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The map label for this gene is pyrD [H]

Identifier: 88657936

GI number: 88657936

Start: 960112

End: 961164

Strand: Direct

Name: pyrD [H]

Synonym: ECH_0940

Alternate gene names: 88657936

Gene position: 960112-961164 (Clockwise)

Preceding gene: 88657716

Following gene: 88658521

Centisome position: 81.62

GC content: 31.05

Gene sequence:

>1053_bases
GTGTCACTACAACATATATTTACCAATCCGCTATTTTGTATACCACCAGAAATTGCACATAAACTAGTAATTTTTGCACT
AAAGAACAATTTCATCCCCACAAAAAAAATTGAAATTCCAAGATCTCTTAATATACAAGTCTTCAATAAGCTTCTCAGAA
CCCCTATAGGGGTTGCTGCTGGTTTTGATAAAAATGCAGAAGTAATTCAACCCTTATTGTCTATTGGGTTTGGATTTGTT
GAAGTAGGAACGGTAACAAAACACCCTCAAAATGGTAATAAAAAACCACGTGTACATAGATTAATTAGTAAAGAAGCAAT
AATTAACAGTCTAGGCTTTAATAATAAGGGGATAAATTTCTTAATAAAGAAAGTAAATAACATTCAACTTAACCATTGTA
TATTTGGAATTAACATAGGATTTAACAAAAAATCCAGTGATCCTATCCAAGACTATTTCGATTCAGTAAAGAAAGTATAT
GGTCTAAGTAATTATATTACAATTAATATATCATCTCCCAATACCCCAGGATTAGATGAGTTTCAAAAAAAAGATCTTCT
TTCAGAATTATTAACAGCTATATCTCAAGTTCGAAAGCTAGCAGATTATGCAGAATCTGTTCCTATAATGCTCAAAATTT
CACCAGACATTAATGATAACAAAAAACAAGATATTGTAGATTTAGCAATAAAATATAAAATTAGCGGTTTAATAATCAGT
AACACTTCATCACAACATAACAAACTATTAAATATGAATACAAACATACATGGAGGATTAAGCGGAAAACCACTATTTGA
TTTATCAACACAAGTATTGTCTGAAATATATCAAGCTTCCCAAGGAAAACTTTTACTAATAGGATGTGGTGGAGTAAGTA
CTGGATATCATGCATATGAAAAAATAAAAGCTGGTGCATCATTAGTACAGTTATACACTGCTATAGTTTACAATGGATTC
AATATAGCTAATAAGATAAGCTTAGAGTTAGCTGATCTTTTAGCCGCAGATGGGTTTCCTACAGTACGCCATGCAATAGG
CCATAATCACTAG

Upstream 100 bases:

>100_bases
TTAACAGTTGTTATACACATTTATTAGTTATATAAGTAGTATTTTTATAAAAAACTGATATAATCAGTGCATATTAAGTA
TAAACTAACCACCAAATATT

Downstream 100 bases:

>100_bases
CAGGTTTAACATGTTAATAGCAATAGATATAGGTAATACAAACATAAAATTAGCAATCTGTGCAAACAATAAAATTATAA
AAAGGATAACTATCTCTTCA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSLQHIFTNPLFCIPPEIAHKLVIFALKNNFIPTKKIEIPRSLNIQVFNKLLRTPIGVAAGFDKNAEVIQPLLSIGFGFV
EVGTVTKHPQNGNKKPRVHRLISKEAIINSLGFNNKGINFLIKKVNNIQLNHCIFGINIGFNKKSSDPIQDYFDSVKKVY
GLSNYITINISSPNTPGLDEFQKKDLLSELLTAISQVRKLADYAESVPIMLKISPDINDNKKQDIVDLAIKYKISGLIIS
NTSSQHNKLLNMNTNIHGGLSGKPLFDLSTQVLSEIYQASQGKLLLIGCGGVSTGYHAYEKIKAGASLVQLYTAIVYNGF
NIANKISLELADLLAADGFPTVRHAIGHNH

Sequences:

>Translated_350_residues
MSLQHIFTNPLFCIPPEIAHKLVIFALKNNFIPTKKIEIPRSLNIQVFNKLLRTPIGVAAGFDKNAEVIQPLLSIGFGFV
EVGTVTKHPQNGNKKPRVHRLISKEAIINSLGFNNKGINFLIKKVNNIQLNHCIFGINIGFNKKSSDPIQDYFDSVKKVY
GLSNYITINISSPNTPGLDEFQKKDLLSELLTAISQVRKLADYAESVPIMLKISPDINDNKKQDIVDLAIKYKISGLIIS
NTSSQHNKLLNMNTNIHGGLSGKPLFDLSTQVLSEIYQASQGKLLLIGCGGVSTGYHAYEKIKAGASLVQLYTAIVYNGF
NIANKISLELADLLAADGFPTVRHAIGHNH
>Mature_349_residues
SLQHIFTNPLFCIPPEIAHKLVIFALKNNFIPTKKIEIPRSLNIQVFNKLLRTPIGVAAGFDKNAEVIQPLLSIGFGFVE
VGTVTKHPQNGNKKPRVHRLISKEAIINSLGFNNKGINFLIKKVNNIQLNHCIFGINIGFNKKSSDPIQDYFDSVKKVYG
LSNYITINISSPNTPGLDEFQKKDLLSELLTAISQVRKLADYAESVPIMLKISPDINDNKKQDIVDLAIKYKISGLIISN
TSSQHNKLLNMNTNIHGGLSGKPLFDLSTQVLSEIYQASQGKLLLIGCGGVSTGYHAYEKIKAGASLVQLYTAIVYNGFN
IANKISLELADLLAADGFPTVRHAIGHNH

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=355, Percent_Identity=39.7183098591549, Blast_Score=268, Evalue=5e-72,
Organism=Escherichia coli, GI1787177, Length=320, Percent_Identity=38.4375, Blast_Score=211, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17509475, Length=346, Percent_Identity=39.5953757225434, Blast_Score=251, Evalue=3e-67,
Organism=Drosophila melanogaster, GI281361352, Length=342, Percent_Identity=41.812865497076, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI17137316, Length=342, Percent_Identity=41.812865497076, Blast_Score=269, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 38541; Mature: 38410

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQHIFTNPLFCIPPEIAHKLVIFALKNNFIPTKKIEIPRSLNIQVFNKLLRTPIGVAA
CCCCHHHCCCCEEECHHHHHHEEEEEECCCCCCCCEECCCCCCCHHHHHHHHHCCCCEEC
GFDKNAEVIQPLLSIGFGFVEVGTVTKHPQNGNKKPRVHRLISKEAIINSLGFNNKGINF
CCCCCHHHHHHHHHCCCCEEEECCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
LIKKVNNIQLNHCIFGINIGFNKKSSDPIQDYFDSVKKVYGLSNYITINISSPNTPGLDE
HEEHHCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHH
FQKKDLLSELLTAISQVRKLADYAESVPIMLKISPDINDNKKQDIVDLAIKYKISGLIIS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHEEEEEEEEEEE
NTSSQHNKLLNMNTNIHGGLSGKPLFDLSTQVLSEIYQASQGKLLLIGCGGVSTGYHAYE
CCCHHHCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHH
KIKAGASLVQLYTAIVYNGFNIANKISLELADLLAADGFPTVRHAIGHNH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
>Mature Secondary Structure 
SLQHIFTNPLFCIPPEIAHKLVIFALKNNFIPTKKIEIPRSLNIQVFNKLLRTPIGVAA
CCCHHHCCCCEEECHHHHHHEEEEEECCCCCCCCEECCCCCCCHHHHHHHHHCCCCEEC
GFDKNAEVIQPLLSIGFGFVEVGTVTKHPQNGNKKPRVHRLISKEAIINSLGFNNKGINF
CCCCCHHHHHHHHHCCCCEEEECCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
LIKKVNNIQLNHCIFGINIGFNKKSSDPIQDYFDSVKKVYGLSNYITINISSPNTPGLDE
HEEHHCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHH
FQKKDLLSELLTAISQVRKLADYAESVPIMLKISPDINDNKKQDIVDLAIKYKISGLIIS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHEEEEEEEEEEE
NTSSQHNKLLNMNTNIHGGLSGKPLFDLSTQVLSEIYQASQGKLLLIGCGGVSTGYHAYE
CCCHHHCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHH
KIKAGASLVQLYTAIVYNGFNIANKISLELADLLAADGFPTVRHAIGHNH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA