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The map label for this gene is serS

Identifier: 88607906

GI number: 88607906

Start: 441782

End: 443068

Strand: Reverse

Name: serS

Synonym: APH_0427

Alternate gene names: 88607906

Gene position: 443068-441782 (Counterclockwise)

Preceding gene: 88606708

Following gene: 88606704

Centisome position: 30.11

GC content: 42.42

Gene sequence:

>1287_bases
ATGCATGATATCGAGTTTATAAAAAACAACCCTGAACTTTTTGATAAAGCAATGCTGTCTCGTGGGCTCGAGAGTCAAGC
TGCAAAGATCATAGAGCTTGATTTACAAAAACGTAAACTGCTAACAGAGCTTTATGCCCTAAGAGAGCAGCGCAATGCGA
TTACTAAAGAGGTAACTGTACTAAAGCAGAGCGGCGCAGATTGCTCGTCACATGTAGAAACTTCTAAGAAGCTTGCTCAT
GAAATTTCAGAGCTTGAAGAGCGTATTAAGCGTGACACCGGGCTCTCGTACCTGCTATGTAGTCTTCCAAATATTCCTGA
TGATGCAGTACCCTTTGGCAAAAGCGCTGATGATAACGTAGAAGTTCGTTCCTACGGACAGAAGAGGAGTTTTTCTTTTG
AAATTAAACCTCACTACGTTCTTGGTGAGATGCTCAACCTCATGGACTTCCGTAGAGCTGCTTTTCTATCAGGATCCAGA
TTTTCCATATTAAGTGGTCAGCTTGCAGCTTTGGAGAGGGGCCTTGCGTCTTTTATGTTGGAGATGCATACAAAGGAGTT
TGGATACACAGAAGTTTTTCATCCATCTCTAGTCAATGACCTTGCAATGTTCAATGTGGGGCAATTACCAAAATTTACCC
ATGACTCCTTTCAGACAACTGATGCCATGCGCTTGGTGCCGACTAGTGAGGTTGTTTTGACTAACTTAGTTGCAAATACA
AATCTGCATCGTAATTCTTTACCTCTCAGGTTTACCGCGTACTCACAATGCTTCCGTTCTGAAGCTGGTAGCGCTGGGCA
AGATACCAGGGGAATGATTCGTCAGCATCAATTTAGCAAGGTAGAGTTGGTAAGTATCACCGATGCTAGCCAGTCTAATG
TAGAACTGGAGCGTATGCTATCTGTGGCTGAAGAAGTGCTAAAAAGGCTCGAGTTACCATATCGAGTGGTGCTGCTATGT
ACGGGAGACATGGGATTTTCTGCTAGCATCTCTTACGATATTGAAGTATGGATGCCTGCTCAAAATAAATACAGAGAGAT
ATCAAGTTGCTCCAATTGTAAAGACTTTCAAGCAAGAAGAATGGGCGCAAAATGTTTCTACCTAGAAAAACAGAATAAGC
GTTCTTCTTTTGTGCATACCTTGAATGGTTCAGCCTTGGCGTTAGGAAGAACTATAGCTGCTATTATGGAGAATTATCAA
AATTCAGATGGGACTATAACAATACCTGATGCTCTGCGGAAGTTCATGTCAGCTGATTATATAAGGCCTGGAACTGCTCT
TCCCTAA

Upstream 100 bases:

>100_bases
TTCAGAATCATAAATAAGCCGCATCGTGCAGTAAAATAGTCTTAACAATTGTATGGCTTATCGTATAGTATGTCTAAGCT
CTTCTGCGTAGAGATAAGTA

Downstream 100 bases:

>100_bases
AACACCGATGCTCCCTCTCCCTTAGAGCATTATTGCGCGGGAATCTTGGCACATAAATGTGCTGCAAGTTCTCAGTCCAT
GCCTTAATACCTATGCTTAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MHDIEFIKNNPELFDKAMLSRGLESQAAKIIELDLQKRKLLTELYALREQRNAITKEVTVLKQSGADCSSHVETSKKLAH
EISELEERIKRDTGLSYLLCSLPNIPDDAVPFGKSADDNVEVRSYGQKRSFSFEIKPHYVLGEMLNLMDFRRAAFLSGSR
FSILSGQLAALERGLASFMLEMHTKEFGYTEVFHPSLVNDLAMFNVGQLPKFTHDSFQTTDAMRLVPTSEVVLTNLVANT
NLHRNSLPLRFTAYSQCFRSEAGSAGQDTRGMIRQHQFSKVELVSITDASQSNVELERMLSVAEEVLKRLELPYRVVLLC
TGDMGFSASISYDIEVWMPAQNKYREISSCSNCKDFQARRMGAKCFYLEKQNKRSSFVHTLNGSALALGRTIAAIMENYQ
NSDGTITIPDALRKFMSADYIRPGTALP

Sequences:

>Translated_428_residues
MHDIEFIKNNPELFDKAMLSRGLESQAAKIIELDLQKRKLLTELYALREQRNAITKEVTVLKQSGADCSSHVETSKKLAH
EISELEERIKRDTGLSYLLCSLPNIPDDAVPFGKSADDNVEVRSYGQKRSFSFEIKPHYVLGEMLNLMDFRRAAFLSGSR
FSILSGQLAALERGLASFMLEMHTKEFGYTEVFHPSLVNDLAMFNVGQLPKFTHDSFQTTDAMRLVPTSEVVLTNLVANT
NLHRNSLPLRFTAYSQCFRSEAGSAGQDTRGMIRQHQFSKVELVSITDASQSNVELERMLSVAEEVLKRLELPYRVVLLC
TGDMGFSASISYDIEVWMPAQNKYREISSCSNCKDFQARRMGAKCFYLEKQNKRSSFVHTLNGSALALGRTIAAIMENYQ
NSDGTITIPDALRKFMSADYIRPGTALP
>Mature_428_residues
MHDIEFIKNNPELFDKAMLSRGLESQAAKIIELDLQKRKLLTELYALREQRNAITKEVTVLKQSGADCSSHVETSKKLAH
EISELEERIKRDTGLSYLLCSLPNIPDDAVPFGKSADDNVEVRSYGQKRSFSFEIKPHYVLGEMLNLMDFRRAAFLSGSR
FSILSGQLAALERGLASFMLEMHTKEFGYTEVFHPSLVNDLAMFNVGQLPKFTHDSFQTTDAMRLVPTSEVVLTNLVANT
NLHRNSLPLRFTAYSQCFRSEAGSAGQDTRGMIRQHQFSKVELVSITDASQSNVELERMLSVAEEVLKRLELPYRVVLLC
TGDMGFSASISYDIEVWMPAQNKYREISSCSNCKDFQARRMGAKCFYLEKQNKRSSFVHTLNGSALALGRTIAAIMENYQ
NSDGTITIPDALRKFMSADYIRPGTALP

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=348, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI8923421, Length=453, Percent_Identity=30.4635761589404, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI225579074, Length=449, Percent_Identity=30.2895322939866, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1787120, Length=436, Percent_Identity=44.7247706422018, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17539260, Length=459, Percent_Identity=29.4117647058824, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17542084, Length=321, Percent_Identity=30.2180685358255, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=445, Percent_Identity=28.9887640449438, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6321799, Length=326, Percent_Identity=34.0490797546012, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24581334, Length=331, Percent_Identity=32.6283987915408, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17737985, Length=277, Percent_Identity=36.101083032491, Blast_Score=158, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ANAPZ (Q2GKS1)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505030.1
- STRING:   Q2GKS1
- GeneID:   3931299
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0427
- NMPDR:   fig|212042.5.peg.414
- TIGR:   APH_0427
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q2GKS1
- ProtClustDB:   PRK05431
- BioCyc:   APHA212042:APH_0427-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48222; Mature: 48222

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 282-282 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIEFIKNNPELFDKAMLSRGLESQAAKIIELDLQKRKLLTELYALREQRNAITKEVTV
CCCCHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKQSGADCSSHVETSKKLAHEISELEERIKRDTGLSYLLCSLPNIPDDAVPFGKSADDNV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCC
EVRSYGQKRSFSFEIKPHYVLGEMLNLMDFRRAAFLSGSRFSILSGQLAALERGLASFML
HHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EMHTKEFGYTEVFHPSLVNDLAMFNVGQLPKFTHDSFQTTDAMRLVPTSEVVLTNLVANT
HHHHHHCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHCC
NLHRNSLPLRFTAYSQCFRSEAGSAGQDTRGMIRQHQFSKVELVSITDASQSNVELERML
CCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHH
SVAEEVLKRLELPYRVVLLCTGDMGFSASISYDIEVWMPAQNKYREISSCSNCKDFQARR
HHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEEEEEEECCCHHHHHHHHCCCCHHHHHHH
MGAKCFYLEKQNKRSSFVHTLNGSALALGRTIAAIMENYQNSDGTITIPDALRKFMSADY
CCCEEEEEECCCCCCHHEEECCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHCCC
IRPGTALP
CCCCCCCC
>Mature Secondary Structure
MHDIEFIKNNPELFDKAMLSRGLESQAAKIIELDLQKRKLLTELYALREQRNAITKEVTV
CCCCHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKQSGADCSSHVETSKKLAHEISELEERIKRDTGLSYLLCSLPNIPDDAVPFGKSADDNV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCC
EVRSYGQKRSFSFEIKPHYVLGEMLNLMDFRRAAFLSGSRFSILSGQLAALERGLASFML
HHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EMHTKEFGYTEVFHPSLVNDLAMFNVGQLPKFTHDSFQTTDAMRLVPTSEVVLTNLVANT
HHHHHHCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHCC
NLHRNSLPLRFTAYSQCFRSEAGSAGQDTRGMIRQHQFSKVELVSITDASQSNVELERML
CCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHH
SVAEEVLKRLELPYRVVLLCTGDMGFSASISYDIEVWMPAQNKYREISSCSNCKDFQARR
HHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEEEEEEECCCHHHHHHHHCCCCHHHHHHH
MGAKCFYLEKQNKRSSFVHTLNGSALALGRTIAAIMENYQNSDGTITIPDALRKFMSADY
CCCEEEEEECCCCCCHHEEECCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHCCC
IRPGTALP
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA