGYGVARVYTPKDFELNRIMMDIVTLVDPTEIAAE
CCCEEEECCCCCCCCCCHHHHCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]