Click here to switch to the map view.

The map label for this gene is typA [H]

Identifier: 88607727

GI number: 88607727

Start: 474418

End: 476256

Strand: Direct

Name: typA [H]

Synonym: APH_0451

Alternate gene names: 88607727

Gene position: 474418-476256 (Clockwise)

Preceding gene: 88607130

Following gene: 88607840

Centisome position: 32.25

GC content: 44.32

Gene sequence:

>1839_bases
ATGTCGAGTGGCTACGATTCCATACGTAATTTAGCTATTGTCGCGCACGTGGATCATGGAAAGACCACGTTGCTGGATAG
TATGCTAAGGCAGAGTGGTGCTTTTAGAGATAATCAAGATGTTGTGGACCGTGTTATGGATAGCAATGATCTTGAGAGGG
AGCGTGGTATTACCATCTTGGCCAAGTGTACTGCCATTACTTGGAAGAACCATAAGATCAATGTTATCGATACTCCTGGA
CATGCTGACTTCGGTGGTGAAGTGGAGCGGGTACTGTCTATGGCAGATGGGGTATTGTTGCTTGTAGATGCCTCTGAGGG
CCCTATGCCTCAGACAAAATTTGTGCTCTCAAAAGCGCTAAAGGCTAAATTATTGCCCATAGTTGTTGTTAATAAGGTAG
ATCGTCCAGATAGTCGCGTAAGTGAGGTTCTTGATGAGGTTTATGAACTTTTTATCAATCTGGATGCTACGAGTGAGCAG
TTAGATTTCCCGGTTCTCTATGCTTCTGGTAGAGAAGGTTGGTGCTCTAAGAGTTTGACTGATGAGAAGAAGGGGTTAGA
GCCGCTGTTTGAGGGAATATTAGAGCATATAAAGCCAAAACAGTACGACTTAAATGCGCCGTTTAGTATGCTATTGACGT
TATTGGAGTCAGACAAGTTTTTGGGTAGGGTGCTGACTGGTAAGGTTTATGGCGGTAGGGCCAAGATAAACTCACAGGTG
AAGGTATTGAACCTCGCTGGTGAGGTTGTAGAGAGTGGTAGGCTCACGAAGCTTTTGTCTTTTTCGGGGCTAAAAAGGGT
TCCTGTTGAAGAGGCAGATGCGGGTGACATAATAGCTGTTGCAGGGCTGGAAAGGGCTTCTGTATCTGATAGCATTGTAG
ATGTATCTGTAACTGTGCCTATAGAGTCTACTCCTGTAGATCCTCCAACTATGGCTGTGACTATTGGTGTGAATGACTCG
CCAATTGCAGGGACTGAGGGAACGAAATTGACTTCTACTGCTATAAAGCAGAGGTTGCTTTCTGAAGCGGAAACTAATGT
TGCGATTACTGTAAAAGAAGGTGCTAGAAGTGAGGCCTATGAGGTAGGCGGTAGAGGTGAATTGCAGCTTGGTGTCTTGA
TAGAGACAATGAGGCGTGAAGGGTTTGAGCTTTCTGTATCGCGACCGCGTGTGATTTTTAAAAAGGAAGGTTCCACAATA
TTAGAGCCTATAGAAGAGGTGATAATAGATGTAGATGAAGAGTATAGTGGCGTTATAATGGAAAAGCTGAGCTTCCGGAA
AGGTGACATGCAAGATATGACTCCTTCTGGGAAGGGCAGGGTTAGAATGGTGTTTTTAATGCCGTCACGTGGTCTAATAG
GTTACCATGGGGAGTTTTTAACAGACTCTAGAGGCACCGGTATAATGAACAGATTGTTCCATGGATATGCTCCACATAAG
GGGGAAATTTCTGGAAGGATGAACGGTGTGCTTATTTCTACAGGGCAGGGAGAGGCCGTTGCATATGCCATTTTTAACTT
ACAAGATCGGGGTATGATGTTTATCAAGCCTCAGGATAAAGTTTATATGGGGATGATTGTTGGGCTTCATAATAGAAATA
ATGATATTGAAGTCAATGTGCTGAAGGGTAAGCAGTTGACTAATGTGAGGGCTGCAGGATCGGATGAAGCTGTGAGGTTA
GTTCCGCCGAAAATGATGTCTTTGGAGGAGATGATAGGGTTCATCAATGACGATGAGCTGGTTGAATGTACTCCGAAATC
AATAAGGTTGAGGAAGAGATTCCTTGATCCAAACGAGCGGAAGCGCTTTGCCAGATCTAAGGGAATTATCGAAGGTTAG

Upstream 100 bases:

>100_bases
AGTAGCATGGTGGGATAACTTACGAGAAGTGTGTTTTTATCTTTGATTATTTTGGCTAATAATATAGATTTATCCCATTG
CGTTTTAGAGAAGATAAATA

Downstream 100 bases:

>100_bases
ATTATGTTGGGATCTCCAATAGGGGATCCTGGCTATTAGGCACTTTATTTGAATATTGCTGTGCTCTGGTATTTAGGCTG
ACGTTTGGGTGAGCTTTGCC

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MSSGYDSIRNLAIVAHVDHGKTTLLDSMLRQSGAFRDNQDVVDRVMDSNDLERERGITILAKCTAITWKNHKINVIDTPG
HADFGGEVERVLSMADGVLLLVDASEGPMPQTKFVLSKALKAKLLPIVVVNKVDRPDSRVSEVLDEVYELFINLDATSEQ
LDFPVLYASGREGWCSKSLTDEKKGLEPLFEGILEHIKPKQYDLNAPFSMLLTLLESDKFLGRVLTGKVYGGRAKINSQV
KVLNLAGEVVESGRLTKLLSFSGLKRVPVEEADAGDIIAVAGLERASVSDSIVDVSVTVPIESTPVDPPTMAVTIGVNDS
PIAGTEGTKLTSTAIKQRLLSEAETNVAITVKEGARSEAYEVGGRGELQLGVLIETMRREGFELSVSRPRVIFKKEGSTI
LEPIEEVIIDVDEEYSGVIMEKLSFRKGDMQDMTPSGKGRVRMVFLMPSRGLIGYHGEFLTDSRGTGIMNRLFHGYAPHK
GEISGRMNGVLISTGQGEAVAYAIFNLQDRGMMFIKPQDKVYMGMIVGLHNRNNDIEVNVLKGKQLTNVRAAGSDEAVRL
VPPKMMSLEEMIGFINDDELVECTPKSIRLRKRFLDPNERKRFARSKGIIEG

Sequences:

>Translated_612_residues
MSSGYDSIRNLAIVAHVDHGKTTLLDSMLRQSGAFRDNQDVVDRVMDSNDLERERGITILAKCTAITWKNHKINVIDTPG
HADFGGEVERVLSMADGVLLLVDASEGPMPQTKFVLSKALKAKLLPIVVVNKVDRPDSRVSEVLDEVYELFINLDATSEQ
LDFPVLYASGREGWCSKSLTDEKKGLEPLFEGILEHIKPKQYDLNAPFSMLLTLLESDKFLGRVLTGKVYGGRAKINSQV
KVLNLAGEVVESGRLTKLLSFSGLKRVPVEEADAGDIIAVAGLERASVSDSIVDVSVTVPIESTPVDPPTMAVTIGVNDS
PIAGTEGTKLTSTAIKQRLLSEAETNVAITVKEGARSEAYEVGGRGELQLGVLIETMRREGFELSVSRPRVIFKKEGSTI
LEPIEEVIIDVDEEYSGVIMEKLSFRKGDMQDMTPSGKGRVRMVFLMPSRGLIGYHGEFLTDSRGTGIMNRLFHGYAPHK
GEISGRMNGVLISTGQGEAVAYAIFNLQDRGMMFIKPQDKVYMGMIVGLHNRNNDIEVNVLKGKQLTNVRAAGSDEAVRL
VPPKMMSLEEMIGFINDDELVECTPKSIRLRKRFLDPNERKRFARSKGIIEG
>Mature_611_residues
SSGYDSIRNLAIVAHVDHGKTTLLDSMLRQSGAFRDNQDVVDRVMDSNDLERERGITILAKCTAITWKNHKINVIDTPGH
ADFGGEVERVLSMADGVLLLVDASEGPMPQTKFVLSKALKAKLLPIVVVNKVDRPDSRVSEVLDEVYELFINLDATSEQL
DFPVLYASGREGWCSKSLTDEKKGLEPLFEGILEHIKPKQYDLNAPFSMLLTLLESDKFLGRVLTGKVYGGRAKINSQVK
VLNLAGEVVESGRLTKLLSFSGLKRVPVEEADAGDIIAVAGLERASVSDSIVDVSVTVPIESTPVDPPTMAVTIGVNDSP
IAGTEGTKLTSTAIKQRLLSEAETNVAITVKEGARSEAYEVGGRGELQLGVLIETMRREGFELSVSRPRVIFKKEGSTIL
EPIEEVIIDVDEEYSGVIMEKLSFRKGDMQDMTPSGKGRVRMVFLMPSRGLIGYHGEFLTDSRGTGIMNRLFHGYAPHKG
EISGRMNGVLISTGQGEAVAYAIFNLQDRGMMFIKPQDKVYMGMIVGLHNRNNDIEVNVLKGKQLTNVRAAGSDEAVRLV
PPKMMSLEEMIGFINDDELVECTPKSIRLRKRFLDPNERKRFARSKGIIEG

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=534, Percent_Identity=26.0299625468165, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=40.6015037593985, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=40.8163265306122, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4503483, Length=163, Percent_Identity=36.8098159509202, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI25306287, Length=160, Percent_Identity=38.75, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI25306283, Length=160, Percent_Identity=38.75, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI19923640, Length=160, Percent_Identity=38.75, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI217272892, Length=175, Percent_Identity=33.7142857142857, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI217272894, Length=175, Percent_Identity=33.7142857142857, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI34147630, Length=300, Percent_Identity=28.3333333333333, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=37.8378378378378, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=37.8378378378378, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=37.8378378378378, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=31.0077519379845, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI223555963, Length=337, Percent_Identity=25.5192878338279, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI5729864, Length=337, Percent_Identity=25.5192878338279, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI48994988, Length=602, Percent_Identity=50.8305647840532, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1788922, Length=503, Percent_Identity=25.0497017892644, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1789738, Length=148, Percent_Identity=38.5135135135135, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790835, Length=146, Percent_Identity=32.1917808219178, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790412, Length=248, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789737, Length=248, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17557151, Length=236, Percent_Identity=33.0508474576271, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=40.8450704225352, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=146, Percent_Identity=41.0958904109589, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=39.2307692307692, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=39.2307692307692, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17552882, Length=194, Percent_Identity=31.4432989690722, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17556456, Length=146, Percent_Identity=35.6164383561644, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323320, Length=515, Percent_Identity=27.1844660194175, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324707, Length=163, Percent_Identity=38.0368098159509, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=163, Percent_Identity=38.0368098159509, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323098, Length=139, Percent_Identity=40.2877697841727, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324166, Length=170, Percent_Identity=36.4705882352941, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322359, Length=148, Percent_Identity=36.4864864864865, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324761, Length=241, Percent_Identity=31.1203319502075, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI78706572, Length=526, Percent_Identity=28.1368821292776, Blast_Score=139, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24582462, Length=147, Percent_Identity=40.8163265306122, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI221458488, Length=160, Percent_Identity=40.625, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585709, Length=167, Percent_Identity=35.9281437125749, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24585711, Length=167, Percent_Identity=35.9281437125749, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24585713, Length=167, Percent_Identity=35.9281437125749, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28574573, Length=137, Percent_Identity=37.956204379562, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21357743, Length=136, Percent_Identity=38.2352941176471, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI19921738, Length=248, Percent_Identity=29.4354838709677, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281363316, Length=297, Percent_Identity=26.5993265993266, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17864358, Length=297, Percent_Identity=26.5993265993266, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28572034, Length=146, Percent_Identity=32.8767123287671, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67282; Mature: 67151

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGYDSIRNLAIVAHVDHGKTTLLDSMLRQSGAFRDNQDVVDRVMDSNDLERERGITIL
CCCCHHHHCCEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHCCCEEE
AKCTAITWKNHKINVIDTPGHADFGGEVERVLSMADGVLLLVDASEGPMPQTKFVLSKAL
EEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
KAKLLPIVVVNKVDRPDSRVSEVLDEVYELFINLDATSEQLDFPVLYASGREGWCSKSLT
HHHCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEECCCCCCCCCCCC
DEKKGLEPLFEGILEHIKPKQYDLNAPFSMLLTLLESDKFLGRVLTGKVYGGRAKINSQV
CHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHEECEEECCCEEECCCE
KVLNLAGEVVESGRLTKLLSFSGLKRVPVEEADAGDIIAVAGLERASVSDSIVDVSVTVP
EEEEEHHHHHHCCCCEEHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEE
IESTPVDPPTMAVTIGVNDSPIAGTEGTKLTSTAIKQRLLSEAETNVAITVKEGARSEAY
ECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHH
EVGGRGELQLGVLIETMRREGFELSVSRPRVIFKKEGSTILEPIEEVIIDVDEEYSGVIM
CCCCCCCEEHHHHHHHHHHCCCEEEECCCEEEEEECCCHHHHHHHHHHEECCCCCCHHHH
EKLSFRKGDMQDMTPSGKGRVRMVFLMPSRGLIGYHGEFLTDSRGTGIMNRLFHGYAPHK
HHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCEECCCCCCHHHHHHHHCCCCCC
GEISGRMNGVLISTGQGEAVAYAIFNLQDRGMMFIKPQDKVYMGMIVGLHNRNNDIEVNV
CCCCCCCCEEEEECCCCCEEEEEEEEECCCCEEEECCCCCEEEEEEEEEECCCCCEEEEE
LKGKQLTNVRAAGSDEAVRLVPPKMMSLEEMIGFINDDELVECTPKSIRLRKRFLDPNER
ECCCCCCEEECCCCCCEEEECCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCHHH
KRFARSKGIIEG
HHHHHHCCCCCC
>Mature Secondary Structure 
SSGYDSIRNLAIVAHVDHGKTTLLDSMLRQSGAFRDNQDVVDRVMDSNDLERERGITIL
CCCHHHHCCEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHCCCEEE
AKCTAITWKNHKINVIDTPGHADFGGEVERVLSMADGVLLLVDASEGPMPQTKFVLSKAL
EEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
KAKLLPIVVVNKVDRPDSRVSEVLDEVYELFINLDATSEQLDFPVLYASGREGWCSKSLT
HHHCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEECCCCCCCCCCCC
DEKKGLEPLFEGILEHIKPKQYDLNAPFSMLLTLLESDKFLGRVLTGKVYGGRAKINSQV
CHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHEECEEECCCEEECCCE
KVLNLAGEVVESGRLTKLLSFSGLKRVPVEEADAGDIIAVAGLERASVSDSIVDVSVTVP
EEEEEHHHHHHCCCCEEHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEE
IESTPVDPPTMAVTIGVNDSPIAGTEGTKLTSTAIKQRLLSEAETNVAITVKEGARSEAY
ECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHH
EVGGRGELQLGVLIETMRREGFELSVSRPRVIFKKEGSTILEPIEEVIIDVDEEYSGVIM
CCCCCCCEEHHHHHHHHHHCCCEEEECCCEEEEEECCCHHHHHHHHHHEECCCCCCHHHH
EKLSFRKGDMQDMTPSGKGRVRMVFLMPSRGLIGYHGEFLTDSRGTGIMNRLFHGYAPHK
HHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCEECCCCCCHHHHHHHHCCCCCC
GEISGRMNGVLISTGQGEAVAYAIFNLQDRGMMFIKPQDKVYMGMIVGLHNRNNDIEVNV
CCCCCCCCEEEEECCCCCEEEEEEEEECCCCEEEECCCCCEEEEEEEEEECCCCCEEEEE
LKGKQLTNVRAAGSDEAVRLVPPKMMSLEEMIGFINDDELVECTPKSIRLRKRFLDPNER
ECCCCCCEEECCCCCCEEEECCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCHHH
KRFARSKGIIEG
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]