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The map label for this gene is argH

Identifier: 88657716

GI number: 88657716

Start: 957508

End: 958920

Strand: Direct

Name: argH

Synonym: ECH_0937

Alternate gene names: 88657716

Gene position: 957508-958920 (Clockwise)

Preceding gene: 88658236

Following gene: 88657936

Centisome position: 81.4

GC content: 33.47

Gene sequence:

>1413_bases
ATGAAAAATCCTTTATGGGGAGGAAGGTTTACTGTATCCCCCAGTGACATTATGAAAAAGATTAATGAATCAATATCGTT
TGACAAAATACTATATGAAGAAGATATATCTGGGTCAATAGCACACTGTAAAATGTTAGTTAACCAAAAAATCATTAGCA
AATATGAAGGTCAACTTATTATTCATGGACTAGAAGTTATACAAAACCAAATTTCATCTGGCACTTTTGAATTCAGCACA
GACCTAGAAGACATACACATGAACATAGAACACCACTTAAAGAAAATGATAGGTAACATTGCAGGAAAGTTGCATACTGC
AAGATCTCGTAATGATCAAGTTGCAACAGATTTTAAACTTTGGATACGGAAATCAATAGTAAAATTAGAAACGCTATTAC
ATGAATTACAACAGACTATACTTAATATAGCTGAAGCTAATTACGATACTATCATGCCAGGATTTACACACTTACAAATT
GCTCAACCTGTAACATTAGGTCATCATTTAATGGCATATTTTGAAATGTTAAAAAGAGACTGTTCACGCTGGCAAGATTT
ACACAAACGCATGAATCAATGTCCTGCAGGATCTGCAGCATTAGCAGGAACATCTTTTCCAATAGACAGACATTTCATCG
CACAAGAACTAAAATTTGACAGCCCAACAGAAAATTCTATAGATGCAGTATCAGACAGAGACTATGTTATTGAATTTTTA
TCAAATGCTTCAATATGCATAATGCATTTATCAAGGTTAGCAGAAGAAATTATACTTTGGTGCAGCTACAATTTTAAGTT
TATAACACTTTCCGATAATATCACAACCGGAAGTTCAATAATGCCACAAAAGAAAAACCCAGATGCAGCAGAACTTATCA
GAGGAAAAACTGGAAGGATTTTTGCATCATTAAACCAAATATTAGTCGTCATGAAAGGACTACCACTAGCATATAGCAAA
GATATGCAAGAAGACAAAGAACCTGTCTTTGATGCAGCAAACAACTTAATGTTATGTATAGAAGCAATGAACAGCATGTT
AAACAATATTACCATTAACAAAAGTAATATGCTAAAAGCAGCAGAGCATGACTATTCAACAGCAACAGATCTTGCAGACT
GGCTAGTCAAAAATCTTAATCTTTCATTTAGAGAATCTCATGAAACTACTGGACAAATAGTCAAGTTAGCAGAGCAAAAC
CACTGTAAACTACATGAATTAACTCTAGAACAAATGAAAACGATCATCCCTTCTATAACTGAAGACGTCTTTTCAATATT
ATCGGTAAAAAACTCAGTAGACAGTAGAACGAGCTATGGAGGAACTGCTCCTGCAAATGTAATCGAAGCAATAAAAAGAG
GAAAGTTATATCTCAGCAATATTACTACTTTACATTCAGAAAACAATATGTAA

Upstream 100 bases:

>100_bases
CATACATCAATGACATTAAATAACCATAAAATAAATATCATTGTAATTTTTAGTTATTTACAAGATAATATCTCAATAAA
CCATACCAAAAAGCAACTAT

Downstream 100 bases:

>100_bases
TTTTTTCTAGCAATCAGTACCTATTACACATTTAGAGAAAATGCAGTACATGTAAACTAGATATAGCAAGATTACTGTTT
TGAAGAATACTACTCCTATT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MKNPLWGGRFTVSPSDIMKKINESISFDKILYEEDISGSIAHCKMLVNQKIISKYEGQLIIHGLEVIQNQISSGTFEFST
DLEDIHMNIEHHLKKMIGNIAGKLHTARSRNDQVATDFKLWIRKSIVKLETLLHELQQTILNIAEANYDTIMPGFTHLQI
AQPVTLGHHLMAYFEMLKRDCSRWQDLHKRMNQCPAGSAALAGTSFPIDRHFIAQELKFDSPTENSIDAVSDRDYVIEFL
SNASICIMHLSRLAEEIILWCSYNFKFITLSDNITTGSSIMPQKKNPDAAELIRGKTGRIFASLNQILVVMKGLPLAYSK
DMQEDKEPVFDAANNLMLCIEAMNSMLNNITINKSNMLKAAEHDYSTATDLADWLVKNLNLSFRESHETTGQIVKLAEQN
HCKLHELTLEQMKTIIPSITEDVFSILSVKNSVDSRTSYGGTAPANVIEAIKRGKLYLSNITTLHSENNM

Sequences:

>Translated_470_residues
MKNPLWGGRFTVSPSDIMKKINESISFDKILYEEDISGSIAHCKMLVNQKIISKYEGQLIIHGLEVIQNQISSGTFEFST
DLEDIHMNIEHHLKKMIGNIAGKLHTARSRNDQVATDFKLWIRKSIVKLETLLHELQQTILNIAEANYDTIMPGFTHLQI
AQPVTLGHHLMAYFEMLKRDCSRWQDLHKRMNQCPAGSAALAGTSFPIDRHFIAQELKFDSPTENSIDAVSDRDYVIEFL
SNASICIMHLSRLAEEIILWCSYNFKFITLSDNITTGSSIMPQKKNPDAAELIRGKTGRIFASLNQILVVMKGLPLAYSK
DMQEDKEPVFDAANNLMLCIEAMNSMLNNITINKSNMLKAAEHDYSTATDLADWLVKNLNLSFRESHETTGQIVKLAEQN
HCKLHELTLEQMKTIIPSITEDVFSILSVKNSVDSRTSYGGTAPANVIEAIKRGKLYLSNITTLHSENNM
>Mature_470_residues
MKNPLWGGRFTVSPSDIMKKINESISFDKILYEEDISGSIAHCKMLVNQKIISKYEGQLIIHGLEVIQNQISSGTFEFST
DLEDIHMNIEHHLKKMIGNIAGKLHTARSRNDQVATDFKLWIRKSIVKLETLLHELQQTILNIAEANYDTIMPGFTHLQI
AQPVTLGHHLMAYFEMLKRDCSRWQDLHKRMNQCPAGSAALAGTSFPIDRHFIAQELKFDSPTENSIDAVSDRDYVIEFL
SNASICIMHLSRLAEEIILWCSYNFKFITLSDNITTGSSIMPQKKNPDAAELIRGKTGRIFASLNQILVVMKGLPLAYSK
DMQEDKEPVFDAANNLMLCIEAMNSMLNNITINKSNMLKAAEHDYSTATDLADWLVKNLNLSFRESHETTGQIVKLAEQN
HCKLHELTLEQMKTIIPSITEDVFSILSVKNSVDSRTSYGGTAPANVIEAIKRGKLYLSNITTLHSENNM

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=42.9515418502203, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=42.9515418502203, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=40.9691629955947, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=40.9691629955947, Blast_Score=369, Evalue=1e-102,
Organism=Escherichia coli, GI1790398, Length=448, Percent_Identity=44.8660714285714, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6321806, Length=450, Percent_Identity=39.7777777777778, Blast_Score=336, Evalue=4e-93,
Organism=Drosophila melanogaster, GI221473854, Length=448, Percent_Identity=37.2767857142857, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI78706858, Length=448, Percent_Identity=37.2767857142857, Blast_Score=322, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_EHRCR (Q2GFQ7)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507726.1
- ProteinModelPortal:   Q2GFQ7
- SMR:   Q2GFQ7
- STRING:   Q2GFQ7
- GeneID:   3927223
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_0937
- TIGR:   ECH_0937
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- PhylomeDB:   Q2GFQ7
- ProtClustDB:   PRK00855
- BioCyc:   ECHA205920:ECH_0937-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 53049; Mature: 53049

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNPLWGGRFTVSPSDIMKKINESISFDKILYEEDISGSIAHCKMLVNQKIISKYEGQLI
CCCCCCCCEEEECHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEE
IHGLEVIQNQISSGTFEFSTDLEDIHMNIEHHLKKMIGNIAGKLHTARSRNDQVATDFKL
EHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
WIRKSIVKLETLLHELQQTILNIAEANYDTIMPGFTHLQIAQPVTLGHHLMAYFEMLKRD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
CSRWQDLHKRMNQCPAGSAALAGTSFPIDRHFIAQELKFDSPTENSIDAVSDRDYVIEFL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
SNASICIMHLSRLAEEIILWCSYNFKFITLSDNITTGSSIMPQKKNPDAAELIRGKTGRI
CCCHHHHHHHHHHHHHHHHHEECCEEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCHH
FASLNQILVVMKGLPLAYSKDMQEDKEPVFDAANNLMLCIEAMNSMLNNITINKSNMLKA
HHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCEECCHHHHHHH
AEHDYSTATDLADWLVKNLNLSFRESHETTGQIVKLAEQNHCKLHELTLEQMKTIIPSIT
HHCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EDVFSILSVKNSVDSRTSYGGTAPANVIEAIKRGKLYLSNITTLHSENNM
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEHHHEECCCCCC
>Mature Secondary Structure
MKNPLWGGRFTVSPSDIMKKINESISFDKILYEEDISGSIAHCKMLVNQKIISKYEGQLI
CCCCCCCCEEEECHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEE
IHGLEVIQNQISSGTFEFSTDLEDIHMNIEHHLKKMIGNIAGKLHTARSRNDQVATDFKL
EHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
WIRKSIVKLETLLHELQQTILNIAEANYDTIMPGFTHLQIAQPVTLGHHLMAYFEMLKRD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
CSRWQDLHKRMNQCPAGSAALAGTSFPIDRHFIAQELKFDSPTENSIDAVSDRDYVIEFL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
SNASICIMHLSRLAEEIILWCSYNFKFITLSDNITTGSSIMPQKKNPDAAELIRGKTGRI
CCCHHHHHHHHHHHHHHHHHEECCEEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCHH
FASLNQILVVMKGLPLAYSKDMQEDKEPVFDAANNLMLCIEAMNSMLNNITINKSNMLKA
HHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCEECCHHHHHHH
AEHDYSTATDLADWLVKNLNLSFRESHETTGQIVKLAEQNHCKLHELTLEQMKTIIPSIT
HHCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EDVFSILSVKNSVDSRTSYGGTAPANVIEAIKRGKLYLSNITTLHSENNM
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA